Yurelax Uses

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What is Yurelax?

Yurelax (Yurelax) is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain.

Yurelax is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

Yurelax may also be used for other purposes not listed in this medication guide.

Yurelax indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Yurelax® (Yurelax hydrochloride extended-release capsules) is indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. Improvement is manifested by relief of muscle spasm and its associated signs and symptoms, namely, pain, tenderness, and limitation of motion.

Limitations of Use:

Yurelax should be used only for short periods (up to two or three weeks) because adequate evidence of effectiveness for more prolonged use is not available and because muscle spasm associated with acute, painful musculoskeletal conditions is generally of short duration and specific therapy for longer periods is seldom warranted.
Yurelax has not been found effective in the treatment of spasticity associated with cerebral or spinal cord disease or in children with cerebral palsy.

How should I use Yurelax?

Use Yurelax extended-release capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Yurelax extended-release capsules by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Swallow Yurelax extended-release capsules whole. Do not break, crush, or chew before swallowing.
  • Yurelax extended-release capsules works best if it is taken at the same time each day.
  • Do not suddenly stop taking Yurelax extended-release capsules without checking with your doctor.
  • If you miss a dose of Yurelax extended-release capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Yurelax extended-release capsules.

Uses of Yurelax in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Yurelax is used along with physical therapy and rest to relieve pain, stiffness or discomfort caused by muscle injury.

Yurelax description

Yurelax is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Yurelax acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord. It is structurally similar to Amitriptyline, differing by only one double bond.

Yurelax dosage

The recommended adult dose for most patients is one (1) Yurelax 15 mg capsule taken once daily. Some patients may require up to 30 mg/day, given as one (1) Yurelax 30 mg capsule taken once daily or as two (2) Yurelax 15 mg capsules taken once daily.

  • It is recommended that doses be taken at approximately the same time each day.
  • Use of Yurelax for periods longer than two or three weeks is not recommended.

How supplied

Dosage Forms And Strengths

Extended-release capsules in the following strengths:

  • 15 mg: Capsules are orange/orange and are embossed in blue ink with “15 mg” on the body, and Cephalon “C” logo, “Cephalon,” and a dashed band on the cap.
  • 30 mg: Capsules are blue/orange and are embossed in white ink with “30 mg” on the body, and Cephalon “C” logo, “Cephalon,” and a dashed band on the cap.

Yurelax extended-release capsules are available in 15 and 30 mg strengths, packaged in bottles of 60 capsules. Yurelax 15 mg capsules (NDC 63459-700-60) are orange/orange and are embossed in blue ink with “15 mg” on the body, and Cephalon “C” logo, “Cephalon”, and a dashed band on the cap. Yurelax 30 mg capsules (NDC 63459-701-60) are blue/orange and are embossed in white ink with “30 mg” on the body, and Cephalon “C” logo, “Cephalon”, and a dashed band on the cap.

Storage And Handling

Dispense in a tight, light-resistant container as defined in the USP/NF.

Store at 25°C (77°F); excursions permitted to 15 - 30°C (59 - 86°F).

Distributed By: Teva Pharmaceuticals USA, Inc., North Wales, PA 19454. Manufactured By: Adare Pharmaceuticals, Inc., Vandalia, OH 45377. Revised August 2015

Yurelax interactions

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What other drugs will affect Yurelax?


Based on its structural similarity to tricyclic antidepressants, Yurelax may have life-threatening interactions with MAO inhibitors, may enhance the effects of alcohol, barbiturates, and other CNS depressants, may enhance the seizure risk in patients taking tramadol, or may block the antihypertensive action of guanethidine and similarly acting compounds.

Postmarketing cases of serotonin syndrome have been reported during combined use of Yurelax and other drugs, such as SSRIs, SNRIs, TCAs, tramadol, bupropion, meperidine, verapamil, or MAO inhibitors.

Drug Abuse And Dependence


Pharmacologic similarities among the tricyclic drugs require that certain withdrawal symptoms be considered when Yurelax is administered, even though they have not been reported to occur with this drug. Abrupt cessation of treatment after prolonged administration rarely may produce nausea, headache, and malaise. These are not indicative of addiction.

Yurelax side effects

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What are the possible side effects of Yurelax?

Most Common Adverse Reactions in the Yurelax Clinical Trials

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

The data described below reflect exposure to Yurelax in 253 patients in 2 clinical trials. Yurelax was studied in two double-blind, parallel-group, placebo-controlled, active-controlled trials of identical design. The study population was composed of patients with muscle spasms associated with acute painful musculoskeletal conditions. Patients received 15 mg or 30 mg of Yurelax taken orally once daily, Yurelax immediate-release (IR) 10 mg three times a day, or placebo for 14 days.

The most common adverse reactions (incidence ≥ 3% in any treatment group and greater than placebo) were dry mouth, dizziness, fatigue, constipation, nausea, dyspepsia, and somnolence.

Table 1: Incidence of the Most Common Adverse Reactions Occurring in ≥ 3% of Patients in any Treatment Group* and Greater Than Placebo in the Two Phase 3, Double-Blind Yurelax Trials



Yurelax 15 mg


Yurelax 30 mg


Dry mouth 2% 6% 14%
Dizziness 2% 3% 6%
Fatigue 2% 3% 3%
Constipation 0% 1% 3%
Somnolence 0% 1% 2%
Nausea 1% 3% 3%
Dyspepsia 1% 0% 4%
*Yurelax 15 mg QD, Yurelax 30 mg QD, or Yurelax IR tablets TID

Additional Adverse Reactions from Clinical Studies and Postmarketing Experience

The following adverse reactions have been reported in clinical studies or postmarketing experience with Yurelax, Yurelax IR, or tricyclic drugs. Because some of these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

In a postmarketing surveillance program of Yurelax IR, the adverse reactions reported most frequently were drowsiness, dry mouth, and dizziness and adverse reactions reported in 1% to 3% of the patients were: fatigue/tiredness, asthenia, nausea, constipation, dyspepsia, unpleasant taste, blurred vision, headache, nervousness, and confusion.

The following adverse reactions have been reported in postmarketing experience (Yurelax or Yurelax IR), in clinical studies of Yurelax IR (incidence < 1%), or in postmarketing experience with other tricyclic drugs:

Body as a Whole: Syncope; malaise; chest pain; edema.

Cardiovascular: Tachycardia; arrhythmia; vasodilatation; palpitation; hypotension; hypertension; myocardial infarction; heart block; stroke.

Digestive: Vomiting; anorexia; diarrhea; gastrointestinal pain; gastritis; thirst; flatulence; edema of the tongue; abnormal liver function and rare reports of hepatitis, jaundice, and cholestasis; paralytic ileus, tongue discoloration; stomatitis; parotid swelling.

Endocrine: Inappropriate ADH syndrome.

Hematologic and Lymphatic: Purpura; bone marrow depression; leukopenia; eosinophilia; thrombocytopenia.

Hypersensitivity: Anaphylaxis; angioedema; pruritus; facial edema; urticaria; rash.

Metabolic, Nutritional and Immune: Elevation and lowering of blood sugar levels; weight gain or loss.

Musculoskeletal: Local weakness; myalgia.

Nervous System and Psychiatric: Seizures, ataxia; vertigo; dysarthria; tremors; hypertonia; convulsions; muscle twitching; disorientation; insomnia; depressed mood; abnormal sensations; anxiety; agitation; psychosis, abnormal thinking and dreaming; hallucinations; excitement; paresthesia; diplopia; serotonin syndrome; neuroleptic malignant syndrome; decreased or increased libido; abnormal gait; delusions; aggressive behavior; paranoia; peripheral neuropathy; Bell's palsy; alteration in EEG patterns; extrapyramidal symptoms.

Respiratory: Dyspnea.

Skin: Sweating; photosensitization; alopecia.

Special Senses: Ageusia; tinnitus.

Urogenital: Urinary frequency and/or retention; impaired urination; dilatation of urinary tract; impotence; testicular swelling; gynecomastia; breast enlargement; galactorrhea.

Yurelax contraindications

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What is the most important information I should know about Yurelax?


Do not take Yurelax if you have used an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take Yurelax before the MAO inhibitor has cleared from your body.

You should not take Yurelax if you have recently had a heart attack, or if you have a heart rhythm disorder, congestive heart failure, heart block, or an overactive thyroid.

Yurelax can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol, which can increase some of the side effects of Yurelax.

Active ingredient matches for Yurelax:

Cyclobenzaprine in Spain.

Cyclobenzaprine Hcl

List of Yurelax substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
MOBRINE 10 MG TABLET IR 1 strip / 10 tablet irs each (Ranbaxy Laboratories Ltd)$ 1.36
Musgud 5 mg x 500's
Musgud 10 mg x 1000's
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Mylan-cyclobenzaprine tablet 10 mg (Mylan Pharmaceuticals Ulc (Canada))
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Novo-cycloprine tablet 10 mg (Teva Canada Limited (Canada))
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
PHL-cyclobenzaprine tablet 10 mg (Pharmel Inc (Canada))
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Ratio-cyclobenzaprine tablet 10 mg (Ratiopharm Inc Division Of Teva Canada Limited (Canada))
Tablet; Oral; Cyclobenzaprine Hydrochloride 5 mg
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet, Film-Coated; Oral; Cyclobenzaprine Hydrochloride 10 mg
Riva-cyclobenzaprine tablet 10 mg (Laboratoire Riva Inc (Canada))
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet, Film-Coated; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet, Film-Coated; Oral; Cyclobenzaprine Hydrochloride 5 mg
Tablet, Film-Coated; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet, Film-Coated; Oral; Cyclobenzaprine Hydrochloride 5 mg
Tablet, Film-Coated; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Tablet; Oral; Cyclobenzaprine Hydrochloride 10 mg
Zym-cyclobenzaprine tablet 10 mg (Zymcan Pharmaceuticals Inc (Canada))


  1. PubChem. "cyclobenzaprine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "cyclobenzaprine". http://www.drugbank.ca/drugs/DB00924 (accessed September 17, 2018).
  3. MeSH. "Tranquilizing Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).


The results of a survey conducted on ndrugs.com for Yurelax are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Yurelax. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

2 consumers reported useful

Was the Yurelax drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.

Consumer reported price estimates

No survey data has been collected yet

6 consumers reported time for results

To what extent do I have to use Yurelax before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Yurelax. To get the time effectiveness of using Yurelax drug by other patients, please click here.
1 day3
2 days1
1 month1
1 week1

37 consumers reported age

> 6018

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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