Zadro CV DT Uses

• Zadro CV DT indications
• Uses of Zadro CV DT in details
• Zadro CV DT description
• Zadro CV DT dosage
• Zadro CV DT interactions
• Zadro CV DT side effects
• Zadro CV DT contraindications

What is Zadro CV DT?

Zadro CV DT is used to treat bacterial infections in many different parts of the body. It belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, Zadro CV DT will not work for colds, flu, or other virus infections.

Zadro CV DT is available only with your doctor's prescription.

Zadro CV DT indications

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Zadro CV DT (Zadro CV DT hemihydrate) Tablets and Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) Capsules and other antibacterial drugs, Zadro CV DT (Zadro CV DT hemihydrate) Tablets and Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) is indicated for the treatment of patients with infection caused by susceptible strains of the designated organisms in the following diseases:

Urinary tract infections caused by E. coli, P. mirabilis, and Klebsiella species.

Skin and skin structure infections caused by staphylococci and/or streptococci.

Pharyngitis and/or tonsillitis caused by Streptococcus pyogenes (Group A beta-hemolytic Streptococci).

Note: Only penicillin by the intramuscular route of administration has been shown to be effective in the prophylaxis of rheumatic fever. Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) is generally effective in the eradication of streptococci from the oropharynx. However, data establishing the efficacy of Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) for the prophylaxis of subsequent rheumatic fever are not available.

Note: Culture and susceptibility tests should be initiated prior to and during therapy.

Renal function studies should be performed when indicated.

How should I use Zadro CV DT?

Use Zadro CV DT suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Zadro CV DT suspension by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Shake well before each use.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• To clear up your infection completely, take Zadro CV DT suspension for the full course of treatment. Keep taking it even if you feel better in a few days.
• If you miss a dose of Zadro CV DT suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zadro CV DT suspension.

Uses of Zadro CV DT in details

Use: Labeled Indications

Pharyngitis and/or tonsillitis: Treatment of pharyngitis and/or tonsillitis caused by Streptococcus pyogenes (group A beta-hemolytic streptococci).

Skin and skin structure infections: Treatment of skin and skin structure infections caused by staphylococci and/or streptococci.

Urinary tract infection: Treatment of urinary tract infections caused by Escherichia coli, Proteus mirabilis, and Klebsiella species.

Off Label Uses

Prosthetic joint infection with Staphylococci (oxacillin-susceptible)

Based on the Infectious Diseases Society of America (IDSA) guidelines for the management of prosthetic joint infection, Zadro CV DT is an effective and recommended agent for chronic oral antimicrobial suppression of prosthetic joint infection with Staphylococci (oxacillin-susceptible) after completion of parenteral therapy.

Zadro CV DT description

Zadro CV DT (Zadro CV DT monohydrate) is a semisynthetic cephalosporin antibiotic intended for oral administration. It is a white to yellowish-white crystalline powder. It is soluble in water and it is acid-stable.

It is 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[amino(4-hydroxy-phenyl)acetyl]amino]-3-methyl-8-oxo-,monohydrate, [6R-[6(α),7(β)(R*)]. It has the formula C₁₆H₁₇N₃O₅S·H₂O and a molecular weight of 381.40.

Zadro CV DT dosage

Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) is acid-stable and may be administered orally without regard to meals. Administration with food may be helpful in diminishing potential gastrointestinal complaints occasionally associated with oral cephalosporin therapy.

Adults

Urinary Tract Infections: For uncomplicated lower urinary tract infections (i.e., cystitis) the usual dosage is 1 or 2 g per day in single (q.d.) or divided doses (b.i.d).

For all other urinary tract infections the usual dosage is 2 g per day in divided doses (b.i.d).

Skin and Skin Structure Infections: For skin and skin structure infections the usual dosage is 1 g per day in single (q.d.) or divided doses (b.i.d).

Pharyngitis and Tonsillitis: Treatment of group A beta-hemolytic streptococcal pharyngitis and tonsillitis - 1 g per day in single (q.d.) or divided doses (b.i.d) for 10 days.

Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) oral suspension may be more suitable for pediatric patients

Children

For urinary tract infections, the recommended daily dosage for children is 30 mg/kg/day in divided doses every 12 hours. For pharyngitis, tonsillitis, and impetigo, the recommended daily dosage for children is 30 mg/kg/day in a single dose or in equally divided doses every 12 hours. For other skin and skin structure infections, the recommended daily dosage is 30 mg/kg/day in equally divided doses every 12 hours. In the treatment of beta-hemolytic streptococcal infections, a therapeutic dosage of Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) should be administered for at least 10 days.

Renal Impairment

In patients with renal impairment, the dosage of Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) should be adjusted according to creatinine clearance rates to prevent drug accumulation. The following schedule is suggested. In adults, the initial dose is 1000 mg of Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) and the maintenance dose (based on the creatinine clearance rate [mL/min/1.73 M]) is 500 mg at the time intervals listed below.

Patients with creatinine clearance rates over 50 mL/min may be treated as if they were patients having normal renal function

How supplied

Zadro CV DT tablets contain Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) hemihydrate equivalent to 1 gram of Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) and are supplied as follows:

Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) 1 gram Tablets: white, oblong, biconvex film-coated tablets, debossed on one side with ‘CF 512’ and scored on the other side.

(50s) NDC 63304-512-50

(100s) NDC 63304-512-01

(unit-dose 100s) NDC 63304-512-80

Zadro CV DT capsules contain Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) hemihydrate equivalent to 500 mg of Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) and are supplied as follows:

Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate) 500 mg Capsules: white opaque body and brown opaque cap imprinted with ‘C’ on the cap and ‘582’ on the body.

(50s) NDC 63304-582-50

(100s) NDC 63304-582-01

Dispense in a tight container as defined in the USP.

Store at 20 - 25° C (68 - 77° F)..Manufactured for: Ranbaxy Pharmaceuticals Inc. Jacksonville, FL 32216 USA by: Ranbaxy Laboratories Ltd. New Delhi - 110 019, India March 2007

FDA rev date: 3/2007

Zadro CV DT interactions

See also:
What other drugs will affect Zadro CV DT?

Positive direct Coombs' tests have been reported during treatment with the cephalosporin antibiotics. In hematologic studies or in transfusion cross-matching procedures when antiglobulin tests are performed on the minor side or in Coombs' testing of newborns whose mothers have received cephalosporin antibiotics before parturition, it should be recognized that a positive Coombs' test may be due to Zadro CV DT.

Zadro CV DT side effects

See also:
What are the possible side effects of Zadro CV DT?

Gastrointestinal

Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment. Dyspepsia, nausea and vomiting have been reported rarely. Diarrhea has also occurred.

Hypersensitivity

Allergies (in the form of rash, urticaria, angioedema, and pruritus) have been observed. These reactions usually subsided upon discontinuation of the drug. Anaphylaxis has also been reported.

Other

Other reactions have included hepatic dysfunction including cholestasis and elevations in serum transaminase, genital pruritus, genital moniliasis, vaginitis, moderate transient neutropenia, fever. Agranulocytosis, thrombocytopenia,idiosyncratic hepatic failure, erythema multiforme, Stevens-Johnson syndrome, serum sickness, and arthralgia have been rarely reported.

In addition to the adverse reactions listed above which have been observed in patients treated with Zadro CV DT (Zadro CV DT (Zadro CV DT hemihydrate) hemihydrate), the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics:

Toxic epidermal necrolysis, abdominal pain, superinfection, renal dysfunction, toxic nephropathy, hepatic dysfunction including cholestasis, aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs’ test, increased BUN, increased creatinine, elevated alkaline phosphatase, elevated aspartate aminotransferase (AST), elevated alanine aminotransferase (ALT), elevated bilirubin, elevated LDH, eosinophilia, pancytopenia, neutropenia.

Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment, when the dosage was not reduced. If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.

Zadro CV DT contraindications

See also:
What is the most important information I should know about Zadro CV DT?

Do not take this medication if you are allergic to Zadro CV DT, or to similar antibiotics, such as Ceftin, Cefzil, Keflex, Omnicef, and others.

Before taking this medication, tell your doctor if you are allergic to any drugs (especially penicillin). Also tell your doctor if you have kidney disease or a history of intestinal problems.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Zadro CV DT will not treat a viral infection such as the common cold or flu.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Active ingredient matches for Zadro CV DT:

Cefadroxil

References

1. DailyMed. "CEFADROXIL/CEFADROXIL HEMIHYDRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "cefadroxil". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "cefadroxil". http://www.drugbank.ca/drugs/DB01140 (accessed September 17, 2018).

Reviews

User reports

Consumer reviews

Information checked by Dr. Sachin Kumar, MD Pharmacology