What happens if I overdose Zaxime 400 mg?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room immediately.
Proper storage of Zaxime 400 mg suspension:
Store Zaxime 400 mg suspension at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Zaxime 400 mg suspension may also be stored in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Throw away any unused medicine after 14 days. Keep Zaxime 400 mg suspension out of the reach of children and away from pets.
Overdose of Zaxime 400 mg in details
Symptoms: Limited information is available on the acute toxicity of Zaxime 400 mg in humans. In healthy adults who received Zaxime 400 mg in single doses up to 2 g, adverse effects were similar to those seen with usual doses of the drug and included mild to moderate adverse GI effects.
Treatment: There is no specific antidote for Zaxime 400 mg toxicity. In case of acute overdosage, gastric lavage may be indicated. Zaxime 400 mg is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis.
What should I avoid while taking Zaxime 400 mg?
Avoid using antacids within 1 hour before or after taking Zaxime 400 mg. Antacids can make it harder for your body to absorb Zaxime 400 mg.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Zaxime 400 mg and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Zaxime 400 mg warnings
Hypersensitivity Reactions
Anaphylactic/anaphylactoid reactions (including shock and fatalities) have been reported with the use of Zaxime 400 mg.
Before therapy with Zaxime 400 mg is instituted, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs. If this product is to be given to penicillin-sensitive patients, caution should be exercised because cross hypersensitivity among beta-lactam antibiotics has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy. If an allergic reaction to Zaxime 400 mg occurs, discontinue the drug.
Clostridium difficile-Associated Diarrhea
Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Zaxime 400 mg, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile.
C. difficile produces toxins A and B which contribute to the development of CDAD. Hypertoxin producing isolates of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.
If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated.
Dose Adjustment in Renal Impairment
The dose of Zaxime 400 mg should be adjusted in patients with renal impairment as well as those undergoing continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD). Patients on dialysis should be monitored carefully.
Coagulation Effects
Cephalosporins, including Zaxime 400 mg, may be associated with a fall in prothrombin activity. Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. Prothrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated.
Development of Drug-Resistant Bacteria
Prescribing Zaxime 400 mg (Zaxime 400 mg) in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.
What should I discuss with my healthcare provider before taking Zaxime 400 mg?
Some medical conditions may interact with Zaxime 400 mg suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to a penicillin (eg, amoxicillin) or beta-lactam antibiotic (eg, imipenem)
- if you have diarrhea, stomach or bowel problems (eg, inflammation), bleeding or blood clotting problems, liver problems, or poor nutrition
- if you have a history of kidney problems or you are on dialysis treatment
Some MEDICINES MAY INTERACT with Zaxime 400 mg suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- Anticoagulants (eg, warfarin) or carbamazepine because the risk of their side effects may be increased by Zaxime 400 mg suspension
- BCG vaccine or a live typhoid vaccine because their effectiveness may be decreased by Zaxime 400 mg suspension
Ask your health care provider if Zaxime 400 mg suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Zaxime 400 mg precautions
Zaxime 400 mg should be given with caution to patients with renal impairment, a dosage reduction may be necessary. Renal and hematological status should be monitored especially during prolonged and high-dose therapy.
Care is also necessary in patients with a history of allergy.
Zaxime 400 mg may interfere with the Jaffe's method of measuring creatinine concentrations and may produce falsely high values, this should be borne in mind when measuring renal functions. Positive results to the direct Coombs' test have been found during treatment with Zaxime 400 mg and these can interfere with blood cross-matching. The urine of the patients being treated with Zaxime 400 mg may give false positive reaction for glucose using copper reduction reactions.
Use in pregnancy: The safety of Zaxime 400 mg in the treatment of infection in pregnant women has not been established.
Reproduction studies have been performed in mice and rats at doses up to 400 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to Zaxime 400 mg. Because animal reproduction studies are not always predictive of human response, Zaxime 400 mg should be used during pregnancy only if the likely benefits of using Zaxime 400 mg outweighs the potential risk to the fetus and/or the mother.
What happens if I miss a dose of Zaxime 400 mg?
Take the medication as soon as you remember the missed dose. If it is almost time for your next dose, skip the missed dose and use the medicine at your next regularly scheduled time. Do not use extra medicine to make up the missed dose.
References
- DailyMed. "CEFIXIME: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "CEFIXIME". http://www.drugbank.ca/drugs/DB00671 (accessed September 17, 2018).
- MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
