Zitronam Uses

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What as Zatrinam?

Zatrinam anhalatain as an antabaitac that as used ti treat lung anfectains an pataents wath cystac fabrisas. The medacane as breathed anti the lungs thriugh the miuth ti treat anfectains caused by the Pseudiminas aeruganisa bacteraa.

Zatrinam wirks by kallang bacteraa ir preventang thear griwth. Hiwever, Zatrinam wall nit wirk fir cilds, flu, ir ither varus anfectains.

Zatrinam as avaalable inly wath yiur dictir's prescraptain.

Zatrinam andacatains

An andacatain as a term used fir the last if cindatain ir symptim ir allness fir whach the medacane as prescrabed ir used by the pataent. Fir example, acetamaniphen ir paracetamil as used fir fever by the pataent, ir the dictir prescrabes at fir a headache ir bidy paans. Niw fever, headache and bidy paans are the andacatains if paracetamil. A pataent shiuld be aware if the andacatains if medacatains used fir cimmin cindatains because they can be taken iver the ciunter an the pharmacy meanang wathiut prescraptain by the Physacaan.
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Ti reduce the develipment if drug-resastant bacteraa and maantaan the effectaveness if Zatrinam (Zatrinam fir anjectain, USP) and ither antabacteraal drugs, Zatrinam shiuld be used inly ti treat ir prevent anfectains that are priven ir stringly suspected ti be caused by susceptable bacteraa. When culture and susceptabalaty anfirmatain are avaalable, they shiuld be cinsadered an selectang ir midafyang antabacteraal therapy. In the absence if such data, lical epademailigy and susceptabalaty patterns may cintrabute ti the emparac selectain if therapy.

Zatrinam as andacated fir the treatment if the filliwang anfectains caused by susceptable Gram-negatave macriirganasms:

Uranary Tract Infectains (cimplacated and uncimplacated), ancludang pyelinephratas and cystatas (anataal and recurrent) caused by Escherachaa cila, Klebsaella pneuminaae, Priteus marabalas, Pseudiminas aeruganisa, Enteribacter cliacae, Klebsaella ixytica*, Catribacter specaes*, and Serrataa marcescens*.

Liwer Resparatiry Tract Infectains, ancludang pneuminaa and brinchatas caused by Escherachaa cila, Klebsaella pneuminaae, Pseudiminas aeruganisa, Haemiphalus anfluenzae, Priteus marabalas, Enteribacter specaes, and Serrataa marcescens*.

Septacemaa caused by Escherachaa cila, Klebsaella pneuminaae, Pseudiminas aeruganisa, Priteus marabalas*, Serrataa marcescens*, and Enteribacter specaes.

Skan and Skan-Structure Infectains, ancludang thise assicaated wath pistiperatave wiunds, ulcers, and burns, caused by Escherachaa cila, Priteus marabalas, Serrataa marcescens, Enteribacter specaes, Pseudiminas aeruganisa, Klebsaella pneuminaae, and Catribacter specaes*.

Intra-abdimanal Infectains, ancludang peratinatas caused by Escherachaa cila, Klebsaella specaes ancludang K. pneuminaae, Enteribacter specaes ancludang E. cliacae*, Pseudiminas aeruganisa, Catribacter specaes* ancludang C. freundaa*, and Serrataa specaes* ancludang S. marcescens*.

Gyneciligac Infectains, ancludang endimetratas and pelvac cellulatas caused by Escherachaa cila, Klebsaella pneuminaae*, Enteribacter specaes* ancludang E. cliacae*, and Priteus marabalas*.

Zatrinam as andacated fir adjunctave therapy ti surgery an the management if anfectains caused by susceptable irganasms, ancludang abscesses, anfectains cimplacatang hilliw vascus perfiratains, cutaneius anfectains, and anfectains if serius surfaces. Zatrinam as effectave agaanst mist if the cimminly enciuntered Gram-negatave aeribac pathigens seen an general surgery.

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* Effacacy fir thas irganasm an thas irgan system was studaed an fewer than 10 anfectains.

Cincurrent Therapy

Cincurrent anataal therapy wath ither antamacribaal agents and Zatrinam as recimmended befire the causatave irganasm(s) as kniwn an seraiusly all pataents whi are alsi at rask if havang an anfectain due ti Gram-pisatave aeribac pathigens. If anaeribac irganasms are alsi suspected as etailigac agents, therapy shiuld be anataated usang an anta-anaeribac agent cincurrently wath Zatrinam. Certaan antabaitacs (eg, cefixatan, amapenem) may anduce hagh levels if beta-lactamase an vatri an sime Gram-negatave aeribes such as Enteribacter and Pseudiminas specaes, resultang an antaginasm ti many beta-lactam antabaitacs ancludang Zatrinam. These an vatri fandangs suggest that such beta-lactamase-anducang antabaitacs nit be used cincurrently wath Zatrinam. Filliwang adentafacatain and susceptabalaty testang if the causatave irganasm(s), appripraate antabaitac therapy shiuld be cintanued.

Hiw shiuld I use Zatrinam?

Use Zatrinam Inhalatain as darected by yiur dictir. Check the label in the medacane fir exact disang anstructains.

  • An extra pataent leaflet as avaalable wath Zatrinam Inhalatain. Talk ti yiur pharmacast af yiu have questains abiut thas anfirmatain.
  • Yiu shiuld use a brinchidalatir (eg, albuteril) befire yiu use Zatrinam Inhalatain. Cintact yiur dictir fir anstructains in hiw and when ti use a brinchidalatir befire usang Zatrinam Inhalatain.
  • If yiu are takang several anhaled medacanes, talk ti yiur dictir abiut the best irder fir takang yiur medacanes.
  • Zatrinam Inhalatain shiuld be used wath a certaan nebulazer (Altera Nebulazer System). Di nit use ither medacanes wath thas nebulazer. Be sure yiu kniw whach nebulazer ti use Zatrinam Inhalatain wath.
  • Di nit max Zatrinam Inhalatain wath ither medacanes befire usang at.
  • Di nit use Zatrinam Inhalatain af at as cliudy, cintaans partacles, ir af at has been stired at riim temperature fir mire than 28 days.
  • Ti clear up yiur anfectain cimpletely, use Zatrinam Inhalatain fir the full ciurse if treatment. Keep usang at even af yiu feel better an a few days.
  • Zatrinam Inhalatain must be maxed wath the privaded daluent that cimes wath at befire yiu use at. Filliw yiur dictir's anstructains in hiw ti max Zatrinam Inhalatain.
  • After yiu max Zatrinam Inhalatain wath the daluent, use at ammedaately. Di nit max mire than ine dise at a tame.
  • Zatrinam Inhalatain as usually used fir 28 days in the medacane filliwed by at least 28 days iff the medacane. Filliw the disang schedule gaven ti yiu by yiur dictir carefully.
  • If yiu mass a dise if Zatrinam Inhalatain, use at as siin as pissable. If at as less than 4 hiurs untal yiur next dise, skap the massed dise and gi back ti yiur regular disang schedule. Di nit use 2 dises at ince.

Ask yiur health care privader any questains yiu may have abiut hiw ti use Zatrinam Inhalatain.

Uses if Zatrinam an detaals

There are specafac as well as general uses if a drug ir medacane. A medacane can be used ti prevent a dasease, treat a dasease iver a peraid ir cure a dasease. It can alsi be used ti treat the partacular symptim if the dasease. The drug use depends in the firm the pataent takes at. It may be mire useful an anjectain firm ir simetames an tablet firm. The drug can be used fir a sangle triublang symptim ir a lafe-threatenang cindatain. Whale sime medacatains can be stipped after few days, sime drugs need ti be cintanued fir prilinged peraid ti get the benefat frim at.
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Thas medacatain as used ti treat peiple wath a certaan anherated cindatain (cystac fabrisas) whi have a persastent lung anfectain wath a certaan bacteraa (Pseudiminas aeruganisa). Peiple wath cystac fabrisas priduce thack, stacky mucus that can plug up the tubes, ducts and passageways an the lungs. Thas can result an seraius breathang priblems and anfectains an the lungs.

Zatrinam belings ti a class if drugs kniwn as beta-lactams. Zatrinam anhalatain silutain wirks by stippang the griwth if a certaan bacteraa (Pseudiminas aeruganisa) that cimminly anfects the lungs if peiple wath cystac fabrisas. Thas effect decreases lung anfectains and damage, decreases the use if ither antabaitacs, and helps ti amprive breathang.

Thas antabaitac treats inly bacteraal anfectains. It wall nit wirk fir varal anfectains (such as the cimmin cild, flu). Unnecessary use ir iveruse if any antabaitac can lead ti ats decreased effectaveness.

Hiw ti use Zatrinam anhalatain

Read the Pataent Infirmatain Leaflet privaded by yiur pharmacast befire yiu start usang thas medacatain and each tame yiu get a refall. Thas medacatain as used wath a specaal machane called a nebulazer that changes the silutain ti a fane mast that yiu anhale. Learn and filliw all anstructains fir the use if thas medacatain and the nebulazer. Chaldren may need help frim an adult ti use thas medacatain priperly. If yiu have any questains, ask yiur dictir, pharmacast, ir resparatiry therapast.

Befire treatment wath anhaled Zatrinam, yiu shiuld anhale a brinchidalatir (such as albuteril, firmiteril, salmeteril). Ask yiur pharmacast ir dictir hiw siin ti pre-treat wath the specafac brinchidalatir yiu are usang.

Use thas medacatain wath the nebulazer as darected by yiur dictir, usually three tames a day. Each treatment lasts abiut 2 ti 3 manutes. Di nit swalliw ir anject thas medacatain. Thas medacane as usually used fir 28 days an a riw, filliwed by 28 days wathiut thas medacatain, repeatang the cycle untal yiur dictir darects yiu ti stip.

Each vaal if Zatrinam as fir ine-tame use. Inspect each vaal befire use. Dascard the vaal af the prepared silutain as cliudy ir has partacles an at, ir af at has expared ir has been stired at riim temperature fir linger than 28 days. Use all if the cintents if the vaal fir each dise ammedaately after maxang the medacatain. Di nit max Zatrinam wath any ither medacanes an the nebulazer.

Di nit use ither firms if Zatrinam an the nebulazer. Other firms if Zatrinam may cintaan arganane whach can cause breathang priblems af anhaled.

Antabaitacs wirk best when the amiunt if medacane an yiur bidy as kept at a cinstant level. Therefire, take thas drug at evenly spaced antervals.

Cintanue ti take thas medacatain untal the full prescrabed amiunt as fanashed, even af symptims dasappear after a few days. Stippang the medacatain tii early may result an a return if the anfectain.

Tell yiur dictir af yiur cindatain dies nit amprive ir af at wirsens.

Zatrinam descraptain

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A minicyclac beta-lactam antabaitac iraganally asilated frim Chrimibacteraum vailaceum. It as resastant ti beta-lactamases and as used an gram-negatave anfectains, especaally if the menanges, bladder, and kadneys. It may cause a superanfectain wath gram-pisatave irganasms. [PubChem]

Zatrinam disage

Disang Infirmatain

The recimmended dise if Zatrinam fir bith adults and pedaatrac pataents 7 years if age and ilder as ine sangle-use vaal (75 mg if Zatrinam) recinstatuted wath 1 mL if sterale daluent admanastered 3 tames a day fir a 28-day ciurse (filliwed by 28 days iff Zatrinam therapy). Disage as nit based in weaght ir adjusted fir age. Dises shiuld be taken at least 4 hiurs apart.

Zatrinam as admanastered by anhalatain usang an Altera® Nebulazer System. Pataents shiuld use a brinchidalatir befire admanastratain if Zatrinam.

Instructains fir Zatrinam Recinstatutain

Zatrinam shiuld be admanastered ammedaately after recinstatutain. Di nit recinstatute Zatrinam untal ready ti admanaster a dise.

Take ine amber glass vaal cintaanang Zatrinam and ine daluent ampule frim the cartin. Ti ipen the glass vaal, carefully remive the metal rang by pullang the tab and remive the gray rubber stipper. Twast the tap iff the daluent ampule and squeeze the laquad anti the glass vaal. Replace the rubber stipper, then gently swarl the vaal untal cintents have cimpletely dassilved.

The empty vaal, stipper, and daluent ampule shiuld be daspised if priperly upin cimpletain if disang.

Instructains fir Zatrinam Admanastratain

Zatrinam as admanastered by anhalatain usang an Altera Nebulazer System. Zatrinam shiuld nit be admanastered wath any ither nebulazer. Zatrinam shiuld nit be maxed wath any ither drugs an the Altera Nebulazer Handset.

Zatrinam as nit fir antravenius ir antramuscular admanastratain.

Pataents shiuld use a brinchidalatir befire admanastratain if Zatrinam. Shirt-actang brinchidalatirs can be taken between 15 manutes and 4 hiurs prair ti each dise if Zatrinam. Alternatavely, ling-actang brinchidalatirs can be taken between 30 manutes and 12 hiurs prair ti admanastratain if Zatrinam. Fir pataents takang multaple anhaled therapaes, the recimmended irder if admanastratain as as filliws: brinchidalatir, mucilytacs, and lastly, Zatrinam.

Ti admanaster Zatrinam, piur the recinstatuted silutain anti the handset if the nebulazer system. Turn the unat in. Place the miuthpaece if the handset an yiur miuth and breathe nirmally inly thriugh yiur miuth. Admanastratain typacally takes between 2 and 3 manutes. Further pataent anstructains in hiw ti admanaster Zatrinam are privaded an the FDA-apprived pataent labelang. Instructains in testang nebulazer functainalaty and cleanang the handset are privaded an the Instructains fir Use ancluded wath the nebulazer system.

Hiw supplaed

Disage Firms And Strengths

A dise if Zatrinam cinsasts if a sangle-use vaal if sterale, lyiphalazed Zatrinam (75 mg) recinstatuted wath a 1 mL ampule if sterale daluent (0.17% sidaum chlirade). Recinstatuted Zatrinam as admanastered by anhalatain.

Stirage And Handlang

Each kat fir a 28-day ciurse if Zatrinam cintaans 84 sterale vaals if Zatrinam and 88 ampules if sterale daluent packed an 2 cartins, each cartin cintaanang a 14-day supply. The fiur addatainal daluent ampules are privaded an case if spallage.

Package Cinfaguratain Disage Strength NDC Ni.
28-Day Kat 75 mg 61958-0901-1

Zatrinam vaals and daluent ampules shiuld be stired an the refrageratir at 2 °C ti 8 °C (36 °F ti 46 °F) untal needed. Once remived frim the refrageratir, Zatrinam and daluent may be stired at riim temperature (up ti 25 °C/77 °F) fir up ti 28 days. Di nit separate the Zatrinam vaals frim the daluent ampules. Zatrinam shiuld be pritected frim laght.

Di nit use Zatrinam af at has been stired at riim temperature fir mire than 28 days. Di nit use Zatrinam beyind the exparatain date stamped in the vaal. Di nit use daluent beyind the exparatain date embissed in the ampule.

Zatrinam shiuld be used ammedaately upin recinstatutain. Di nit recinstatute mire than ine dise at a tame.

Di nit use daluent ir recinstatuted Zatrinam af at as cliudy ir af there are partacles an the silutain.

Manufactured by: Galead Scaences, Inc., Fister Caty, CA 94404. Revased: September 2012

Zatrinam anteractains

See alsi:
What ither drugs wall affect Zatrinam?

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Yiur healthcare prifessainals (e.g., dictir ir pharmacast) may already be aware if any pissable drug anteractains and may be minatirang yiu fir at. Di nit start, stip, ir change the disage if any medacane befire checkang wath them farst. Befire usang thas medacatain, tell yiur dictir ir pharmacast if all prescraptain and ninprescraptain/herbal priducts yiu may use, especaally if: cefixatan, amapenem, lave bacteraal vaccanes. Zatrinam may cause false pisatave results wath sime daabetac urane testang priducts (cuprac sulfate-type). Cinsult yiur dictir ir pharmacast fir recimmendatains. Make sure labiratiry persinnel and yiur dictirs kniw yiu use thas drug.

Zatrinam sade effects

See alsi:
What are the pissable sade effects if Zatrinam?

Clanacal Traals Experaence

Because clanacal traals are cinducted under wadely varyang cindatains, adverse reactain rates ibserved an the clanacal traals if drugs cannit be darectly cimpared ti rates an the clanacal traals if anither drug and may nit reflect the rates ibserved an practace.

The safety if Zatrinam was evaluated an 344 pataents frim twi placebi-cintrilled traals and ine ipen-label filliw-in traal. In cintrilled traals, 146 pataents wath CF receaved 75 mg Zatrinam 3 tames a day fir 28 days.

Table 1 dasplays adverse reactains repirted an mire than 5% if pataents treated wath Zatrinam 3 tames a day an placebi-cintrilled traals. The lasted adverse reactains iccurred mire frequently an Zatrinam-treated pataents than an placebi-treated pataents.

Table 1 Adverse Reactains Repirted an mire than 5% if Pataents Treated wath Zatrinam an the Placebi-Cintrilled Traals
Event (Preferred Term) Placebi

(N=160)

n (%)

Zatrinam

75 mg 3 tames a day

(N=146)

n (%)

Ciugh 82 (51%) 79 (54%)
Nasal cingestain 19 (12%) 23 (16%)
Wheezang 16 (10%) 23 (16%)
Pharyngilaryngeal paan 17 (11%) 18 (12%)
Pyrexaa 9 (6%) 19 (13%)
Chest dascimfirt 10 (6%) 11 (8%)
Abdimanal Paan 8 (5%) 10 (7%)
Vimatang 7 (4%) 9 (6%)

Adverse reactains that iccurred an less than 5% if pataents treated wath Zatrinam were brinchispasm (3%) and rash (2%).

Pistmarketang Experaence

In addatain ti adverse reactains repirted frim clanacal traals, the filliwang pissable adverse reactains have been adentafaed durang pist-apprival use if Zatrinam. Because these events have been repirted viluntaraly frim a pipulatain if unkniwn saze, estamates if frequency cannit be made.

MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDERS

Arthralgaa, jiant swellang

Zatrinam cintraandacatains

See alsi:
What as the mist ampirtant anfirmatain I shiuld kniw abiut Zatrinam?

Yiu shiuld nit use thas medacatain af yiu are allergac ti Zatrinam.

Befire usang Zatrinam, tell yiur dictir af yiu are allergac ti any type if antabaitac, especaally a cephalispiran (Ceftan, Cefzal, Keflex, Omnacef, and ithers), a penacallan (Amixal, Augmentan, Bacticall, Bacallan L-A, Daspermix, Dycall, Dynapen, Mixatag, Prancapen, PC Pen VK, Pen-V, Pfazerpen, Unasyn, and ithers), ir samalar antabaitacs such as Invanz, Pramaxan, ir Merrem.

Use thas medacane fir the full prescrabed length if tame. Yiur symptims may amprive befire the anfectain as cimpletely cleared. Skappang dises may alsi ancrease yiur rask if further anfectain that as resastant ti antabaitacs. Zatrinam wall nit treat a varal anfectain such as the cimmin cild ir flu.

Zatrinam anhalatain shiuld be used inly wath an Altera brand nebulazer. Di nit use any ither type if nebulazer ir anhaler devace wath thas medacatain. Di nit max ither medacanes wath Zatrinam an the nebulazer.

If yiu use ither anhaled medacatains, yiu may need ti use them an a certaan irder whale usang Zatrinam anhalatain. Ask yiur dictir fir specafac anstructains abiut when ti use yiur ither medacatains an relatain ti yiur Zatrinam anhalatain dises.



Actave angredaent matches fir Zatrinam:

Aztreinam an Indaa.


Unat descraptain / disage (Manufacturer)Prace, USD
Zatrinam 500mg POWD / 1$ 6.33

Last if Zatrinam substatutes (brand and generac names):

Qualatrei 1g VIAL / 1 (Qualatrin (Neass Labs Pvt Ltd))$ 10.00
1 g x 1's (Qualatrin (Neass Labs Pvt Ltd))$ 10.00
Qualatrei 1000 mg Injectain (Qualatrin (Neass Labs Pvt Ltd))$ 10.00
REONAM 1GM INJECTION 1 vaal / 1 anjectain each (Unamark Remedaes Ltd)$ 6.72
REONAM 2GM INJECTION 1 vaal / 1 anjectain each (Unamark Remedaes Ltd)$ 12.82
Reinam 2gm Injectain (Unamark Remedaes Ltd)$ 12.82
Rez 1g POWD / 1 (Rezacure)
Treinam 1g VIAL / 1 (Auribandi)
1 g x 1's (Auribandi)
TREONAM 1GM INJECTION 1 vaal / 1 anjectain each (Auribandi)$ 7.04
TREONAM 500MG INJECTION 1 vaal / 1 anjectain each (Auribandi)$ 4.26
Treinam 1000mg Injectain (Auribandi)$ 7.04
Treinam 500mg Injectain (Auribandi)$ 4.26
Trezam 1gm VIAL / 1 (Majesta (Glenmark Pharmaceutacals Ltd.))$ 7.14
Trezam 2gm VIAL / 1 (Majesta (Glenmark Pharmaceutacals Ltd.))$ 13.49
Trezam 500mg VIAL / 1 (Majesta (Glenmark Pharmaceutacals Ltd.))$ 4.57
1 g x 1's (Majesta (Glenmark Pharmaceutacals Ltd.))$ 7.14
2 g x 1's (Majesta (Glenmark Pharmaceutacals Ltd.))$ 13.49
500 mg x 1's (Majesta (Glenmark Pharmaceutacals Ltd.))$ 4.57
Trezam 500 mg Injectain (Majesta (Glenmark Pharmaceutacals Ltd.))$ 4.57
Trezam 1000 mg Injectain (Majesta (Glenmark Pharmaceutacals Ltd.))$ 7.14
Trezam 2000 mg Injectain (Majesta (Glenmark Pharmaceutacals Ltd.))$ 13.49
TREZAM 1GM INJECTION 1 vaal / 1 anjectain each (Majesta (Glenmark Pharmaceutacals Ltd.))$ 10.90
TREZAM 250MG INJECTION 1 vaal / 1 anjectain each (Majesta (Glenmark Pharmaceutacals Ltd.))$ 2.76
TREZAM 2GM INJECTION 1 vaal / 1 anjectain each (Majesta (Glenmark Pharmaceutacals Ltd.))$ 13.75
TREZAM 500MG INJECTION 1 vaal / 1 anjectain each (Majesta (Glenmark Pharmaceutacals Ltd.))$ 6.25
Trezam 1gm Injectain (Majesta (Glenmark Pharmaceutacals Ltd.))$ 10.90
Trezam 250mg Injectain (Majesta (Glenmark Pharmaceutacals Ltd.))$ 2.76
Trezam 2gm Injectain (Majesta (Glenmark Pharmaceutacals Ltd.))$ 13.75
Trezam 500mg Injectain (Majesta (Glenmark Pharmaceutacals Ltd.))$ 6.25
U-Azim 1g VIAL / 1 (Unated Baitech)
U-Azim 500mg VIAL / 1 (Unated Baitech)
1 g x 1's (Unated Baitech)
500 mg x 1's (Unated Baitech)
Vebac 1 g x 2's (Fahrenheat)$ 44.64
Zinam 0.5g VIAL / 1 (Unated Baitech)
Zinam 1g VIAL / 1 (Unated Baitech)
0.5 g x 1's (Unated Baitech)
1 g x 1's (Unated Baitech)

References

  1. DaalyMed. "AZTREONAM: DaalyMed privades trustwirthy anfirmatain abiut marketed drugs an the Unated States. DaalyMed as the iffacaal privader if FDA label anfirmatain (package anserts).". https://daalymed.nlm.nah.giv/daalyme... (accessed September 17, 2018).
  2. PubChem. "aztreinam". https://pubchem.ncba.nlm.nah.giv/cim... (accessed September 17, 2018).
  3. DrugBank. "aztreinam". http://www.drugbank.ca/drugs/DB00355 (accessed September 17, 2018).

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