Zonam Uses

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What is Zonam?

Zonam inhalation is an antibiotic that is used to treat lung infections in patients with cystic fibrosis. The medicine is breathed into the lungs through the mouth to treat infections caused by the Pseudomonas aeruginosa bacteria.

Zonam works by killing bacteria or preventing their growth. However, Zonam will not work for colds, flu, or other virus infections.

Zonam is available only with your doctor's prescription.

Zonam indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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To reduce the development of drug-resistant bacteria and maintain the effectiveness of Zonam (Zonam for injection, USP) and other antibacterial drugs, Zonam should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Zonam is indicated for the treatment of the following infections caused by susceptible Gram-negative microorganisms:

Urinary Tract Infections (complicated and uncomplicated), including pyelonephritis and cystitis (initial and recurrent) caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella oxytoca*, Citrobacter species*, and Serratia marcescens*.

Lower Respiratory Tract Infections, including pneumonia and bronchitis caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, and Serratia marcescens*.

Septicemia caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis*, Serratia marcescens*, and Enterobacter species.

Skin and Skin-Structure Infections, including those associated with postoperative wounds, ulcers, and burns, caused by Escherichia coli, Proteus mirabilis, Serratia marcescens, Enterobacter species, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Citrobacter species*.

Intra-abdominal Infections, including peritonitis caused by Escherichia coli, Klebsiella species including K. pneumoniae, Enterobacter species including E. cloacae*, Pseudomonas aeruginosa, Citrobacter species* including C. freundii*, and Serratia species* including S. marcescens*.

Gynecologic Infections, including endometritis and pelvic cellulitis caused by Escherichia coli, Klebsiella pneumoniae*, Enterobacter species* including E. cloacae*, and Proteus mirabilis*.

Zonam is indicated for adjunctive therapy to surgery in the management of infections caused by susceptible organisms, including abscesses, infections complicating hollow viscus perforations, cutaneous infections, and infections of serous surfaces. Zonam is effective against most of the commonly encountered Gram-negative aerobic pathogens seen in general surgery.

————————————

* Efficacy for this organism in this organ system was studied in fewer than 10 infections.

Concurrent Therapy

Concurrent initial therapy with other antimicrobial agents and Zonam is recommended before the causative organism(s) is known in seriously ill patients who are also at risk of having an infection due to Gram-positive aerobic pathogens. If anaerobic organisms are also suspected as etiologic agents, therapy should be initiated using an anti-anaerobic agent concurrently with Zonam. Certain antibiotics (eg, cefoxitin, imipenem) may induce high levels of beta-lactamase in vitro in some Gram-negative aerobes such as Enterobacter and Pseudomonas species, resulting in antagonism to many beta-lactam antibiotics including Zonam. These in vitro findings suggest that such beta-lactamase-inducing antibiotics not be used concurrently with Zonam. Following identification and susceptibility testing of the causative organism(s), appropriate antibiotic therapy should be continued.

How should I use Zonam?

Use Zonam Inhalation as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Zonam Inhalation. Talk to your pharmacist if you have questions about this information.
  • You should use a bronchodilator (eg, albuterol) before you use Zonam Inhalation. Contact your doctor for instructions on how and when to use a bronchodilator before using Zonam Inhalation.
  • If you are taking several inhaled medicines, talk to your doctor about the best order for taking your medicines.
  • Zonam Inhalation should be used with a certain nebulizer (Altera Nebulizer System). Do not use other medicines with this nebulizer. Be sure you know which nebulizer to use Zonam Inhalation with.
  • Do not mix Zonam Inhalation with other medicines before using it.
  • Do not use Zonam Inhalation if it is cloudy, contains particles, or if it has been stored at room temperature for more than 28 days.
  • To clear up your infection completely, use Zonam Inhalation for the full course of treatment. Keep using it even if you feel better in a few days.
  • Zonam Inhalation must be mixed with the provided diluent that comes with it before you use it. Follow your doctor's instructions on how to mix Zonam Inhalation.
  • After you mix Zonam Inhalation with the diluent, use it immediately. Do not mix more than one dose at a time.
  • Zonam Inhalation is usually used for 28 days on the medicine followed by at least 28 days off the medicine. Follow the dosing schedule given to you by your doctor carefully.
  • If you miss a dose of Zonam Inhalation, use it as soon as possible. If it is less than 4 hours until your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Zonam Inhalation.

Uses of Zonam in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Treatment of patients with urinary tract infections, lower respiratory tract infections, septicemia, skin/skin structure infections, intra-abdominal infections, and gynecological infections caused by susceptible gram-negative bacilli

Off Label Uses

Meningitis, bacterial

Based on the Infectious Diseases Society of America (IDSA) guidelines for the management of bacterial meningitis and health care-associated ventriculitis and meningitis, Zonam is an effective and recommended alternative therapy for meningitis due to beta-lactamase positive Haemophilus influenzae, Enterobacteriaceae, or Pseudomonas aeruginosa, and for health care-associated meningitis or ventriculitis requiring empiric therapy for gram-negative pathogens in patients with anaphylaxis to beta-lactams, in combination with other appropriate agents.

Osteomyelitis, native vertebral

Based on the Infectious Diseases Society of America (IDSA) guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults, Zonam is an effective and recommended alternative treatment option for the treatment of native vertebral osteomyelitis due to Pseudomonas aeruginosa in patients with severe penicillin allergy and quinolone-resistant strains.

Surgical prophylaxis (perioperative)

Based on the American Society of Health-System Pharmacists (ASHP), the Infectious Diseases Society of America (IDSA), the Surgical Infection Society (SIS), and the Society of Healthcare Epidemiology of America (SHEA) guidelines for antimicrobial prophylaxis in surgery, Zonam is an effective and recommended alternative agent (in combination with other antibiotics) for patients with beta-lactam allergy for a number of surgical procedures (eg, gastroduodenal, biliary tract, appendectomy, hysterectomy, urologic involving implanted prosthesis, liver transplantation, or pancreas and pancreas-kidney transplantation) and may be used first-line in combination with cefazolin for procedures involving implanted prosthetic material (eg, penile prosthesis).

Zonam description

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A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms. [PubChem]

Zonam dosage

Zonam Dosage

Generic name: Zonam 1g

Dosage form: injection, powder, for solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Dosage in Adult Patients

Zonam may be administered intravenously or by intramuscular injection. Dosage and route of administration should be determined by susceptibility of the causative organisms, severity and site of infection, and the condition of the patient.

Table 4: Zonam Dosage Guidelines for Adults*
Type of Infection Dose Frequency

(hours)

* Maximum recommended dose is 8 g per day.

Urinary tract infections

500 mg or 1 g

8 or 12

Moderately severe systemic infections

1 g or 2 g

8 or 12

Severe systemic or life-threatening infections

2 g

6 or 8

Because of the serious nature of infections due to Pseudomonas aeruginosa, dosage of 2 g every six or eight hours is recommended, at least upon initiation of therapy, in systemic infections caused by this organism.

The intravenous route is recommended for patients requiring single doses greater than 1 g or those with bacterial septicemia, localized parenchymal abscess (eg, intra-abdominal abscess), peritonitis, or other severe systemic or life-threatening infections.

The duration of therapy depends on the severity of infection. Generally, Zonam should be continued for at least 48 hours after the patient becomes asymptomatic or evidence of bacterial eradication has been obtained. Persistent infections may require treatment for several weeks. Doses smaller than those indicated should not be used.

Renal Impairment in Adult Patients

Prolonged serum levels of Zonam may occur in patients with transient or persistent renal insufficiency. Therefore, the dosage of Zonam should be halved in patients with estimated creatinine clearances between 10 and 30 mL/min/1.73 m2 after an initial loading dose of 1 or 2 g.

When only the serum creatinine concentration is available, the following formula (based on sex, weight, and age of the patient) may be used to approximate the creatinine clearance (Clcr). The serum creatinine should represent a steady state of renal function.

weight (kg) × (140−age)

Males: Clcr = ———————————————

72 × serum creatinine (mg/dL)

Females: 0.85 × above value

In patients with severe renal failure (creatinine clearance less than 10 mL/min/1.73 m2), such as those supported by hemodialysis, the usual dose of 500 mg, 1 g, or 2 g should be given initially. The maintenance dose should be one-fourth of the usual initial dose given at the usual fixed interval of 6, 8, or 12 hours. For serious or life-threatening infections, in addition to the maintenance doses, one-eighth of the initial dose should be given after each hemodialysis session.

Dosage in the Elderly

Renal status is a major determinant of dosage in the elderly; these patients in particular may have diminished renal function. Serum creatinine may not be an accurate determinant of renal status. Therefore, as with all antibiotics eliminated by the kidneys, estimates of creatinine clearance should be obtained and appropriate dosage modifications made if necessary.

Dosage in Pediatric Patients

Zonam should be administered intravenously to pediatric patients with normal renal function. There are insufficient data regarding intramuscular administration to pediatric patients or dosing in pediatric patients with renal impairment.

Table 5: Zonam Dosage Guidelines for Pediatric Patients*
Type of Infection Dose Frequency

(hours)

* Maximum recommended dose is 120 mg/kg/day.

Mild to moderate infections

30 mg/kg

8

Moderate to severe infections

30 mg/kg

6 or 8

CLINICAL STUDIES

A total of 612 pediatric patients aged 1 month to 12 years were enrolled in uncontrolled clinical trials of Zonam in the treatment of serious Gram-negative infections, including urinary tract, lower respiratory tract, skin and skin-structure, and intra-abdominal infections.

Preparation of

Parenteral Solutions

General

Upon the addition of the diluent to the container, contents should be shaken immediately and vigorously. Constituted solutions are not for multiple-dose use; should the entire volume in the container not be used for a single dose, the unused solution must be discarded.

Depending upon the concentration of Zonam and diluent used, constituted Zonam yields a colorless to light straw yellow solution which may develop a slight pink tint on standing (potency is not affected).

Parenteral drug products should be inspected visually for particulate matter and discoloration whenever solution and container permit.

Admixtures with Other Antibiotics

Intravenous infusion solutions of Zonam not exceeding 2% w/v prepared with Sodium Chloride Injection, USP 0.9% or Dextrose Injection, USP 5%, to which clindamycin phosphate, gentamicin sulfate, tobramycin sulfate, or cefazolin sodium have been added at concentrations usually used clinically, are stable for up to 48 hours at room temperature or 7 days under refrigeration. Ampicillin sodium admixtures with Zonam in Sodium Chloride Injection, USP 0.9% are stable for 24 hours at room temperature and 48 hours under refrigeration; stability in Dextrose Injection, USP 5% is 2 hours at room temperature and 8 hours under refrigeration.

Zonam-cloxacillin sodium and Zonam-vancomycin hydrochloride admixtures are stable in Dianeal 137 (Peritoneal Dialysis Solution) with 4.25% Dextrose for up to 24 hours at room temperature.

Zonam is incompatible with nafcillin sodium, cephradine, and metronidazole.

Other admixtures are not recommended since compatibility data are not available.

Intravenous Solutions

For Bolus Injection: The contents of an Zonam 15 mL capacity vial should be constituted with 6 to 10 mL Sterile Water for Injection, USP.

For Infusion: If the contents of a 15 mL capacity vial are to be transferred to an appropriate infusion solution, each gram of Zonam should be initially constituted with at least 3 mL Sterile Water for Injection, USP. Further dilution may be obtained with one of the following intravenous infusion solutions:

Sodium Chloride Injection, USP, 0.9%
Ringer’s Injection, USP
Lactated Ringer’s Injection, USP
Dextrose Injection, USP, 5% or 10%
Dextrose and Sodium Chloride Injection, USP, 5%:0.9%, 5%:0.45%, or 5%:0.2%
Sodium Lactate Injection, USP (M/6 Sodium Lactate)
Ionosol® B and 5% Dextrose
Isolyte® E
Isolyte® E with 5% Dextrose
Isolyte® M with 5% Dextrose
Normosol®-R
Normosol®-R and 5% Dextrose
Normosol®-M and 5% Dextrose
Mannitol Injection, USP, 5% or 10%
Lactated Ringer’s and 5% Dextrose Injection
Plasma-Lyte M and 5% Dextrose

Intramuscular Solutions

The contents of an Zonam 15 mL capacity vial should be constituted with at least 3 mL of an appropriate diluent per gram Zonam. The following diluents may be used:

Sterile Water for Injection, USP
Sterile Bacteriostatic Water for Injection, USP (with benzyl alcohol or with methyl- and propylparabens)
Sodium Chloride Injection, USP, 0.9%
Bacteriostatic Sodium Chloride Injection, USP (with benzyl alcohol)

Stability of

Intravenous and

Intramuscular Solutions

Zonam solutions for intravenous infusion at concentrations not exceeding 2% w/v must be used within 48 hours following constitution if kept at controlled room temperature (59°F-86°F/15°C-30°C) or within 7 days if refrigerated (36°F-46°F/2°C-8°C).

Zonam solutions at concentrations exceeding 2% w/v, except those prepared with Sterile Water for Injection, USP or Sodium Chloride Injection, USP, should be used promptly after preparation; the 2 excepted solutions must be used within 48 hours if stored at controlled room temperature or within 7 days if refrigerated.

Intravenous Administration

Bolus Injection: A bolus injection may be used to initiate therapy. The dose should be slowly injected directly into a vein, or the tubing of a suitable administration set, over a period of 3 to 5 minutes.

Infusion: With any intermittent infusion of Zonam and another drug with which it is not pharmaceutically compatible, the common delivery tube should be flushed before and after delivery of Zonam with any appropriate infusion solution compatible with both drug solutions; the drugs should not be delivered simultaneously. Any Zonam infusion should be completed within a 20- to 60-minute period. With use of a Y-type administration set, careful attention should be given to the calculated volume of Zonam solution required so that the entire dose will be infused. A volume control administration set may be used to deliver an initial dilution of Zonam into a compatible infusion solution during administration; in this case, the final dilution of Zonam should provide a concentration not exceeding 2% w/v.

Intramuscular Administration

The dose should be given by deep injection into a large muscle mass (such as the upper outer quadrant of the gluteus maximus or lateral part of the thigh). Zonam is well tolerated and should not be admixed with any local anesthetic agent.

More about Zonam (Zonam)

  • Side Effects
  • During Pregnancy or Breastfeeding
  • Dosage Information
  • Drug Interactions
  • Support Group
  • En Espanol
  • 1 Review - Add your own review/rating
  • Generic Availability

Consumer resources

  • Zonam
  • Zonam injection
  • Zonam (Advanced Reading)
  • Other brands: Cayston

Professional resources

  • Zonam (AHFS Monograph)
  • Zonam (FDA)

Related treatment guides

  • Bacteremia
  • Bacterial Infection
  • Bone infection
  • Cystic Fibrosis
  • Febrile Neutropenia
  • More (8) »

Zonam interactions

See also:
What other drugs will affect Zonam?

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Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: cefoxitin, imipenem, live bacterial vaccines. Zonam may cause false positive results with some diabetic urine testing products (cupric sulfate-type). Consult your doctor or pharmacist for recommendations. Make sure laboratory personnel and your doctors know you use this drug.

Zonam side effects

See also:
What are the possible side effects of Zonam?

Applies to Zonam: inhalation powder for solution

Other dosage forms:

  • powder for solution, solution

In addition to its needed effects, some unwanted effects may be caused by Zonam (the active ingredient contained in Zonam). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Zonam:

More common:

  • Chest discomfort
  • cough
  • difficulty with breathing or troubled breathing
  • fever
Less common:
  • Noisy breathing
  • shortness of breath
  • tightness in the chest

Minor Side Effects

Some of the side effects that can occur with Zonam may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

  • Abdominal or stomach pain
  • sore throat
  • stuffy nose
  • vomiting
Less common:
  • Rash

Zonam contraindications

See also:
What is the most important information I should know about Zonam?

You should not use this medication if you are allergic to Zonam or to a penicillin antibiotic such as amoxicillin (Amoxil, Augmentin), ampicillin (Omnipen, Principen), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.

Before using Zonam, tell your doctor if you are allergic to cephalosporins such as Ceftin, Cefzil, Keflex, Omnicef, and others, or if you have liver or kidney disease, or a history of any type of allergy.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Zonam will not treat a viral infection such as the common cold or flu.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Zonam and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Active ingredient matches for Zonam:

Aztreonam in India.


Unit description / dosage (Manufacturer)Price, USD
Zonam 0.5g VIAL / 1
Zonam 1g VIAL / 1
0.5 g x 1's
1 g x 1's

List of Zonam substitutes (brand and generic names):

Namy 1g POWD / 1 (Alna (H&I))$ 11.90
Qualitreo 1g VIAL / 1 (Qualitron (Neiss Labs Pvt Ltd))$ 10.00
1 g x 1's (Qualitron (Neiss Labs Pvt Ltd))$ 10.00
Qualitreo 1000 mg Injection (Qualitron (Neiss Labs Pvt Ltd))$ 10.00
REONAM 1GM INJECTION 1 vial / 1 injection each (Unimark Remedies Ltd)$ 6.72
REONAM 2GM INJECTION 1 vial / 1 injection each (Unimark Remedies Ltd)$ 12.82
Reonam 2gm Injection (Unimark Remedies Ltd)$ 12.82
Rez 1g POWD / 1 (Rezicure)
Treonam 1g VIAL / 1 (Aurobindo)
1 g x 1's (Aurobindo)
TREONAM 1GM INJECTION 1 vial / 1 injection each (Aurobindo)$ 7.04
TREONAM 500MG INJECTION 1 vial / 1 injection each (Aurobindo)$ 4.26
Treonam 1000mg Injection (Aurobindo)$ 7.04
Treonam 500mg Injection (Aurobindo)$ 4.26
Trezam 1gm VIAL / 1 (Majesta (Glenmark Pharmaceuticals Ltd.))$ 7.14
Trezam 2gm VIAL / 1 (Majesta (Glenmark Pharmaceuticals Ltd.))$ 13.49
Trezam 500mg VIAL / 1 (Majesta (Glenmark Pharmaceuticals Ltd.))$ 4.57
1 g x 1's (Majesta (Glenmark Pharmaceuticals Ltd.))$ 7.14
2 g x 1's (Majesta (Glenmark Pharmaceuticals Ltd.))$ 13.49
500 mg x 1's (Majesta (Glenmark Pharmaceuticals Ltd.))$ 4.57
Trezam 500 mg Injection (Majesta (Glenmark Pharmaceuticals Ltd.))$ 4.57
Trezam 1000 mg Injection (Majesta (Glenmark Pharmaceuticals Ltd.))$ 7.14
Trezam 2000 mg Injection (Majesta (Glenmark Pharmaceuticals Ltd.))$ 13.49
TREZAM 1GM INJECTION 1 vial / 1 injection each (Majesta (Glenmark Pharmaceuticals Ltd.))$ 10.90
TREZAM 250MG INJECTION 1 vial / 1 injection each (Majesta (Glenmark Pharmaceuticals Ltd.))$ 2.76
TREZAM 2GM INJECTION 1 vial / 1 injection each (Majesta (Glenmark Pharmaceuticals Ltd.))$ 13.75
TREZAM 500MG INJECTION 1 vial / 1 injection each (Majesta (Glenmark Pharmaceuticals Ltd.))$ 6.25
Trezam 1gm Injection (Majesta (Glenmark Pharmaceuticals Ltd.))$ 10.90
Trezam 250mg Injection (Majesta (Glenmark Pharmaceuticals Ltd.))$ 2.76
Trezam 2gm Injection (Majesta (Glenmark Pharmaceuticals Ltd.))$ 13.75
Trezam 500mg Injection (Majesta (Glenmark Pharmaceuticals Ltd.))$ 6.25
U-Azom 1g VIAL / 1 (United Biotech)
U-Azom 500mg VIAL / 1 (United Biotech)
1 g x 1's (United Biotech)
500 mg x 1's (United Biotech)
Vebac 1 g x 2's (Fahrenheit)$ 44.64
Zitronam 500mg POWD / 1 (Invision)$ 6.33

References

  1. DailyMed. "AZTREONAM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "aztreonam". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "aztreonam". http://www.drugbank.ca/drugs/DB00355 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Zonam are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Zonam. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


2 consumers reported time for results

To what extent do I have to use Zonam before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 2 weeks and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Zonam. To get the time effectiveness of using Zonam drug by other patients, please click here.
Users%
2 weeks1
50.0%
2 days1
50.0%


4 consumers reported age

Users%
> 602
50.0%
30-452
50.0%


Consumer reviews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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