Zonaxson Uses

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Zonaxson indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Spastic paralysis in cerebrovascular disease, spastic spinal paralysis, cervical spondylosis, post-op sequelae (including cerebrovascular tumor), sequelae to trauma (eg, spinal trauma, head injury), amyotrophic lateral sclerosis, cerebral palsy, spinocerebellar degeneration, spinal vascular diseases & other encephalomyelopathies. Improvement of muscular hypertonic symptoms in conditions eg, cervical syndrome, periarthritis of the shoulder, lumbago.

Uses of Zonaxson in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Zonaxson is used to relieve muscle stiffness and pain (muscle spasm) in several conditions including low back pain, painful conditions of neck, shoulder and arm and in spastic paralysis (weakness and stiffness of muscles causing loss or impairment of movement).

Zonaxson description

Zonaxson is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex. It is not approved for use in the United States, but is available in other countries like India, South Korea, and Bangladesh.

Zonaxson dosage

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Adult Muscle relaxant 1 tab tid. Spastic paralysis 1-2 tab tid.

Zonaxson interactions

Zonaxson appears to decrease the rate at which certain drugs are metabolized and therefore may increase the blood levels and the possibility of clinical toxicity of drugs given concomitantly.

DISULFIRAM SHOULD BE USED WITH CAUTION IN THOSE PATIENTS REVEIVING PHENYTOIN AND ITS CONGENERS. SINCE THE CONCOMITANT ADMINISTRATION OF THESE TWO DRUGS CAN LEAD TO PHENYTOIN INTOXICATION, PRIOR TO ADMINISTERING DISULFIRAM TO A PATIENT ON PHENYTOIN THERAPY, A BASELINE PHENYTOIN SERUM LEVEL SHOULD BE OBTAINED. SUBSEQUENT TO INITIATION OF DISULFIRAM THERAPY. SERUM LEVELS OF PHENYTOIN SHOULD BE DETERMINED ON DIFFERENT DAYS FOR EVIDENCE OF AN INCREASE OR FOR A CONTINUING RISE IN LEVELS. INCREASED PHENYTOIN LEVELS SHOULD BE TREATED WITH APPROPRIATE DOSAGE ADJUSTMENT.

It may be necessary to adjust the dosage of oral anticoagulants upon beginning or stopping disulfiram. since disulfiram may prolong prothrombin time.

Patients taking isoniazid when disulfiram is given should be observed for the appearance of unsteady gait or marked changes in mental status; the disulfiram should be discontinued if such signs appear.

In rats, simultaneous ingestion of disulfiram and nitrite in the diet for 78 weeks has been reported to cause tumors, and it has been suggested that disulfiram may react with nitrites in the rat stomach to form a nitrosamine, which is tumorigenic. Zonaxson alone in the ratís diet did not lead to such tumors. The relevance of this finding to humans is not known at this time.

Zonaxson side effects

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Liver or kidney function impairment; erythrocyte or Hb count abnormalities, skin rash, insomnia, headache, drowsiness, stiffness, numbness & trembling of extremities, nausea, vomiting, anorexia, gastric discomfort, dry mouth, constipation, diarrhea/soft stool, abdominal pain, full abdominal sensation, urinary disorders, weakness, dizziness, fatigue, flushing, sweating.

Zonaxson contraindications

Patients who are receiving or have recently received metronidazole. paraldehyde. alcohol, or alcohol-containing preparations, e.g. cough syrups, tonics and the like, should not be given disulfiram.

Zonaxson is contraindicated in the presence of severe myocardial disease or coronary occlusion, psychoses, and hypersensitivity to disulfiram or to other thiuram derivatives used in pesticides and rubber vulcanization.

Active ingredient matches for Zonaxson:

Eperisone HCl in Vietnam.


Unit description / dosage (Manufacturer)Price, USD
Zonaxson 50 mg x 3 Blister x 10 Tablet

List of Zonaxson substitutes (brand and generic names):

Doterco 50 2 Blister x 10 Tablet
Doterco 50 3 Blister x 10 Tablet
Doterco 50 6 Blister x 10 Tablet
Doterco 50 10 Blister x 10 Tablet
Doterco 50 1 Bottle 20 Tablet
Doterco 50 1 Bottle 30 Tablet
Doterco 50 1 Bottle 60 Tablet
Doterco 50 1 Bottle 100 Tablet
Doterco 50 1 Bottle 250 Tablet
Epelax Tablet 50 mg x 10 Blister x 10 Tablet
Epezan 50 mg x 10 Blister x 10 Tablet
Koruan 50 mg x 2 Blister x 10 Tablet
Koruan 50 mg x 10 Blister x 10 Tablet
Mysolax 50 mg x 10 Blister x 10 Tablet
Skeson 50 mg x 10 Blister x 10 Tablet
Ton-dine 50 mg x 10 Blister x 10 Tablet

References

  1. PubChem. "eperisone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "Eperisone". http://www.drugbank.ca/drugs/DB08992 (accessed September 17, 2018).
  3. MeSH. "Parasympatholytics". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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