Aekil indications
Management of duodenal ulcer; treatment of gastroesophageal reflux disease (GERD), including erosive esophagitis; therapy for benign gastric ulcer; treatment of pathologic hypersecretory conditions; prevention of upper GI bleeding.
Unlabeled Uses
Prevention of aspiration pneumonia and stress ulcers; herpes virus infection; chronic idiopathic urticaria; anaphylaxis (relieves dermatologic symptoms only); dyspepsia; used before anesthesia to prevent aspiration pneumonitis; treatment of hyperparathyroidism and control of secondary hyperparathyroidism in chronic hemodialysis patient; treatment of chronic viral warts in children.
Aekil description
Each caplet contains acetaminophen 500 mg and Caffeine (Aekil) 65 mg.
Aekil dosage
Adults and Children ≥12 years: Take 1-2 caplets, every 4-6 hours as required. Do not take more frequently than every 4 hrs. Do not take more than 8 caplets in 24 hours. It can be taken on an empty stomach.
Panadol Extra Advance should not be used with other acetaminophen-containing products. Do not exceed the stated dose.
Aekil interactions
The speed of absorption of Paracetamol (Aekil) may be increased by metoclopramide or domperidone and absorption reduced by colestyramine.
The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular use of Paracetamol (Aekil) with increased risk of bleeding. Occasional doses have no significant effect.
The use of drugs which induce hepatic microsomal enzymes, such as anticonvulsants and oral contraceptive steroids, may increase the extent of metabolism of Paracetamol (Aekil), resulting in reduced plasma concentrations of the drug and a faster elimination rate.
Drugs which induce hepatic microsomal enzymes, such as alcohol and barbiturates, may increase the hepatotoxicity of Paracetamol (Aekil), particularly after overdose.
CNS depression or excitation may occur if codeine is given to patients receiving monoamine oxidase inhibitors, or within two weeks of stopping treatment with them. The effects of CNS depressants (including alcohol) may be potentiated by codeine.
Concurrent use of codeine with antidiarrhoeal and antiperistaltic agents may increase the risk of severe constipation. Concomitant use of antimuscarinics or medications with antimuscarinic action may result in an increased risk of severe constipation, which may lead to paralytic ileus and/or urinary retention.
Quinidine can inhibit the analgesic effect of codeine.
Codeine may delay the absorption of mexiletine and thus reduce the antiarrhythmic effect of the latter. Codeine may antagonise the gastrointestinal effects of metoclopramide and domperidone. Cimetidine inhibits the metabolism of opioid analgesics resulting in increased plasma concentrations.
Naltrexone blocks the therapeutic effect of opioids.
Aekil side effects
Adverse effects of Paracetamol (Aekil) are rare, but hypersensitivity including skin rash may occur. There have been a few reports of blood dyscrasias including thrombocytopenia and agranulocytosis, but these were not necessarily causally related to Paracetamol (Aekil).
Codeine can produce constipation and drowsiness. Occasional effects are nausea, vomiting, sweating, facial flushing, dry mouth, blurred or double vision, dizziness, postural hypotension, headache, vertigo, palpitations, allergic reactions (itch, skin rash, facial oedema), and difficulties in micturition (dysuria, increased frequency, decrease in amount). Side-effects which occur rarely include hallucinations, nightmares, restlessness and stomach cramps. The frequency and severity are determined by dosage, duration of treatment and individual sensitivity and are unlikely at this dosage. Tolerance and dependency can occur, especially with prolonged high doses of codeine.
High doses of Caffeine (Aekil) may produce headache, tremor, nervousness and irritability.
Aekil contraindications
Do not use with an MAOI or within 14 days of discontinuing an MAOI
due to risk of drug interaction. At least 5 weeks should be allowed after
stopping FLUOXETINE before treatment with an MAOI
• Do not use with pimozide due to risk of drug interaction or QTc
prolongation
• Do not use with thioridazine due to QTc interval prolongation or
potential for elevated thioridazine plasma levels. Do not use thioridazine
within 5 weeks of discontinuing FLUOXETINE
Active ingredient matches for Aekil:
Caffeine/Paracetamol in India.
Anhydrous caffeine/Caffeine/paracetamol in India.
| Unit description / dosage (Manufacturer) | Price, USD |
| AEKIL tab 10's (Agron Rem. (Agrogem)) | $ 0.13 |
List of Aekil substitutes (brand and generic names): | |
| Adorem Plus (Colombia) | |
| AEKIL PLUS (India) | |
| AEKIL PLUS tab 10's (Agron Rem. (Agrogem)) | $ 0.24 |
| AgripinoExtra | |
| Albert Heijn Paracetamol/coffeine (Netherlands) | |
| Alfin forte (Ecuador) | |
| Algesic extra (Tunisia) | |
| Algik (Portugal) | |
| Algine (Greece) | |
| Algodol Caféine (France) | |
| Algofen Duofast (Malta) | |
| Algostase (Belgium, Luxembourg) | |
| Aljil (Turkey) | |
| Almigripe (Portugal) | |
| Alres (Venezuela) | |
| Amadol Extra (Pakistan) | |
| Amol Extra (Kuwait, Oman) | |
| Amole Plus (Pakistan) | |
| Analgan Extra (Tunisia) | |
| Analper CAF (Colombia) | |
| Antalgine (Colombia) | |
| Antalgine Forte (Colombia) | |
| Antigripal (Romania) | |
| Antigriphine (Belgium, Luxembourg) | |
| Apap Extra (Bulgaria, Poland) | |
| Apap NBG (Poland) | |
| APAP-Plus (United States) | |
| Apotel Extra (Greece) | |
| Arax Extra (Denmark) | |
| Archi Extra (Bangladesh) | |
| Arfen Plus (Hong Kong) | |
| Arfen Plus 20's (Medochemie) | |
| Arfen Plus 100's (Medochemie) | |
| Arfen Plus 1000's (Medochemie) | |
| Ascafyl (Venezuela) | |
| Ascafyl Infantil (Venezuela) | |
| Ascafyl Plus (Venezuela) | |
| Asko (Turkey) | |
| Asta Plus (Bangladesh) | |
| Atamel plus (Venezuela) | |
| Atopen Plus (Bangladesh) | |
| Azur (Germany, Italy) | |
| Tablet; Oral; Acetaminophen; Caffeine (Biores) | |
| Suspension, Concentrated; Topical; Diflufenican 20 g; Ioxynil Sodium 105.9 g; Isoproturon 400 g / l (Biores) | |
| Bazagin (Vietnam) | |
| Bazagin 10 Blister x 10 Tablet | |
See 437 substitutes for Aekil | |
References
- DailyMed. "CAFFEINE; ERGOTAMINE TARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "caffeine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "caffeine". http://www.drugbank.ca/drugs/DB00201 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Aekil are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Aekil. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
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Information checked by Dr. Sachin Kumar, MD Pharmacology
