Arestal 1 mg Uses

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What is Arestal 1 mg?

Arestal 1 mg slows the rhythm of digestion so that the small intestines have more time to absorb fluid and nutrients from the foods you eat.

Arestal 1 mg is used to treat diarrhea. Arestal 1 mg is also used to reduce the amount of stool in people who have an ileostomy (re-routing of the bowel through a surgical opening in the stomach).

Arestal 1 mg may also be used for purposes not listed in this medication guide.

Arestal 1 mg indications

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(Arestal 1 mg hydrochloride) is indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease. (Arestal 1 mg hydrochloride) is also indicated for reducing the volume of discharge from ileostomies.

How should I use Arestal 1 mg?

Use Arestal 1 mg as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Arestal 1 mg.

Uses of Arestal 1 mg in details

This medication is used to treat sudden diarrhea (including traveler's diarrhea). It works by slowing down the movement of the gut. This decreases the number of bowel movements and makes the stool less watery. Arestal 1 mg is also used to reduce the amount of discharge in patients who have had an ileostomy. It is also used to treat ongoing diarrhea in people with inflammatory bowel disease.

Arestal 1 mg treats only the symptoms, not the cause of the diarrhea (e.g., infection). Treatment of other symptoms and the cause of the diarrhea should be determined by your doctor.

Do not use in children younger than 6 years unless directed by your doctor. This medication should not be used in infants younger than 24 months.

How to use Arestal 1 mg (Arestal 1 mg)

If you are using the over-the-counter product to self-treat, read all the directions on the product package before taking this medication. If your doctor has prescribed this medication, follow your doctor's directions and the directions on your prescription label.

Take this medication by mouth, usually after each loose stool or as directed by your doctor. Shake the bottle well before each use. Measure each dose carefully using the attached measuring cup. Do not use a household spoon since you may not get the correct dose.

The dosage is based on your condition and response to treatment. In children, dosage is also based on age and weight. Adults should not use more than 8 milligrams in 24 hours if self-treating, or 16 milligrams in 24 hours if under a doctor's direction.

Improper use of this medication (overuse or abuse) - or use with certain other medications - may cause serious harm, such as fast/irregular heartbeat or death. Do not increase your dose, take it more often, or use it for longer than directed. Be sure to tell your doctor or pharmacist about all the products you use (including prescription, nonprescription, and herbal products).

Diarrhea can cause a serious loss of body water (dehydration). Drink plenty of fluids and minerals (electrolytes) to replace what is lost. Tell your doctor right away if you develop signs of dehydration (e.g., extreme thirst, decreased urination, muscle cramps, weakness, fainting). You may also need to change to a bland diet during this time to reduce irritation to your stomach/intestines. Consult your doctor or pharmacist for more information.

Tell your doctor if your diarrhea does not improve after 2 days, if your condition worsens, or if you develop new symptoms. If you develop blood in the stool, fever, or an uncomfortable fullness/swelling of the stomach/abdomen, or if you think you may have a serious medical problem, seek immediate medical attention.

If you are taking this medication under your doctor's direction for ongoing diarrhea, tell your doctor if your diarrhea continues after 10 days of treatment.

Arestal 1 mg description

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One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally. [PubChem]

Arestal 1 mg dosage

Acute diarrhea Initially 2 tab. Then 1 tab after each unformed stool until diarrhea is controlled. Chronic diarrhea Initially 2 tab.

Maintenance: 1-6 tab daily.

Arestal 1 mg interactions

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What other drugs will affect Arestal 1 mg?

Nonclinical data have shown that Arestal 1 mg is a P-glycoprotein substrate. Concomitant administration of Arestal 1 mg (16 mg single dose) with a 600 mg single dose of either quinidine, or ritonavir, both of which are P-glycoprotein inhibitors, resulted in a 2- to 3- fold increase in Arestal 1 mg plasma levels. Due to the potential for enhanced central effects when Arestal 1 mg is coadministered with quinidine and with ritonavir, caution should be exercised when Arestal 1 mg is administered at the recommended dosages (2 mg, up to 16 mg maximum daily dose) with P-glycoprotein inhibitors.

When a single 16-mg dose of Arestal 1 mg is coadministered with a 600 mg single dose of saquinavir, Arestal 1 mg decreased saquinavir exposure by 54%, which may be of clinical relevance due to reduction of therapeutic efficacy of saquinavir. The effect of saquinavir on Arestal 1 mg is of less clinical significance. Therefore, when Arestal 1 mg is given with saquinavir, the therapeutic efficacy of saquinavir should be closely monitored.

Arestal 1 mg side effects

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What are the possible side effects of Arestal 1 mg?

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CNS

Fatigue; drowsiness; dizziness.

Dermatologic

Rash.

GI

Abdominal pain; distention or discomfort; constipation; nausea; vomiting; dry mouth.

Arestal 1 mg contraindications

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What is the most important information I should know about Arestal 1 mg?

Pseudomembranous colitis caused by antibiotic use; acute diarrhea associated with organisms that penetrate intestinal wall (eg, toxigenic Escherichia coli, Salmonella, Shigella ); conditions in which constipation should be avoided; bloody diarrhea; fever; acute ulcerative colitis (potential for toxic megacolon).

Active ingredient matches for Arestal 1 mg:

Loperamide Oxide in France.


List of Arestal 1 mg substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Loperamide Oxyde Monohydrate 1 mg (Janssen-cilag)
Arestal 1 mg x 2 Blister x 10 Tablet (Janssen-cilag)
Primodium 2 mg x 10 x 6's (Ikapharmindo)$ 11.46

References

  1. PubChem. "loperamide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "loperamide". http://www.drugbank.ca/drugs/DB00836 (accessed September 17, 2018).
  3. MeSH. "Antidiarrheals". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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