Calcium Carbonate/Etidronic Acid indications
Osteoporosis
Calcium Carbonate/Etidronic Acid interactions
food in the stomach or upper portions of the small intestine, particularly materials with a high calcium content such as milk, may reduce absorption of the etidronate disodium. Vitamins with mineral supplements such as iron, calcium supplements, laxatives containing magnesium, or antacids containing calcium or aluminum should not be taken within 2 hours before or after dosing etidronate disodium, since these also may reduce the absorption of etidronate disodium and could lead to treatment failure.
A small number of patients in the clinical trials received either thiazide diuretics or intravaginal estrogen while on the regimen. The concomitant use of either of these agents did not interfere with the positive effects of the this medicine therapy on bone.
The concurrent use of etidronate disodium with warfarin has been associated with isolated reports of patients experiencing increases in their prothrombin time. The majority of these reports concerned variable elevations in prothrombin times without clinically significant sequelae. Although the relevance of these reports and any mechanism of coagulation alterations is unclear, patients on warfarin should have their prothrombin time more closely monitored.
Calcium carbonate may interfere with the absorption of tetracycline given concomitantly.
Pregnancy: this medicine is not intended for administration to pregnant women. In teratology and developmental toxicity studies conducted in rats and rabbits treated with oral dose levels of up to 100 mg/kg (12 times the human dose), no adverse or teratogenic effects have been observed in the offspring. Etidronate disodium has been shown to cause skeletal abnormalities in rat offspring when given to dams in mid-pregnancy at oral dose levels of 300 mg/kg (35 times the human dose); these effects are thought to be the result of the pharmacological effects of the drug on bone. Other effects on the offspring (including decreased live births) have been observed at dose levels that cause significant toxicity in the parent generation and are 60 to 125 times the human dose. There are no adequate and well-controlled studies in pregnant women.
Lactation: this medicine is not intended for administration during lactation. It is not known whether etidronate is excreted in human milk; it is excreted in the milk of rats. Because many drugs are excreted in human milk and because of the potential for adverse effects on the skeletons of infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Children: The safety and effectiveness of this medicine in children have not been established.
Dependence Liability: Not applicable.
Laboratory Tests: Depending on the time elapsed since the last dose of etidronate, this medicine therapy may prevent bone-imaging diagnostic agents (e.g., technetium-9mmethylene diphosphonate) used in bones scans, from adhering to bone and thus affect the interpretation of imaging results.
Patients: The patient should adhere to the prescribed regimen. The response to therapy is one of slow onset that continues over time.
A patient’s risk for developing fractures may also be reduced if, subsequent to health care counseling, she consumes adequate dietary calcium, gets enough weight-bearing exercise, and uses proper lifting and fall-avoidance techniques.
Each etidronate disodium tablet should be taken as a single oral dose on an empty stomach with a full glass of water. The calcium carbonate tablet may be taken with food and this is recommended if the patient has achlorhydria.
Calcium Carbonate/Etidronic Acid side effects
Reactions reported less frequently include flatulence, dyspepsia, abdominal pain, constipation and vomiting. The incidence of these events was comparable to that with placebo. In addition, 4 events, headache, gastritis, leg cramps and arthralgia, occurred with a significantly greater incidence in patients who received Calcium Carbonate/Etidronic Acid cyclical therapy compared with those who received placebo. All episodes of leg cramps were transient in nature, most occurred at night, and most required no treatment. All patients with arthralgia reported joint discomfort or pain that was generally mild and related to underlying osteoarthritis.
Calcium Carbonate/Etidronic Acid contraindications
Patients with known hypersensitivity to etidronate disodium. Calcium Carbonate/Etidronic Acid is also contraindicated for patients with clinically overt osteomalacia; appropriate treatment to resolve their osteomalacia should be initiated before prescribing Calcium Carbonate/Etidronic Acid therapy.
Active ingredient matches for Calcium Carbonate/Etidronic Acid:
Calcium Carbonate/Etidronic Acid
List of Calcium Carbonate/Etidronic Acid substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| ACT Etidrocal (Canada) | |
| CO Etidrocal (Canada) | |
| Tablet; Oral; Calcium / Calcium Carbonate 500 mg; Etidronate Disodium 400 mg | |
| Didrocal (Australia, Canada) | |
| Tablet; Oral; Calcium Carbonate 500 mg; Etidronate Disodium 400 mg (Pfizer) | |
| Didrokit (Netherlands) | |
| Didronate +Calcium (Finland) | |
| Didronate/Calcium Procter & Gamble (Denmark) | |
| Didronel PMO (Ireland, United Kingdom) | |
| Capsule; Oral; Etidronate Disodium 400 mg / Didronel / Tablet; Oral; Calcium Citrate 500 mg / Cacit (Procter & gamble) | |
| Didronel-Kit (Germany) | |
| Etidrocal Sanis Health (Canada) | |
| Gen-Eti-Cal Carepac (Canada) | |
| Kit; Tablet; Oral; Calcium / Calcium Carbonate 500 mg; Etidronate Disodium 400 mg | |
| Teva-Etidronate Calcium (Canada) | |
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References
- DailyMed. "CALCIUM CARBONATE; FAMOTIDINE; MAGNESIUM HYDROXIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "CALCIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "Calcium". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
