What is Cambia Powder Packets?
Cambia Powder Packets is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such as inflammation, swelling, stiffness, and joint pain. However, Cambia Powder Packets does not cure osteoarthritis and will help you only as long as you continue to use it.
Cambia Powder Packets topical 3% gel is also used to treat actinic keratosis, a skin problem that may become cancerous if not treated. The exact way that topical Cambia Powder Packets helps this condition is unknown.
Cambia Powder Packets topical solution is used to treat pain and swelling caused by osteoarthritis of the knees.
Cambia Powder Packets topical patch is used to treat acute pain caused by minor strains, sprains, and contusions (bruises).
Cambia Powder Packets is available only with your doctor's prescription.
Cambia Powder Packets indications
Intramuscular
Renal colic
Adult: As Cambia Powder Packets Na: 75 mg, may repeat once after 30 min if needed. Max: 150 mg/day. Max period: 2 days.
Intramuscular
Bursitis, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis, Acute gout, Dysmenorrhoea
Adult: As Cambia Powder Packets Na: 75 mg once daily, injected into the gluteal muscle, may increase to 75 mg bid in severe conditions. Max period: 2 days.
Intravenous
Postoperative pain
Adult: As Cambia Powder Packets Na: 75 mg infusion in glucose 5% or NaCl 0.9% (previously buffered w/ Na bicarbonate) given over 30-120 min or as bolus inj, may repeat after 4-6 hr if necessary. Max period: 2 days.
Intravenous
Prophylaxis of postoperative pain
Adult: As Cambia Powder Packets Na: Initially, 25-50 mg infusion given after surgery over 15-60 min followed by 5 mg/hr. Alternatively, initial dose may be given as bolus inj over 5-60 sec followed by additional inj, may repeat after 4-6 hr if necessary. Max: 150 mg/day. Max period: 2 days.
Ophthalmic
Postoperative ocular inflammation
Adult: As Cambia Powder Packets Na (0.1% soln): Instill into the appropriate eye 4 times daily starting 24 hr after surgery for up to 28 days.
Ophthalmic
Inflammation and discomfort after strabismus surgery
Adult: As Cambia Powder Packets Na (0.1% soln): Instill 1 drop 4 times daily for the 1st wk; then tid in the 2nd wk, bid in the 3rd wk, and as required for the 4th wk.
Ophthalmic
Pain and discomfort after radial keratotomy
Adult: As Cambia Powder Packets Na (0.1% soln): Instill 1 drop before surgery followed by 1 drop immediately after surgery, and then 1 drop 4 times daily for up to 2 days.
Ophthalmic
Pain after accidental trauma
Adult: As Cambia Powder Packets Na (0.1% soln): Instill 1 drop 4 times daily for up to 2 days.
Ophthalmic
Control of inflammation after argon laser trabeculoplasty
Adult: As Cambia Powder Packets Na (0.1% soln): Instill 1 drop 4 times during the 2 hr before procedure followed by 1 drop 4 times daily, up to 7 days after procedure.
Ophthalmic
Prophylaxis of intra-operative miosis
Adult: As Cambia Powder Packets Na (0.1% soln): Instill into appropriate eye 4 times w/in 2 hr before surgery.
Ophthalmic
Post-photorefractive keratectomy pain
Adult: As Cambia Powder Packets Na (0.1% soln): Instill into the affected eye twice, an hr before surgery, then 1 drop twice at 5-min intervals immediately after surgery, then every 2-5 hr while awake for up to 24 hr.
Ophthalmic
Seasonal allergic conjunctivitis
Adult: As Cambia Powder Packets Na (0.1% soln): Instill 1 drop before surgery followed by 1 drop immediately after surgery, and then 1 drop 4 times daily for up to 2 days.
Oral
Bursitis, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis, Acute gout, Dysmenorrhoea
Adult: As Cambia Powder Packets Na: 75-150 mg/day in divided doses. Max: 150 mg/day.
Oral
Migraine
Adult: As Cambia Powder Packets K: Initially, 50 mg taken at the 1st sign of an attack, an additional dose of 50 mg may be taken after 2 hr if symptoms persist. If needed, further doses of 50 mg may be taken 4-6 hrly. Max: 200 mg/day.
Rectal
Acute gout, Bursitis, Dysmenorrhoea, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis
Adult: As Cambia Powder Packets Na: 100 mg once daily.
Topical/Cutaneous
Actinic keratoses
Adult: As Cambia Powder Packets Na (3% gel): Apply bid for 60-90 days.
Topical/Cutaneous
Osteoarthritis
Adult: As Cambia Powder Packets Na (1.6% soln): Apply in small amounts (20 or 40 drops) onto affected area 4 times daily. As Na: (1% gel): Apply to the affected area 4 times daily. Max: 32 g/day over the affected area.
Topical/Cutaneous
Local symptomatic relief of pain and inflammation
Adult: As Cambia Powder Packets Na (1% gel): Apply onto affected area 3 or 4 times daily.
Transdermal
Acute pain
Adult: Sprains, strains, contusions: 1 patch bid.
How should I use Cambia Powder Packets?
Use Cambia Powder Packets solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Cambia Powder Packets solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Cambia Powder Packets solution refilled.
- Do not apply Cambia Powder Packets solution to infected skin; open wounds; or red, swollen, or peeling skin.
- Wash your hands immediately before and after using Cambia Powder Packets solution.
- Wash the affected area and dry completely before using Cambia Powder Packets solution.
- To apply Cambia Powder Packets solution, dispense 10 drops at a time onto the knee or into your hand. Spread Cambia Powder Packets solution evenly around the front, back, and sides of the knee. Repeat until you have used the whole dose.
- Be sure that you cover your entire knee with your dose of Cambia Powder Packets solution. Do not use more than the recommended amount.
- Do not apply sunscreens, cosmetics, insect repellants, other topical medicines, or any other substance to the treated area until it is completely dry.
- Do not put on clothes over the treated area until it is completely dry.
- Do not wrap, bandage, or apply heat to the treated area.
- Let the treated skin dry before touching it or letting it touch anyone else's skin.
- Do not shower, bathe, or wash the treated area for at least 30 minutes after you use Cambia Powder Packets solution.
- If you miss a dose of Cambia Powder Packets solution, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Cambia Powder Packets solution.
Uses of Cambia Powder Packets in details
Cambia Powder Packets is used to relieve pain from various conditions. This form of Cambia Powder Packets is used to treat migraine headaches. Cambia Powder Packets is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
This medication may also be used to treat gout attacks.
How to use Cambia Powder Packets
Read the Medication Guide provided by your pharmacist before you start taking Cambia Powder Packets and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth as directed by your doctor. Empty the contents of one packet into a cup containing 1 to 2 ounces (30 to 60 milliliters) of water. Mix well and drink all of it right away. Do not mix with any liquid other than water. If stomach upset occurs while taking this medication, take it with food, milk, or an antacid. However, if you take this medication with a meal high in fat, it may not work as well.
There are different brands and forms of this medication available. Because different forms do not have the same effects at equal strengths, do not switch forms of Cambia Powder Packets unless your doctor tells you to.
To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose. Do not increase your dose or take it more often than prescribed.
Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.
Tell your doctor if your condition persists or worsens.
Cambia Powder Packets description
The active substance is sodium-[o[(2,6-dichlorophenyl)-amino]-phenyl]-acetate (= Cambia Powder Packets sodium).
Each enteric tablet contains 25 mg or 50 mg of Cambia Powder Packets sodium.
One prolonged-release tablet contains 100 mg of Cambia Powder Packets sodium.
Excipients/Inactive Ingredients: Gastro-Resistant Tablet: Core for 25 mg and 50 mg: Cellulose microcrystalline; lactose monohydrate; magnesium stearate; maize starch; povidone; silica, colloidal anhydrous; sodium starch glycolate (type A).
Coating for 25 mg and 50 mg: Hypromellose; iron oxide yellow (E172); macrogoglycerol hydroxystearate; methacrylic acid-ethyl acrylate copolymer; macrogol 8000; talc; titanium dioxide (E171); simeticone; alpha-octadecyl-omega-hydroxy-polyglykolether; sorbic acid.
Coating for 50 mg: Iron oxide red (E172).
SR Tablet: Tablet Core: Cetyl alcohol; magnesium stearate; povidone; silica; colloidal anhydrous; sucrose.
Tablet Coating: Hypromellose; iron oxide red (E172); macrogol 8000; polysorbate 80; sucrose; talc; titanium dioxide (E171). Printing Ink: Carbon black, shellac, ammonium hydroxide, simethicone.
Injection: Each ampoule also contains the following excipients: Mannitol, sodium metabisulfite (E223), benzyl alcohol, propylene glycol, water for injection, sodium hydroxide.
Cambia Powder Packets dosage
General Dosing Instructions
Carefully consider the potential benefits and risks of Cambia Powder Packets and other treatment options before deciding to use Cambia Powder Packets. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.
The effectiveness of Cambia Powder Packets when taken with food has not been studied in clinical studies. Taking Cambia Powder Packets with food may cause a reduction in effectiveness compared to taking Cambia Powder Packets on an empty stomach.
Acute Pain
For management of mild to moderate acute pain, the dosage is 18 mg or 35 mg orally three times daily.
Osteoarthritis Pain
For management of osteoarthritis pain, the dosage is 35 mg orally three times daily.
Dosage Adjustments in Patients with Hepatic Impairment
Patients with hepatic disease may require reduced doses of Cambia Powder Packets compared to patients with normal hepatic function. As with other Cambia Powder Packets products, start treatment at the lowest dose. If efficacy is not achieved with the lowest dose, discontinue use.
Non-Interchangeability with Other Formulations of Cambia Powder Packets
Cambia Powder Packets capsules are not interchangeable with other formulations of oral Cambia Powder Packets even if the milligram strength is the same. Cambia Powder Packets capsules contain Cambia Powder Packets free acid whereas other Cambia Powder Packets products contain a salt of Cambia Powder Packets, i.e., Cambia Powder Packets or sodium. A 35 mg dose of Cambia Powder Packets is approximately equal to 37.6 mg of sodium Cambia Powder Packets or 39.5 mg of potassium Cambia Powder Packets. Therefore, do not substitute similar dosing strengths of other Cambia Powder Packets products without taking this into consideration.
Cambia Powder Packets interactions
See also:
What other drugs will affect Cambia Powder Packets?
Aspirin: Concomitant administration of Cambia Powder Packets and aspirin is not recommended because Cambia Powder Packets is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels and AUC values.
Anticoagulants: While studies have not shown Cambia Powder Packets to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs. Because prostaglandins play an important role in hemostasis and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including Cambia Powder Packets and warfarin, requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required.
Digoxin, Methotrexate, Cyclosporine: Cambia Powder Packets, like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. Ingestion of Cambia Powder Packets may increase serum concentrations of digoxin and methotrexate and increase cyclosporine's nephrotoxicity. Patients who begin taking Cambia Powder Packets or who increase their Cambia Powder Packets dose or any other NSAID while taking digoxin, methotrexate or cyclosporine may develop toxicity characteristics for these drugs. They should be observed closely, particularly if renal function is impaired. In the case of digoxin, serum levels should be monitored.
Lithium: Cambia Powder Packets decreases lithium renal clearance and increases lithium plasma levels. In patients taking Cambia Powder Packets and lithium concomitantly, lithium toxicity may develop.
Oral Hypoglycemics:
Cambia Powder Packets does not alter glucose metabolism in normal subjects nor does it alter the effects of oral hypoglycemic agents. There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of Cambia Powder Packets that necessitated changes in the doses of such agents. Both hypo- and hyperglycemic effects have been reported. A direct causal relationship has not been established, but physicians should consider the possibility that Cambia Powder Packets may alter a diabetic patient's response to insulin or oral hypoglycemic agents.Diuretics: Cambia Powder Packets and other NSAIDs can inhibit the activity of diuretics. Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels.
Other Drugs: In small groups of patients (7-10/interaction study), the concomitant administration of azathioprine, gold, chloroquine, D-penicillamine, prednisolone, doxycycline or digitoxin did not significantly affect the peak levels and AUC values of Cambia Powder Packets. Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of Cambia Powder Packets therapy.
Cambia Powder Packets side effects
See also:
What are the possible side effects of Cambia Powder Packets?
There have been cases reported of Cambia Powder Packets being associated with the development of symptoms resembling the syndrome of inappropriate antidiuretic hormone secretion in elderly women. A patient who had been taking Cambia Powder Packets for several years and had increasingly complained of dry, gritty eyes noticed that eye irritation disappeared within 3 days when Cambia Powder Packets had to be discontinued because of GI effects.
The most frequent adverse effects reported in patients given Cambia Powder Packets are GI in nature. Typical reactions include epigastric pain, nausea, vomiting and diarrhoea. Rarely, peptic ulcer and GI bleeding have occurred. Cambia Powder Packets has also been implicated as the causative agent in colonic ulceration, small bowel perforation and pseudomembranous colitis.
Renal papillary necrosis and nephritic syndrome have been reported in patients taking Cambia Powder Packets. Elevations of serum aminotransferase activity and clinical hepatitis, including fetal fulminant hepatitis have occurred in patients taking Cambia Powder Packets. Self-limiting skin reaction eg, rash or pruritus may occur in patients given Cambia Powder Packets.
Aspirin-sensitive asthmatic patients have developed reactions (rhinorrhoea, tightness of chest, wheezing, dyspnoea) when challenged with Cambia Powder Packets in doses of 10-25 mg and the CMS in the UK have received a report of 1 aspirin-sensitive patient who died from acute asthma 4 hrs after a single 25-mg dose of Cambia Powder Packets.
Cambia Powder Packets contraindications
See also:
What is the most important information I should know about Cambia Powder Packets?
Hypersensitivity to Cambia Powder Packets sodium or to any of the excipients of Cambia Powder Packets.
Active gastric or intestinal ulcer, bleeding or perforation.
Last trimester of pregnancy.
Hepatic, renal and severe cardiac failure.
Patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid and/or other drugs with prostaglandin-synthetase inhibitory activity.
Treatment of peri-operative pain in setting of coronary artery bypass graft (CABG) surgery.
The use of high dose Cambia Powder Packets (150 mg/day) for >4 weeks is contraindicated in patients with established cardiovascular disease (congestive heart failure, established ischemic heart disease, peripheral arterial disease) or uncontrolled hypertension.
Established Cardiovascular Disease or Significant Cardiovascular Risk Factors: The use of high dose Cambia Powder Packets (150mg/day) for >4 weeks is contraindicated in patients with established cardiovascular disease (congestive heart failure, established ischemic heart disease, peripheral arterial disease) or uncontrolled hypertension. If Cambia Powder Packets treatment is needed, patients with established cardiovascular disease, uncontrolled hypertension or significant cardiovascular risk factors (eg, hypertension, hyperlipidaemia, diabetes mellitus and smoking) should be treated only after careful consideration and at doses ≤100 mg daily if the treatment is for >4 weeks. As the cardiovascular risks of Cambia Powder Packets may increase with dose and duration of exposure, Cambia Powder Packets should always be prescribed at the lowest effective daily dose and for the shortest duration possible.
Renal Impairment: Cambia Powder Packets is contraindicated in patients with renal failure. No specific studies have been carried out in patients with renal impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering Cambia Powder Packets to patients with mild to moderate renal impairment.
Hepatic Impairment: Cambia Powder Packets is contraindicated in patients with hepatic failure. No specific studies have been carried out in patients with hepatic impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering Cambia Powder Packets to patients with mild to moderate hepatic impairment.
Active ingredient matches for Cambia Powder Packets:
List of Cambia Powder Packets substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Cambia | |
| Camotaren (Pakistan) | |
| Campal (Venezuela) | |
| Can-D | |
| Can-D 50+10 Tablet (Saviour Drugs) | $ 0.06 |
| Canefol (Philippines) | |
| Canefol 25 mg/1 mL x 3 mL x 10's | |
| Cannact (India) | |
| Cannact Diclofenac Sodium 50mg TAB / 10 (Astra-IDL Ltd) | $ 0.07 |
| 50 mg x 10's (Astra-IDL Ltd) | $ 0.06 |
| Cannact 50 mg Tablet (Astra-IDL Ltd) | $ 0.01 |
| CANNACT enteric-coated tab 50 mg x 10's (Astra-IDL Ltd) | $ 0.06 |
| Capridase | |
| Capridase 50+10 Tablet (Capri Pharmaceuticals) | $ 0.07 |
| Capsigyl-D Gel (India) | |
| Capsigyl-D Gel Capsicum oleo resin 0.075 %, Diclofenac sodium 1 %, Methylsalicylate 20 %, Menthol 10 %, Camphor 5 %. GEL / 15g (Shalaks) | $ 0.23 |
| Capsigyl-D Gel Capsicum oleo resin 0.075 %, Diclofenac sodium 1 %, Methylsalicylate 20 %, Menthol 10 %, Camphor 5 %. GEL / 30g (Shalaks) | $ 0.43 |
| 15g (Shalaks) | $ 0.23 |
| 30g (Shalaks) | $ 0.43 |
| CAPSIGYL-D GEL topical gel 15g (Shalaks) | $ 0.23 |
| CAPSIGYL-D GEL topical gel 30g (Shalaks) | $ 0.43 |
| Capsitop Spy (India) | |
| Capsitop Spy Capsicum 0.025 %, Diclofenacdiethylammonium 1.16 % w/w, Menthol 1 %, Methyl salicylate3 %. SPY / 40g (Stedman) | $ 1.02 |
| 40g (Stedman) | $ 0.90 |
| CAPSITOP SPY topical spray 40g (Stedman) | $ 1.02 |
| Car D | |
| Car D 50+10 Tablet (American Biocare) | $ 0.07 |
| Car-D (India) | |
| Car-D Diclofenac potassium 50 mg, Serratiopeptidase 10 mg. TAB / 100 (Am. Biocare) | $ 7.47 |
| 100's (Am. Biocare) | $ 7.47 |
| CAR-D tab 10's (Am. Biocare) | $ 0.75 |
| Caredec (India) | |
| Caredec 75mg x 3mL INJ / 1 (Arvincare) | $ 0.12 |
| 75 mg x 3 mL x 1's (Arvincare) | $ 0.12 |
| Caredec 75 mg Injection (Arvincare) | $ 0.04 |
| CAREDEC inj 75 mg x 3 mL x 3ml (Arvincare) | $ 0.12 |
| Catafast (Georgia, Malta) | |
| Catafast 50mg - 3 Powder | $ 9.00 |
| Catafast 50mg - 21 Powder | $ 43.00 |
| Catafast 50mg - 9 Powder | $ 13.00 |
| Catafen (Pakistan) | |
| Catafen supp 50 mg 10's (Bliss GVS) | |
| Cataflam (Bahrain, Bangladesh, Belgium, Benin, Brazil, Bulgaria, Burkina Faso, Cameroon, Central African Republic, Chad, Chile, Congo, Cote D'ivoire, Ecuador, Egypt, Estonia, Gabon, Ghana, Guinea, Guyana, Hong Kong, Hungary, Indonesia, Ireland, Israel, Kenya, Latvia, Lithuania, Luxembourg, Madagascar, Malaysia, Mali, Malta, Mauritania, Mauritius, Mexico, Netherlands, New Zealand, Niger, Nigeria, Norway, Oman, Peru, Philippines, Poland, Portugal, Senegal, Singapore, South Africa, Sri Lanka, Sudan, Taiwan, Tanzania, Thailand, Togo, Turkey, United States, Venezuela, Vietnam, Zaire, Zimbabwe) | |
| Suppositories; Rectal; Diclofenac Potassium 12.5 mg (Novartis) | |
| Suppositories; Rectal; Diclofenac Potassium 25 mg (Novartis) | |
| Suppositories; Rectal; Diclofenac Potassium 50 mg (Novartis) | |
| Suspension; Oral; Diclofenac Potassium 75 mg / 5 ml (Novartis) | |
| Tablet; Oral; Diclofenac Potassium 25 mg (Novartis) | |
| Tablet; Oral; Diclofenac Potassium 50 mg (Novartis) | |
| Cataflam 50 mg x 100's (Novartis) | $ 49.44 |
| Cataflam 15 mg/1 mL x 15 mL x 1's (Novartis) | |
| Cataflam 25 mg x 10 Tablet (Novartis) | |
| Cataflam 25 mg x 20's (Novartis) | |
| Cataflam 25 mg x 100's (Novartis) | $ 29.20 |
See 8243 substitutes for Cambia Powder Packets | |
References
- DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "diclofenac". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "diclofenac". http://www.drugbank.ca/drugs/DB00586 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Cambia Powder Packets are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cambia Powder Packets. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yet1 consumer reported time for results
To what extent do I have to use Cambia Powder Packets before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 5 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Cambia Powder Packets. To get the time effectiveness of using Cambia Powder Packets drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 5 days | 1 | 100.0% | |
Consumer reported age
No survey data has been collected yetConsumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
