What is Canderm?
Canderm is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).
Canderm belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, Canderm will not work for colds, flu, or other virus infections.
Canderm is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Canderm is used in certain patients with the following medical conditions:
- Clostridium difficile diarrhea or colitis (antibiotic-associated colitis).
- Crohn's disease (inflammatory bowel disease).
- Gastritis or stomach ulcers due to Helicobacter pylori.
- Giardiasis (parasite infection in the intestines).
Canderm indications
Symptomatic Trichomoniasis. Canderm Capsules USP 375 mg are indicated for the treatment of T. vaginalis infection in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures).
Asymptomatic Trichomoniasis. Canderm Capsules USP 375 mg are indicated in the treatment of asymptomatic T. vaginalis infection in females when the organism is associated with endocervicitis, cervicitis, or cervical erosion. Since there is evidence that presence of the trichomonad can interfere with accurate assessment of abnormal cytological smears, additional smears should be performed after eradication of the parasite.
Treatment of Asymptomatic Sexual Partners. T. vaginalis infection is a venereal disease. Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously if the organism has been found to be present, in order to prevent reinfection of the partner. The decision as to whether to treat an asymptomatic male partner who has a negative culture or one for whom no culture has been attempted is an individual one. In making this decision, it should be noted that there is evidence that a woman may become reinfected if her sexual partner is not treated. Also, since there can be considerable difficulty in isolating the organism from the asymptomatic male carrier, negative smears and cultures cannot be relied upon in this regard. In any event, the sexual partner should be treated with Canderm in cases of reinfection.
Amebiasis. Canderm Capsules USP 375 mg are indicated in the treatment of acute intestinal amebiasis (amebic dysentery) and amebic liver abscess.
In amebic liver abscess, Canderm Capsules USP 375 mg therapy does not obviate the need for aspiration or drainage of pus.
Anaerobic Bacterial Infections. Canderm Capsules USP 375 mg are indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. Indicated surgical procedures should be performed in conjunction with Canderm therapy. In a mixed aerobic and anaerobic infection, antimicrobials appropriate for the treatment of the aerobic infection should be used in addition to Canderm Capsules USP 375 mg.
INTRA-ABDOMINAL INFECTIONS, including peritonitis, intra-abdominal abscess, and liver abscess, caused by Bacteroides species including the B. fragilis group (B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Clostridium species, Eubacterium species, Peptococcus species, or Peptostreptococcus species.
SKIN AND SKIN STRUCTURE INFECTIONS caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.
GYNECOLOGIC INFECTIONS, including endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection, caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.
BACTERIAL SEPTICEMIA caused by Bacteroides species including the B. fragilis group or Clostridium species.
BONE AND JOINT INFECTIONS (as adjunctive therapy) caused by Bacteroides species including the B. fragilis group.
CENTRAL NERVOUS SYSTEM (CNS) INFECTIONS, including meningitis and brain abscess, caused by Bacteroides species including the B. fragilis group.
LOWER RESPIRATORY TRACT INFECTIONS, including pneumonia, empyema, and lung abscess, caused by Bacteroides species including the B. fragilis group.
ENDOCARDITIS caused by Bacteroides species including the B. fragilis group.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Canderm Capsules USP 375 mg and other antibacterial drugs, Canderm Capsules USP 375 mg should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
How should I use Canderm?
Use Canderm cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Wash and completely dry the affected area. Be sure the area is completely dry before applying Canderm cream.
- Apply a thin layer of Canderm cream to the affected area. Gently rub the medicine in until it is evenly distributed.
- Wash your hands immediately after using Canderm cream.
- You may apply cosmetics after you use Canderm cream. If you are using the lotion, wait 5 minutes after you use Canderm cream before you apply cosmetics so that the lotion has time to dry.
- Use Canderm cream on a regular schedule to get the most benefit from it. Using it at the same time(s) each day will help you remember to use it.
- Continue to use Canderm cream even if your condition improves, unless a doctor tells you otherwise. Do not miss any doses.
- If you miss a dose of Canderm cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Canderm cream.
Uses of Canderm in details
Canderm is an antibiotic that is used to treat a wide variety of infections. It works by stopping the growth of certain bacteria and parasites.
This antibiotic treats only certain bacterial and parasitic infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
Canderm may also be used with other medications to treat certain stomach/intestinal ulcers caused by a bacteria (H. pylori).
How to use Canderm
Take this medication by mouth as directed by your doctor. To prevent stomach upset, take this medication with food or a full glass of water or milk. The dosage is based on your medical condition and response to treatment.
Antibiotics work best when the amount of medicine in your body is kept at a constant level. Take this drug at evenly spaced intervals.
Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.
Tell your doctor if your condition lasts or gets worse.
Canderm description
Each 100 mL contains Metronidazole USP 500 mg, sodium chloride USP 0.72% w/v, water for injection USP as needed.
Canderm injection, USP is a parenteral dosage form of the synthetic antibacterial agent 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole. The empirical formula is C6H9N3O3 and the molecular weight is 171.15.
Canderm injection, USP in 100 mL is a sterile, nonpyrogenic, iso-osmotic, buffered solution of 500 mg Canderm, USP, 790 mg sodium chloride, USP, 47.6 mg dried dibasic sodium phosphate, USP and 22.9 mg anhydrous citric acid, USP. Canderm injection, USP has an osmolarity of 310 mOsmol/L (calc) and a pH of 5.5 (4.5 to 7).
Canderm dosage
Canderm ER Dosage
Generic name: Canderm 750mg
Dosage form: tablet, film coated, extended release
See also:
- Canderm tablet, film coated
- Canderm Capsules capsule
- Canderm Injection injection, solution
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Bacterial Vaginosis
750 mg once daily by mouth for seven consecutive days.
Canderm ER 750 mg tablets should be taken under fasting conditions, at least one hour before or two hours after meals. The optimum extended-release characteristics of Canderm ER 750 mg are obtained when the drug is taken under fasting conditions.
Canderm ER tablets should not be split, chewed, or crushed.
Dosage Adjustments
Patients Undergoing Hemodialysis
Hemodialysis removes significant amounts of Canderm and its metabolites from systemic circulation. The clearance of Canderm will depend on the type of dialysis membrane used, the duration of the dialysis session, and other factors. If the administration of Canderm cannot be separated from a hemodialysis session, supplementation of Canderm dosage following the hemodialysis session should be considered, depending on the patient's clinical situation.
More about Canderm ER (Canderm)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- En Espanol
- 6 Reviews - Add your own review/rating
- Generic Availability
Consumer resources
- Canderm ER extended-release tablets
- Canderm ER
- Canderm ER (Advanced Reading)
- Other brands: Metro
Professional resources
- Canderm ER (FDA)
- Canderm Hydrochloride (AHFS Monograph)
Other formulations
- Canderm
- Canderm IV
- Canderm
Related treatment guides
- Bacterial Vaginitis
- Balantidium coli
- Dientamoeba fragilis
- Nongonococcal Urethritis
- STD Prophylaxis
Canderm interactions
See also:
What other drugs will affect Canderm?
Simultaneous administration of Zol with:
Canderm side effects
See also:
What are the possible side effects of Canderm?
In a controlled clinical trial, safety data from 141 patients who used Canderm Lotion
Topical Lotion (n=71), or the lotion vehicle (n=70), twice daily and experienced a local cutaneous adverse event which may or may not have been related to the treatments include: local allergic reaction, Canderm
Topical Lotion 2 (3%), lotion vehicle 0; contact dermatitis, Canderm Lotion
Topical Lotion 2 (3%), lotion vehicle 1 (1%); pruritus, Canderm Lotion
Topical Lotion 1 (1%), lotion vehicle 0; skin discomfort (burning and stinging), Canderm Lotion
Topical Lotion 1 (1%), lotion vehicle 2 (3%); erythema, Canderm Lotion
Topical Lotion 4 (6%), lotion vehicle 0; dry skin, Canderm Lotion
Topical Lotion 0, lotion vehicle 1 (1%); and worsening of rosacea, Canderm Lotion
Topical Lotion 1 (1%), lotion vehicle 7 (10%).
The following additional adverse experiences have been reported with the topical use of Canderm: skin irritation, transient redness, metallic taste, tingling or numbness of extremities, and nausea.
Canderm contraindications
See also:
What is the most important information I should know about Canderm?
Hypersensitivity
Canderm Capsules 375 mg are contraindicated in patients with a prior history of hypersensitivity to Canderm or other nitroimidazole derivatives.
In patients with trichomoniasis, Canderm Capsules 375 mg are contraindicated during the first trimester of pregnancy.
Psychotic Reaction with Disulfiram
Use of oral Canderm is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently. Do not administer Canderm to patients who have taken disulfiram within the last two weeks.
Interaction with Alcohol
Use of oral Canderm is associated with a disulfiram-like reaction to alcohol, including abdominal cramps, nausea, vomiting, headaches, and flushing. Discontinue consumption of alcohol or products containing propylene glycol during and for at least three days after therapy with Canderm.
Active ingredient matches for Canderm:
Metronidazole in Brazil.
Metronidazole or metronidazole benzoate in Brazil.
List of Canderm substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Camezol (Ghana, Kenya, Latvia, Malawi, Nigeria, Sudan, Tanzania, Uganda, Zambia) | |
| Canderme | |
| Cariodent ZOL (Paraguay) | |
| Carvezole (Philippines) | |
| Cezyl-N | |
| Cezyl-N 30 ml Suspension (Ceza Formulations Pvt.Ltd) | $ 0.05 |
| Chemagyl (Bangladesh) | |
| Chomozin (Taiwan) | |
| Chomozin 250 mg | |
| Chozine (Taiwan) | |
| Chozine 250 mg | |
| Ciniflox-M | |
| Ciniflox-M 30 ml Syrup (Hinglaj Laboratories of India) | $ 0.05 |
| Cipfun M | |
| Cipfun M 30 ml Suspension (Moraceae Pharmaceuticals (P) Ltd.) | $ 0.07 |
| Ciptrogil (Russian Federation) | |
| Cironite M | |
| Cironite M 50 ml Suspension (Ciron Drugs & Pharmaceuticals Pvt Ltd) | $ 0.03 |
| Claraze (Pakistan) | |
| Clinazole (South Africa) | |
| Clogel (Taiwan) | |
| Clogel 7.5 mg/1 g x 1 g (Oyster Labs Limited) | |
| Clogel 7.5 mg/1 g x 10 g (Oyster Labs Limited) | |
| Clogel 7.5 mg/1 g x 12 g (Oyster Labs Limited) | |
| Clogel 7.5 mg/1 g x 15 g (Oyster Labs Limited) | |
| Clogel 7.5 mg/1 g x 20 g (Oyster Labs Limited) | |
| Clogel 7.5 mg/1 g x 30 g (Oyster Labs Limited) | |
| Clogel Mouth/Throat 100 ml Mouth Wash/Gargle (Oyster Labs Limited) | $ 0.47 |
| Clogel Mouth/Throat 50 gm Tooth Paste (Oyster Labs Limited) | $ 0.45 |
| CLOGEL CREAM 1 tube / 20 GM cream each (Oyster Labs Limited) | $ 0.69 |
| Clogel Cream (Oyster Labs Limited) | $ 0.69 |
| Clovizole (Philippines) | |
| Clovizole 500 mg/100 mL x 100 mL | $ 4.22 |
| Collazole (France) | |
| Sponge; Dental; Metronidazole 4.5 mg | |
| Colpocin T (Greece, Malta, Serbia) | |
| Colpocin-T (Bosnia & Herzegowina, Georgia, Greece, Malta, Serbia) | |
| Colpofilin (Argentina) | |
| Combizol F | |
| Combizol F 30 ml Syrup (Navil Laboratories) | $ 0.08 |
| Combizol F Syrup (Navil Laboratories) | $ 0.57 |
| COMPEBA (India) | |
| COMPEBA Capsule/ Tablet / 200mg / 10 units (Indian Drugs & Pharmaceuticals Ltd.) | $ 0.05 |
| 200 mg x 10's (Indian Drugs & Pharmaceuticals Ltd.) | $ 0.05 |
| Compeba 200mg TAB / 10 (Indian Drugs & Pharmaceuticals Ltd.) | $ 0.05 |
| Compeba 200 mg Tablet (Indian Drugs & Pharmaceuticals Ltd.) | $ 0.00 |
| COMPEBA tab 200 mg x 10's (Indian Drugs & Pharmaceuticals Ltd.) | $ 0.05 |
| Compeba 200mg TAB / 10 (Indian Drugs & Pharmaceuticals Ltd.) | $ 0.05 |
| Cont | |
| Corsagyl (Indonesia) | |
| Corsagyl 250 mg x 10 x 10's (Corsa) | $ 8.32 |
| Corsagyl 500 mg x 10 x 10's (Corsa) | $ 15.00 |
| Cresac (Bangladesh) | |
| Cryozol (Mexico) | |
See 2353 substitutes for Canderm | |
References
- DailyMed. "BISMUTH SUBCITRATE POTASSIUM; METRONIDAZOLE; TETRACYCLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "metronidazole". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "metronidazole". http://www.drugbank.ca/drugs/DB00916 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Canderm are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Canderm. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yetConsumer reported age
No survey data has been collected yetConsumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
