What is Cefoperazone?
Cefoperazone injection is used to treat bacterial infections in the different parts of the body.
Cefoperazone injection belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, Cefoperazone will not work for colds, flu, or other virus infections.
Cefoperazone is to be given only by or under the supervision of your doctor.
Cefoperazone indications
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefoperazone and other antibacterial drugs, Cefoperazone should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Cefoperazone is indicated for the treatment of the following infections when caused by susceptible organisms:
Respiratory Tract Infections caused by S. pneumoniae, H. influenzae, S. aureus (penicillinase and non-penicillinase producing strains), S. pyogenes* (Group A beta-hemolytic streptococci), P. aeruginosa, Klebsiella pneumoniae, E. coli, Proteus mirabilis, and Enterobacter species.
Peritonitis and Other Intra-abdominal Infections caused by E. coli, P. aeruginosa,* and anaerobic gram-negative bacilli (including Bacteroides fragilis).
Bacterial Septicemia caused by S. pneumoniae, S. agalactiae,* S. aureus, Pseudomonas aeruginosa,* E. coli, Klebsiella spp.,* Klebsiella pneumoniae,* Proteus species* (indole-positive and indole-negative), Clostridium spp.* and anaerobic gram-positive cocci.*
Infections of the Skin and Skin Structures caused by S. aureus (penicillinase and non-penicillinase producing strains), S. pyogenes,* and P. aeruginosa.
Pelvic Inflammatory Disease, Endometritis, and Other Infections of the Female Genital Tract caused by N. gonorrhoeae, S. epidermidis,* S. agalactiae, E. coli, Clostridium spp.,* Bacteroides species (including Bacteroides fragilis), and anaerobic gram-positive cocci.
Cefoperazone® has no activity against Chlamydia trachomatis. Therefore, when Cefoperazone is used in the treatment of patients with pelvic inflammatory disease and C. trachomatis is one of the suspected pathogens, appropriate anti-chlamydial coverage should be added.
Urinary Tract Infections caused by Escherichia coli and Pseudomonas aeruginosa.
Enterococcal Infections: Although Cefoperazone has been shown to be clinically effective in the treatment of infections caused by enterococci in cases of peritonitis and other intra-abdominal infections, infections of the skin and skin structures, pelvic inflammatory disease, endometritis and other infections of the female genital tract, and urinary tract infections,* the majority of clinical isolates of enterococci tested are not susceptible to Cefoperazone but fall just at or in the intermediate zone of susceptibility, and are moderately resistant to Cefoperazone. However, in vitro susceptibility testing may not correlate directly with in vivo results. Despite this, Cefoperazone therapy has resulted in clinical cures of enterococcal infections, chiefly in polymicrobial infections. Cefoperazone should be used in enterococcal infections with care and at doses that achieve satisfactory serum levels of Cefoperazone.
* Efficacy against this organism in this organ system was studied in fewer than 10 infections.
Combination Therapy
Synergy between Cefoperazone and aminoglycosides has been demonstrated with many gram-negative bacilli. However, such enhanced activity of these combinations is not predictable. If such therapy is considered, in vitro susceptibility tests should be performed to determine the activity of the drugs in combination, and renal function should be monitored carefully.
Uses of Cefoperazone in details
Cefoperazone is used to treat bacterial infection of the respiratory tract, the abdomen and abdominal wall (peritonitis), the urinary tract, the female genital tract (endometritis, pelvic inflammatory disease), the blood (septicemia), and the skin and soft tissues.
Cefoperazone description
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Cefoperazone is considered an antioxidant.
Cefoperazone dosage
Cefoperazone Dosage
Generic name: sterile Cefoperazone
Dosage form: Injection
See also:
- Cefoperazone injection
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
The usual adult daily dose of Cefoperazone (sterile Cefoperazone) is 2 to 4 grams per day administered in equally divided doses every 12 hours.
In severe infections or infections caused by less sensitive organisms, the total daily dose and/or frequency may be increased. Patients have been successfully treated with a total daily dosage of 6–12 grams divided into 2, 3 or 4 administrations ranging from 1.5 to 4 grams per dose.
In a pharmacokinetic study, a total daily dose of 16 grams was administered to severely immunocompromised patients by constant infusion without complications. Steady state serum concentrations were approximately 150 mcg/mL in these patients.
When treating infections caused by Streptococcus pyogenes, therapy should be continued for at least 10 days.
Solutions of Cefoperazone and aminoglycoside should not be directly mixed, since there is a physical incompatibility between them. If combination therapy with Cefoperazone and an aminoglycoside is contemplated this can be accomplished by sequential intermittent intravenous infusion provided that separate secondary intravenous tubing is used, and that the primary intravenous tubing is adequately irrigated with an approved diluent between doses. It is also suggested that Cefoperazone be administered prior to the aminoglycoside. In vitro testing of the effectiveness of drug combination(s) is recommended.
More about Cefoperazone (Cefoperazone)
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Professional resources
- Cefoperazone (FDA)
- Cefoperazone injection (FDA)
Related treatment guides
- Bacteremia
- Bacterial Infection
- Endometritis
- Febrile Neutropenia
- Intraabdominal Infection
- More (7) »
Cefoperazone interactions
Drug/Laboratory Test Interactions: A false-positive reaction for glucose in the urine may occur with copper reduction tests (Benedictís or Fehlingís solution or with ClinitestÒ tablets) but not with enzyme-based tests for glycosuria. As a false-negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase method be used to determine blood plasma glucose levels in patients receiving cefuroxime.
Cefoperazone does not interfere with the assay of serum and urine creatinine by the alkaline picrate method.
Cefoperazone side effects
See also:
What are the possible side effects of Cefoperazone?
In clinical studies the following adverse effects were observed and were considered to be related to Cefoperazone therapy or of uncertain etiology:
Hypersensitivity
As with all cephalosporins, hypersensitivity manifested by skin reactions (1 patient in 45), drug fever (1 in 260), or a change in Coombs' test (1 in 60) has been reported. These reactions are more likely to occur in patients with a history of allergies, particularly to penicillin.
Hematology
As with other beta-lactam antibiotics, reversible neutropenia may occur with prolonged administration. Slight decreases in neutrophil count (1 patient in 50) have been reported. Decreased hemoglobins (1 in 20) or hematocrits (1 in 20) have been reported, which is consistent with published literature on other cephalosporins. Transient eosinophilia has occurred in 1 patient in 10.
Hepatic
Of 1285 patients treated with Cefoperazone in clinical trials, one patient with a history of liver disease developed significantly elevated liver function enzymes during Cefoperazone therapy. Clinical signs and symptoms of nonspecific hepatitis accompanied these increases. After Cefoperazone therapy was discontinued, the patient's enzymes returned to pre-treatment levels and the symptomatology resolved. As with other antibiotics that achieve high bile levels, mild transient elevations of liver function enzymes have been observed in 5–10% of the patients receiving Cefoperazone therapy. The relevance of these findings, which were not accompanied by overt signs or symptoms of hepatic dysfunction, has not been established.
Gastrointestinal
Diarrhea or loose stools has been reported in 1 in 30 patients. Most of these experiences have been mild or moderate in severity and self-limiting in nature. In all cases, these symptoms responded to symptomatic therapy or ceased when Cefoperazone therapy was stopped. Nausea and vomiting have been reported rarely.
Symptoms of pseudomembranous colitis can appear during or for several weeks subsequent to antibiotic therapy.
Renal Function Tests
Transient elevations of the BUN (1 in 16) and serum creatinine (1 in 48) have been noted.
Local Reactions
Cefoperazone is well tolerated following intramuscular administration. Occasionally, transient pain (1 in 140) may follow administration by this route. When Cefoperazone is administered by intravenous infusion some patients may develop phlebitis (1 in 120) at the infusion site.
Cefoperazone contraindications
Cefoperazone for Injection USP and Dextrose Injection USP is contraindicated in patients with known allergy to the cephalosporin group of antibiotics. Solutions containing dextrose may be contraindicated in patients with hypersensitivity to corn products.
Active ingredient matches for Cefoperazone:
Cefoperazone
| Unit description / dosage (Manufacturer) | Price, USD |
| Injectable; Injection; Cefoperazone Sodium 1 g | |
| Injectable; Injection; Cefoperazone Sodium 2 g | |
| Injectable; Injection; Cefoperazone Sodium 500 mg | |
| Cefoperazone 1000 mg Injection | $ 1.93 |
| Cefoperazone 500 mg Injection | $ 0.93 |
| Cefoperazone 250 mg Injection | $ 0.84 |
List of Cefoperazone substitutes (brand and generic names): | |
| Cefoperazona Richmond (Argentina) | |
| CEFOPERAZONE 1GM INJETION | |
| CEFOPERAZONE 1GM INJETION 1 vial / 1 injection each (Jan Aushadhi) | $ 0.72 |
| Cefoperazone AbiPharm (Georgia) | |
| Cefoperazone ABR (Bulgaria) | |
| Cefoperazone ABR 1g (Bulgaria) | |
| Cefoperazone ABR 2g (Bulgaria) | |
| Cefoperazone Fisiopharma (Vietnam) | |
| Cefoperazone Fisiopharma 1 g x 1 Bottle | |
| Cefoperazone Flamingo (Vietnam) | |
| Cefoperazone Flamingo 1 g x 10 Bottle | |
| Cefoperazone Kaifeng Yugang (Vietnam) | |
| Cefoperazone Kaifeng Yugang 1 g x 1 Bottle | |
| Cefoperazone Sigma (Egypt) | |
| Cefoperazone Sodium - CSPC Pharm (China) | |
| Cefoperazone Yarindo (Indonesia) | |
| Cefoperazone Yarindo / vial 1000 mg x 2's (Yarindo Farmatama) | $ 12.40 |
| Cefoperazone-Heng Rui (China) | |
| Cefoperazone-Zizhu Pharm (China) | |
| Cefoperon (India) | |
| Cefoperon 500 mg Injection (Agron Remedies Pvt Ltd) | $ 0.96 |
| Cefoperon 1000 mg Injection (Agron Remedies Pvt Ltd) | $ 2.00 |
| Cefoperon-S (India) | |
| Cefoperon-S 500+500 Injection (Agron Remedies Pvt Ltd) | $ 2.13 |
| Cefoperon-S Cefoperazone 500 mg, sulbactam500 mg. POWD / 1 (Agron Remedies Pvt Ltd) | $ 2.17 |
| Cefoperon-S Cefoperazone 250 mg, sulbactam125 mg. POWD / 1 (Agron Remedies Pvt Ltd) | $ 0.71 |
| Cefoperone | |
| Cefoperone 250 mg Injection (Agron Remedies Pvt Ltd) | $ 0.88 |
| Cefoperus | |
| Injectable; Injection; Cefoperazone Sodium 1 g | |
| Injectable; Injection; Cefoperazone Sodium 2 g | |
| Injectable; Injection; Cefoperazone Sodium 500 mg | |
| Cefophar (Indonesia) | |
| Cefophar 1 g x 1's (Pharos) | $ 15.40 |
| Cefosint (Italy) | |
| Cefosun S | |
| Cefosun S 500+500 Injection (Sunshine Pharmaceuticals) | $ 1.67 |
| Cefotron (Portugal) | |
| Cefotus S | |
| Cefotus S 500+500 Injection (Kapeetus Medicorp) | $ 1.45 |
| Cefovik | |
| Cefovik 500+500 Injection (Hi-Tech Pharmaceuticals Pvt Ltd) | $ 2.11 |
| Cefozen D | |
| Cefozen D 1000+500 Injection (Zentis Drugs Pvt Ltd) | $ 1.99 |
| Cefozile (Vietnam) | |
| Cefozile 1 g x 1 Bottle | |
| Cefozon (Romania) | |
| Cefozon 0.5 g x 1's (E.i.p.i.co. med) | |
| Cefozon 1 g x 1's (E.i.p.i.co. med) | |
| CEFOZON 1g | |
| Cefozon 500mg | |
| Cefozone (Singapore) | |
| Cefozone 1 g x 1's (Atlantic) | |
| Cefozone 0.5 g x 1's (Atlantic) | |
| CEFPAR (KARNATA ANTIBIOTIC) | |
| CEFPAR 1GM INJECTION 1 vial / 1 injection each (Karnataka Antibiotics & Pharmaceuticals Ltd) | $ 0.54 |
| Cefpoper | |
| Cefpoper 500+500 Injection (Agron Remedies Pvt Ltd) | $ 2.05 |
| CEFPRA | |
| CEFPRA 1GM INJECTION 1 vial / 1 injection each (Ampra Pharmaceuticals) | $ 0.79 |
| Cefrazon (Egypt) | |
| Cefrone (Egypt) | |
| Cefrone 1000 mg Injection (Aero-Chem Neutron Pvt Ltd) | $ 0.96 |
See 572 substitutes for Cefoperazone | |
Reviews
The results of a survey conducted on ndrugs.com for Cefoperazone are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cefoperazone. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yet3 consumers reported age
| Users | % | ||
|---|---|---|---|
| 6-15 | 1 | 33.3% | |
| 16-29 | 1 | 33.3% | |
| > 60 | 1 | 33.3% | |
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Information checked by Dr. Sachin Kumar, MD Pharmacology
