Chloramphenicol belongs to the family of medicines called antibiotics. Chloramphenicol ophthalmic preparations are used to treat infections of the eye. Chloramphenicol may be given alone or with other medicines that are taken by mouth for eye infections.
Chloramphenicol is available only with your doctor's prescription.
Chloramphenicol indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Chloramphenicol should be used only in those serious infections for which less potentially dangerous drugs are ineffective or contraindicated. Bacteriological studies should be performed to determine the causative organisms and their sensitivity to Chloramphenicol.
Chloramphenicol, 1% (Chloramphenicol Ophthalmic Ointment, USP) is indicated for the treatment of surface ocular infections involving the conjunctiva and/or cornea caused by Chloramphenicol-susceptible organisms.
The particular antiinfective drug in this product is active against the following common bacterial eye pathogens:
Staphylococcus aureus
Streptococcus, including Streptococcus pneumoniae
Escherichia coli
Haemophilus influenzae
Klebsiella/Enterobacter species
Moraxella lucunata
(Morax-Axenfeld bacillus)
Neisseria species
This product does not provide adequate coverage against:
Pseudomonas aeruginosa
Serratia marcescens
How should I use Chloramphenicol?
Use Chloramphenicol as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Chloramphenicol is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Chloramphenicol at home, carefully follow the injection procedures taught to you by your health care provider.
If Chloramphenicol contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
To clear up your infection completely, continue using Chloramphenicol for the full course of treatment even if you feel better in a few days.
Keep this product, as well as syringes and needles, out of the reach of children. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
If you miss a dose of Chloramphenicol, use it as soon as possible. Then use your doses at evenly spaced times as directed by your doctor. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Chloramphenicol.
Uses of Chloramphenicol in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications
Serious infections: Treatment of serious infections, including cystic fibrosis exacerbations, bacterial meningitis, and bacteremia, caused by Chlamydiaceae, Haemophilus influenzae, Rickettsia, Salmonella spp. (acute infections), and other organisms when other less toxic agents are ineffective or contraindicated.
Guideline recommendations: Chloramphenicol may be considered for use as an alternative agent to doxycycline in the treatment of tickborne rickettsial diseases (eg, Rocky Mountain spotted fever [RMSF]); however, epidemiologic studies suggest that Chloramphenicol-treated patients with RMSF are at a higher risk of death compared to tetracycline-treated patients. In addition, Chloramphenicol is not effective in the treatment of human ehrlichiosis or anaplasmosis, therefore, use with caution in the empiric treatment of tickborne rickettsial diseases (CDC [Biggs 2016]).
Chloramphenicol description
Each 100 g contains Chloramphenicol 1 g.
Chloramphenicol dosage
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Chloramphenicol Dosage
Generic name: Chloramphenicol
Dosage form: ophthalmic ointment
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
A small amount of ointment placed in the lower conjunctival sac every three hours, or more frequently if deemed advisable by the prescribing physician. Administration should be continued day and night the first 48 hours, after which the interval between applications may be increased. Treatment should be continued for at least 48 hours after the eye appears normal.
More about Chloromycetin Ophthalmic (Chloramphenicol ophthalmic)
Side Effects
Breastfeeding
Dosage Information
Drug Interactions
Support Group
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Consumer resources
Other brands: Ocu-Chlor, Chloroptic, AK-Chlor
Professional resources
Chloramphenicol (FDA)
Other formulations
Chloromycetin
Chloromycetin Sodium Succinate
Chloramphenicol interactions
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Alcohol (Ethyl): Chloramphenicol (Systemic) may enhance the adverse/toxic effect of Alcohol (Ethyl). Monitor therapy
Barbiturates: Chloramphenicol (Systemic) may decrease the metabolism of Barbiturates. Barbiturates may increase the metabolism of Chloramphenicol (Systemic). Monitor therapy
BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
BCG (Intravesical): Myelosuppressive Agents may diminish the therapeutic effect of BCG (Intravesical). Avoid combination
BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Monitor therapy
Carbocisteine: Chloramphenicol (Systemic) may enhance the adverse/toxic effect of Carbocisteine. Specifically, Chloramphenicol may enhance adverse effects of alcohol that is present in liquid formulations of carbocisteine-containing products. Monitor therapy
CefTAZidime: Chloramphenicol (Systemic) may diminish the therapeutic effect of CefTAZidime. Management: Consider using a different combination of antimicrobials, especially if bactericidal activity is desired. If these agents are combined, monitor for reduced antimicrobial effectiveness and/or therapeutic failure. Consider therapy modification
Chloramphenicol (Ophthalmic): May enhance the adverse/toxic effect of Myelosuppressive Agents. Monitor therapy
Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Avoid combination
Cladribine: May enhance the myelosuppressive effect of Myelosuppressive Agents. Avoid combination
CloZAPine: Myelosuppressive Agents may enhance the adverse/toxic effect of CloZAPine. Specifically, the risk for neutropenia may be increased. Monitor therapy
CycloSPORINE (Systemic): Chloramphenicol (Systemic) may increase the serum concentration of CycloSPORINE (Systemic). Management: Cyclosporine dose reductions will likely be required with initiation of concurrent Chloramphenicol. Monitor cyclosporine concentrations and response closely following initiation and/or discontinuation of Chloramphenicol. Consider therapy modification
Deferiprone: Myelosuppressive Agents may enhance the neutropenic effect of Deferiprone. Management: Avoid the concomitant use of deferiprone and myelosuppressive agents whenever possible. If this combination cannot be avoided, monitor the absolute neutrophil count more closely. Consider therapy modification
Dipyrone: May enhance the adverse/toxic effect of Myelosuppressive Agents. Specifically, the risk for agranulocytosis and pancytopenia may be increased Avoid combination
Fosphenytoin: May decrease the serum concentration of Chloramphenicol (Systemic). Fosphenytoin may increase the serum concentration of Chloramphenicol (Systemic). Chloramphenicol (Systemic) may increase the serum concentration of Fosphenytoin. Monitor therapy
Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Monitor therapy
Mesalamine: May enhance the myelosuppressive effect of Myelosuppressive Agents. Monitor therapy
Phenytoin: May decrease the serum concentration of Chloramphenicol (Systemic). Phenytoin may increase the serum concentration of Chloramphenicol (Systemic). Chloramphenicol (Systemic) may increase the serum concentration of Phenytoin. Monitor therapy
Promazine: May enhance the myelosuppressive effect of Myelosuppressive Agents. Monitor therapy
RifAMPin: May increase the metabolism of Chloramphenicol (Systemic). Monitor therapy
Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Consider therapy modification
Sulfonylureas: Chloramphenicol (Systemic) may decrease the metabolism of Sulfonylureas. Monitor therapy
Tacrolimus (Systemic): Chloramphenicol (Systemic) may increase the serum concentration of Tacrolimus (Systemic). Management: Tacrolimus dose reductions will likely be required with initiation of concurrent Chloramphenicol. Monitor tacrolimus concentrations and response closely following initiation and/or discontinuation of Chloramphenicol. Consider therapy modification
Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Vaccination with live attenuated typhoid vaccine (Ty21a) should be avoided in patients being treated with systemic antibacterial agents. Use of this vaccine should be postponed until at least 3 days after cessation of antibacterial agents. Consider therapy modification
Vitamin B12: Chloramphenicol (Systemic) may diminish the therapeutic effect of Vitamin B12. Monitor therapy
Vitamin K Antagonists (eg, warfarin): Chloramphenicol (Systemic) may enhance the anticoagulant effect of Vitamin K Antagonists. Chloramphenicol (Systemic) may increase the serum concentration of Vitamin K Antagonists. Monitor therapy
Voriconazole: Chloramphenicol (Systemic) may increase the serum concentration of Voriconazole. Monitor therapy
Applies to Chloramphenicol: capsule, powder for solution, suspension
In addition to its needed effects, some unwanted effects may be caused by Chloramphenicol (the active ingredient contained in Chloramphenicol). In the event that any of these side effects do occur, they may require medical attention.
Stop taking Chloramphenicol and get emergency help immediately if any of the following effects occur:
Rare - in babies only
Bloated stomach
drowsiness
gray skin color
low body temperature
uneven breathing
unresponsiveness
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Chloramphenicol:
Less common:
Pale skin
sore throat and fever
unusual bleeding or bruising
unusual tiredness or weakness (the above side effects may also occur up to weeks or months after you Stop taking Chloramphenicol)
Rare
Confusion, delirium, or headache
eye pain, blurred vision, or loss of vision
numbness, tingling, burning pain, or weakness in the hands or feet
skin rash, fever, or difficulty in breathing
Minor Side Effects
Some of the side effects that can occur with Chloramphenicol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Chloramphenicol Lotion is contraindicated for premature neonates because their skin may be more permeable than full term infants and their liver enzymes may not be sufficiently developed. It is also contraindicated for patients with Norwegian (crusted) scabies due to possible increased absorption. It is also contraindicated for patients with known seizure disorders and for individuals with a known sensitivity to the product or any of its components.
Active ingredient matches for Chloramphenicol:
Chloramphenicol
Unit description / dosage (Manufacturer)
Price, USD
Ointment; Ophthalmic; Chloramphenicol 1%
Injectable; Injection; Chloramphenicol Sodium Succinate 1 g
Solution; Ophthalmic; Chloramphenicol 0.5%
Tablet; Oral; Chloramphenicol 200 mg
Capsule; Oral; Chloramphenicol 250 mg
Injectable; Injection; Chloramphenicol 15%
Powder; Oral; Chloramphenicol 55 mg / g
Chloramphen na succ 1 gm vial
$ 28.74
Chloramphenicol palm powder
$ 2.52
Chloramphenicol crystals
$ 1.32
Chloramphenicol / C.R. 250 mg x 1000's
Chloramphenicol / Shinlon 250 mg x 1000's
Chloramphenicol / K.S. 250 mg/1 mL x 2 mL
Chloramphenicol 125mg/5mL SUSP / 60ml
$ 0.27
Chloramphenicol / Yuan Chou 250 mg x 1000's
Chloramphenicol / Astar 250 mg x 1000's
Chloramphenicol / Astar 125 mg/1 g x 1 g
Chloramphenicol / Central 250 mg x 1000's
Chloramphenicol / Y.Y. 125 mg/1 mL x 2 mL
Chloramphenicol / Oriental 250 mg x 1000's
Chloramphenicol / VPP 250 mg x 1000's
125 mg x 5 mL x 60ml
$ 0.27
Chloramphenicol / TAH-AN 250 mg x 1000's
Chloramphenicol / Sinphar 250 mg x 1000's
Chloramphenicol / Oasis 0.25 % x 5 mL
Chloramphenicol / Oasis 0.5 % x 5 mL
Chloramphenicol / Oasis 10 mg/1 g x 3.5 g
Chloramphenicol 250 mg Capsule
$ 0.03
Chloramphenicol 500 mg Modern Capsule
$ 0.04
Chloramphenicol 250 mg Tosc international Capsule
$ 0.01
Chloramphenicol 500 mg Capsule
$ 0.02
Chloramphenicol 250 mg Acichem Capsule
$ 0.01
Chloramphenicol 250 mg Modern Capsule
$ 0.02
Chloramphenicol 1000 mg Injection
$ 0.42
Chloramphenicol 3 ml Drop
$ 0.10
Chloramphenicol 250 mg agron Capsule
$ 0.02
CHLORAMPHENICOL / SANOFI AVENTIS oral susp 125 mg x 5 mL x 60ml (Sanofi Aventis)
$ 0.27
List of Chloramphenicol substitutes (brand and generic names):
DailyMed. "CHLORAMPHENICOL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
The results of a survey conducted on ndrugs.com for Chloramphenicol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Chloramphenicol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
Consumer reported useful
No survey data has been collected yet
Consumer reported price estimates
No survey data has been collected yet
1 consumer reported time for results
To what extent do I have to use Chloramphenicol before I begin to see changes in my health conditions? As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions. Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Chloramphenicol. To get the time effectiveness of using Chloramphenicol drug by other patients, please click here.
Users
%
1 day
1
100.0%
1 consumer reported age
Users
%
46-60
1
100.0%
Consumer reviews
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