is used to induce ovulation (egg production) in women who do not produce ova (eggs) but wish to become pregnant. Clomiphene is in a class of medications called ovulatory stimulants. It works similarly to estrogen, a female hormone that causes eggs to develop in the ovaries and be released.
Clomiphene is also sometimes used to treat male infertility, menstrual abnormalities, fibrocystic breasts, and persistent breast milk production. Talk to your doctor about the possible risks of using this medication for your condition.
Clomifene is used to treat infertility in women caused by failure or improper release of eggs from ovary (ovulation).It is also used to treat infertility in males due to decreased production of sperms (oligozoospermia).
A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. [PubChem]
Once ovulation has been established, start each course of Clomifene on or about the 5th day of cycle. Max: 6 cycles (including 3 ovulatory cycles).
* If you think you might be pregnant, stop taking this medicine and tell your doctor. Talk to your doctor before taking this medicine if you have thyroid problems. Multiple births (such as twins or triplets) are possible when taking clomiphene. This medicine may cause changes in vision such as blurring or trouble focusing.
* If this becomes severe, tell your doctor.
* Be careful driving or operating machinery.
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
Long-term use of clomiphene may increase the risk of ovarian cancer. Clomiphene should not be used for more than about six cycles. Talk to your doctor about the risks of taking this medication.
Clomiphene may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
this medicine is contraindicated in patients with a known hypersensitivity or allergy to clomiphene citrate or to any of its ingredients.
this medicine should not be administered during pregnancy. this medicine may cause fetal harm in animals. Although no causative evidence of a deleterious effect of CLOMID therapy on the human fetus has been established, there have been reports of birth anomalies which, during clinical studies, occurred at an incidence within the range reported for the general population. To avoid inadvertent this medicine administration during early pregnancy, appropriate tests should be utilized during each treatment cycle to determine whether ovulation occurs. The patient should be evaluated carefully to exclude pregnancy, ovarian enlargement, or ovarian cyst formation between each treatment cycle. The next course of this medicine therapy should be delayed until these conditions have been excluded.
Fetal/Neonatal Anomalies and Mortality. The following fetal abnormalities have been reported subsequent to pregnancies following ovulation induction therapy with this medicine during clinical trials. Each of the following fetal abnormalities were reported at a rate of < 1% (experiences are listed in order of decreasing frequency): Congenital heart lesions, Down syndrome, club foot, congenital gut lesions, hypospadias, microcephaly, harelip and cleft palate, congenital hip, hemangioma, undescended testicles, polydactyly, conjoined twins and teratomatous malformation, patent ductus arteriosus, amaurosis, arteriovenous fistula, inguinal hernia, umbilical hernia, syndactyly, pectus excavatum, myopathy, dermoid cyst of scalp, omphalocele, spina bifida occulta, ichthyosis, and persistent lingual frenulum. Neonatal death and fetal death/stillbirth in infants with birth defects have also been reported at a rate of < 1%. The overall incidence of reported birth anomalies from pregnancies associated with maternal CLOMID ingestion during clinical studies was within the range of that reported for the general population.
In addition, reports of birth anomalies have been received during postmarketing surveillance of this medicine.
Oral administration of clomiphene citrate to pregnant rats during organogenesis at doses of 1 to 2 mg/kg/day resulted in hydramnion and weak, edematous fetuses with wavy ribs and other temporary bone changes. Doses of 8 mg/kg/day or more also caused increased resorptions and dead fetuses, dystocia, and delayed parturition, and 40 mg/kg/day resulted in increased maternal mortality. Single doses of 50 mg/kg caused fetal cataracts, while 200 mg/kg caused cleft palate.
Following injection of clomiphene citrate 2 mg/kg to mice and rats during pregnancy, the offspring exhibited metaplastic changes of the reproductive tract. Newborn mice and rats injected during the first few days of life also developed metaplastic changes in uterine and vaginal mucosa, as well as premature vaginal opening and anovulatory ovaries. These findings are similar to the abnormal reproductive behavior and sterility described with other estrogens and antiestrogens.
In rabbits, some temporary bone alterations were seen in fetuses from dams given oral doses of 20 or 40 mg/kg/day during pregnancy, but not following 8 mg/kg/day. No permanent malformations were observed in those studies. Also, rhesus monkeys given oral doses of 1.5 to 4.5 mg/kg/day for various periods during pregnancy did not have any abnormal offspring.
Liver Disease. this medicine therapy is contraindicated in patients with liver disease or a history of liver
|Unit description / dosage (Manufacturer)||Price, USD|
|Tablet; Oral; Clomiphene Citrate 50 mg|
|ClomiPHENE Citrate 30 50 mg tablet Box||$ 215.90|
|Clomiphene citrate powder||$ 47.74|
|Clomid 50 mg tablet||$ 6.09|
|Serophene 50 mg tablet||$ 5.52|
|Clomiphene citrate 50 mg tab||$ 6.86|
List of Clomifene substitutes (brand and generic names):
|Clomifene Citrate F (Japan)|
|Clomifene Remedica (Bosnia & Herzegowina)|
|Clomifeno Ethical (Dominican Republic)|
|Clomifert (Bahrain, Iraq, Jordan, Kuwait, Lebanon, Libya, Nigeria, Oman, Qatar, Saudi Arabia, Somalia, Sudan, United Arab Emirates, Yemen)|
|CLOMIGENE 25MG TABLET 1 strip / 10 tablets each (Vhb Life Sciences Inc)||$ 0.49|
|Clomihexal (South Africa)|
|Clominfene Citrate Fuji (Japan)|
|Clomiphen (New Zealand)|
|Tablet; Oral; Clomiphene Citrate|
|Clomiphen Anfarm (Greece)|
|Clomiphen Arcana (Austria)|
|Clomiphen Citrate (Greece)|
|Clomiphen Citrate Anfarm (Greece)|
|CLOMIPHENE 50MG TABLET|
|CLOMIPHENE 50MG TABLET 1 strip / 10 tablets each (Jan Aushadhi)||$ 0.23|
|Clomiphene Adco (Egypt)|
|Clomiphene Citrate Actavis (United States)|
|Clomiphene Citrate Jean-Marie (Hong Kong)|
|Clomiphene Citrate Jean-Marie 50 mg x 3 x 10's|
|Clomiphene Citrate Par (United States)|
|Clomiphene Honten (Taiwan)|
|Clomiphene Update (Taiwan)|
|Clomiphene YSP (Malaysia)|
|Clomiphene YSP 50 mg x 10's x 10 x 6|
|Clomiphene YSP Industries (Thailand)|
|Clomiphene YSP Industries 50 mg x 10 x 10's (YSP Industries)|
|Clomiphene YSP Industries tab 50 mg 10's (YSP Industries)|
|Clomiphene Yu Sheng (Taiwan)|
|Clomiphene Yuan Chou (Taiwan)|
|Clomiphene Yung Shin (Singapore, Taiwan)|
|Clomiphene Yung Shin 50 mg x 100's|
|Clomiriv 25mg TAB / 100 (East African (I) Remedies Pvt Ltd)||$ 5.08|
|25 mg x 100's (East African (I) Remedies Pvt Ltd)||$ 5.08|
|Clomiriv 25 mg Tablet (East African (I) Remedies Pvt Ltd)||$ 0.05|
|CLOMIRIV tab 25 mg x 10's (East African (I) Remedies Pvt Ltd)||$ 0.62|
|CLOMISUR 100 MG TABLET 1 strip / 10 tablets each (Surge Biotech Pvt Ltd)||$ 1.74|
|CLOMISUR 25 MG TABLET 1 strip / 10 tablets each (Surge Biotech Pvt Ltd)||$ 0.46|
|CLOMISUR 50 MG TABLET 1 strip / 10 tablets each (Surge Biotech Pvt Ltd)||$ 0.52|
|Clomisur 100mg Tablet (Surge Biotech Pvt Ltd)||$ 0.17|
|Clomisur 25mg Tablet (Surge Biotech Pvt Ltd)||$ 0.05|
|Clomisur 50mg Tablet (Surge Biotech Pvt Ltd)||$ 0.05|
|Clomit 50mg TAB / 10 (Beulah)||$ 1.02|
|50 mg x 10's (Beulah)||$ 1.02|
|CLOMIT tab 25 mg x 10's (Beulah)|
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Information checked by Dr. Sachin Kumar, MD Pharmacology