Clopidrax 75mg Uses

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What is Clopidrax 75mg?

Clopidrax 75mg is used alone or together with aspirin to lessen the chance of a heart attack or stroke. It is given to patients who have already had a heart attack, severe chest pain, or a stroke, or to patients with other circulation problems that could cause a stroke or heart attack.

A heart attack or stroke may occur when a blood vessel is blocked by a blood clot. Clopidrax 75mg is a platelet inhibitor. It reduces the chance that a harmful blood clot will form by preventing platelets from clumping together in the blood. Clopidrax 75mg may also increase the chance of serious bleeding in some people.

Clopidrax 75mg is available only with your doctor's prescription.

Clopidrax 75mg indications

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Prevention of atherothrombotic events in: Recent MI, Recent Stroke or Established Peripheral Arterial Disease: For patients with a history of recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease, Clopidrax 75mg has been shown to reduce the rate of a combined endpoint of new ischemic stroke (fatal or not), new MI (fatal or not), and other vascular death.

Acute Coronary Syndrome: For patients with non-ST-segment elevation acute coronary syndrome (unstable angina/non-Q-wave MI) including patients who are to be managed medically and those who are to be managed with percutaneous coronary intervention (with or without stent) or coronary artery bypass graft (CABG), Clopidrax 75mg has been shown to decrease the rate of a combined endpoint of cardiovascular death, MI or stroke as well as the rate of a combined endpoint of cardiovascular death, MI, stroke or refractory ischemia.

For patients with ST-segment elevation acute MI, Clopidrax 75mg has been shown to reduce the rate of death from any cause and the rate of a combined endpoint of death, reinfarction or stroke.

Atrial Fibrillation: In patients with atrial fibrillation (AF) at increased risk of vascular events who can take vitamin K antagonist (VKA) therapy, VKA has been shown to be associated with a better clinical benefit than acetylsalicylic acid (aspirin) alone or the combination of Clopidrax 75mg and aspirin for the reduction of stroke.

In patients with atrial fibrillation who have at least 1 risk factor for vascular events and who cannot take VKA therapy [eg, specific risk of bleeding, physician assessment that patient is unable to comply with international normalized ratio (INR) monitoring or that VKA use is inappropriate], Clopidrax 75mg is indicated in combination with aspirin for the prevention of atherothrombotic and thromboembolic events, including stroke. Clopidrax 75mg in combination with aspirin has been shown to reduce the rate of the combined endpoint of stroke, myocardial infarction (MI), non-CNS systemic embolism, or vascular death, largely through a reduction in stroke.

How should I use Clopidrax 75mg?

Use Clopidrax 75mg as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Clopidrax 75mg.

Uses of Clopidrax 75mg in details

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Use: Labeled Indications

Acute coronary syndrome:

ST-segment elevation myocardial infarction: To reduce the rate of myocardial infarction (MI) and stroke in conjunction with aspirin in patients with acute ST-elevation MI who are to be managed medically.

Non-ST-segment elevation acute coronary syndromes: To decrease the rate of MI and stroke in conjunction with aspirin in patients with non-ST-segment elevation acute coronary syndromes (unstable angina/non-ST-elevation MI), including patients who are to be managed medically and those who are to be managed with coronary revascularization.

Myocardial infarction, ischemic stroke, or peripheral atherosclerotic disease: To reduce the rate of MI and stroke in patients with a history of recent MI, recent stroke, or established peripheral atherosclerotic disease.

Off Label Uses

Carotid artery atherosclerosis, symptomatic

Based on the American College of Chest Physicians guidelines for antithrombotic therapy in peripheral artery disease, Clopidrax 75mg is effective and recommended for patients with symptomatic carotid artery atherosclerosis.

Carotid artery stenting

A randomized, controlled trial with blinded end point adjudication evaluated carotid artery stenting versus carotid endarterectomy in patients with carotid artery stenosis. In this trial, aspirin in combination with Clopidrax 75mg was used for patients who underwent carotid artery stenting, which suggests that this antiplatelet combination is effective.

Clopidrax 75mg description

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Each film-coated tablet contains Clopidogrel hydrogen sulphate 97.875 mg (molar equivalent of Clopidrax 75mg base 75 mg) or Clopidrax 75mg hydrogen sulphate 391.5 mg (molar equivalent of Clopidrax 75mg base 300 mg).

Clopidrax 75mg also contains the following excipients: Hydrogenated castor oil, hydroxypropyl cellulose, mannitol E421, microcrystalline cellulose and polyethylene glycol 6000 as inactive ingredient. The pink film coating contains ferric oxide E172, hypromellose 2910, lactose, titanium dioxide and triacetin. The tablets are polished with carnauba wax.

Clopidrax 75mg hydrogen sulfate is methyl(+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate sulfate (1:1). It has an empirical formula of C16H16CINO2S·H2SO4 and a molecular weight of 419.9.

Clopidrax 75mg hydrogen sulfate is an inhibitor of ADP-induced platelet aggregation acting by direct inhibition of adenosine diphosphate (ADP) binding to its receptor and of the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex.

Clopidrax 75mg hydrogen sulfate is a white to off-white powder. It is practically insoluble in water at neutral pH but freely soluble at pH 1. It also dissolves freely in methanol, dissolves slightly in methylene chloride, and is practically insoluble in ethyl ether. It has a specific optical rotation of about +56°.

Clopidrax 75mg dosage

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Clopidrax 75mg Dosage

Generic name: Clopidrax 75mg bisulfate 75mg

Dosage form: tablet, film coated

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Acute Coronary Syndrome

Clopidrax 75mg can be administered with or without food.

Recent MI, Recent Stroke, or Established Peripheral Arterial Disease

The recommended daily dose of Clopidrax 75mg is 75 mg once daily orally, with or without food.

CYP2C19 Poor Metabolizers

CYP2C19 poor metabolizer status is associated with diminished antiplatelet response to Clopidrax 75mg. Although a higher dose regimen in poor metabolizers increases antiplatelet response, an appropriate dose regimen for this patient population has not been established.

Use with Proton Pump Inhibitors (PPI)

Avoid using omeprazole or esomeprazole with Clopidrax 75mg. Omeprazole and esomeprazole significantly reduce the antiplatelet activity of Clopidrax 75mg. When concomitant administration of a PPI is required, consider using another acid-reducing agent with minimal or no CYP2C19 inhibitory effect on the formation of Clopidrax 75mg active metabolite.

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Clopidrax 75mg interactions

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What other drugs will affect Clopidrax 75mg?

In vitro studies using higher concentrations of Clopidrax 75mg showed inhibition of CYP2C9 isoenzyme. Interaction of Clopidrax 75mg with drugs eg, tamoxifen, phenytoin, tolbutamide, warfarin, torsemide, fluvastatin and many nonsteroidal anti-inflammatory drugs may be possible. But there are no data to predict the magnitude of these interactions.

The anticoagulant properties of heparin were unaffected by concurrent administration of clinically relevant dosages of Clopidrax 75mg.

Concomitant administration of aspirin ≥300 mg/day plus Clopidrax 75mg 75 mg/day did not prolong bleeding time to a significantly greater extent than that attributable to Clopidrax 75mg alone. The safety of chronic concomitant administration of aspirin and Clopidrax 75mg is not established. Clopidrax 75mg potentiated the effect of aspirin on collagen-induced platelet aggregation.

Concomitant administration of Clopidrax 75mg and naproxen resulted in an increase of occult gastrointestinal blood loss in healthy volunteers.

Co-administration with warfarin has not been studied. Consequently, concomitant administration of these 2 agents should be undertaken with caution.

The steady-state pharmacokinetics profile of digoxin and theophylline was unaffected by co-administration of Clopidrax 75mg for 10 days. Similarly, the platelet anti-aggregating properties of Clopidrax 75mg were unchanged by co-administration of theophylline in these studies.

There is no evidence of pharmacodynamic interaction between Clopidrax 75mg and commonly prescribed cardiovascular medication in patients with symptomatic atherothrombotic disease. Clopidrax 75mg retained its full antiplatelet effect, in patients with peripheral arterial obstructive disease taking nifedipine, atenolol or nifedipine and atenolol.

Food: Clopidrax 75mg can be taken either before or after food.

Laboratory Tests: None known.

Clopidrax 75mg side effects

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What are the possible side effects of Clopidrax 75mg?

Adverse effects occurring in at least 2.5% of patients with recent MI, stroke, or established peripheral arterial occlusive disease receiving Clopidrax 75mg in the Clopidrax 75mg versus Aspirin in Patients at Risk of Ischemic Events (CAPRIE) study included chest pain, accidental injury, influenza-like symptoms, pain, fatigue, edema, hypertension, headache, dizziness, abdominal pain, dyspepsia, diarrhea, nausea, hypercholesterolemia, arthralgia, back pain, purpura (bruising), epistaxis, depression, upper respiratory tract infection, dyspnea, rhinitis, bronchitis, coughing, rash, pruritus, and urinary tract infection. Rash and diarrhea were reported more frequently with Clopidrax 75mg therapy. Rash classified as severe was more common with Clopidrax 75mg therapy.

Adverse effects occurring in at least 2% of patients with unstable angina or non-ST-segment elevation acute coronary syndromes receiving Clopidrax 75mg and aspirin in the CURE study included chest pain, headache, dizziness, abdominal pain, dyspepsia or diarrhea. The incidence of major bleeding (principally GI hemorrhage and bleeding at puncture sites), including life-threatening bleeding, was substantially greater in patients receiving Clopidrax 75mg and aspirin.

Patients with ST-segment elevation MI, the incidence of major bleeding (intracranial hemorrhage or bleeding associated with a decrease in hemoglobin >5 mg/dL) was similar in patients receiving Clopidrax 75mg and aspirin.

The incidence of severe neutropenia (neutrophil count <450/mm3) was similar in patients receiving Clopidrax 75mg or aspirin.

Clopidrax 75mg contraindications

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What is the most important information I should know about Clopidrax 75mg?

Clopidrax 75mg should not be used whenever stimulation of gastrointestinal motility might be dangerous, e.g., in the presence of gastrointestinal hemorrhage, mechanical obstruction, or perforation.

Clopidrax 75mg is contraindicated in patients with pheochro-mocytoma because the drug may cause a hypertensive crisis, probably due to release of catecholamines from the tumor. Such hypertensive crises may be controlled by phen-tolamine.

Clopidrax 75mg is contraindicated in patients with known sensitivity or intolerance to the drug.

Clopidrax 75mg should not be used in epileptics or patients receiving other drugs which are likely to cause extrapyramidal reactions, since the frequency and severity of seizures or extrapyramidal reactions may be increased.

Active ingredient matches for Clopidrax 75mg:

Clopidogrel in Switzerland.


List of Clopidrax 75mg substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
CLOPIGARD 75 MG TABLET 1 strip / 10 tablets each (Cipla Ltd)$ 0.19
Clopigard 75mg Tablet (Cipla Ltd)$ 0.02
Clopiget 75mg TAB / 15 (Klokter Life Sciences)$ 1.25
Clopiget 75 mg Tablet (Klokter Life Sciences)$ 0.08
Clopigold 75 mg x 2 Blister x 14 Tablet
CLOPIGREL Capsule/ Tablet / 75mg / 10 units (USV Limited)$ 2.17
Clopigrel 75mg FC-TAB / 10 (USV Limited)$ 2.59
Clopigrel 75 mg x 4 Blister x 7 Tablet (USV Limited)
75 mg x 10's (USV Limited)$ 2.37
Clopigrel 75 mg Tablet (USV Limited)$ 0.26
CLOPIGREL 300 MG TABLET 1 strip / 2 tablets each (USV Limited)$ 0.35
CLOPIGREL 75 MG TABLET 1 strip / 10 tablets each (USV Limited)$ 0.81
CLOPIGREL film-coated tab 75 mg x 10's (USV Limited)$ 0.14
Clopigrel 300mg Tablet (USV Limited)$ 0.18
Clopigrel 75mg Tablet (USV Limited)$ 0.08
Clopiheal 75mg TAB / 10
CLOPIJOY 75MG TABLET 1 strip / 10 tablets each (Torrent Pharmaceuticals Ltd)$ 0.47
Clopikare 75mg TAB / 100 (Nitro Cardineur)$ 5.64
75 mg x 100's (Nitro Cardineur)$ 5.64
Clopikare 75 mg Tablet (Nitro Cardineur)$ 0.06
CLOPIKARE tab 75 mg x 10's (Nitro Cardineur)$ 0.56
Clopikind 75 mg Tablet (Mankind Pharmaceuticals Pvt. Ltd.)$ 0.03
CLOPIKIND 75 MG TABLET 1 strip / 10 tablets each (Mankind Pharmaceuticals Pvt. Ltd.)$ 0.32
CLOPIKIND tab 75 mg x 10's (Mankind Pharmaceuticals Pvt. Ltd.)$ 0.27
Clopikind 75mg Tablet (Mankind Pharmaceuticals Pvt. Ltd.)$ 0.03
Clopikind AS 75+150 Tablet (Mankind Pharmaceuticals Pvt. Ltd.)$ 0.03
Clopikind AS 75+75 Tablet (Mankind Pharmaceuticals Pvt. Ltd.)$ 0.03
CLOPIKIND AS 75MG/75MG TABLET 1 strip / 10 tablets each (Mankind Pharmaceuticals Pvt. Ltd.)$ 0.38
Clopikind AS 75mg/75mg Tablet (Mankind Pharmaceuticals Pvt. Ltd.)$ 0.04
CLOPIKLOT tab 75 mg x 10's (Biochem)$ 0.75
CLOPILET Capsule/ Tablet / 75mg / 10 units (Sun Pharmaceutical Industries Ltd.)$ 0.90
Clopilet 75mg FC-TAB / 10 (Sun Pharmaceutical Industries Ltd.)$ 0.77

References

  1. PubChem. "clopidogrel". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "clopidogrel". http://www.drugbank.ca/drugs/DB00758 (accessed September 17, 2018).
  3. DTP/NCI. "clopidogrel: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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