Consists of Mebeverine, Sulpiride
Mebeverine (Colovatil) indications
Irritable bowel syndrome & allied conditions eg, chronic irritable colon, spastic constipation, mucous colitis and spastic colitis. Symptomatic treatment of abdominal pain, cramps, nonspecific diarrhoea & flatulence. GI spasm secondary to organic diseases eg, diverticulitis, gastritis, duodenitis, oesophagitis, cholecystitis, Crohn's disease, ulcerative colitis, peptic ulcer, gallbladder disease, hiatus hernia, GIT inflammation.
Uses of Mebeverine (Colovatil) in details
Mebeverine (Colovatil) is used to treat irritable bowel syndrome (disorder of the intestines that leads to cramps in the abdomen, gas, bloating and changes in bowel habits). It is also used to treat other conditions that involve spasm and pain related to small and large bowel.
Mebeverine (Colovatil) description
Each capsule contains Mebeverine (Colovatil) HCl 200 mg.
Mebeverine (Colovatil) also contains the following excipients: Capsule Content (Granules): Magnesium stearate, polyacrylate dispersion 30%, talc, hypromellose, methacrylic acid-ethyl acrylate copolymer (1:1) dispersion 30% and glycerol triacetate. Capsule Shell: Gelatin, titanium dioxide (E171). Printing Ink: Shellac (E904), black iron oxide (E172), propylene glycol, concentrated ammonia solution, potassium hydroxide.
Mebeverine (Colovatil) dosage
Adults: 1 capsule twice daily (1 in the morning and 1 in the evening).
Special Populations: Elderly, Renal and Hepatic Impairment: No posology studies in elderly, renal and/or hepatically impaired patients have been performed. However, no specific risk for elderly, renal and/or hepatically impaired patients could be identified from available post-marketing data. No dosage adjustment is deemed necessary in these patients.
Missed Dose: In case of ≥1 doses missed, continue with the next dose as prescribed; the missed doses are not to be taken in addition to the regular dose.
Administration: The capsules should be swallowed with a sufficient amount of water (at least 100 mL of water).
It should not be chewed because the coating is intended to ensure a prolonged release mechanism.
Mebeverine (Colovatil) interactions
No interaction studies have been performed except with alcohol. In vitro and in vivo studies in animals have demonstrated the absence of any interaction between Mebeverine (Colovatil) and ethanol.
Incompatibilities: Not applicable.
Mebeverine (Colovatil) side effects
Although adverse effects appear rare, gastrointestinal disturbances, dizziness, headache, insomnia, anorexia and tachycardia have been reported in patients receiving Mebeverine (Colovatil).
Mebeverine (Colovatil) contraindications
Hypersensitivity to Mebeverine (Colovatil) HCl or to any of the excipients of Mebeverine (Colovatil).
Sulpiride (Colovatil) indications
Sulpiride (Colovatil) is indicated for the treatment of schizophrenia.
Sulpiride (Colovatil) description
An analgesic and antipyretic that has been given by mouth and as ear drops. Sulpiride (Colovatil) is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
Sulpiride (Colovatil) dosage
The dosing regimen of Sulpiride (Colovatil) East West Pharma is individual. For oral administration the starting dose is 20 mg, the single dose is 40-80 mg, the frequency of reception is 2-3 times / day.
For IV jet slowly injection the initial dose is 1 mg; after 2 minutes is administered the same dose again. In the absence of the effect of it is possible repeated injections.
Maximum doses: for oral administration - 320 mg / day; the repeated IV total dose is 10 mg (under the control of blood pressure and ECG).
Sulpiride (Colovatil) interactions
Combination w/ bradycardia-inducing medications (e.g. β-blockers, some Ca channel blockers) or medications which induce electrolyte imbalance (e.g. hypokalaemic diuretics, stimulant laxatives, IV amphotericin B, glucocorticoids, tetracosactides) may induce torsades de pointes or prolong the QT interval. Enhanced postural hypotension if used w/ other antihypertensive drugs. Concurrent use w/ other CNS depressants may cause increased CNS depression. Co-admin w/ antacids or sucralfate may decrease Sulpiride (Colovatil) absorption. Concurrent use w/ lithium increases the risk of extrapyramidal side effects. May reduce effectiveness of ropinorole.
Potentially Fatal: Reciprocal antagonism of effects between levodopa and neuroleptics.
Sulpiride (Colovatil) side effects
CNS and peripheral nervous system: fatigue, weakness, dizziness, headache, drowsiness or insomnia, vivid dreams, depression, anxiety, confusion, hallucinations, tremors, nervousness, anxiety.
Sensory organs: a decrease in the secretion of tear fluid (dryness and soreness of the eyes).
Cardiovascular system: sinus bradycardia, AV block (up to the full development of cross-blockade and cardiac arrest), arrhythmia, development (worsening) of chronic heart failure, decreased blood pressure, orthostatic hypotension, manifestation of angiospasm (increased peripheral circulatory disorders, cold lower extremities, Raynaud's syndrome), pain in the chest.
Digestive system: nausea, vomiting, epigastric discomfort, constipation or diarrhea, liver problems (dark urine, yellow skin or sclera, cholestasis), changes in taste, elevated liver enzymes, lactate dehydrogenase.
Respiratory system: nasal congestion, bronchospasm.
Endocrine: changes in blood glucose (hypo- or hyperglycemia).
hematopoietic system: thrombocytopenia (unusual bleeding and hemorrhage), leukopenia.
Dermatological reactions: increased sweating, psoriasis such as skin reactions, exacerbation of psoriasis symptoms.
Allergic reactions: itching, skin rash, urticaria.
Other: back pain, arthralgia, reduced potency, withdrawal symptoms (increasing stenocardia attacks, myocardial infarction, increased blood pressure).
Sulpiride (Colovatil) contraindications
AV-block II and III degree, sinoatrial block, bradycardia (heart rate is less than 55 beats / min), SSS, hypotension (systolic blood pressure is less than 90 mm Hg, especially in myocardial infarction), chronic heart failure IIB-III stages, acute heart failure, cardiogenic shock, hypersensitivity to propranolol.
Active ingredient matches for Colovatil:
Mebeverine/Sulpiride in Egypt.
List of Colovatil substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Colona (Egypt) | |
| Mebeverine/Sulpiride (Egypt) | |
References
- PubChem. "sulpiride". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "mebeverine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Mebeverine". http://www.drugbank.ca/drugs/DB12554 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Colovatil are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Colovatil. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
2 consumers reported useful
Was the Colovatil drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
| Users | % | ||
|---|---|---|---|
| Useful | 1 | 50.0% | |
| Not useful | 1 | 50.0% | |
3 consumers reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Colovatil drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
| Users | % | ||
|---|---|---|---|
| Not expensive | 2 | 66.7% | |
| Expensive | 1 | 33.3% | |
2 consumers reported time for results
To what extent do I have to use Colovatil before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 5 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Colovatil. To get the time effectiveness of using Colovatil drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 5 days | 1 | 50.0% | |
| 1 week | 1 | 50.0% | |
13 consumers reported age
| Users | % | ||
|---|---|---|---|
| 16-29 | 8 | 61.5% | |
| 30-45 | 2 | 15.4% | |
| > 60 | 1 | 7.7% | |
| 46-60 | 1 | 7.7% | |
| < 1 | 1 | 7.7% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
