Consists of Mebeverine, Sulpiride
Actions of Mebeverine (Colovatil) in details
Pharmacotherapeutic Group: Synthetic anticholinergics, esters with tertiary amino group. ATC Code: A03AA04.
Pharmacology: Pharmacodynamics: Mechanism of Action and Pharmacodynamic Effects: Mebeverine is a musculotropic antispasmodic with a direct effect on the smooth muscle of the gastrointestinal tract, relieving spasm without affecting normal gut motility. Since this effect is not mediated by the autonomic nervous system, the typical anticholinergic side effects are absent.
Pharmacokinetics: Absorption: Mebeverine is rapidly and completely absorbed after oral administration. The modified-release formulation permits a twice-daily dosing scheme.
Distribution: No significant accumulation occurs after multiple doses.
Biotransformation: Mebeverine HCl is mainly metabolized by esterases, which split the ester bonds into veratric acid and mebeverine alcohol firstly.
In plasma, demethylated carboxylic acid (DMAC) is the main metabolite. The steady-state elimination half-life t½ of DMAC is approximately 5.77 hrs. During multiple dosing (200 mg twice daily) the maximum plasma concentration (Cmax) of DMAC is 804 ng/mL and time to maximum plasma concentration (tmax) is about 3 hrs. The relative bioavailability appears to be optimal with a mean ratio of 97%.
Elimination: Mebeverine is not excreted as such, but metabolized completely; the metabolites are excreted nearly completely. Veratric acid is excreted into the urine, mebeverine alcohol is also excreted into the urine, partly as the corresponding carboxylic acid (MAC) and partly as DMAC.
Paediatric Population: No pharmacokinetic studies have been conducted in children with any formulation of mebeverine.
Mebeverine (Colovatil) pharmacology
The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.
Actions of Sulpiride (Colovatil) in details
Sulpiride (Colovatil) East West Pharma is a non-selective beta-blocker. This medication has antihypertensive, antianginal and antiarrhythmic action.
The hypotensive effect is associated with a decrease in minute volume of blood, sympathetic stimulation of peripheral vascular disease, decreased activity of the renin-angiotensin system (has a value in patients with initial hypersecretion of renin), sensitivity of baroreceptors of the aortic arch (not going to enhance their activity in response to decreased blood pressure) and the effect on the CNS. The hypotensive effect is stabilized by the end of the second week of the prescription course.
The antianginal effect of Sulpiride (Colovatil) East West Pharma is due to reduced myocardial oxygen demand (due to the negative chronotropic and inotropic effect).
The antiarrhythmic effect is due to the elimination of arrhythmogenic factors (tachycardia, increased activity of the sympathetic nervous system, increase of cAMP, hypertension), decrease in the rate of spontaneous excitation of the sinus and ectopic pacemakers and slowing of AV-holding.
The ability of this drug to prevent the development of headache of vascular origin is due to a decrease in expression of the expansion of cerebral arteries due to beta-adrenoblockade vascular receptors, inhibition induced by catecholamines platelet aggregation and lipolysis, reduction of platelet adhesiveness, prevention of activation of coagulation factors during the release of adrenaline, the stimulation of oxygen supply to tissues and decreased secretion of renin.
Reduction of tremor during treatment with propranolol caused mainly by the blockade of peripheral beta2-adrenergic receptors.
This medicine increases the atherogenic properties of blood; strengthens uterine contractions (spontaneous or induced by means of stimulating the myometrium); increases the tone of the bronchi; in high doses cause sedation.
Sulpiride (Colovatil) administration
May be taken with or without food.
Sulpiride (Colovatil) pharmacology
In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride (Colovatil) is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride (Colovatil) appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.
References
- EPA DSStox. "Mebeverine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
- EPA DSStox. "(RS)-(+/-)-sulpiride: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Colovatil are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Colovatil. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
3 consumers reported administration
When best can I take Colovatil, on an empty stomach, before or after food?ndrugs.com website users have also released a report stating that Colovatil should be taken Before food. In any case, this may not be the right description on how you ought to take this Colovatil. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Colovatil can be taken.
| Users | % | ||
|---|---|---|---|
| Before food | 2 | 66.7% | |
| With a meal | 1 | 33.3% | |
Consumer reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
