How long did you take this medication to work?
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
* this medicineis used to relieve constipation (difficulty with bowel movements).
* It is a stimulant laxative, which induces a laxative effect (stimulating stool production).
* It is used to relieve constipation and works by stimulating nerve endings in the walls of part of the gut called the large intestine (colon) and rectum. This causes the muscles in the intestine wall to contract more often and with increased force, emptying the bowel and relieving constipation. As this medicineis activated by natural bacteria found in the colon, it does not start working until it reaches this part of the gut.
* In general, this drug is used to relieve constipation and to empty the bowel before surgery, childbirth or certain medical procedures such as radiological examination of the bowel.
* Benefits of being on this drug can include regular bowel movements.
Listed below are the typical uses of Cremalax.
* Short-term relief of constipation
* Management of constipation (of any cause)
* Clearing the bowel before surgery, childbirth or radiological investigations.
Uses of Cremalax in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
Cremalax is used to provide relief from constipation (difficulty in passing stools). It also used (in combination with magnesium oxide and anhydrous citric acid) to empty the bowel before colonoscopy (internal examination of colon to check for cancers or other abnormalities).
Each 5 mL syrup contains 5 mg 4,4'-(2-pyridyl-methylene)-diphenol-bis(hydrogen sulfate-ester) disodium salt (equivalent to Cremalax 5 mg). It also contains the following excipients: Sodium carboxymethylcellulose, methylparaben, propylparaben, glycerin, aroma tutti frutti, sodium saccharin, FD & C yellow #6, ethanol and purified water.
A low residue diet is recommended on the day prior to the hospital procedure. To avoid dehydration, it is recommended to drink a sufficient amount of clear liquids whilst the effects of Cremalax persist. Clear liquids may include water, clear soup, fruit juice without pulp, softdrinks, tea and/or even coffee without milk.
Adults (including the Elderly): Split-Dose Regimen (evening-before and day of the procedure): The 1st Cremalax sachet is taken the night before the procedure and the 2nd is taken the next day, in the morning prior to the procedure. On the day before the procedure: 1 sachet. The 1st reconstituted sachet is taken in the evening (eg, 5-9 PM), followed by at least five 250 mL drinks of clear liquids, spread over several hrs.
On the day of the procedure: 1 sachet. The 2nd reconstituted sachet is taken in the morning (5-9 hrs before the procedure), followed by at least three 250 mL drinks of clear liquids, spread over several hours.
Day-Before Regimen (evening-before the procedure): The 1st Cremalax sachet is taken in the afternoon or early evening and the 2nd is taken approximately 6 hrs later, the night before the procedure.
On the day before the procedure: 2 sachets. The 1st reconstituted sachet is taken in the afternoon or early evening (eg, 4-6 PM), followed by at least five 250 mL drinks of clear liquids, spread over several hours. The 2nd reconstituted sachet is taken in the late evening (eg, 10-12 AM), followed by at least three 250 mL drinks of clear liquids, spread over several hours.
Clear liquids may be consumed until 2 hrs before the time of the procedure.
Administration: Directions for Reconstitution: Reconstitute the Cremalax powder right before each administration. Do not prepare the solution in advance. Reconstitute the contents of 1 sachet in a cup of water (approximately 150 mL). Stir for 2-3 minutes, the solution should now become an off-white, cloudy liquid with a faint odour of orange.
As a purgative, Cremalax increases the gastrointestinal transit rate. The absorption of other orally administered medicines (eg, antiepileptics, contraceptives, antidiabetics, antibiotics) may therefore be modified during the treatment period.
Oral medication administered within 1 hr of the start of administration of Cremalax solution may be flushed from the gastrointestinal tract and the medication may not be absorbed. Tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine and penicillamine, should be taken at least 2 hrs before and ≥6 hrs after administration of Cremalax to avoid chelation with magnesium.
The efficacy of Cremalax is lowered by bulk-forming laxatives.
Prior or concomitant use of antibiotics with Cremalax may reduce efficacy of Cremalax as conversion of Cremalax to its active metabolite, bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM) is mediated by colonic bacteria.
Use caution when prescribing Cremalax for patients with conditions or who are using medications that increase the risk for fluid and electrolyte disturbances or may increase the risk of seizure, arrhythmias and prolonged QT in the setting of fluid and electrolyte abnormalities. This include patients receiving drugs which may be associated with hypokalemia (eg, diuretics or corticosteroids, or drugs where hypokalaemia is a particular risk ie, cardiac glycosides). Caution is also advised when Cremalax is used in patients on angiotensin converting enzyme inhibitors, NSAIDs or drugs known to induce syndrome of inappropriate antidiuretic hormone secretion (SIADH) eg, tricyclic antidepressants, selective serotonin re-uptake inhibitors, antipsychotic drugs and carbamazepine as these drugs may increase the risk of water retention and/or electrolyte imbalance.
Cremalax side effects
MedDRA Organ Class: Common (≥1/100 to ≤1/10); uncommon (≥1/1000 to ≤1/100); not known (cannot be estimated from the available data).
Immune System Disorder: Uncommon: Anaphylactic reaction, hypersensitivity.
Metabolism and Nutrition Disorders: Uncommon: Hyponatremia and hypokalaemia.
Nervous System Disorders: Common: Headache. Uncommon: Epilepsy, grand mal convulsion, convulsions, confusional state.
Gastrointestinal Disorders: Common: Nausea and proctalgia. Uncommon: Vomiting, abdominal pain, aphthoid ileal ulcers*. Not Known: Diarrhea, faecal incontinence.
Skin and Subcutaneous Tissue Disorders: Uncommon: Rash (including erythematous and maculopapular rash, urticaria, purpura).
*Isolated cases of mild reversible aphthoid ileal ulcers have been reported.
The frequencies of the side effects are based on post-marketing experience.
Diarrhea and faecal incontinence are the primary clinical effect of Cremalax. Isolated cases of severe diarrhea have been reported post-marketing.
Hyponatremia has been reported with or without associated convulsions. In epileptic patients, there have been isolated reports of seizure/grand mal convulsion without associated hyponatraemia. There have been isolated reports of anaphylactoid reaction.
Hypersensitivity to Cremalax or any of the component of Dulcolax. In case of rare hereditary conditions that may be incompatible with the excipients, the use of Cremalax is contraindicated. Patients with ileus, intestinal obstruction, acute abdominal conditions including appendicitis, acute inflammatory bowel diseases and severe abdominal pain associated with nausea and vomiting which may be indicative of the aforementioned severe conditions. It is also contraindicated in severe dehydration.
Active ingredient matches for Cremalax:
Sodium Picosulfate in India.
ReviewsThe results of a survey conducted on ndrugs.com for Cremalax are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cremalax. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
2 consumers reported usefulWas the Cremalax drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
3 consumers reported price estimatesWas the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Cremalax drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
2 consumers reported time for resultsTo what extent do I have to use Cremalax before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Cremalax. To get the time effectiveness of using Cremalax drug by other patients, please click here.
11 consumers reported age
Information checked by Dr. Sachin Kumar, MD Pharmacology