Consists of cyproheptadine, sorbitol, tricholine citrate
What is Cyproheptadine?
Cyproheptadine an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose
Cyproheptadine is used to treat sneezing, itching, watery eyes, runny nose, and other symptoms of allergies.
Cyproheptadine may also be used for purposes not listed in this medication guide.
Cyproheptadine indications
For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine. (Allergic conjunctivitis; Allergic reaction; Anaphylaxis; Anorexia nervosa; Cold urticaria; Cushing's disease; Decreased appetite caused by Chronic disease; Dermatographic urticaria; Migraine; Sexual dysfunction caused by antipsychotic agents; Sexual dysfunction caused by fluoxetine; Sexual dysfunction caused by monoamine oxidase inhibitors; Sexual dysfunction caused by tricyclic antidepressants; Vasomotor rhinitis; seasonal Allergic rhinitis;)
How should I use Cyproheptadine?
Use Cyproheptadine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Cyproheptadine by mouth with or without food.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- If you miss a dose of Cyproheptadine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Cyproheptadine.
Uses of Cyproheptadine in details
Use: Labeled Indications
Allergic conditions: Perennial and seasonal allergic rhinitis; vasomotor rhinitis; allergic conjunctivitis caused by inhalant allergens and foods; mild, uncomplicated allergic skin manifestations of urticaria and angioedema; amelioration of allergic reactions to blood or plasma; cold urticaria; dermatographism; adjunctive anaphylactic therapy.
Off Label Uses
Decreased appetite secondary to chronic disease
Data from a small randomized, double-blind, placebo-controlled trial with a long-term extension phase supports the use of cyproheptadine in the treatment of decreased appetite secondary to chronic disease. Additional trials may be necessary to further define the role of cyproheptadine in this condition.
Serotonin syndrome
Data from a limited number of patients studied (case series) suggests that cyproheptadine may be beneficial for the treatment of serotonin syndrome. Additional trials may be necessary to define the role of cyproheptadine in this condition.
Cyproheptadine description
Each capsule contains: Cyproheptadine hydrochloride 2 mg, dried yeast IP'85 100 mg and approved colours used in the capsule shell.
Each 5 mL syrup contains: Cyproheptadine hydrochloride 2 mg, tricholine citrate 275 mg, non-crystallising 70% sorbitol solution 2 g and flavoured syrupy base. Colour: Caramel.
Each 5 mL plain oral solution contains: Cyproheptadine hydrochloride equivalent to anhydrous cyproheptadine hydrochloride 2 mg and flavoured syrupy base. Colour: Caramel.
Each mL drops contains: Cyproheptadine hydrochloride 1.5 mg, tricholine citrate 55 mg and flavoured syrupy sorbitol base. Colour: Caramel.
Cyproheptadine dosage
DOSAGE SHOULD BE INDIVIDUALIZED ACCORDING TO THE NEEDS AND THE RESPONSE OF THE PATIENT.
Each tablet contains 4 mg of cyproheptadine hydrochloride.
Pediatric Patients
Age 2 To 6 Years
The total daily dosage for pediatric patients may be calculated on the basis of body weight or body area using approximately 0.25 mg/kg/day or 8 mg per square meter of body surface (8 mg/m2).
The usual dose is 2 mg (1/2 tablet) two or three times a day, adjusted as necessary to the size and response of the patient. The doe is not to exceed 12 mg a day.
Age 7 To 14 Years
The usual dose is 4 mg (1 tablet) two or three times a day adjusted as necessary to the size and response of the patient. The dose is not to exceed 16 mg a day.
Adults
The total daily dose for adults should bot exceed 0.5 mg/kg/day. The therapeutic range is 4 to 20 mg a day, with the majority of patients requiring 12 to 16 mg a day. An occasional patient may require as much as 32 mg a day for adequate relief. It is suggested that dosage be initiated with 4 mg (1 tablet) three times a day and adjusted according to the size and response of the patient.
How supplied
Cyproheptadine Hydrochloride Tablets USP are available as white to off white, flat-faced, beveledged, round shaped tablets, one side debossed with "CYP", the other side bisected, containing 4 mg of Cyproheptadine packaged in bottles of 100 tablets, NDC 62033-0346-0, and 1000 tablets, NDC 62033-0346-2.
PHARMACIST: Dispense in a well-closed container as defined in the USP. Use child-resistant closure (as required).
Store at 20 - 25 C (68 - 77 F) excursions permitted to 15 - 30 C (59 - 86 F)
Manufactured by: Stason Pharmaceuticals, Inc., Irvine, CA 92618. Revised: Nov 2010
Cyproheptadine interactions
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What other drugs will affect Cyproheptadine?
Monoamine oxidase inhibitors (MAOIs) prolong and intensify the anticholinergic effects of antihistamines.
Cyproheptadine may have additive effects with alcohol and other CNS depressants like hypnotics, sedatives, tranquilizers and antianxiety agents.
Cyproheptadine side effects
See also:
What are the possible side effects of Cyproheptadine?
Applies to cyproheptadine: oral solution, oral tablets
Side effects include:
Sedation, sleepiness (often transient), dizziness, disturbed coordination, restlessness, excitation.
Cyproheptadine contraindications
See also:
What is the most important information I should know about Cyproheptadine?
Always ask a doctor before giving a cold or allergy medicine to a child. Death can occur from the misuse of cold and allergy medicines in very young children.
You should not use this medication if you are allergic to cyproheptadine, or if you have narrow-angle glaucoma, a stomach ulcer or obstruction, an enlarged prostate or urination problems, if you are having an asthma attack, or if you are elderly or have a debilitating disease.
Before taking cyproheptadine, tell your doctor if you have glaucoma, a history of asthma, high blood pressure, heart disease, or an overactive thyroid.
Cyproheptadine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Drinking alcohol can increase certain side effects of cyproheptadine.
What is Sorbitol?
Preventing infection during prostate surgery or other urinary tract surgeries. It may also be used for other conditions as determined by your doctor.
Sorbitol is a hexitol irrigant. It works by flushing debris out of the surgical area to help prevent infection.
Sorbitol indications
It has been employed as a 30% solution as an alternative to glucose in parenteral nutrition but its use is not recommended because of the risk of lactic acidosis.
Sorbitol may be administered by mouth or rectally as an osmotic laxative in the management of constipation doses of 20 to 50 g have been suggested.
Solutions containing about 3% of sorbitol are used as irrigating fluids in transurethral surgical procedures.
Sorbitol also acts as a bulk sweetening agent. It is used in limited quantities as a sweetener in energy-reduced diabetic food products. It is also used as an alternative to sucrose in many sugar-free oral liquid preparations and in sugar-free foods as it is less likely to cause dental caries.
Sorbitol also has humectant and stabilising properties and is used in various pharmaceutical and cosmetic products including toothpaste.
How should I use Sorbitol?
Use Sorbitol as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Sorbitol may be taken with or without food.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Do not take additional laxatives or stool softeners while taking Sorbitol unless directed by your doctor.
- If you are using Sorbitol as a rectal enema, follow the directions given with the enema. Ask your doctor or pharmacist any questions you may have about giving an enema.
- Do not exceed the recommended dose or use Sorbitol for longer than 1 week without checking with your doctor.
- If you miss a dose of Sorbitol, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Sorbitol.
Uses of Sorbitol in details
Sorbitol is used to treat occasional constipation.
Sorbitol description
A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures.
Sorbitol dosage
Sorbitol Dosage
Applies to the following strength(s): 70%; 3.3%; 3%
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
- Constipation
Usual Pediatric Dose for:
- Constipation
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Precautions
- Dialysis
Usual Adult Dose for Constipation
Oral: 30 to 150 mL (70% solution) once.
Rectal: 120 mL (25% to 30% solution) as a rectal enema once.
Usual Pediatric Dose for Constipation
2 to 11 years:
Oral: 2 mL/kg (70% solution) once.
Rectal: 30 to 60 mL (25% to 30% solution) as a rectal enema once.
Greater than or equal to 12 years:
Oral: 30 to 150 mL (70% solution) once.
Rectal: 120 mL (25% to 30% solution) as a rectal enema once.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
The use of sorbitol is contraindicated in patients with anuria. Sorbitol should not be used in patients with suspected or documented fructose intolerance. Sorbitol should not given by injection.
Sudden severe abdominal bloating and diarrhea have been reported in patients ingesting sorbitol.
Solutions for urologic irrigation should be used with caution in patients with severe cardiopulmonary or renal dysfunction.
Irrigating fluids used during transurethral prostatectomy have been demonstrated to enter the systemic circulation in relatively large volumes; thus sorbitol irrigating solution must be regarded as a systemic agent. Absorption of large amounts of fluids containing sorbitol may significantly alter cardiopulmonary and renal dynamics. Appropriate patient monitoring should be conducted due to the possibility of fluid overload. If fluid overload occurs, intensive fluid and electrolyte management should be initiated. Monitoring of fluid and electrolyte levels beyond the acute phase may be necessary due to the possibility of delayed fluid absorption.
Hyperglycemia from metabolism of absorbed sorbitol may be observed in patients with diabetes mellitus.
The cardiovascular status, especially of the patient with cardiac disease, should be carefully monitored before and during transurethral resection of the prostate when using 3% sorbitol urologic irrigating solution, because the quantity of fluid absorbed into the systemic circulation by opened prostatic veins may produce significant expansion of the intravascular fluid and lead to fulminating congestive heart failure.
Shift of sodium free intracellular fluid into the extracellular compartment, following systemic absorption could lower serum concentration and aggravate preexisting hyponatremia.
Excessive loss of water and electrolytes may lead to serious imbalances. With continuous use of solution, loss of water may occur in excess of electrolytes, producing hypernatremia.
Sustained diuresis that results from transurethral irrigation with sorbitol irrigating solutions could obscure and intensify inadequate hydration or hypovolemia.
Dialysis
Data not available
More about sorbitol
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Consumer resources
- Sorbitol
- Sorbitol
Related treatment guides
- Constipation
Sorbitol interactions
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What other drugs will affect Sorbitol?
Calcium Polystyrene Sulfonate: Sorbitol may enhance the adverse/toxic effect of Calcium Polystyrene Sulfonate. More specifically, concomitant use of these agents may increase the risk for intestinal necrosis. Avoid combination
LamiVUDine: Sorbitol may decrease the serum concentration of LamiVUDine. Management: When possible, avoid chronic coadministration of sorbitol-containing solutions with lamivudine, but if this combination cannot be avoided, monitor patients more closely for possible therapeutic failure associated with decreased lamivudine exposure. Consider therapy modification
Sodium Polystyrene Sulfonate: Sorbitol may enhance the adverse/toxic effect of Sodium Polystyrene Sulfonate. More specifically, concomitant use of these agents may increase the risk for intestinal necrosis. Avoid combination
Sorbitol side effects
See also:
What are the possible side effects of Sorbitol?
Life threatening adverse reactions with intravenous Sorbitol infusions have been reported in patients with fructose intolerance.
The literature reports occasional adverse reactions for intravenous Sorbitol infusions. These include disturbances such as acidosis, electrolyte loss, marked diuresis, urinary retention, edema, dryness of mouth and thirst, and dehydration; cardiovascular/pulmonary disorders such as pulmonary congestion, hypotension, tachycardia, angina-like pains, and other general reactions such as blurred vision, convulsions, nausea, vomiting, diarrhea, rhinitis, chills, vertigo, and backache. Allergic reactions reported to occur from Sorbitol include urticaria.
Should adverse reactions occur, discontinue the irrigant and reevaluate the clinical status of the patient.
Post-Marketing Experience
Following off-label use of 3% Sorbitol Urologic Irrigating Solution for hysteroscopic procedures in women, life-threatening adverse events related to fluid overload have been reported.
Sorbitol contraindications
See also:
What is the most important information I should know about Sorbitol?
Sorbitol should not be given to patients with hereditary fructose intolerance. It should be given with caution to patients with impaired kidney function or severe liver damage.
Tricholine citrate indications
Fatty liver, dyspepsia & atonic constipation.
Uses of Tricholine citrate in details
Tricholine citrate is indicated for the treatment and management of hepatic disorders and asthma symptoms in adults.
Tricholine citrate dosage
10 ml bid or tid.
Child: proportionately lower dose.
Active ingredient matches for Cyproheptadine/sorbitol/tricholine citrate:
Cyproheptadine/sorbitol/tricholine citrate
List of Cyproheptadine/sorbitol/tricholine citrate substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| 3 TONE TC | |
| 3 TONE TC SYRUP 1 bottle / 200 ML syrup each (Embiotic Laboratories Pvt Ltd) | $ 0.69 |
| APETIZ PLUS | |
| APETIZ PLUS 2MG/275MG/2G SYRUP 1 bottle / 200 ML syrup each (Meridian Medicare Ltd) | $ 1.00 |
| Apetiz Plus 2 mg/275 mg/2 G Syrup (Meridian Medicare Ltd) | $ 1.00 |
| APETON PLUS | |
| APETON PLUS SYRUP 2MG/275MG/3.575MG 1 bottle / 200 ML syrup each (Olcare) | $ 0.68 |
| APETON PLUS syr 200ml (Olcare) | $ 1.02 |
| Apeton Plus 2mg/275mg/3.575mg Syrup (Olcare) | $ 0.68 |
| APILYSIN | |
| APILYSIN SYRUP 1 bottle / 200 ML syrup each (Diamond Drugs Pvt Ltd) | $ 1.02 |
| APITAT | |
| APITAT SYRUP 1 bottle / 200 ML syrup each (Lupin Ltd) | $ 0.78 |
| APPCYP | |
| APPCYP 0.275G/2MG/3.75G SYRUP 1 bottle / 200 ML syrup each (Pacific Drugs & Chemicals) | $ 0.93 |
| APPCYP SYRUP 1 bottle / 100 ML syrup each (Pacific Drugs & Chemicals) | $ 0.42 |
| Appcyp 2 mg/0.275 G/3.75 G Syrup (Pacific Drugs & Chemicals) | $ 0.93 |
| Appcyp Syrup (Pacific Drugs & Chemicals) | $ 0.42 |
| APPEGAIN | |
| APPEGAIN SYRUP | |
| APPEGAIN SYRUP 1 bottle / 200 ML syrup each (Proctor Organics P Ltd) | $ 0.79 |
| APTIMUST | |
| APTIMUST SYRUP 1 bottle / 200 ML syrup each (Mankind Pharma Ltd) | $ 1.09 |
| CIPLACTIN PLUS | |
| CIPLACTIN PLUS 1 bottle / 200 ML syrup each (Cipla Ltd) | $ 1.23 |
| Ciplactin Plus Syrup (Cipla Ltd) | $ 1.23 |
| CYCOLINE | |
| Cypomak Syrup | |
| Cypomak Syrup (Makers Laboratories Ltd) | $ 0.42 |
| EPCYP | |
| EPCYP SYRUP 1 bottle / 200 ML syrup each (Estragen Pharma) | $ 0.92 |
| EPISURE | |
| EPISURE SYRUP 1 bottle / 200 ML syrup each (UTH Healthcare) | $ 0.86 |
| INCYP-T (India) | |
| INCYP-T syr 300ml (Xieon (Indo-German)) | $ 1.69 |
| MALINE (India) | |
| MALINE syr 200ml (Aamorb (St. Morison)) | $ 0.82 |
| RANPON SYRUP | |
| RANPON SYRUP 1 bottle / 200 ML syrup each (Ranbaxy Laboratories Ltd) | $ 0.35 |
| RITODINE-T (India) | |
| RITODINE-T syr 200ml (Xieon (Critocare)) | $ 0.90 |
| TRICYP (India) | |
| 200ml (Daffohils) | |
| Tricyp Cyproheptadine 2 mg, Tricholine citrate 275 mg, Sorbitol 3.575 g. SYR / 200ml (Daffohils) | |
| TRICYP SYRUP 1 bottle / 200 ML syrup each (Daffohils) | $ 2.78 |
| TRICYP syr 200ml (Daffohils) | |
| Tricyp Cyproheptadine 2 mg, Tricholine citrate 275 mg, Sorbitol 3.575 g. SYR / 200ml (Daffohils) | |
| YOPON | |
| YOPON SYRUP 1 bottle / 200 ML syrup each (Maxamus International) | $ 0.90 |
References
- PubChem. "CYPROHEPTADINE". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "CYPROHEPTADINE". http://www.drugbank.ca/drugs/DB00434 (accessed September 17, 2018).
- MeSH. "Serotonin Antagonists". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Cyproheptadine/sorbitol/tricholine citrate are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Cyproheptadine/sorbitol/tricholine citrate. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yet1 consumer reported age
| Users | % | ||
|---|---|---|---|
| 46-60 | 1 | 100.0% | |
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Information checked by Dr. Sachin Kumar, MD Pharmacology
