Consists of diclofenac sodium, linseed oil, menthol, methyl salicylate
What is Diclofenac sodium (Delete GEL)?
Diclofenac sodium (Delete GEL) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such as inflammation, swelling, stiffness, and joint pain. However, Diclofenac sodium (Delete GEL) does not cure osteoarthritis and will help you only as long as you continue to use it.
Diclofenac sodium (Delete GEL) topical 3% gel is also used to treat actinic keratosis, a skin problem that may become cancerous if not treated. The exact way that topical Diclofenac sodium (Delete GEL) helps this condition is unknown.
Diclofenac sodium (Delete GEL) topical solution is used to treat pain and swelling caused by osteoarthritis of the knees.
Diclofenac sodium (Delete GEL) topical patch is used to treat acute pain caused by minor strains, sprains, and contusions (bruises).
Diclofenac sodium (Delete GEL) is available only with your doctor's prescription.
Diclofenac sodium (Delete GEL) indications
Carefully consider the potential benefits and risks of Diclofenac sodium (Delete GEL) sodium delayed-release tablets and other treatment options before deciding to use Diclofenac sodium (Delete GEL) sodium delayed-release tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Diclofenac sodium (Delete GEL) sodium delayed-release tablets are indicated:
- •
- For relief of the signs and symptoms of osteoarthritis
- •
- For relief of the signs and symptoms of rheumatoid arthritis
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- For acute or long-term use in the relief of signs and symptoms of ankylosing spondylitis
How should I use Diclofenac sodium (Delete GEL)?
Use Diclofenac sodium (Delete GEL) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Diclofenac sodium (Delete GEL) comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Diclofenac sodium (Delete GEL) refilled.
- Do not apply Diclofenac sodium (Delete GEL) to infected skin; open wounds; or red, swollen, or peeling skin.
- Wash your hands immediately before and after using Diclofenac sodium (Delete GEL).
- Wash the affected area and dry completely before using Diclofenac sodium (Delete GEL).
- To apply Diclofenac sodium (Delete GEL), dispense 10 drops at a time onto the knee or into your hand. Spread Diclofenac sodium (Delete GEL) evenly around the front, back, and sides of the knee. Repeat until you have used the whole dose.
- Be sure that you cover your entire knee with your dose of Diclofenac sodium (Delete GEL). Do not use more than the recommended amount.
- Do not apply sunscreens, cosmetics, insect repellants, other topical medicines, or any other substance to the treated area until it is completely dry.
- Do not put on clothes over the treated area until it is completely dry.
- Do not wrap, bandage, or apply heat to the treated area.
- Let the treated skin dry before touching it or letting it touch anyone else's skin.
- Do not shower, bathe, or wash the treated area for at least 30 minutes after you use Diclofenac sodium (Delete GEL).
- If you miss a dose of Diclofenac sodium (Delete GEL), skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Diclofenac sodium (Delete GEL).
Uses of Diclofenac sodium (Delete GEL) in details
Use: Labeled Indications
Ankylosing spondylitis (delayed-release tablets only): Acute or long-term use in the relief of signs and symptoms of ankylosing spondylitis.
Dysmenorrhea (immediate-release tablets only): Treatment of primary dysmenorrhea.
Migraine (powder for oral solution only): Acute treatment of migraine attacks with or without aura in adults.
Osteoarthritis (immediate-release, extended-release, and delayed-release tablets; capsules [Zorvolex]; and suppositories [Canadian product] only): Relief of signs and symptoms of osteoarthritis.
Pain
Capsules/immediate-release tablets only: Relief of mild to moderate acute pain.
Injection only: Management of mild to moderate pain and moderate to severe pain (alone or in combination with opioid analgesics) in adults.
Rheumatoid arthritis (immediate-release, extended-release, and delayed-release tablets; and suppositories [Canadian product] only): Relief of signs and symptoms of rheumatoid arthritis.
Off Label Uses
Gout, treatment (acute flares)
Data from a limited number of trials support the efficacy of Diclofenac sodium (Delete GEL) in the treatment of acute gout flares.
Based on the 2012 American College of Rheumatology guidelines for management of gout, nonsteroidal anti-inflammatory drugs are effective and recommended agents in the treatment of acute gout flares.
Diclofenac sodium (Delete GEL) description
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
Diclofenac sodium (Delete GEL) dosage
Carefully consider the potential benefits and risks of Diclofenac sodium (Delete GEL) sodium extended-release tablets, and other treatment options before deciding to use Diclofenac sodium (Delete GEL) sodium extended-release tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
After observing the response to initial therapy with Diclofenac sodium (Delete GEL) sodium extended-release tablets the dose and frequency should be adjusted to suit an individual patient’s needs.
For the relief of osteoarthritis, the recommended dosage is 100 mg daily.
For the relief of rheumatoid arthritis, the recommended dosage is 100 mg daily. In the rare patient where Diclofenac sodium (Delete GEL) sodium extended-release tablets 100 mg/day is unsatisfactory, the dose may be increased to 100 mg twice a day if the benefits outweigh the clinical risks of increased side effects.
Different formulations of Diclofenac sodium (Delete GEL) (Diclofenac sodium (Delete GEL) sodium enteric-coated tablets; Diclofenac sodium (Delete GEL) sodium extended-release tablets; Diclofenac sodium (Delete GEL) potassium immediate-release tablets) are not necessarily bioequivalent even if the milligram strength is the same.
Diclofenac sodium (Delete GEL) interactions
See also:
What other drugs will affect Diclofenac sodium (Delete GEL)?
Aspirin: Concomitant administration of Diclofenac sodium (Delete GEL) and aspirin is not recommended because Diclofenac sodium (Delete GEL) is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels, and AUC values.
Anticoagulants: While studies have not shown Diclofenac sodium (Delete GEL) to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs. Because prostaglandins play an important role in hemostasis, and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including Diclofenac sodium (Delete GEL), and warfarin requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required.
Digoxin, Methotrexate, Cyclosporine: Diclofenac sodium (Delete GEL), like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. Ingestion of Diclofenac sodium (Delete GEL) may increase serum concentrations of digoxin and methotrexate and increase cyclosporineís nephrotoxicity. Patients who begin taking Diclofenac sodium (Delete GEL) or who increase their Diclofenac sodium (Delete GEL) dose or any other NSAID while taking digoxin, methotrexate, or cyclosporine may develop toxicity characteristics for these drugs. They should be observed closely, particularly if renal function is impaired. In the case of digoxin, serum levels should be monitored.
Lithium: Diclofenac sodium (Delete GEL) decreases lithium renal clearance and increases lithium plasma levels. In patients taking Diclofenac sodium (Delete GEL) and lithium concomitantly, lithium toxicity may develop.
Oral Hypoglycemics:
Diclofenac sodium (Delete GEL) does not alter glucose metabolism in normal subjects nor does it alter the effects of oral hypoglycemic agents. There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of Diclofenac sodium (Delete GEL) that necessitated changes in the doses of such agents. Both hypo- and hyperglycemic effects have been reported. A direct causal relationship has not been established, but physicians should consider the possibility that Diclofenac sodium (Delete GEL) may alter a diabetic patientís response to insulin or oral hypoglycemic agents.
Diuretics: Diclofenac sodium (Delete GEL) and other NSAIDs can inhibit the activity of diuretics. Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels.
Other Drugs: In small groups of patients (7-10/interaction study), the concomitant administration of azathioprine, gold, chloroquine, D-penicillamine, prednisolone, doxycycline, or digitoxin did not significantly affect the peak levels and AUC values of Diclofenac sodium (Delete GEL). Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of Diclofenac sodium (Delete GEL) therapy.
Protein Binding
In vitro, Diclofenac sodium (Delete GEL) interferes minimally or not at all with the protein binding of salicylic acid (20% decrease in binding), tolbutamide, prednisolone (10% decrease in binding), or warfarin. Benzylpenicillin, ampicillin, oxacillin, chlortetracycline, doxycycline, cephalothin, erythromycin, and sulfamethoxazole have no influence in vitro on the protein binding of Diclofenac sodium (Delete GEL) in human serum.
Drug/Laboratory Test Interactions
Effect on Blood Coagulation: Diclofenac sodium (Delete GEL) increases platelet aggregation time but does not affect bleeding time, plasma thrombin clotting time, plasma fibrinogen, or factors V and VII to XII. Statistically significant changes in prothrombin and partial thromboplastin times have been reported in normal volunteers. The mean changes were observed to be less than 1 second in both instances, however, and are unlikely to be clinically important. Diclofenac sodium (Delete GEL) is a prostaglandin synthetase inhibitor, however, and all drugs that inhibit prostaglandin synthesis interfere with platelet function to some degree; therefore, patients who may be adversely affected by such an action should be carefully observed.
Diclofenac sodium (Delete GEL) side effects
See also:
What are the possible side effects of Diclofenac sodium (Delete GEL)?
Ocular
Transient burning and stinging were reported in approximately 15% of patients across studies with the use of Diclofenac sodium (Delete GEL) sodium ophthalmic solution, 0.1%. In cataract surgery studies, keratitis was reported in up to 28% of patients using Diclofenac sodium (Delete GEL) sodium ophthalmic solution, 0.1%, although in many of these cases keratitis was initially noted prior to the initiation of treatment. Elevated intraocular pressure following cataract surgery was reported in approximately 15% of patients undergoing cataract surgery. Lacrimation complaints were reported in approximately 30% of case studies undergoing incisional refractive surgery. The following adverse reactions were reported in approximately 10% or less of the patients: abnormal vision, acute elevated IOP, blurred vision, conjunctivitis, corneal deposits, corneal edema, corneal opacity, corneal lesions, discharge, eyelid swelling, eye pain, injection (redness), iritis, irritation, itching, lacrimation disorder, and ocular allergy.
Systemic
The following adverse reactions were reported in 3% or less of the patients: abdominal pain, asthenia, chills, dizziness, facial edema, fever, headache, insomnia, nausea, pain, rhinitis, viral infection and vomiting.
Clinical Practice
The following reactions have been identified during postmarketing use of topical Diclofenac sodium (Delete GEL) sodium ophthalmic solution, 0.1% in clinical practice. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. The reactions, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to topical Diclofenac sodium (Delete GEL) sodium ophthalmic solution, 0.1%, or a combination of these factors, include corneal erosion, corneal infiltrates, corneal perforation, corneal thinning, corneal ulceration and epithelilal breakdown.
TO REPORT SUSPECTED ADVERSE REACTIONS, contact Altaire Pharmaceuticals, Inc., at 1-800-258-2471 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Diclofenac sodium (Delete GEL) contraindications
See also:
What is the most important information I should know about Diclofenac sodium (Delete GEL)?
Diclofenac sodium (Delete GEL) in all formulations, Cataflam, Voltaren, and Voltaren-XR, is contraindicated in patients with known hypersensitivity to Diclofenac sodium (Delete GEL) and Diclofenac sodium (Delete GEL)-containing products. Diclofenac sodium (Delete GEL) should not be given to patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to Diclofenac sodium (Delete GEL) have been reported in such patients.
Linseed oil (Delete GEL) indications
essential fatty acid supplement
Uses of Linseed oil (Delete GEL) in details
Used to reduce cholesterol levels, to slow prostate cancer growth before surgery, and topically for skin irritation.
Linseed oil (Delete GEL) side effects
Shortness of breath, Lip swelling, Throat tightness
What is Menthol (Delete GEL)?
Relieving minor pain caused by conditions such as arthritis, backache, bruising, bursitis, cramping, muscle strains or sprains, and tendonitis. It may also be used for other conditions as determined by your doctor.
Menthol (Delete GEL) is a topical analgesic. It works by temporarily relieving minor pain.
Menthol (Delete GEL) indications
Oral
Nasal congestion; Throat irritation
Adult: As a loz (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 loz every 3 hr, to be sucked slowly.
Child: >6 yr: As a lozenge (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 lozenge every 3 hr, to be sucked slowly.
Topical/Cutaneous
Muscular aches and pains
Adult: As an ointment/cream (usually in combination with camphor, clove oil or methyl salicylate): Apply and rub gently onto the affected skin areas 2-3 times daily.
How should I use Menthol (Delete GEL)?
Use Menthol (Delete GEL) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Wash your hands before and right after using Menthol (Delete GEL).
- Spray Menthol (Delete GEL) directly onto the affected area. Do not rub or massage the medicine into the skin.
- Do not wrap, bandage, or use a heating pad on the treated area.
- Do not apply Menthol (Delete GEL) more than 4 times daily.
- If you miss a dose of Menthol (Delete GEL), use it as soon as you remember. Continue to use it as directed by your doctor or on the package label.
Ask your health care provider any questions you may have about how to use Menthol (Delete GEL).
Uses of Menthol (Delete GEL) in details
Pharmaceutical Aid
Menthol (Delete GEL) description
Menthol (Delete GEL) is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. It is a waxy, crystalline substance, clear or white in color, which is solid at room temperature and melts slightly above. The main form of Menthol (Delete GEL) occurring in nature is (-)-Menthol (Delete GEL), which is assigned the (1R,2S,5R) configuration. Menthol (Delete GEL) has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation.
Menthol (Delete GEL) dosage
Oral
Nasal congestion; Throat irritation
Adult: As a loz (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 loz every 3 hr, to be sucked slowly.
Child: >6 yr: As a lozenge (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 lozenge every 3 hr, to be sucked slowly.
Topical/Cutaneous
Muscular aches and pains
Adult: As an ointment/cream (usually in combination with camphor, clove oil or methyl salicylate): Apply and rub gently onto the affected skin areas 2-3 times daily.
Menthol (Delete GEL) interactions
Tell your doctor of any over-the-counter or prescription medication you may take including: blood thinners.
Do not start or stop any medicine without doctor or pharmacist approval.
Menthol (Delete GEL) side effects
See also:
What are the possible side effects of Menthol (Delete GEL)?
May cause hypersensitivity reactions such as cutaneous dermatitis. Ingestion of large amount of Menthol (Delete GEL) may cause GI effects such as severe abdominal pain, nausea, vomiting, vertigo, ataxia, drowsiness and coma.
Menthol (Delete GEL) contraindications
See also:
What is the most important information I should know about Menthol (Delete GEL)?
Not to be used in
No known conditions.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Methyl salicylate (Delete GEL) indications
Methyl salicylate (Delete GEL) cream is for the temporary relief of pain associated with strains of joints and muscles, arthritis, rheumatism, lumbago, and fibrositis. Methyl salicylate (Delete GEL) cream can also be used for pre-sport warm-up and after sport as required.
Uses of Methyl salicylate (Delete GEL) in details
Methyl salicylate (Delete GEL) is used as an anti-pain topical medication, as cream, gel, ointment, lotion or spray. It is used to temporarily relieve muscle or joint pain caused by strains, pains, arthritis, bruising or backaches.
Methyl salicylate (Delete GEL) description
Each 100 g of cream contains Methyl salicylate (Delete GEL) 11 g, eugenol 1.4 g, Methyl salicylate (Delete GEL) 5.6 g, cajuput oil 0.8 g and washable base.
Methyl salicylate (Delete GEL) dosage
Apply generously on the affected area 2-3 times daily or whenever necessary.
Methyl salicylate (Delete GEL) interactions
Absorption of Methyl salicylate (Delete GEL) through the skin can occur after excessive topical application, and interactions would be expected to be as for other salicylates
Methyl salicylate (Delete GEL) side effects
See also:
What are the possible side effects of Methyl salicylate (Delete GEL)?
As aspirin, The most common adverse effects of therapeutic doses of aspirin are gastrointestinal disturbances such as nausea, dyspepsia, and vomiting. Gastrointestinal symptoms may be minimised by giving aspirin with food. Irritation of the gastric mucosa with erosion, ulceration, haematemesis, and melaena may occur. Histamine H2-antagonists, proton pump inhibitors, and prostaglandin analogues such as misoprostol may be used in the management of aspirin-induced mucosal damage. Slight blood loss, which is often asymptomatic, may occur in about 70% of patients; it is not usually of clinical significance but may, in a few patients, cause iron-deficiency anaemia during long-term therapy. Such occult blood loss is not affected by giving aspirin with food but may be reduced by use of enteric-coated or other modified-release tablets, H2-antagonists, or high doses of antacids. Major upper gastrointestinal bleeding occurs rarely.
Some persons, especially those with asthma, chronic urticaria, or chronic rhinitis, exhibit notable hypersensitivity to aspirin, which may provoke reactions including urticaria and other skin eruptions, angioedema, rhinitis, and severe, even fatal, paroxysmal bronchospasm and dyspnoea. Persons sensitive to aspirin often exhibit cross-sensitivity to other NSAIDs.
Aspirin increases bleeding time, decreases platelet adhesiveness, and, in large doses, can cause hypoprothrombinaemia. It may cause other blood disorders, including thrombocytopenia.
Aspirin and other salicylates may cause hepatotoxicity, particularly in patients with juvenile idiopathic arthritis or other connective tissue disorders. In children the use of aspirin has been implicated in some cases of Reye’s syndrome, leading to severe restrictions on the indications for aspirin therapy in children. For further details see under Reye’s Syndrome,.
Aspirin given rectally may cause local irritation; anorectal stenosis has been reported.
Methyl salicylate (Delete GEL) contraindications
All NSAIDs are contra-indicated in patients with active peptic ulceration; in addition, the non-selective NSAIDs should be used with caution, if at all, in patients with a history of such disorders. To reduce the risk of gastrointestinal effects, NSAIDs may be taken with or after food or milk
Active ingredient matches for Delete GEL:
Diclofenac sodium/linseed oil/menthol/methyl salicylate in India.
Unit description / dosage (Manufacturer) | Price, USD |
DELETE GEL topical gel 30g (Nitro Organics) | $ 0.87 |
List of Delete GEL substitutes (brand and generic names): | |
ANDIC GEL (India) | |
ANDIC GEL topical gel 30g (Andic) | |
AVINIM GEL (India) | |
30g (Avalanche) | $ 0.58 |
Avinim Gel Diclofenac sodium 1 % w/w, linseed oil 3 % w/w, methylsalicylate 10 % w/w, menthol 5% w/w. GEL / 30g (Avalanche) | $ 0.58 |
AVINIM GEL topical gel 30g (Avalanche) | $ 0.58 |
Avinim Gel Diclofenac sodium 1 % w/w, linseed oil 3 % w/w, methylsalicylate 10 % w/w, menthol 5% w/w. GEL / 30g (Avalanche) | $ 0.58 |
diclofenac sodium/linseed oil/menthol/methyl salicylate (India) | |
DIXER GEL (India) | |
DIXER GEL topical gel 30g (Biophar) | $ 0.78 |
DOLEND (India) | |
DOLEND topical gel 30g (Lifecare) | $ 0.70 |
FARFLAM (India) | |
FARFLAM topical gel 20g (Cosset) | $ 0.54 |
FEVORON (India) | |
FEVORON topical spray 50g (Fitwel) | |
GRELAX GEL (India) | |
GRELAX GEL topical gel 30g (Green Lab) | $ 0.72 |
KILPAIN (India) | |
KILPAIN oint 30g (Treatwell) | $ 0.72 |
NANOMAX (India) | |
NANOMAX topical gel 30g (D.R John's Lab Pharma) | $ 1.02 |
NOVAMOL GEL (India) | |
NOVAMOL GEL topical gel 30g (Novagen) | $ 0.70 |
OPNAC (India) | |
OPNAC topical gel 10g (TNT) | $ 0.28 |
OPNAC topical gel 30g (TNT) | $ 0.71 |
POFINAC GEL (India) | |
POFINAC GEL topical gel 30g (Aurz) | $ 0.77 |
References
- DailyMed. "MENTHOL; METHYL SALICYLATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "methyl salicylate". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Delete GEL are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Delete GEL. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yet1 consumer reported age
Users | % | ||
---|---|---|---|
16-29 | 1 | 100.0% |
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Information checked by Dr. Sachin Kumar, MD Pharmacology