Delete GEL Dosage

• Dosage of Diclofenac sodium (Delete GEL) in details
• Diclofenac sodium (Delete GEL) interactions
• Dosage of Menthol (Delete GEL) in details
• Menthol (Delete GEL) interactions
• Dosage of Methyl salicylate (Delete GEL) in details
• Methyl salicylate (Delete GEL) interactions
• Delete GEL reviews

Consists of diclofenac sodium, linseed oil, menthol, methyl salicylate

Dosage of Diclofenac sodium (Delete GEL) in details

Carefully consider the potential benefits and risks of Diclofenac sodium (Delete GEL) sodium extended-release tablets, and other treatment options before deciding to use Diclofenac sodium (Delete GEL) sodium extended-release tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

After observing the response to initial therapy with Diclofenac sodium (Delete GEL) sodium extended-release tablets the dose and frequency should be adjusted to suit an individual patient’s needs.

For the relief of osteoarthritis, the recommended dosage is 100 mg daily.

For the relief of rheumatoid arthritis, the recommended dosage is 100 mg daily. In the rare patient where Diclofenac sodium (Delete GEL) sodium extended-release tablets 100 mg/day is unsatisfactory, the dose may be increased to 100 mg twice a day if the benefits outweigh the clinical risks of increased side effects.

Different formulations of Diclofenac sodium (Delete GEL) (Diclofenac sodium (Delete GEL) sodium enteric-coated tablets; Diclofenac sodium (Delete GEL) sodium extended-release tablets; Diclofenac sodium (Delete GEL) potassium immediate-release tablets) are not necessarily bioequivalent even if the milligram strength is the same.

What other drugs will affect Diclofenac sodium (Delete GEL)?

Ask your doctor before using Diclofenac sodium (Delete GEL) if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Tell your doctor about all your current medicines and any you start or stop using, especially:

• cyclosporine;

• lithium;

• methotrexate;

• rifampin;

• antifungal medicine;

• a blood thinner (warfarin, Coumadin, Jantoven);

• heart or blood pressure medication, including a diuretic or "water pill";

• other forms of Diclofenac sodium (Delete GEL) (Flector, Pennsaid, Solaraze, Voltaren Gel);

• other NSAIDs - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), indomethacin, meloxicam, and others; or

• steroid medicine (prednisone and others).

This list is not complete. Other drugs may interact with Diclofenac sodium (Delete GEL), including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Diclofenac sodium (Delete GEL) interactions

Aspirin: Concomitant administration of Diclofenac sodium (Delete GEL) and aspirin is not recommended because Diclofenac sodium (Delete GEL) is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels, and AUC values.

Anticoagulants: While studies have not shown Diclofenac sodium (Delete GEL) to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs. Because prostaglandins play an important role in hemostasis, and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including Diclofenac sodium (Delete GEL), and warfarin requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required.

Digoxin, Methotrexate, Cyclosporine: Diclofenac sodium (Delete GEL), like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. Ingestion of Diclofenac sodium (Delete GEL) may increase serum concentrations of digoxin and methotrexate and increase cyclosporineís nephrotoxicity. Patients who begin taking Diclofenac sodium (Delete GEL) or who increase their Diclofenac sodium (Delete GEL) dose or any other NSAID while taking digoxin, methotrexate, or cyclosporine may develop toxicity characteristics for these drugs. They should be observed closely, particularly if renal function is impaired. In the case of digoxin, serum levels should be monitored.

Lithium: Diclofenac sodium (Delete GEL) decreases lithium renal clearance and increases lithium plasma levels. In patients taking Diclofenac sodium (Delete GEL) and lithium concomitantly, lithium toxicity may develop.

Oral Hypoglycemics:

Diclofenac sodium (Delete GEL) does not alter glucose metabolism in normal subjects nor does it alter the effects of oral hypoglycemic agents. There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of Diclofenac sodium (Delete GEL) that necessitated changes in the doses of such agents. Both hypo- and hyperglycemic effects have been reported. A direct causal relationship has not been established, but physicians should consider the possibility that Diclofenac sodium (Delete GEL) may alter a diabetic patientís response to insulin or oral hypoglycemic agents.

Diuretics: Diclofenac sodium (Delete GEL) and other NSAIDs can inhibit the activity of diuretics. Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels.

Other Drugs: In small groups of patients (7-10/interaction study), the concomitant administration of azathioprine, gold, chloroquine, D-penicillamine, prednisolone, doxycycline, or digitoxin did not significantly affect the peak levels and AUC values of Diclofenac sodium (Delete GEL). Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of Diclofenac sodium (Delete GEL) therapy.

Protein Binding

In vitro, Diclofenac sodium (Delete GEL) interferes minimally or not at all with the protein binding of salicylic acid (20% decrease in binding), tolbutamide, prednisolone (10% decrease in binding), or warfarin. Benzylpenicillin, ampicillin, oxacillin, chlortetracycline, doxycycline, cephalothin, erythromycin, and sulfamethoxazole have no influence in vitro on the protein binding of Diclofenac sodium (Delete GEL) in human serum.

Drug/Laboratory Test Interactions

Effect on Blood Coagulation: Diclofenac sodium (Delete GEL) increases platelet aggregation time but does not affect bleeding time, plasma thrombin clotting time, plasma fibrinogen, or factors V and VII to XII. Statistically significant changes in prothrombin and partial thromboplastin times have been reported in normal volunteers. The mean changes were observed to be less than 1 second in both instances, however, and are unlikely to be clinically important. Diclofenac sodium (Delete GEL) is a prostaglandin synthetase inhibitor, however, and all drugs that inhibit prostaglandin synthesis interfere with platelet function to some degree; therefore, patients who may be adversely affected by such an action should be carefully observed.

Dosage of Menthol (Delete GEL) in details

Oral

Nasal congestion; Throat irritation

Adult: As a loz (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 loz every 3 hr, to be sucked slowly.

Child: >6 yr: As a lozenge (usually in combination with eucalyptus oil or cetylpyridinium chloride): 1 lozenge every 3 hr, to be sucked slowly.

Topical/Cutaneous

Muscular aches and pains

Adult: As an ointment/cream (usually in combination with camphor, clove oil or methyl salicylate): Apply and rub gently onto the affected skin areas 2-3 times daily.

Menthol (Delete GEL) interactions

Tell your doctor of any over-the-counter or prescription medication you may take including: blood thinners.

Do not start or stop any medicine without doctor or pharmacist approval.

Dosage of Methyl salicylate (Delete GEL) in details

Apply generously on the affected area 2-3 times daily or whenever necessary.

Methyl salicylate (Delete GEL) interactions

Absorption of methyl salicylate through the skin can occur after excessive topical application, and interactions would be expected to be as for other salicylates

References

1. DailyMed. "MENTHOL; METHYL SALICYLATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
3. FDA/SPL Indexing Data. "LAV5U5022Y: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Delete GEL are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Delete GEL. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology