• Depram indications
• Uses of Depram in details
• Depram description
• Depram dosage
• Depram interactions
• Depram side effects
• Depram contraindications

What is Depram?

Depram is a tricyclic antidepressant. Depram affects chemicals in the brain that may become unbalanced.

Depram is used to treat symptoms of depression. Depram is sometimes used to treat bed-wetting in children ages 6 and older.

Depram may also be used for purposes not listed in this medication guide.

Depram indications

Depression

For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than other depressive states. One to three weeks of treatment may be needed before optimal therapeutic effects are evident.

Childhood Enuresis

May be useful as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older, after possible organic causes have been excluded by appropriate tests. In patients having daytime symptoms of frequency and urgency, examination should include voiding cystourethrography and cystoscopy, as necessary. The effectiveness of treatment may decrease with continued drug administration.

How should I use Depram?

Use Depram capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Depram capsules comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Depram capsules refilled.
• Take Depram capsules by mouth with or without food.
• Taking Depram capsules at bedtime may help reduce side effects (eg, daytime drowsiness). Discuss this possibility with your doctor.
• It may take 1 to 3 weeks before you notice the effect of Depram capsules. Continue to use Depram capsules even if you feel well. Do not miss any doses.
• If you miss a dose of Depram capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you take 1 dose daily at bedtime, do not take the missed dose the next morning.

Ask your health care provider any questions you may have about how to use Depram capsules.

Uses of Depram in details

Use: Labeled Indications

Childhood enuresis (Depram hydrochloride only): As temporary adjunctive therapy in reducing enuresis in children ≥6 years of age, after possible organic causes have been excluded by appropriate tests

Major depressive disorder (unipolar): Treatment of unipolar major depressive disorder (MDD)

Off Label Uses

Bulimia nervosa

Data from double-blind placebo-controlled trials support the use of Depram in the treatment of bulimia nervosa; however, all studies were limited by reliance on self-reporting of eating behavior.

The American Psychiatric Association guidelines for the treatment of patients with eating disorders indicate that tricyclic antidepressants may be a second-line option in patients who are at low risk for suicide. According to World Federation of Societies of Biological Psychiatry guidelines for the pharmacological treatment of eating disorders, Depram is effective and recommended in the management of bulimia nervosa.

Neuropathic pain

Data from two randomized, double-blind, placebo-controlled, crossover trials.

Depram description

Depram, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, Depram does not affect mood or arousal, but may cause sedation. In depressed individuals, Depram exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as Depram and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Depram has less sedative and anticholinergic effects than the tertiary amine TCAs, amitriptyline and clomipramine. See toxicity section below for a complete listing of side effects. Depram may be used to treat depression and nocturnal enuresis in children. Unlabeled indications include chronic and neuropathic pain (including diabetic neuropathy), panic disorder, attention-deficit/hyperactivity disorder (ADHD), and post-traumatic stress disorder (PTSD).

Depram dosage

Depram Dosage

Generic name: Depram hydrochloride USP

Dosage form: injection

See also:

• Depram tablet, sugar coated
• Depram capsule

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Initially, up to 100 mg/day intramuscularly in divided doses.

Parenteral administration should be used only for starting therapy in patients unable or unwilling to use oral medication. The oral form should supplant the injectable as soon as possible.

Lower dosages are recommended for elderly patients and adolescents. Lower dosages are also recommended for outpatients as compared to hospitalized patients who will be under close supervision. Dosage should be initiated at a low level and increased gradually, noting carefully the clinical response and any evidence of intolerance. Following remission, oral maintenance medication may be required for a longer period of time, at the lowest dose that will maintain remission.

More about Depram (Depram)

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Consumer resources

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• Depram (Advanced Reading)

Professional resources

• Depram (FDA)
• More (2) »

Other formulations

• Depram

Related treatment guides

• Pain
• Depression
• Enuresis
• Interstitial Cystitis
• Primary Nocturnal Enuresis

Depram interactions

See also:
What other drugs will affect Depram?

If Apo-Depram is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Patient should check with doctor before combining Apo-Depram with the following

Antidepressants that boost serotonin, including Paxil, Prozac, and Zolof Antipsychotic medications such as Mellaril and chlopromazin Barbiturates such as Nembutal and Secona Certain blood pressure medications such as guanethidin Cimetidine (Tagamet Decongestants such as Sudafe Drugs that quell spasms, such as Donnatal and Levsi Epinephrine (EpiPen Flecainide (Tambocor Narcotic painkillers such as Percodan and Vicodi Norepinephrin Other antidepressants such as Elavil and Tofrani Propafenone (Rythmol Quinidin Tramadol (Ultram Tranquilizers and sleep aids such as Halcion, Valium, and Xanax

Apo-Depram must never be combined with monoamine inhibitors such as Nardil and Parnate.

Depram side effects

See also:
What are the possible side effects of Depram?

Applies to Depram: oral capsule, oral tablet

As well as its needed effects, Depram (the active ingredient contained in Depram) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking Depram, check with your doctor immediately:

Incidence not known:

• Abdominal or stomach pain
• agitation
• blurred vision
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• chest pain or discomfort
• clay-colored stools
• cold sweats
• confusion about identity, place, and time
• continuing ringing or buzzing or other unexplained noise in the ears
• cough or hoarseness
• dark urine
• decrease in the frequency of urination
• difficulty in passing urine (dribbling)
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• double vision
• dry mouth
• false beliefs that cannot be changed by facts
• fast, pounding, or irregular heartbeat or pulse
• feeling, seeing, or hearing things that are not there
• feeling that others are watching you or controlling your behavior
• feeling that others can hear your thoughts
• fever with or without chills
• flushed, dry skin
• general feeling of tiredness or weakness
• hearing loss
• hostility
• hyperventilation
• inability to move the arms, legs, or facial muscles
• irritability
• itching or rash
• lack of coordination
• lethargy
• loss of balance control
• lower back or side pain
• mood or mental changes
• muscle spasm or jerking of all extremities
• muscle trembling, jerking, or stiffness
• nightmares
• pain or discomfort in the arms, jaw, back, or neck
• painful or difficult urination
• pinpoint red or purple spots on the skin
• rapid weight gain
• redness of the face, neck, arms, and occasionally, upper chest
• restlessness
• seizures
• shakiness and unsteady walk
• slow speech
• sore throat
• stiffness of the limbs
• stupor
• sweating
• swelling of the face, ankles, legs, or hands
• talking, feeling, and acting with excitement
• trouble sleeping
• twisting movements of the body
• uncontrolled movements, especially of the face, neck, and back
• unusual behavior
• unusual tiredness or weakness
• weakness in the arms, hands, legs, or feet
• yellow eyes or skin

If any of the following symptoms of overdose occur while taking Depram, get emergency help immediately:

Symptoms of overdose:

• Bluish color of fingernails, lips, skin, palms, or nail beds
• cold, clammy skin
• decreased awareness or responsiveness
• difficult or troubled breathing
• disorientation
• fast, weak pulse
• hallucinations
• irregular, fast, slow, or shallow breathing
• severe sleepiness

Minor Side Effects

Some Depram side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:

• Bigger, dilated, or enlarged pupils (black part of the eye)
• black tongue
• decreased interest or ability in sexual intercourse
• difficulty having a bowel movement (stool)
• enlargement of the breast
• hives or welts
• increase in sexual ability, desire, drive, or performance
• increased sensitivity of the eyes to light
• increased urge to urinate during the night
• peculiar taste
• redness or other discoloration of the skin
• severe sunburn
• swelling of the testicles
• swelling of the breasts or breast soreness in both females and males
• swollen, painful, or tender lymph glands on the side of the face or neck
• unexpected or excess milk flow from the breasts
• waking to urinate at night

Depram contraindications

See also:
What is the most important information I should know about Depram?

Monoamine Oxidase Inhibitors (MAOIs)

The use of MAOIs intended to treat psychiatric disorders with Depram Pamoate or within 14 days of stopping treatment with Depram Pamoate is contraindicated because of an increased risk of serotonin syndrome. The use of Depram Pamoate within 14 days of stopping an MAOI intended to treat psychiatric disorders is also contraindicated.

Starting Depram Pamoate in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue is also contraindicated because of an increased risk of serotonin syndrome.

Myocardial Infarction

The drug is contraindicated during the acute recovery period after a myocardial infarction.

Hypersensitivity to Tricyclic Antidepressants

Patients with a known hypersensitivity to this compound should not be given the drug. The possibility of cross-sensitivity to other dibenzazepine compounds should be kept in mind.

Active ingredient matches for Depram:

Imipramine in Bangladesh.

Escitalopram in Indonesia.

References

1. PubChem. "imipramine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
2. PubChem. "Escitalopram". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "Escitalopram". http://www.drugbank.ca/drugs/DB01175 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology