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• Desloratadine indications
• Uses of Desloratadine in details
• Desloratadine description
• Desloratadine dosage
• Desloratadine interactions
• Desloratadine side effects
• Desloratadine contraindications

What is Desloratadine?

Desloratadine is an antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Desloratadine is used to treat the symptoms of allergies, such as sneezing, watery eyes, and runny nose. It is also used to treat skin hives and itching in people with chronic skin reactions.

Desloratadine may also be used for purposes not listed in this medication guide.

Desloratadine indications

1.1 Seasonal Allergic Rhinitis

Desloratadine Tablets are indicated for the relief of the nasal and non-nasal symptoms of seasonal allergic rhinitis in patients 12 years of age and older.

1.2 Perennial Allergic Rhinitis

Desloratadine Tablets are indicated for the relief of the nasal and non-nasal symptoms of perennial allergic rhinitis in patients 12 years of age and older.

1.3 Chronic Idiopathic Urticaria

Desloratadine Tablets are indicated for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 12 years of age and older.

How should I use Desloratadine?

Use Desloratadine orally disintegrating tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Desloratadine orally disintegrating tablets. Talk to your pharmacist if you have questions about this information.
• Take Desloratadine orally disintegrating tablets by mouth with or without food.
• Do not remove the blister from the outer pouch until you are ready to take Desloratadine orally disintegrating tablets. Make sure that your hands are dry when you open the blister pack. Do not push the tablet through the foil. Peel back the foil on the blister pack and place the tablet on your tongue. The tablet dissolves quickly and can be swallowed with saliva. Desloratadine orally disintegrating tablets may be taken with or without water. Take the tablet immediately after opening the blister pack. Do not store the removed tablet for future use.
• If you miss a dose of Desloratadine orally disintegrating tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Desloratadine orally disintegrating tablets.

Uses of Desloratadine in details

Use: Labeled Indications

Allergic rhinitis: Relief of nasal and non-nasal symptoms of seasonal (SAR) and perennial (PAR) allergic rhinitis

Urticaria: Symptomatic relief of pruritus, reduction in number of hives, and reduction in size of hives associated with chronic idiopathic urticaria (CIU)

Off Label Uses

NSAID-associated urticaria (prophylaxis)

Data from a retrospective study with a limited number of patients suggest that Desloratadine may be beneficial for prophylactic therapy in patients with NSAID-associated urticaria prior to receiving a strong COX-1 inhibitor. Additional trials may be needed to further define the role of Desloratadine in this setting.

Desloratadine description

Desloratadine Tab: Each tablet contains 5.0 mg of Desloratadine.

Desloratadine Syr: Each mL of Desloratadine syrup contains 500 mcg of Desloratadine.

Excipients/Inactive Ingredients: Desloratadine Tab: Dibasic calcium phosphate dihydrate, microcrystalline cellulose, maize starch, talc, blue color film-coat material, clear film coat material, white wax and carnauba wax.

Desloratadine dosage

Desloratadine Dosage

Generic name: Desloratadine 5mg

Dosage form: tablet, film coated; oral solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Although an orally disintegrating tablet formulation of Desloratadine may be available in the marketplace, Desloratadine® RediTabs® Tablets are no longer marketed.

Desloratadine Tablets,

Oral Solution, or RediTabs Tablets may be taken without regard to meals. Place Desloratadine (Desloratadine) RediTabs Tablets on the tongue and allow to disintegrate before swallowing. Tablet disintegration occurs rapidly. Administer with or without water. Take tablet immediately after opening the blister.

The age-appropriate dose of Desloratadine

Oral Solution should be administered with a commercially available measuring dropper or syringe that is calibrated to deliver 2 mL and 2.5 mL (½ teaspoon).

Adults and Adolescents 12 Years of Age and Over

The recommended dose of Desloratadine Tablets or Desloratadine Tablets is one 5-mg tablet once daily. The recommended dose of Desloratadine

Oral Solution is 2 teaspoonfuls (5 mg in 10 mL) once daily.

Children 6 to 11 Years of Age

The recommended dose of Desloratadine

Oral Solution is 1 teaspoonful (2.5 mg in 5 mL) once daily. The recommended dose of Desloratadine Tablets is one 2.5-mg tablet once daily.

Children 12 Months to 5 Years of Age

The recommended dose of Desloratadine

Oral Solution is ½ teaspoonful (1.25 mg in 2.5 mL) once daily.

Children 6 to 11 Months of Age

The recommended dose of Desloratadine

Oral Solution is 2 mL (1 mg) once daily.

Adults with Hepatic or Renal Impairment

In adult patients with liver or renal impairment, a starting dose of one 5-mg tablet every other day is recommended based on pharmacokinetic data. Dosing recommendation for children with liver or renal impairment cannot be made due to lack of data.

More about Desloratadine (Desloratadine)

• Side Effects
• During Pregnancy or Breastfeeding
• Dosage Information
• Drug Images
• Drug Interactions
• Support Group
• Pricing & Coupons
• En Espanol
• 5 Reviews - Add your own review/rating
• Generic Availability

Consumer resources

• Desloratadine
• Desloratadine syrup
• Desloratadine (Advanced Reading)

Professional resources

• Desloratadine (AHFS Monograph)
• Desloratadine (FDA)

Other formulations

• Desloratadine-D 24 Hour
• Desloratadine-D 12 Hour
• Desloratadine

Related treatment guides

• Allergic Rhinitis
• Urticaria

Desloratadine interactions

See also:
What other drugs will affect Desloratadine?

Inhibitors Of Cytochrome P450 3A4

In controlled clinical studies co-administration of Desloratadine with ketoconazole, erythromycin, or azithromycin resulted in increased plasma concentrations of Desloratadine and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Desloratadine.

Fluoxetine

In controlled clinical studies co-administration of Desloratadine with fluoxetine, a selective serotonin reuptake inhibitor (SSRI), resulted in increased plasma concentrations of Desloratadine and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Desloratadine.

Cimetidine

In controlled clinical studies co-administration of Desloratadine with cimetidine, a histamine H2-receptor antagonist, resulted in increased plasma concentrations of Desloratadine and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile of Desloratadine.

Drug Abuse And Dependence

There is no information to indicate that abuse or dependency occurs with Desloratadine Tablets.

Desloratadine side effects

See also:
What are the possible side effects of Desloratadine?

In clinical trials in a range of indications including allergic rhinitis and chronic idiopathic urticaria, at the recommended dose of 5 mg daily, undesirable effects with Desloratadine tablets were reported in 3 % of patients in excess of those treated with placebo. The most frequent adverse events reported in excess of placebo were fatigue (1.2 %), dry mouth (0.8 %), and headache (0.6 %).

Very rare cases of hypersensitivity reactions (including anaphylaxis and rash) tachycardia, palpitations, psychomotor hyperactivity, seizures, elevations of liver enzymes, hepatitis, and increased bilirubin have been reported during the marketing of Desloratadine.

Desloratadine Syr: In clinical trials in a paediatric population, Desloratadine Syrup was administered to a total of 246 children aged 6 months through 11 years. The overall incidence of adverse events in children 2 through 11 years of age was similar for Desloratadine Syrup and the placebo groups. In infants and toddlers aged 6 to 23 months, the most frequent adverse events reported in excess of placebo were diarrhea (3.7%), fever (2.3%) and insomnia (2.3%).

Desloratadine contraindications

See also:
What is the most important information I should know about Desloratadine?

You should not take this medication if you are allergic to Desloratadine or to loratadine (Claritin).

Before taking Desloratadine, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease.

Do not give this medication to a child younger than 2 years old without the advice of a doctor.

Desloratadine disintegrating tablets (Desloratadine) may contain phenylalanine. Talk to your doctor before using this form of Desloratadine if you have phenylketonuria (PKU).

Active ingredient matches for Desloratadine:

Desloratadine

References

1. DailyMed. "DESLORATADINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "Desloratadine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "Desloratadine". http://www.drugbank.ca/drugs/DB00967 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology