Divido 75mg Uses

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What is Divido 75mg?

Divido 75mg is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such as inflammation, swelling, stiffness, and joint pain. However, Divido 75mg does not cure osteoarthritis and will help you only as long as you continue to use it.

Divido 75mg topical 3% gel is also used to treat actinic keratosis, a skin problem that may become cancerous if not treated. The exact way that topical Divido 75mg helps this condition is unknown.

Divido 75mg topical solution is used to treat pain and swelling caused by osteoarthritis of the knees.

Divido 75mg topical patch is used to treat acute pain caused by minor strains, sprains, and contusions (bruises).

Divido 75mg is available only with your doctor's prescription.

Divido 75mg indications

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Intramuscular

Renal colic

Adult: As Divido 75mg Na: 75 mg, may repeat once after 30 min if needed. Max: 150 mg/day. Max period: 2 days.

Intramuscular

Bursitis, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis, Acute gout, Dysmenorrhoea

Adult: As Divido 75mg Na: 75 mg once daily, injected into the gluteal muscle, may increase to 75 mg bid in severe conditions. Max period: 2 days.

Intravenous

Postoperative pain

Adult: As Divido 75mg Na: 75 mg infusion in glucose 5% or NaCl 0.9% (previously buffered w/ Na bicarbonate) given over 30-120 min or as bolus inj, may repeat after 4-6 hr if necessary. Max period: 2 days.

Intravenous

Prophylaxis of postoperative pain

Adult: As Divido 75mg Na: Initially, 25-50 mg infusion given after surgery over 15-60 min followed by 5 mg/hr. Alternatively, initial dose may be given as bolus inj over 5-60 sec followed by additional inj, may repeat after 4-6 hr if necessary. Max: 150 mg/day. Max period: 2 days.

Ophthalmic

Postoperative ocular inflammation

Adult: As Divido 75mg Na (0.1% soln): Instill into the appropriate eye 4 times daily starting 24 hr after surgery for up to 28 days.

Ophthalmic

Inflammation and discomfort after strabismus surgery

Adult: As Divido 75mg Na (0.1% soln): Instill 1 drop 4 times daily for the 1st wk; then tid in the 2nd wk, bid in the 3rd wk, and as required for the 4th wk.

Ophthalmic

Pain and discomfort after radial keratotomy

Adult: As Divido 75mg Na (0.1% soln): Instill 1 drop before surgery followed by 1 drop immediately after surgery, and then 1 drop 4 times daily for up to 2 days.

Ophthalmic

Pain after accidental trauma

Adult: As Divido 75mg Na (0.1% soln): Instill 1 drop 4 times daily for up to 2 days.

Ophthalmic

Control of inflammation after argon laser trabeculoplasty

Adult: As Divido 75mg Na (0.1% soln): Instill 1 drop 4 times during the 2 hr before procedure followed by 1 drop 4 times daily, up to 7 days after procedure.

Ophthalmic

Prophylaxis of intra-operative miosis

Adult: As Divido 75mg Na (0.1% soln): Instill into appropriate eye 4 times w/in 2 hr before surgery.

Ophthalmic

Post-photorefractive keratectomy pain

Adult: As Divido 75mg Na (0.1% soln): Instill into the affected eye twice, an hr before surgery, then 1 drop twice at 5-min intervals immediately after surgery, then every 2-5 hr while awake for up to 24 hr.

Ophthalmic

Seasonal allergic conjunctivitis

Adult: As Divido 75mg Na (0.1% soln): Instill 1 drop before surgery followed by 1 drop immediately after surgery, and then 1 drop 4 times daily for up to 2 days.

Oral

Bursitis, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis, Acute gout, Dysmenorrhoea

Adult: As Divido 75mg Na: 75-150 mg/day in divided doses. Max: 150 mg/day.

Oral

Migraine

Adult: As Divido 75mg K: Initially, 50 mg taken at the 1st sign of an attack, an additional dose of 50 mg may be taken after 2 hr if symptoms persist. If needed, further doses of 50 mg may be taken 4-6 hrly. Max: 200 mg/day.

Rectal

Acute gout, Bursitis, Dysmenorrhoea, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis

Adult: As Divido 75mg Na: 100 mg once daily.

Topical/Cutaneous

Actinic keratoses

Adult: As Divido 75mg Na (3% gel): Apply bid for 60-90 days.

Topical/Cutaneous

Osteoarthritis

Adult: As Divido 75mg Na (1.6% soln): Apply in small amounts (20 or 40 drops) onto affected area 4 times daily. As Na: (1% gel): Apply to the affected area 4 times daily. Max: 32 g/day over the affected area.

Topical/Cutaneous

Local symptomatic relief of pain and inflammation

Adult: As Divido 75mg Na (1% gel): Apply onto affected area 3 or 4 times daily.

Transdermal

Acute pain

Adult: Sprains, strains, contusions: 1 patch bid.

How should I use Divido 75mg?

Use Divido 75mg solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Divido 75mg solution.

Uses of Divido 75mg in details

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Divido 75mg is used to relieve pain from various conditions. This form of Divido 75mg is used to treat migraine headaches. Divido 75mg is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat gout attacks.

How to use Divido 75mg

Read the Medication Guide provided by your pharmacist before you start taking Divido 75mg and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor. Empty the contents of one packet into a cup containing 1 to 2 ounces (30 to 60 milliliters) of water. Mix well and drink all of it right away. Do not mix with any liquid other than water. If stomach upset occurs while taking this medication, take it with food, milk, or an antacid. However, if you take this medication with a meal high in fat, it may not work as well.

There are different brands and forms of this medication available. Because different forms do not have the same effects at equal strengths, do not switch forms of Divido 75mg unless your doctor tells you to.

To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose. Do not increase your dose or take it more often than prescribed.

Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Tell your doctor if your condition persists or worsens.

Divido 75mg description

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The active substance is sodium-[o[(2,6-dichlorophenyl)-amino]-phenyl]-acetate (= Divido 75mg sodium).

Each enteric tablet contains 25 mg or 50 mg of Divido 75mg sodium.

One prolonged-release tablet contains 100 mg of Divido 75mg sodium.

Excipients/Inactive Ingredients: Gastro-Resistant Tablet: Core for 25 mg and 50 mg: Cellulose microcrystalline; lactose monohydrate; magnesium stearate; maize starch; povidone; silica, colloidal anhydrous; sodium starch glycolate (type A).

Coating for 25 mg and 50 mg: Hypromellose; iron oxide yellow (E172); macrogoglycerol hydroxystearate; methacrylic acid-ethyl acrylate copolymer; macrogol 8000; talc; titanium dioxide (E171); simeticone; alpha-octadecyl-omega-hydroxy-polyglykolether; sorbic acid.

Coating for 50 mg: Iron oxide red (E172).

SR Tablet: Tablet Core: Cetyl alcohol; magnesium stearate; povidone; silica; colloidal anhydrous; sucrose.

Tablet Coating: Hypromellose; iron oxide red (E172); macrogol 8000; polysorbate 80; sucrose; talc; titanium dioxide (E171). Printing Ink: Carbon black, shellac, ammonium hydroxide, simethicone.

Injection: Each ampoule also contains the following excipients: Mannitol, sodium metabisulfite (E223), benzyl alcohol, propylene glycol, water for injection, sodium hydroxide.

Divido 75mg dosage

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General Dosing Instructions

Carefully consider the potential benefits and risks of Divido 75mg and other treatment options before deciding to use Divido 75mg. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.

The effectiveness of Divido 75mg when taken with food has not been studied in clinical studies. Taking Divido 75mg with food may cause a reduction in effectiveness compared to taking Divido 75mg on an empty stomach.

Acute Pain

For management of mild to moderate acute pain, the dosage is 18 mg or 35 mg orally three times daily.

Osteoarthritis Pain

For management of osteoarthritis pain, the dosage is 35 mg orally three times daily.

Dosage Adjustments in Patients with Hepatic Impairment

Patients with hepatic disease may require reduced doses of Divido 75mg compared to patients with normal hepatic function. As with other Divido 75mg products, start treatment at the lowest dose. If efficacy is not achieved with the lowest dose, discontinue use.

Non-Interchangeability with Other Formulations of Divido 75mg

Divido 75mg capsules are not interchangeable with other formulations of oral Divido 75mg even if the milligram strength is the same. Divido 75mg capsules contain Divido 75mg free acid whereas other Divido 75mg products contain a salt of Divido 75mg, i.e., Divido 75mg potassium or sodium. A 35 mg dose of Divido 75mg is approximately equal to 37.6 mg of sodium Divido 75mg or 39.5 mg of potassium Divido 75mg. Therefore, do not substitute similar dosing strengths of other Divido 75mg products without taking this into consideration.

Divido 75mg interactions

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What other drugs will affect Divido 75mg?

Aspirin: Concomitant administration of Divido 75mg and aspirin is not recommended because Divido 75mg is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels and AUC values.

Anticoagulants: While studies have not shown Divido 75mg to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs. Because prostaglandins play an important role in hemostasis and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including Divido 75mg and warfarin, requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required.

Digoxin, Methotrexate, Cyclosporine: Divido 75mg, like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. Ingestion of Divido 75mg may increase serum concentrations of digoxin and methotrexate and increase cyclosporine's nephrotoxicity. Patients who begin taking Divido 75mg or who increase their Divido 75mg dose or any other NSAID while taking digoxin, methotrexate or cyclosporine may develop toxicity characteristics for these drugs. They should be observed closely, particularly if renal function is impaired. In the case of digoxin, serum levels should be monitored.

Lithium: Divido 75mg decreases lithium renal clearance and increases lithium plasma levels. In patients taking Divido 75mg and lithium concomitantly, lithium toxicity may develop.

Oral Hypoglycemics:

Divido 75mg does not alter glucose metabolism in normal subjects nor does it alter the effects of oral hypoglycemic agents. There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of Divido 75mg that necessitated changes in the doses of such agents. Both hypo- and hyperglycemic effects have been reported. A direct causal relationship has not been established, but physicians should consider the possibility that Divido 75mg may alter a diabetic patient's response to insulin or oral hypoglycemic agents.

Diuretics: Divido 75mg and other NSAIDs can inhibit the activity of diuretics. Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels.

Other Drugs: In small groups of patients (7-10/interaction study), the concomitant administration of azathioprine, gold, chloroquine, D-penicillamine, prednisolone, doxycycline or digitoxin did not significantly affect the peak levels and AUC values of Divido 75mg. Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of Divido 75mg therapy.

Divido 75mg side effects

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What are the possible side effects of Divido 75mg?

There have been cases reported of Divido 75mg being associated with the development of symptoms resembling the syndrome of inappropriate antidiuretic hormone secretion in elderly women. A patient who had been taking Divido 75mg for several years and had increasingly complained of dry, gritty eyes noticed that eye irritation disappeared within 3 days when Divido 75mg had to be discontinued because of GI effects.

The most frequent adverse effects reported in patients given Divido 75mg are GI in nature. Typical reactions include epigastric pain, nausea, vomiting and diarrhoea. Rarely, peptic ulcer and GI bleeding have occurred. Divido 75mg has also been implicated as the causative agent in colonic ulceration, small bowel perforation and pseudomembranous colitis.

Renal papillary necrosis and nephritic syndrome have been reported in patients taking Divido 75mg. Elevations of serum aminotransferase activity and clinical hepatitis, including fetal fulminant hepatitis have occurred in patients taking Divido 75mg. Self-limiting skin reaction eg, rash or pruritus may occur in patients given Divido 75mg.

Aspirin-sensitive asthmatic patients have developed reactions (rhinorrhoea, tightness of chest, wheezing, dyspnoea) when challenged with Divido 75mg in doses of 10-25 mg and the CMS in the UK have received a report of 1 aspirin-sensitive patient who died from acute asthma 4 hrs after a single 25-mg dose of Divido 75mg.

Divido 75mg contraindications

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What is the most important information I should know about Divido 75mg?

Hypersensitivity to Divido 75mg sodium or to any of the excipients of Divido 75mg.

Active gastric or intestinal ulcer, bleeding or perforation.

Last trimester of pregnancy.

Hepatic, renal and severe cardiac failure.

Patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid and/or other drugs with prostaglandin-synthetase inhibitory activity.

Treatment of peri-operative pain in setting of coronary artery bypass graft (CABG) surgery.

The use of high dose Divido 75mg (150 mg/day) for >4 weeks is contraindicated in patients with established cardiovascular disease (congestive heart failure, established ischemic heart disease, peripheral arterial disease) or uncontrolled hypertension.

Established Cardiovascular Disease or Significant Cardiovascular Risk Factors: The use of high dose Divido 75mg (150mg/day) for >4 weeks is contraindicated in patients with established cardiovascular disease (congestive heart failure, established ischemic heart disease, peripheral arterial disease) or uncontrolled hypertension. If Divido 75mg treatment is needed, patients with established cardiovascular disease, uncontrolled hypertension or significant cardiovascular risk factors (eg, hypertension, hyperlipidaemia, diabetes mellitus and smoking) should be treated only after careful consideration and at doses ≤100 mg daily if the treatment is for >4 weeks. As the cardiovascular risks of Divido 75mg may increase with dose and duration of exposure, Divido 75mg should always be prescribed at the lowest effective daily dose and for the shortest duration possible.

Renal Impairment: Divido 75mg is contraindicated in patients with renal failure. No specific studies have been carried out in patients with renal impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering Divido 75mg to patients with mild to moderate renal impairment.

Hepatic Impairment: Divido 75mg is contraindicated in patients with hepatic failure. No specific studies have been carried out in patients with hepatic impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering Divido 75mg to patients with mild to moderate hepatic impairment.



Active ingredient matches for Divido 75mg:

Diclofenac in Oman.


List of Divido 75mg substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Divifen 75mg/ml Injection (Flagship Biotech International)$ 0.18
Divinase Forte Diclofenac potassium 50 mg, Serratiopeptidase 10 mg. TAB / 100 (Quest Pharmaceuticals)$ 6.86
Divinase Forte 50+10 Tablet (Quest Pharmaceuticals)$ 0.07
DIVINASE FORTE tab 10's (Quest Pharmaceuticals)$ 0.69
Divoltar 50 mg x 5 x 10's (Hexpharm)$ 2.52
DIVON Capsule/ Tablet / 50mg / 10 units (Eros Pharma Ltd (Micro Labs Ltd))$ 0.22
DIVON Modified Release Capsule/ Tablet / 100mg / 10 units (Eros Pharma Ltd (Micro Labs Ltd))$ 0.34
DIVON Injection / 25mg per ml / 5x3ml units (Eros Pharma Ltd (Micro Labs Ltd))$ 0.54
Divon 50mg EC-TAB / 10 (Eros Pharma Ltd (Micro Labs Ltd))$ 0.23
Divon 100mg SR-TAB / 10 (Eros Pharma Ltd (Micro Labs Ltd))$ 0.39
Divon 25mg/ml INJ / 3ml (Eros Pharma Ltd (Micro Labs Ltd))$ 0.11
Divon 75 mg Injection (Eros Pharma Ltd (Micro Labs Ltd))$ 0.04
Divon 50 mg Tablet (Eros Pharma Ltd (Micro Labs Ltd))$ 0.02
DIVON 0.24% W/W GEL 1 tube / 10 GM gel each (Eros Pharma Ltd (Micro Labs Ltd))$ 0.39
DIVON 0.24% W/W GEL 1 tube / 30 GM gel each (Eros Pharma Ltd (Micro Labs Ltd))$ 1.14
DIVON 100 MG TABLET SR 1 strip / 10 tablet srs each (Eros Pharma Ltd (Micro Labs Ltd))$ 0.52
DIVON 25 MG INJECTION 1 vial / 3 ML injection each (Eros Pharma Ltd (Micro Labs Ltd))$ 0.13
DIVON 50 MG TABLET 1 strip / 10 tablets each (Eros Pharma Ltd (Micro Labs Ltd))$ 0.27
DIVON inj 25 mg x 1 mL x 3ml (Eros Pharma Ltd (Micro Labs Ltd))$ 0.11
DIVON enteric-coated tab 50 mg x 10's (Eros Pharma Ltd (Micro Labs Ltd))$ 0.29
DIVON SR tab 100 mg x 10's (Eros Pharma Ltd (Micro Labs Ltd))$ 0.39
Divon 0.24% w/w Gel (Eros Pharma Ltd (Micro Labs Ltd))$ 0.42
Divon 100mg Tablet SR (Eros Pharma Ltd (Micro Labs Ltd))$ 0.05
Divon 25mg Injection (Eros Pharma Ltd (Micro Labs Ltd))$ 0.04
Divon 50mg Tablet (Eros Pharma Ltd (Micro Labs Ltd))$ 0.03
Divon Gel Diclofenac sodium 1 % w/w, Methyl salicylate 10 % w/w, Linseed oil 3 % w/w, Menthol 5% w/w. GEL / 10g (Eros Pharma Ltd (Micro Labs Ltd))$ 0.28
Divon Gel Diclofenac sodium 1 % w/w, Methyl salicylate 10 % w/w, Linseed oil 3 % w/w, Menthol 5% w/w. GEL / 30g (Eros Pharma Ltd (Micro Labs Ltd))$ 0.70
Divon Gel 10 gm Gel (Eros Pharma Ltd (Micro Labs Ltd))$ 0.28
Divon Gel 30 gm Gel (Eros Pharma Ltd (Micro Labs Ltd))$ 0.70
DIVON GEL topical gel 10g (Eros Pharma Ltd (Micro Labs Ltd))$ 0.28
DIVON GEL topical gel 30g (Eros Pharma Ltd (Micro Labs Ltd))$ 0.70
Divon Spy - SPY / 1$ 0.90
Divon SR 100 mg Tablet (Eros Pharma Ltd (Micro Labs Ltd))$ 0.04
Divorel CR 100 mg Capsule (Medisys Biotech Pvt. Ltd.)$ 0.02
Divorel K 50 mg Tablet (Medisys Biotech Pvt. Ltd.)$ 0.02
DIVOREL K 50MG TABLET 1 strip / 10 tablets each (Medisys Biotech Pvt. Ltd.)$ 0.23
Divorel K 50mg Tablet (Medisys Biotech Pvt. Ltd.)$ 0.02
Diwot INJ 75mg x 3mL INJ / 1 (Edward)$ 0.08
DIWOT INJ inj 75 mg x 3 mL x 3ml (Edward)$ 0.06
DIWOT-AQ inj 1 mL x 1's (Edward)$ 0.18
Diwot-S Diclofenac potassium 50 mg, Serratiopeptidase 15 mg. TAB / 10 (Edward)$ 0.66

References

  1. DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "diclofenac". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "diclofenac". http://www.drugbank.ca/drugs/DB00586 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Divido 75mg are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Divido 75mg. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


1 consumer reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Divido 75mg drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Not expensive1
100.0%


2 consumers reported time for results

To what extent do I have to use Divido 75mg before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 5 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Divido 75mg. To get the time effectiveness of using Divido 75mg drug by other patients, please click here.
Users%
5 days1
50.0%
3 days1
50.0%


7 consumers reported age

Users%
30-453
42.9%
46-603
42.9%
16-291
14.3%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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