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• Aspirin (Ecosprin AV) indications
• Uses of Aspirin (Ecosprin AV) in details
• Aspirin (Ecosprin AV) description
• Aspirin (Ecosprin AV) dosage
• Aspirin (Ecosprin AV) interactions
• Aspirin (Ecosprin AV) side effects
• Aspirin (Ecosprin AV) contraindications
• Atorvastatin (Ecosprin AV) indications
• Uses of Atorvastatin (Ecosprin AV) in details
• Atorvastatin (Ecosprin AV) description
• Atorvastatin (Ecosprin AV) dosage
• Atorvastatin (Ecosprin AV) interactions
• Atorvastatin (Ecosprin AV) side effects
• Atorvastatin (Ecosprin AV) contraindications

Consists of Aspirin, Atorvastatin

What is Aspirin (Ecosprin AV)?

Aspirin may also be used to lessen the chance of heart attack, stroke, or other problems that may occur when a blood vessel is blocked by blood clots. Aspirin helps prevent dangerous blood clots from forming. However, this effect of aspirin may increase the chance of serious bleeding in some people. Therefore, aspirin should be used for this purpose only when your doctor decides, after studying your medical condition and history, that the danger of blood clots is greater than the risk of bleeding. Do not take aspirin to prevent blood clots or a heart attack unless it has been ordered by your doctor.

Salicylates may also be used for other conditions as determined by your doctor.

The caffeine present in some of these products may provide additional relief of headache pain or faster pain relief.

Some salicylates are available only with your medical doctor's or dentist's prescription. Others are available without a prescription; however, your medical doctor or dentist may have special instructions on the proper dose of these medicines for your medical condition.

Aspirin (Ecosprin AV) indications

Prevention of Cardiovascular Disease: Encourage aspirin use in men (45-79 years) and women (55-79 years) when potential benefit (ie, prevention of myocardial infarction in men and prevention of ischemic stroke in women) outweighs potential harm of gastrointestinal hemorrhage.

Primary Prevention of Thromboembolic Disorders and Cardiovascular Events: Ischemic stroke; transient ischemic attack (TIA); prevention of recurrent myocardial infarction (MI); unstable angina pectoris; chronic stable angina pectoris.

Secondary Prevention of Cardiovascular Disease in Persons with Diabetes Mellitus Especially in the Following Subgroups: History of MI, vascular bypass procedure, stroke or transient ischemic attack and angina. Persons with additional risk factors: Hypertension, smoking, dyslipidemia and family history of cardiovascular disease.

Revascularization Procedures: Patients who have undergone revascularization procedures eg, coronary artery bypass graft (CABG), percutaneous transluminal coronary angioplasty (PTCA) and carotid endarterectomy when there is a preexisting condition for which aspirin is already indicated.

Pregnancy-Induced Hypertension: Primary prevention of pregnancy-induced hypertension, preeclampsia and intrauterine growth retardation particularly in pregnant women with preexisting chronic hypertension, auto-immune disorders like systemic lupus erythematosus (SLE), positive cardiolipin antibody test, history of recurring toxemia in successive pregnancies, and hypotension developing before the 20th week of gestation.

How should I use Aspirin (Ecosprin AV)?

Use Aspirin (Ecosprin AV) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Aspirin (Ecosprin AV) by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Take Aspirin (Ecosprin AV) with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Aspirin (Ecosprin AV).
• Swallow Aspirin (Ecosprin AV) whole. Do not break, crush, or chew before swallowing.
• Use Aspirin (Ecosprin AV) exactly as directed on the package, unless instructed differently by your doctor. If you are taking Aspirin (Ecosprin AV) without a prescription, follow any warnings and precautions on the label.
• If you miss a dose of Aspirin (Ecosprin AV) and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Aspirin (Ecosprin AV).

Uses of Aspirin (Ecosprin AV) in details

Aspirin is used to reduce fever and relieve mild to moderate pain from conditions such as muscle aches, toothaches, common cold, and headaches. It may also be used to reduce pain and swelling in conditions such as arthritis. Aspirin is known as a salicylate and a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking a certain natural substance in your body to reduce pain and swelling. Consult your doctor before giving this drug to a child younger than 12 years. It is very important to keep this and all medication out of the reach of children. Aspirin is a common cause of poisoning in children.

Your doctor may direct you to take a low dose of aspirin to prevent blood clots. This effect reduces the risk of stroke and heart attack. If you have recently had surgery on clogged arteries (such as bypass surgery, carotid endarterectomy, coronary stent), your doctor may direct you to use aspirin in low doses as a "blood thinner" to prevent blood clots. Aspirin prevents blood clots by stopping certain blood cells (platelets) from clumping together.

How to use Aspirin (Ecosprin AV)

If you are taking this medication for self-treatment, follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist. If your doctor has directed you to take this medication, take it exactly as prescribed.

Chew the tablet thoroughly before swallowing. This medication may also be crushed or swallowed whole. If stomach upset occurs while you are taking this medication, you may take it with food or milk.

The dosage and length of treatment are based on your medical condition and response to treatment. Read the product label to find recommendations on how many tablets you can take in a 24-hour period and how long you may self-treat before seeking medical advice. Do not take more medication or take it for longer than recommended unless directed by your doctor. Use the smallest effective dose. Consult your doctor or pharmacist if you have any questions.

If you are taking this medication for self-treatment of headache, seek immediate medical attention if you also have slurred speech, weakness on one side of the body, or sudden vision changes. Before using this drug, consult a doctor or pharmacist if you have headaches caused by head injury, coughing, or bending, or if you have a headache with persistent/severe vomiting, fever, and stiff neck. These may be signs of serious medical conditions.

If you are taking this medication as needed (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medicine may not work as well.

You should not take this medication for self-treatment of pain for longer than 10 days. You should not use this drug to self-treat a fever that lasts longer than 3 days. In these cases, consult a doctor because you may have a more serious condition. Tell your doctor promptly if you develop ringing in the ears or difficulty hearing.

If your condition persists or worsens (such as new or unusual symptoms, redness/swelling of the painful area, pain/fever that does not go away or gets worse) or if you think you may have a serious medical problem, tell your doctor promptly.

Aspirin (Ecosprin AV) description

The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin (Ecosprin AV) also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)

Aspirin (Ecosprin AV) dosage

Aspirin (Ecosprin AV) Dosage

Generic name: Aspirin 162.5mg

Dosage form: capsule, extended release

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

The recommended dose of Aspirin (Ecosprin AV) is one capsule (162.5 mg) once daily. Take the capsules with a full glass of water at the same time each day.

Swallow Aspirin (Ecosprin AV) capsules whole. Do not cut, crush or chew capsules.

Do not take Aspirin (Ecosprin AV) 2 hours before or 1 hour after consuming alcohol.

More about Aspirin (Ecosprin AV) (aspirin)

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Consumer resources

• Aspirin (Ecosprin AV)

• Other brands: Ecotrin, Aspirin (Ecosprin AV) Aspirin, Aspir 81, Aspir-Low, More (20) »

Professional resources

• Aspirin (Ecosprin AV) (FDA)
• Aspirin (AHFS Monograph)

Related treatment guides

• Ischemic Stroke, Prophylaxis

Aspirin (Ecosprin AV) interactions

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What other drugs will affect Aspirin (Ecosprin AV)?

Uricosuric Agents: Aspirin (Ecosprin AV) may decrease the effects of probenecid, sulfinpyrazone, and phenylbutazone. Alcohol: Has a synergistic effect with aspirin in causing gastrointestinal bleeding. Corticosteroids: Concomitant administration with aspirin may increase the risk of gastrointestinal ulceration and may reduce serum salicylate levels. Pyrazolone Derivatives (phenylbutazone, oxyphenbutazone, and possibly dipyrone): Concomitant administration with aspirin may increase the risk of gastrointestinal ulceration. Nonsteroidal Antiinflammatory Agents: Aspirin (Ecosprin AV) is contraindicated in patients who are hypersensitive to nonsteroidal anti-inflammatory agents. Urinary Alkalinizers: Decrease aspirin effectiveness by increasing the rate of salicylate renal excretion. Phenobarbital: Decreases aspirin effectiveness by enzyme induction. Phenytoin: Serum phenytoin levels may be increased by aspirin. Propranolol: May decrease aspirins anti-inflammatory action by competing for the same receptors. Antacids: Enteric Coated Aspirin (Ecosprin AV) should not be given concurrently with antacids, since an increase in the pH of the stomach may effect the enteric coating of the tablets.

Aspirin (Ecosprin AV) side effects

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What are the possible side effects of Aspirin (Ecosprin AV)?

Applies to aspirin: oral capsule extended release 24 hr, oral capsule liquid filled, oral tablet, oral tablet chewable, oral tablet enteric coated

Side effects requiring immediate medical attention

Along with its needed effects, aspirin (the active ingredient contained in Aspirin (Ecosprin AV)) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking aspirin:

Incidence not known

• Abdominal or stomach pain, cramping, or burning
• black, tarry stools
• bloody or cloudy urine
• change in consciousness
• chest pain or discomfort
• confusion
• constipation
• convulsions, severe or continuing
• dark urine
• decreased frequency or amount of urine
• diarrhea
• difficult breathing
• drowsiness
• fainting
• fast breathing
• feeling that something terrible will happen
• fever
• general tiredness and weakness
• greatly decreased frequency of urination or amount of urine
• headache
• heartburn
• increased thirst
• indigestion
• irregular heartbeat
• light-colored stools
• loss of appetite
• loss of consciousness
• lower back or side pain
• muscle cramping and weakness
• muscle tremors
• nausea or vomiting
• nervousness
• numbness or tingling in the hands, feet, or lips
• panic
• rapid, deep breathing
• restlessness
• seizures
• skin rash
• stomach cramps
• swelling of the face, fingers, or lower legs
• unusual bleeding or bruising
• unusual tiredness or weakness
• upper right abdominal or stomach
• vomiting of blood or material that looks like coffee grounds
• weakness or heaviness of the legs
• weight gain
• yellow eyes and skin

Side effects not requiring immediate medical attention

Some side effects of aspirin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Acid or sour stomach
• anxiety
• belching
• dizziness
• dry mouth
• hyperventilation
• irritability
• shaking
• stomach discomfort, upset, or pain
• trouble sleeping
• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Managing side effects (general information)

Aspirin (Ecosprin AV) contraindications

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What is the most important information I should know about Aspirin (Ecosprin AV)?

There are many brands and forms of aspirin available and not all brands are listed on this leaflet.

Aspirin should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin can cause a serious and sometimes fatal condition called Reye's syndrome in children.

Stop using this medication and call your doctor at once if you have any symptoms of bleeding in your stomach or intestines. Symptoms include black, bloody, or tarry stools, and coughing up blood or vomit that looks like coffee grounds.

Avoid drinking alcohol while you are taking aspirin. Alcohol may increase your risk of stomach bleeding.

Aspirin is sometimes used to treat or prevent heart attacks, strokes, and chest pain (angina). Aspirin should be used for cardiovascular conditions only under the supervision of a doctor.

What is Atorvastatin (Ecosprin AV)?

Atorvastatin (Ecosprin AV) is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Atorvastatin (Ecosprin AV) reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

Atorvastatin (Ecosprin AV) is used to treat high cholesterol, and to lower the risk of stroke, heart attack, or other heart complications in people with type 2 diabetes, coronary heart disease, or other risk factors.

Atorvastatin (Ecosprin AV) is used in adults and children who are at least 10 years old.

Atorvastatin (Ecosprin AV) may also be used for purposes not listed in this medication guide.

Atorvastatin (Ecosprin AV) indications

Atorvastatin (Ecosprin AV) is indicated as an adjunct to diet for the treatment of patients with elevated total cholesterol (total-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein B (apo B), and triglycerides (TG) and to increase high density lipoprotein cholesterol (HDL-C) in patients with primary hypercholesterolemia (heterozygous familial and non-familial hypercholesterolemia), combined (mixed) hyperlipidemia (Fredrickson Types IIa and IIb), elevated serum TGlevels (Fredrickson Type IV), and for patients with dysbetalipoproteinemia (Fredrickson Type III) who do not respond adequately to diet.

Atorvastatin (Ecosprin AV) is also indicated for the reduction of total-C and LDL-C in patients with homozygous familial hypercholesterolemia.

Prevention of Cardiovascular Complications: In patients without clinically evident cardiovascular disease (CVD), and with or without dyslipidemia, but with multiple risk factors for coronary heart disease (CHD), such as smoking, hypertension, diabetes, low HDL-C, or a family history of early CHD, Atorvastatin (Ecosprin AV) is indicated to: Reduce the risk of fatal CHD and non-fatal myocardial infarction (MI); reduce the risk of stroke; reduce the risk of revascularization procedures and angina pectoris.

In patients with clinically evident CHD, Atorvastatin (Ecosprin AV) is indicated to: Reduce the risk of non-fatal MI; reduce the risk of fatal and non-fatal stroke; reduce the risk for revascularization procedures; reduce the risk of hospitalization for congestive heart failure (CHF); reduce the risk of angina.

As adjunct to lifestyle changes, such as proper diet and exercise, intensive Atorvastatin (Ecosprin AV) treatment has been shown to halt the progression of atherosclerosis (total atheroma or plaque volume) in patients with coronary artery disease and other individuals who are at high risk for cardiovascular disease.

Chronic Kidney Disease: In patients with diabetes with moderately decreased eGFR, Atorvastatin (Ecosprin AV) is indicated to reduce the risk for cardiovascular disease.

In patients with clinically evident coronary heart disease and CKD not requiring dialysis, Atorvastatin (Ecosprin AV) is indicated to reduce the risk of major cardiovascular events including stroke.

In patients with clinically evident coronary heart disease and/or diabetes with microalbuminuria, Atorvastatin (Ecosprin AV) is indicated to reduce the rate of GFR decline and progression of CKD.

Pediatric Patients (10-17 Years of Age): Atorvastatin (Ecosprin AV) is indicated as an adjunct to diet to reduce total-C, LDL-C, and apo B levels in boys and post-menarchal girls, 10 to 17 years of age, with heterozygous familial hyperchlolesterolemia if, after an adequate trial of diet therapy, the following findings are present: LDL-C remains ≥190 mg/dL or, LDL-C remains ≥160 mg/dL and there is a positive family history of premature CVD or, two or more other CVD risk factors are present in the pediatric patient.

How should I use Atorvastatin (Ecosprin AV)?

Use Atorvastatin (Ecosprin AV) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Atorvastatin (Ecosprin AV). Talk to your pharmacist if you have questions about this information.
• Take Atorvastatin (Ecosprin AV) by mouth with or without food.
• Swallow Atorvastatin (Ecosprin AV) whole. Do not break, crush, or chew before swallowing.
• Taking Atorvastatin (Ecosprin AV) at the same time each day will help you remember to take it.
• Eating grapefruit or drinking grapefruit juice may increase the amount of Atorvastatin (Ecosprin AV) in your blood, which may increase your risk for serious side effects. The risk may be greater with large amounts of grapefruit or grapefruit juice. Avoid large amounts of grapefruit or grapefruit juice (eg, more than 1 quart daily). Talk with your doctor or pharmacist if you have questions about including grapefruit or grapefruit juice in your diet while you are taking Atorvastatin (Ecosprin AV).
• Continue to take Atorvastatin (Ecosprin AV) even if you feel well. Do not miss any doses.
• If you miss a dose of Atorvastatin (Ecosprin AV), take it as soon as possible if you remember within 12 hours of the missed dose. If it is more than 12 hours since the missed dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Atorvastatin (Ecosprin AV).

Uses of Atorvastatin (Ecosprin AV) in details

Use: Labeled Indications

Heterozygous familial hypercholesterolemia: To reduce elevated total cholesterol (total-C), LDL cholesterol (LDL-C), apolipoprotein B (apo B), and triglyceride levels, and to increase HDL cholesterol in patients with primary hypercholesterolemia.

Heterozygous familial hypercholesterolemia (pediatrics): To reduce total-C, LDL-C, and apo B levels in pediatric patients 10 to 17 years of age with heterozygous familial hypercholesterolemia with LDL-C ≥190 mg/dL, LDL-C ≥160 mg/dL with positive family history of premature cardiovascular disease (CVD), or LDL-C ≥160 mg/dL with 2 or more other CVD risk factors.

Homozygous familial hypercholesterolemia: To reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments (eg, LDL apheresis) or if such treatments are unavailable.

Prevention of atherosclerotic cardiovascular disease:

Primary prevention of atherosclerotic cardiovascular disease (ASCVD): To reduce the risk of myocardial infarction (MI), stroke, revascularization procedures, and angina in adult patients without a history of coronary heart disease (CHD) but who have multiple CHD risk factors.

Secondary prevention in patients with established ASCVD: To reduce the risk of MI, stroke, revascularization procedures, and angina in patients with a history of CHD.

Off Label Uses

Transplantation, post heart or post kidney

Based on the 2010 International Society of Heart and Lung Transplantation guidelines for the care of heart transplant recipients, Atorvastatin (Ecosprin AV) is effective and recommended following heart transplant, regardless of cholesterol levels, to reduce cardiac allograft vasculopathy and improve long-term outcomes.

Based on the 2013 Kidney Disease: Improving Global Outcomes clinical practice guideline for lipid management in chronic kidney disease, Atorvastatin (Ecosprin AV) is suggested following kidney transplant to reduce cardiovascular events (eg, myocardial infarction, stroke, cardiovascular death).

Atorvastatin (Ecosprin AV) description

Atorvastatin (Ecosprin AV) 10: Each tablet contains Atorvastatin (Ecosprin AV) calcium equivalent to 10 mg Atorvastatin (Ecosprin AV).

Atorvastatin (Ecosprin AV) 20 mg: Each tablet contains Atorvastatin (Ecosprin AV) calcium equivalent to 20 mg Atorvastatin (Ecosprin AV).

Atorvastatin (Ecosprin AV) 40 mg: Each tablet contains Atorvastatin (Ecosprin AV) calcium equivalent to 40 mg Atorvastatin (Ecosprin AV).

Atorvastatin (Ecosprin AV) 80 mg: Each tablet contains atorvastin calcium equivalent to 80 mg Atorvastatin (Ecosprin AV).

Atorvastatin (Ecosprin AV) is a white, elliptical film coated tablet containing Atorvastatin (Ecosprin AV) calcium. Atorvastatin (Ecosprin AV) calcium is a synthetic lipid-lowering agent, which is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis.

The empirical formula of Atorvastatin (Ecosprin AV) calcium is (C₃₃H₃₄FN₂O₅)₂Ca·3H₂O and its molecular weight is 1209.42.

Atorvastatin (Ecosprin AV) calcium is a white to off-white crystalline powder, practically insoluble in aqueous solutions of pH 4 and below. It is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile; slightly soluble in ethanol; and freely soluble in methanol.

Atorvastatin (Ecosprin AV) dosage

Always take Atorvastatin (Ecosprin AV) exactly as prescribed.

The following instructions may apply only if the doctor has not prescribed a different regimen for administering Atorvastatin (Ecosprin AV). Observe the instructions closely, otherwise the medicine cannot be effective.

Before the start of treatment, the physician will prescribe a low-cholesterol diet and should be strictly observe throughout the treatment with Atorvastatin (Ecosprin AV).

Usual Starting Dose: Adults and Children ≥10 years: 10 mg once daily. The physician will determine further doses to achieve the desired blood cholesterol levels. Thereafter, the dose will be adjusted individually every ≤4 weeks frequently. Maximum Daily Dose: 80 mg for adults and 20 mg once daily for children.

Elevated Blood Cholesterol Levels (Hypercholesterolemia) or Concurrent Elevation of Blood Cholesterol and Triglyceride Levels (Mixed Hyperlipidemia): In the majority of patients, the effective daily dose of Atorvastatin (Ecosprin AV) is 20 mg. The effect of treatment can be seen after 2 weeks; it is usually greatest after 4 weeks. This therapeutic effect is then maintained with long-term administration of Atorvastatin (Ecosprin AV).

Hereditary Increase of Blood Cholesterol Levels (Familial Hypercholesterolemia): Heterozygous Familial Hypercholesterolemia: Starting Dose: 10 mg once daily. The dose should be determined for each individual patient. The physician will increases the dose up to 80 mg daily every 4 weeks.

Homozygous Familial Hypercholesterolemia: Adults: In the majority of patients (taking Atorvastatin (Ecosprin AV) 80 mg daily), blood cholesterol levels (LDL cholesterol) decreased by 17-31% in clinical trials.

Patients with Renal Insufficiency and the

Elderly: Kidney diseases do not affect treatment with Atorvastatin (Ecosprin AV). Consequently, dosage adjustment is not necessary in patients with renal insufficiency.

In clinical trials, it was ascertained that no dosage adjustment is necessary in elderly patients.

Administration: Take Atorvastatin (Ecosprin AV) with some liquid at any time of the day and regardless of food intake.

Atorvastatin (Ecosprin AV) are designated for long-term administration.

Missed Dose: Do not take a double dose, but only the normal dose.

Atorvastatin (Ecosprin AV) interactions

See also:
What other drugs will affect Atorvastatin (Ecosprin AV)?

The risk of myopathy during treatment with statins is increased with concurrent administration of fibric acid derivatives, lipid-modifying doses of niacin, cyclosporine, or strong CYP 3A4 inhibitors (e.g., clarithromycin, HIV protease inhibitors, and itraconazole).

Strong Inhibitors of CYP 3A4

Atorvastatin (Ecosprin AV) is metabolized by cytochrome P450 3A4. Concomitant administration of Atorvastatin (Ecosprin AV) with strong inhibitors of CYP 3A4 can lead to increases in plasma concentrations of Atorvastatin (Ecosprin AV). The extent of interaction and potentiation of effects depend on the variability of effect on CYP 3A4.

Clarithromycin

Atorvastatin (Ecosprin AV) AUC was significantly increased with concomitant administration of Atorvastatin (Ecosprin AV) 80 mg with clarithromycin (500 mg twice daily) compared to that of Atorvastatin (Ecosprin AV) alone. Therefore, in patients taking clarithromycin, caution should be used when the Atorvastatin (Ecosprin AV) dose exceeds 20 mg.

Combination of Protease Inhibitors

Atorvastatin (Ecosprin AV) AUC was significantly increased with concomitant administration of Atorvastatin (Ecosprin AV) 40 mg with ritonavir plus saquinavir (400 mg twice daily) or Atorvastatin (Ecosprin AV) 20 mg with lopinavir plus ritonavir (400 mg + 100 mg twice daily) compared to that of Atorvastatin (Ecosprin AV) alone. Therefore, in patients taking HIV protease inhibitors, caution should be used when the Atorvastatin (Ecosprin AV) dose exceeds 20 mg.

Itraconazole

Atorvastatin (Ecosprin AV) AUC was significantly increased with concomitant administration of Atorvastatin (Ecosprin AV) 40 mg and itraconazole 200 mg. Therefore, in patients taking itraconazole, caution should be used when the Atorvastatin (Ecosprin AV) dose exceeds 20 mg.

Grapefruit Juice

Contains one or more components that inhibit CYP 3A4 and can increase plasma concentrations of Atorvastatin (Ecosprin AV), especially with excessive grapefruit juice consumption ( > 1.2 liters per day).

Cyclosporine

Atorvastatin (Ecosprin AV) and Atorvastatin (Ecosprin AV)-metabolites are substrates of the OATP1B1 transporter. Inhibitors of the OATP1B1 (e.g., cyclosporine) can increase the bioavailability of Atorvastatin (Ecosprin AV). Atorvastatin (Ecosprin AV) AUC was significantly increased with concomitant administration of Atorvastatin (Ecosprin AV) 10 mg and cyclosporine 5.2 mg/kg/day compared to that of Atorvastatin (Ecosprin AV) alone. In cases where co-administration of Atorvastatin (Ecosprin AV) with cyclosporine is necessary, the dose of Atorvastatin (Ecosprin AV) should not exceed 10 mg.

Rifampin or other Inducers of Cytochrome P450 3A4

Concomitant administration of Atorvastatin (Ecosprin AV) with inducers of cytochrome P450 3A4 (e.g., efavirenz, rifampin) can lead to variable reductions in plasma concentrations of Atorvastatin (Ecosprin AV). Due to the dual interaction mechanism of rifampin, simultaneous co-administration of Atorvastatin (Ecosprin AV) with rifampin is recommended, as delayed administration of Atorvastatin (Ecosprin AV) after administration of rifampin has been associated with a significant reduction in Atorvastatin (Ecosprin AV) plasma concentrations.

Digoxin

When multiple doses of Atorvastatin (Ecosprin AV) and digoxin were coadministered, steady state plasma digoxin concentrations increased by approximately 20%. Patients taking digoxin should be monitored appropriately.

Oral Contraceptives

Co-administration of Atorvastatin (Ecosprin AV) and an oral contraceptive increased AUC values for norethindrone and ethinyl estradiol. These increases should be considered when selecting an oral contraceptive for a woman taking Atorvastatin (Ecosprin AV).

Warfarin

Atorvastatin (Ecosprin AV) had no clinically significant effect on prothrombin time when administered to patients receiving chronic warfarin treatment.

Atorvastatin (Ecosprin AV) side effects

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What are the possible side effects of Atorvastatin (Ecosprin AV)?

Adverse reactions have usually been mild and transient. Less than 2% of patients were discontinued from clinical trials due to adverse reactions attributed to Atorvastatin (Ecosprin AV).

The most frequent (≥1%) adverse effects associated with Atorvastatin (Ecosprin AV) therapy, in patients participating in controlled clinical studies were: Psychiatric Disorders: Insomnia.

Nervous System Disorders: Headache.

Gastrointestinal Disorders: Abdominal pain, dyspepsia, nausea, flatulence, constipation, diarrhea.

Musculoskeletal and Connective Tissue Disorders: Myalgia.

General Disorders and Administration Site Conditions: Asthenia.

Elevated serum ALT levels have been reported in 1.3% of patients receiving Atorvastatin (Ecosprin AV). Clinically important (>3 x UNL) elevations in serum ALT levels occurred in 19 of the 2,483 (0.8%) patients on Atorvastatin (Ecosprin AV). It was dose-related and was reversible in all 19 patients. In 10 cases, the increase was first observed within 12 weeks of starting the treatment. Only 1 case occurred after 36 weeks and only 1 patient had symptoms suggestive of hepatitis. Treatment was discontinued in only 9 of these 19 cases.

Elevated serum CPK levels (>3x ULN) occurred in 62 of the 2,452 (2.5%) patients on Atorvastatin (Ecosprin AV) compared with 3.1% with other HMG-CoA reductase inhibitors in clinical trials. Levels >10 times the normal upper range occurred in only 11 (0.4%) Atorvastatin (Ecosprin AV)-treated patients. Only 3 (0.1%) of these 11 patients had concurrent muscle pain, tenderness or weakness.

Atorvastatin (Ecosprin AV) contraindications

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What is the most important information I should know about Atorvastatin (Ecosprin AV)?

Active liver disease, which may include unexplained persistent elevations in hepatic transaminase levels

Hypersensitivity to any component of this medication

Pregnancy

Women who are pregnant or may become pregnant. Atorvastatin (Ecosprin AV) may cause fetal harm when administered to a pregnant woman. Serum cholesterol and triglycerides increase during normal pregnancy, and cholesterol or cholesterol derivatives are essential for fetal development. Atherosclerosis is a chronic process and discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia. There are no adequate and well-controlled studies of Atorvastatin (Ecosprin AV) use during pregnancy; however in rare reports, congenital anomalies were observed following intrauterine exposure to statins. In rat and rabbit animal reproduction studies, Atorvastatin (Ecosprin AV) revealed no evidence of teratogenicity. Atorvastatin (Ecosprin AV) SHOULD BE ADMINISTERED TO WOMEN OF CHILDBEARING AGE ONLY WHEN SUCH PATIENTS ARE HIGHLY UNLIKELY TO CONCEIVE AND HAVE BEEN INFORMED OF THE POTENTIAL HAZARDS. If the patient becomes pregnant while taking this drug, Atorvastatin (Ecosprin AV) should be discontinued immediately and the patient apprised of the potential hazard to the fetus.

Nursing mothers

It is not known whether Atorvastatin (Ecosprin AV) is excreted into human milk; however a small amount of another drug in this class does pass into breast milk. Because statins have the potential for serious adverse reactions in nursing infants, women who require Atorvastatin (Ecosprin AV) treatment should not breastfeed their infants.

Active ingredient matches for Ecosprin AV:

Aspirin/Atorvastatin

References

1. DailyMed. "AMLODIPINE BESYLATE; ATORVASTATIN CALCIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. DailyMed. "ASPIRIN; DIPYRIDAMOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
3. PubChem. "atorvastatin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology