Estradiol Uses

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What is Estradiol?

Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.

Some Estradiol products placed directly into the vagina are used for "local" treatment of vaginal menopause symptoms (such as dryness, burning, and irritation). Other vaginal Estradiol products are used for treating vaginal menopause symptoms and symptoms that affect other parts of the body (such as hot flashes). This type of vaginal Estradiol has "systemic" effects, meaning that it can affect parts of the body other than where the medicine is directly applied.

This medication guide provides information about Estradiol for local treatment of vaginal symptoms of menopause (such as dryness, itching, irritation, and pain during sexual intercourse).

Estradiol (local) may also be used for purposes not listed in this medication guide.

Estradiol indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Estradiol is a Hormone Replacement Therapy (HRT). It contains the female hormone Estradiol.

Estradiol is used in postmenopausal women, particularly in women who have had their womb removed (have had a hysterectomy) and therefore do not require combined oestrogen/progestagen therapy.

Estradiol is

Used for: Relief of symptoms occurring after menopause: During the menopause, the amount of oestrogen produced by a woman’s body drops. This can cause symptoms such as hot face, neck and chest (‘hot flushes’). Estradiol alleviates these symptoms after menopause. Estradiol should only be prescribed if the symptoms seriously hinder the patient’s daily life.

Prevention of osteoporosis (thinning of the bones), if the patient is at high risk of future fracture and if unable to take other medications for this purpose.

There is only limited experience of treating women older than 65 years.

How should I use Estradiol?

Use Estradiol spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Estradiol spray.

Uses of Estradiol in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This medication is a female hormone (estrogen). It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected. This medication may also be used by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure) and by men to treat prostate cancer.

How to use Estradiol intramuscular

Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

This medication is injected into a muscle as directed by your doctor, usually every 4 weeks. For the treatment of prostate cancer, this medication is usually given every 1 to 2 weeks. The dosage is based on your medical condition and response to treatment.

If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. If stored at low temperatures, crystal may form in the liquid. To dissolve these crystals, simply warm the product to room temperature prior to use. Learn how to store and discard medical supplies safely.

Use this medication regularly to get the most benefit from it. To help you remember, mark your calendar with a reminder of when to receive your doses.

Tell your doctor if your condition does not improve or if it worsens.

Estradiol description

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Generally refers to the 17-beta-isomer of Estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of Estradiol binds weakly to estrogen receptors (receptors, estrogen) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.

Estradiol dosage

Generally, when estrogen is prescribed for a postmenopausal woman with a uterus, a progestin should also be considered to reduce the risk of endometrial cancer. A woman without a uterus does not need a progestin. In some cases, however, hysterectomized women with a history of endometriosis may need a progestin.

Use of estrogen-alone, or in combination with a progestin, should be with the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual woman. Postmenopausal women should be re-evaluated periodically as clinically appropriate to determine if treatment is still necessary.

Treatment Of Moderate To Severe Vasomotor Symptoms Due To Menopause

Start therapy with 0.025 mg per day applied to the skin once weekly. Therapy should be started at the lowest effective dose and the shortest duration consistent with the treatment goals. Attempts to taper or discontinue the medication should be made at 3 to 6 month intervals.

Treatment Of Moderate To Severe Symptoms Of Vulvar And Vaginal Atrophy Due To Menopause

Start therapy with 0.025 mg per day applied to the skin once weekly. Therapy should be started at the lowest effective dose and the shortest duration consistent with the treatment goals. Attempts to taper or discontinue the medication should be made at 3 to 6 month intervals.

Treatment Of Hypoestrogenism Due To Hypogonadism, Castration, Or Primary Ovarian Failure

Start therapy with 0.025 mg per day applied to the skin once weekly. The dose should be adjusted as necessary to control symptoms. Clinical responses (relief of symptoms) at the lowest effective dose should be the guide for establishing administration of the Estradiol transdermal system, especially in women with an intact uterus.

Prevention Of Postmenopausal Osteoporosis

Start therapy with 0.025 mg per day applied to the skin once weekly.

Application Of The Estradiol Transdermal System

Site Selection
Application

Removal Of The Estradiol Transdermal System

How supplied

Dosage Forms And Strengths

Estradiol (Estradiol transdermal system), 0.025 mg per day — each 6.5 cm² system contains 2 mg of Estradiol USP Individual Carton of 4 systems NDC 50419-454-04

Estradiol (Estradiol transdermal system), 0.0375 mg per day — each 9.375 cm² system contains 2.85 mg of Estradiol USP Individual Carton of 4 systems NDC 50419-456-04

Estradiol (Estradiol transdermal system), 0.05 mg per day — each 12.5 cm² system contains 3.8 mg of Estradiol USP Individual Carton of 4 systems NDC 50419-451-04

Estradiol (Estradiol transdermal system), 0.06 mg per day — each 15 cm² system contains 4.55 mg of Estradiol USP Individual Carton of 4 systems NDC 50419-459-04

Estradiol (Estradiol transdermal system), 0.075 mg per day — each 18.75 cm² system contains 5.7 mg of Estradiol USP Individual Carton of 4 systems NDC 50419-453-04

Estradiol (Estradiol transdermal system), 0.1 mg per day — each 25 cm² system contains 7.6 mg of Estradiol USP Individual Carton of 4 systems NDC 50419-452-04

Storage And Handling

Store at 20°C to 25°C (66°F to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F). Do not store above 86°F (30°C).

Do not store unpouched. Apply immediately upon removal from the protective pouch.

Used transdermal systems still contain active hormone. To discard, fold the sticky side of the transdermal system together, place it in a sturdy child-proof container, and place this container in the trash. Used transdermal systems should not be flushed in the toilet.

Manufactured for: Bayer HealthCare Pharmaceuticals Inc. Whippany, NJ 07981. Manufactured by 3M Drug Delivery Systems, Northridge, CA 91324. Revised: Oct 2013

Estradiol interactions

See also:
What other drugs will affect Estradiol?

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CYP3A4 Interaction

Estradiol is metabolized by CYP3A4 but has no CYP3A4 inhibitory activity; therefore it is not expected to affect the plasma concentrations of other drugs metabolized by CYP3A4. Potent inhibitors of CYP3A4 (below) increase the risk of myopathy by reducing the elimination of lovastatin

Pharmacokinetics Itraconazol Ketoconazol Erythromyci Clarithromyci Telithromyci HIV protease inhibitor Nefazodon Cyclosporin Large quantities of grapefruit juice (>1 quart daily

Interactions with lipid-lowering drugs that can cause myopathy when given alone

The risk of myopathy is also increased by the following lipid-lowering drugs that are not potent CYP3A4 inhibitors, but which can cause myopathy when given alone

See WARNINGS, Myopathy/Rhabdomyolysis Gemfibrozi Other fibrate Niacin (nicotinic acid) (=1 g/day

Other drug interaction

Danazol: The risk of myopathy/rhabdomyolysis is increased by concomitant administration of danazol particularly with higher doses of lovastatin

Amiodarone or Verapamil: The risk of myopathy/rhabdomyolysis is increased when either amiodarone or verapamil is used concomitantly with a closely related member of the HMG-CoA reductase inhibitor class

Coumarin Anticoagulants: In a small clinical trial in which lovastatin was administered to warfarin treated patients, no effect on prothrombin time was detected. However, another HMG-CoA reductase inhibitor has been found to produce a less than two-second increase in prothrombin time in healthy volunteers receiving low doses of warfarin. Also, bleeding and/or increased prothrombin time have been reported in a few patients taking coumarin anticoagulants concomitantly with lovastatin. It is recommended that in patients taking anticoagulants, prothrombin time be determined before starting lovastatin and frequently enough during early therapy to insure that no significant alteration of prothrombin time occurs Once a stable prothrombin time has been documented, prothrombin times can be monitored at the intervals usually recommended for patients on coumarin anticoagulants. If the dose of lovastatin is changed, the same procedure should be repeated. Estradiol therapy has not been associated with bleeding or with changes in prothrombin time in patients not taking anticoagulants

Propranolol: In normal volunteers, there was no clinically significant pharmacokinetic o pharmacodynamic interaction with concomitant administration of single doses of lovastatin and propranolol

Digoxin: In patients with hypercholesterolemia, concomitant administration of lovastatin and digoxin resulted in no effect on digoxin plasma concentrations

Oral Hypoglycemic Agents: In pharmacokinetic studies of MEVACOR in hypercholesterolemic noninsulin dependent diabetic patients, there was no drug interaction with glipizide or with chlorpropamide

Estradiol side effects

See also:
What are the possible side effects of Estradiol?

See WARNINGS and Boxed Warning regarding the potential adverse effects on the fetus, the induction of malignant neoplasms, gallbladder disease, cardiovascular disease, elevated blood pressure, and hypercalcemia.

Skin irritation: In controlled clinical studies with Estradiol (Estradiol transdermal), the most commonly reported adverse events were topical reactions of erythema and/or pruritus at the application site. In general these reactions caused patients little or no discomfort, and led to premature discontinuation of treatment in 0.9% (3/317) of patients in these trials. The rate of application site reactions, based on 8,135 applications of the 0.025, 0.05, and 0.1 Estradiol (Estradiol transdermal) systems in these trials was 6.1 per 100 applications (4.9, 5.4, 10.7 for the 3 Estradiol (Estradiol transdermal) doses respectively) compared to 6.2 in the placebo treated patients (2,014 applications).

In a placebo-controlled trial of Estradiol (Estradiol transdermal) 0.025, 0.05, and 0.1 conducted in 196 patients in the US, the adverse events reported by at least 5% of patients in 1 or more of the treatment groups are shown in Table 5.

Table 5: Incidence of Adverse Events >5% in a Placebo-Controlled Study of Estradiol Data Are Expressed as % of Treatment Group

Placebo

Estradiol

Estradiol

Estradiol

Adverse Event

0.025 mg/day

0.05 mg/day

0.1 mg/day

(N=54)

(N=48)

(N=47)

(N=47)

Breast Pain

3.7

25.0

44.7

46.8

Headache

22.2

18.8

8.5

6.4

Infection

7.4

10.4

10.6

8.5

Injury Accident

3.7

10.4

4.3

2.1

Anxiety

0

8.3

2.1

0

Emotional Lability

1.9

8.3

2.1

6.4

Arthralgia

1.9

6.3

2.1

4.3

Flu Syndrome

7.4

6.3

6.4

8.5

Joint Disorder

0

6.3

0

0

Pruritus

1.9

6.3

12.8

0

Rhinitis

1.9

6.3

4.3

4.3

Abdominal Pain

9.3

4.2

10.6

2.1

General Edema

1.9

4.2

6.4

6.4

Monilia Vagina

5.6

4.2

8.5

4.3

Nausea

1.9

4.2

10.6

8.5

Peripheral Edema

0

4.2

2.1

6.4

Sinusitis

7.4

4.2

2.1

4.3

Asthenia

1.9

2.1

10.6

6.4

Back Pain

3.7

2.1

2.1

6.4

Diarrhea

1.9

2.1

8.5

0

Dysmenorrhea

0

2.1

2.1

6.4

Enlarged Abdomen

0

2.1

2.1

6.4

Enlarged Breast

0

2.1

2.1

8.5

Rash

5.6

2.1

4.3

2.1

Anemia

0

0

6.4

4.3

Gastroenteritis

1.9

0

0

6.4

Hyperlipemia

5.6

0

0

2.1

Leukorrhea

0

0

12.8

0

Paresthesia

1.9

0

6.4

0

Urogenital Adverse Events : In the US placebo-controlled study, 72 patients were included who had intact uteri. As expected, after 12-13 weeks of continuous unopposed therapy, findings of endometrial hyperplasia (diagnosed either by endometrial biopsy and/or ultrasonography) were increased with increasing doses of Estradiol (placebo: 0/18 patients; Estradiol (Estradiol transdermal) 0.025: 1/14 (7.1%); Estradiol (Estradiol transdermal) 0.05: 12/22 (54.5%); Estradiol (Estradiol transdermal) 0.1: 10/18 (55.6%). In the 86 patients who had not previously undergone a total hysterectomy, vaginal bleeding was also increased with increasing doses of Estradiol [placebo: 2/21 patients (9.5%); Estradiol (Estradiol transdermal) 0.025: 6/19 (31.6%); Estradiol (Estradiol transdermal) 0.05: 14/25 (56.0%); Estradiol (Estradiol transdermal) 0.1: 12/21 (57.1%)].

In 2 long-term studies involving a total of 488 patients treated for a mean duration of 618 days and up to 3.5 years, the nature and incidence of adverse events did not change with prolonged duration of treatment.

The following additional adverse reactions have been reported with estrogen therapy:

1. Genitourinary System. Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow; breakthrough bleeding, spotting; increase in size of uterine leiomyomata; vaginal candidiasis; change in amount of cervical secretion.

2. Breasts. Tenderness, enlargement.

3. Gastrointestinal. Nausea, vomiting; abdominal cramps, bloating; cholestatic jaundice; gallbladder disease.

4. Skin. Chloasma or melasma that may persist when drug is discontinued; erythema multiforme; erythema nodosum; hemorrhagic eruption; loss of scalp hair; hirsutism.

5. Eyes. Steepening of corneal curvature: intolerance to contact lenses.

6. Central Nervous System. Headache, migraine, dizziness; mental depression; chorea.

7. Miscellaneous. Increase or decrease in weight; reduced carbohydrate tolerance; aggravation of porphyria; edema; changes in libido.

Estradiol contraindications

See also:
What is the most important information I should know about Estradiol?

Estradiol can harm an unborn baby or cause birth defects. Do not use if you are pregnant.

You should not use this medication if you have any of the following conditions: liver disease, a bleeding disorder, unusual vaginal bleeding, a history of breast or uterine cancer, or if you have ever had a heart attack, stroke, or a blood clot.

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin while you are using Estradiol, to help lower this risk. Report any unusual vaginal bleeding right away.

Long-term use of Estradiol may increase your risk of breast cancer, heart attack, stroke, or blood clot. Talk with your doctor about your individual risks before using Estradiol transdermal long term.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Estradiol transdermal.

Estradiol transdermal should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.



Active ingredient matches for Estradiol:

Estradiol


Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Estradiol Valerate 2 mg
Tablet; Oral; Estradiol Valerate 4 mg
Injectable; Injection; Estradiol Cypionate 5 mg / ml
Film, Extended Release; Transdermal; Estradiol 0.025 mg / 24 h
Film, Extended Release; Transdermal; Estradiol 0.0375 mg / 24 h
Film, Extended Release; Transdermal; Estradiol 0.05 mg / 24 h
Film, Extended Release; Transdermal; Estradiol 0.06 mg / 24 h
Film, Extended Release; Transdermal; Estradiol 0.075 mg / 24 h
Film, Extended Release; Transdermal; Estradiol 0.1 mg / 24 h
Tablet; Oral; Estradiol 0.5 mg
Tablet; Oral; Estradiol 1 mg
Tablet; Oral; Estradiol 2 mg
Injectable; Injection; Estradiol Cypionate; Estradiol Valerate 10 mg / ml
Injectable; Injection; Estradiol Cypionate; Estradiol Valerate 20 mg / ml
Injectable; Injection; Estradiol Cypionate; Estradiol Valerate 40 mg / ml
Injectable; Injection; Estradiol Cypionate; Estradiol Valerate 5 mg / ml
Injectable; Injection; Estradiol Cypionate 4 mg / ml
Patch; Topical; Estradiol 50 mcg / 24 h
Injectable; Injection; Estradiol Benzoate 5 mg / ml
Injectable; Injection; Estradiol Valerate 10 mg / ml
Injectable; Injection; Estradiol Valerate 20 mg / ml
Injectable; Injection; Estradiol Valerate 40 mg / ml
Patch; Topical; Estradiol Valerate 100 mcg
Patch; Topical; Estradiol Valerate 50 mcg
Patch; Topical; Estradiol Valerate 75 mcg
Femring 0.1 mg/24hr Ring$ 218.60
Estring 2 mg Ring Box$ 210.39
Femring 0.10 mg vaginal ring$ 210.19
Femring 0.05 mg/24hr Ring$ 205.15
Estring 2 mg vaginal ring$ 202.30
Femring 0.05 mg vaginal ring$ 197.26
Elestrin 0.52 mg/0.87 gm/ 0.06% Gel 144 gm Bottle$ 162.06
Ethinyl estradiol powder$ 140.00
Vagifem 18 25 mcg tablet Box$ 139.78
Estrace 0.1 mg/gm Cream 42.5 gm Tube$ 133.27
Estradiol cypionate powder$ 88.74
Delestrogen 10 mg/ml Oil 5ml Vial$ 88.04
Evamist 1.53 mg/spray Solution 8.1ml Bottle$ 87.18
Divigel 1 mg/gm Gel Box Of 30 gm$ 85.53
Estrogel 0.75 mg/1.25 gm/ 0.06% Gel 50 gm Bottle$ 84.24
Divigel 30 0.25 mg/0.25 gm Gel 30 Patches/box$ 81.24
Climara 4 0.025 mg/24hr Patches Box$ 75.58
Climara 4 0.05 mg/24hr Patches Box$ 75.58
Climara 4 0.1 mg/24hr Patches Box$ 75.58
Menostar 4 14 mcg/24hr Patches Box$ 73.18
Divigel 0.5 mg/0.5 gm Gel Box$ 72.99
Estraderm 8 0.1 mg/24hr Patches Box$ 72.47
Vivelle-Dot 8 0.1 mg/24hr Patches Box$ 72.46
Vivelle-Dot 8 0.025 mg/24hr Patches Box$ 70.69
Climara 4 0.075 mg/24hr Patches Box$ 69.04
Climara Pro 4 0.045-0.015 mg/day Patches Box$ 69.04
Vivelle-Dot 8 0.0375 mg/24hr Patches Box$ 68.84
Vivelle-Dot 8 0.075 mg/24hr Patches Box$ 66.89
CombiPatch 8 0.05-0.25 mg/day Patches Box$ 66.45
Estraderm 8 0.05 mg/24hr Patches Box$ 66.35
Vivelle-Dot 8 0.05 mg/24hr Patches Box$ 65.99
Estring 2 mg Slow-Release Ring$ 65.39
Alora 8 0.1 mg/24hr Patches Box$ 62.99
Alora 8 0.05 mg/24hr Patches Box$ 60.99
Alora 8 0.075 mg/24hr Patches Box$ 58.27
Vagifem 8 25 mcg tablet Box$ 58.23
Vagifem 8 10 mcg tablet Box$ 54.99
Vivelle 8 0.05 mg/24hr Patches Box$ 49.99
Estradiol benzoate powder$ 42.00
Estradiol 4 0.025 mg/24hr Patches Box$ 40.92
Estradiol 4 0.05 mg/24hr Patches Box$ 40.92
Estradiol 4 0.075 mg/24hr Patches Box$ 40.92
Estradiol 4 0.1 mg/24hr Patches Box$ 40.92
Estradiol 4 0.06 mg/24hr Patches Box$ 39.99
Delestrogen 40 mg/ml Oil$ 39.52
Estradiol 4 0.0375 mg/24hr Patches Box$ 39.35
Delestrogen 40 mg/ml vial$ 38.00
Estradiol valerate 40 mg/ml vial$ 35.62
Estradiol valerate powder$ 32.13
Delestrogen 20 mg/ml Oil$ 23.82
Delestrogen 20 mg/ml vial$ 22.91
Estradiol valerate 20 mg/ml vial$ 21.25
Estradiol 0.1 mg/day patch$ 20.55
Estradiol powder$ 17.86
Climara 0.0375 mg/24hr Patches$ 17.26
Climara 0.06 mg/24hr Patches$ 17.26
Estradiol 0.05 mg/day patch$ 16.91
Delestrogen 10 mg/ml vial$ 16.25
Climara 0.025 mg/day patch$ 15.77
Climara 0.0375 mg/day patch$ 15.77
Climara 0.05 mg/day patch$ 15.77
Climara 0.06/mg day patch$ 15.77
Climara 0.075 mg/day patch$ 15.77
Climara 0.1 mg/day patch$ 15.77
Climara pro patch$ 15.77
Estradiol valerate 10 mg/ml vial$ 15.24
Evamist 1.53 mg/spray$ 10.43
Estradiol tds 0.025 mg/day$ 9.84
Estradiol tds 0.0375 mg/day$ 9.84
Estradiol tds 0.06 mg/day$ 9.84
Estradiol tds 0.075 mg/day$ 9.84
Depo-Estradiol 5 mg/ml Oil$ 9.66
Estraderm 0.1 mg patch$ 8.66
CombiPatch 0.05-0.14 mg/day Patches$ 8.65
Vivelle-dot 0.075 mg patch$ 8.49
Estraderm 0.05 mg patch$ 8.07
Combipatch 0.05-0.14 mg ptch$ 7.92
Combipatch 0.05-0.25 mg ptch$ 7.91
Depo-estradiol 5 mg/ml vial$ 7.89
Vivelle-dot 0.1 mg patch$ 7.89
Vivelle-dot 0.05 mg patch$ 7.61
Vivelle-dot 0.0375 mg patch$ 7.54
Vivelle-dot 0.025 mg patch$ 7.53
Alora 0.1 mg patch$ 7.16
Alora 0.075 mg patch$ 7.00
Alora 0.05 mg patch$ 6.86
Vagifem 10 mcg vaginal tab$ 6.78
Vagifem 25 mcg vaginal tab$ 6.78
Climara 100 / 7.8 Mg/Pth 100 mcg/day Patch$ 6.67
Climara 75 / 5.7 Mg/Pth 75 mcg/day Patch$ 6.31
Alora 0.025 mg patch$ 6.26
Vivelle 0.1 mg patch$ 5.94
Climara 50 / 3.9 Mg/Pth 50 mcg/day Patch$ 5.91
Vivelle 0.05 mg patch$ 5.74
Climara 25 / 2 Mg/Pth 25 mcg/day Patch$ 5.54
Estraderm-100 / 8.0 Mg/Pth 100 mcg/day Patch$ 4.52
Estraderm-25 / 2 Mg/Pth 25 mcg/day Patch$ 3.74
Estradot 100 / 1.56 Mg/Pth 100 mcg/day Patch$ 3.49
Estradot 75 / 1.17 Mg/Pth 75 mcg/day Patch$ 3.30
Vagifem 25 mcg Tablet$ 3.21
Estradot 50 / 0.78 Mg/Pth 50 mcg/day Patch$ 3.07
Oesclim 50 / 10 Mg/Pth 50 mcg/day Patch$ 3.06
Estrace 0.01% cream$ 3.05
Estrace 2 mg tablet$ 0.44
Estradot 37.5 / 0.585 Mg/Pth 37.5 mcg/day Patch$ 2.88
Estradot 25 / 0.39 Mg/Pth 25 mcg/day Patch$ 2.86
Estrasorb 4.35 mg/1.74 gm Emulsion 1.74 gm Packet$ 2.83
Oesclim 25 / 5 Mg/Pth 25 mcg/day Patch$ 2.83
Divigel 0.25 mg gel packet$ 2.74
Divigel 0.5 mg gel packet$ 2.74
Divigel 1 mg gel packet$ 2.74
Sandoz Estradiol Derm 100 / 8 Mg/Pth 100 mcg/day Patch$ 2.64
Menest 2.5 mg tablet$ 2.60
Femtrace 1.8 mg tablet$ 2.59
Sandoz Estradiol Derm 75 / 6 Mg/Pth 75 mcg/day Patch$ 2.50
Sandoz Estradiol Derm 50 / 4 Mg/Pth 50 mcg/day Patch$ 2.34
Estrace 0.5 mg tablet$ 0.13
Femtrace 0.45 mg tablet$ 2.02
Femtrace 0.9 mg tablet$ 2.02
Estrace 1 mg tablet$ 0.25
Estrogel 0.06% gel$ 1.63
Menest 1.25 mg tablet$ 1.56
Menest 0.625 mg tablet$ 1.41
Estrasorb packet$ 1.21
Elestrin 0.06% gel$ 0.94
Menest 0.3 mg tablet$ 0.89
Gynodiol 1.5 mg tablet$ 0.50
Estradiol 2 mg tablet$ 0.49
Estradiol 1 mg tablet$ 0.42
Estradiol 0.5 mg tablet$ 0.36
Estrogel 0.06 % Gel$ 0.31
Tablets; Oral; Estradiol Valerate 2 mg
Tablets; Oral; Estradiol Valerate 4 mg
Tablets; Oral; Estradiol 0.5 mg
Tablets; Oral; Estradiol 1 mg
Tablets; Oral; Estradiol 2 mg
Estradiol tablet 0.5 mg (Acerus Pharmaceuticals Corporation (Canada))
Estradiol patch, extended release .075 mg/d (Sandoz Inc (US))
Estradiol tablet 1 mg (Acerus Pharmaceuticals Corporation (Canada))
Estradiol patch, extended release .025 mg/d (Sandoz Inc (US))
Estradiol patch, extended release .1 mg/d (Sandoz Inc (US))
Estradiol patch, extended release .0375 mg/d (Sandoz Inc (US))
Estradiol tablet 2 mg (Acerus Pharmaceuticals Corporation (Canada))
Estradiol patch, extended release .05 mg/d (Sandoz Inc (US))
Estradiol tablet 1 mg/1 (Mayne Pharma Inc. (US))
Estradiol tablet 2 mg/1 (Blenheim Pharmacal, Inc. (US))
Estradiol patch .025 mg/d (Mylan Pharmaceuticals Inc. (US))
Estradiol patch .075 mg/d (Mylan Pharmaceuticals Inc. (US))
Estradiol tablet .5 mg/1 (A S Medication Solutions (US))
Estradiol patch .0375 mg/d (Mylan Pharmaceuticals Inc. (US))
Estradiol patch .05 mg/d (Mylan Pharmaceuticals Inc. (US))
Estradiol patch .06 mg/d (Mylan Pharmaceuticals Inc. (US))
Estradiol patch .97 mg/48[USP'U] (Physicians Total Care, Inc. (US))
Estradiol patch 1.46 mg/48[USP'U] (Physicians Total Care, Inc. (US))
Estradiol patch .1 mg/d (Mylan Pharmaceuticals Inc. (US))
Estradiol patch 1.94 mg/48[USP'U] (Physicians Total Care, Inc. (US))
Estradiol tablet 10 ug/1 (Amneal Pharmaceuticals of New York, LLC (US))
Estradiol pellet 25 mg/1 (Qualgen Llc (US))
Estradiol pellet 6 mg/1 (Qualgen Llc (US))
Estradiol pellet 18 mg/1 (Qualgen Llc (US))
Estradiol pellet 10 mg/1 (Qualgen Llc (US))
Estradiol pellet 20 mg/1 (Qualgen Llc (US))
Estradiol pellet 12.5 mg/1 (Qualgen Llc (US))
Estradiol pellet 22 mg/1 (Qualgen Llc (US))
Estradiol pellet 15 mg/1 (Qualgen Llc (US))

List of Estradiol substitutes (brand and generic names):

Estraderm-MX 0.1mg PATCH / 2 (Novartis (Biochemie))$ 2.27
Implant; Injection; Estradiol 100 mg
Implant; Injection; Estradiol 25 mg
Implant; Injection; Estradiol 50 mg
Estradiol Implants 50 mg x 1's
Estradiol Transdermal System patch .0375 mg/d (Alvogen, Inc. (US))
Estradiol Transdermal System patch .1 mg/d (Alvogen, Inc. (US))
Estradiol Transdermal System patch .05 mg/d (Alvogen, Inc. (US))
Estradiol Transdermal System patch .06 mg/d (Alvogen, Inc. (US))
Estradiol Transdermal System patch .025 mg/d (Alvogen, Inc. (US))
Estradiol Transdermal System patch .075 mg/d (Alvogen, Inc. (US))

References

  1. DailyMed. "ESTRADIOL HEMIHYDRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "estradiol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "estradiol". http://www.drugbank.ca/drugs/DB00783 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Estradiol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Estradiol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported useful

Was the Estradiol drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Useful1
100.0%


Consumer reported price estimates

No survey data has been collected yet


2 consumers reported time for results

To what extent do I have to use Estradiol before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 1 week and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Estradiol. To get the time effectiveness of using Estradiol drug by other patients, please click here.
Users%
1 week2
100.0%


6 consumers reported age

Users%
46-603
50.0%
> 602
33.3%
1-51
16.7%


Consumer reviews


There are no reviews yet. Be the first to write one!


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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