Estradiol Valerate Uses

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How do you administer this medicine?
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What is Estradiol Valerate?

Treating certain symptoms of menopause (eg, hot flashes, vaginal itching, burning, or dryness). It is used to treat low levels of estrogen caused by certain conditions. It may be used to treat certain types of prostate cancer (advanced androgen-dependent). It may also be used for other conditions as determined by your doctor.

Estradiol Valerate is a female estrogen hormone. It works by replacing natural estrogens in a woman who can no longer produce enough estrogen. It works for advanced prostate cancer by antagonizing male hormones.

Estradiol Valerate indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Prostate cancer,Moderate to severe vasomotor symptoms associated with menopause,Prophylaxis of osteoporosis in postmenopausal women,Hypogonadism,Vulvular and vaginal atrophy,Postmenopausal vaginal atrophy,Urogenital symptoms,Atrophic vaginitis.

How should I use Estradiol Valerate?

Use Estradiol Valerate as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Estradiol Valerate.

Uses of Estradiol Valerate in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This medication is a female hormone (estrogen). It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected. This medication may also be used by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure) and by men to treat prostate cancer.

How to use Estradiol Valerate intramuscular

Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

This medication is injected into a muscle as directed by your doctor, usually every 4 weeks. For the treatment of prostate cancer, this medication is usually given every 1 to 2 weeks. The dosage is based on your medical condition and response to treatment.

If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. If stored at low temperatures, crystal may form in the liquid. To dissolve these crystals, simply warm the product to room temperature prior to use. Learn how to store and discard medical supplies safely.

Use this medication regularly to get the most benefit from it. To help you remember, mark your calendar with a reminder of when to receive your doses.

Tell your doctor if your condition does not improve or if it worsens.

Estradiol Valerate description

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Generally refers to the 17-beta-isomer of Estradiol Valerate, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol Valerate-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of Estradiol Valerate binds weakly to estrogen receptors (receptors, estrogen) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized. [PubChem]

Estradiol Valerate dosage

1 white tab daily starting on the 5th day of cycle for 11 days (1st day menstrual bleeding = 1st day of cycle) followed by 1 brown tab daily for 10 days, then stop for 7 days.

Estradiol Valerate interactions

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What other drugs will affect Estradiol Valerate?

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: aromatase inhibitors (such as anastrozole, exemestane, letrozole), fulvestrant, ospemifene, raloxifene, tamoxifen, toremifene, tranexamic acid.

This medication may interfere with certain laboratory tests (including metyrapone test), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Estradiol Valerate side effects

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What are the possible side effects of Estradiol Valerate?

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Nausea/vomiting, bloating, breast tenderness, headache, or weight changes may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as depression, memory loss), breast lumps, unusual vaginal bleeding (such as spotting, breakthrough bleeding, prolonged/recurrent bleeding), increased or new vaginal irritation/itching/odor/discharge, severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine, swelling hands/ankles/feet, increased thirst/urination.

This medication may rarely cause serious problems from blood clots (such as heart attacks, strokes, deep vein thrombosis, pulmonary embolism). Get medical help right away if you have any serious side effects, including: chest/jaw/left arm pain, unusual sweating, sudden/severe headache, weakness on one side of the body, confusion, slurred speech, sudden vision changes (such as partial/complete blindness), pain/redness/swelling of legs, tingling/weakness/numbness in the arms/legs, trouble breathing, coughing up blood, sudden dizziness/fainting.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Estradiol Valerate contraindications

See also:
What is the most important information I should know about Estradiol Valerate?

Pregnancy & lactation. Patients w/ undiagnosed vag bleeding, suspected breast cancer, malignancies influenced by sex hormones, benign or malignant liver tumors, severe liver disease, DVT, pulmonary embolism, hypertriglyceridemia. Suspected adenoma of the anterior lobe of the pituitary gland.

Active ingredient matches for Estradiol Valerate:

Estradiol Valerate


Unit description / dosage (Manufacturer)Price, USD
Estradiol Valerate injection 20 mg/mL (JHP Pharmaceuticals, LLC (US))
Estradiol Valerate injection 40 mg/mL (JHP Pharmaceuticals, LLC (US))
Estradiol Valerate injection 10 mg/mL (JHP Pharmaceuticals, LLC (US))
Estradiol Valerate injection, solution 20 mg/mL (Perrigo Company (US))
Estradiol Valerate injection, solution 40 mg/mL (Perrigo Company (US))

List of Estradiol Valerate substitutes (brand and generic names):

BESTRADIOL tab 2 mg x 28's (Xeno)$ 3.16
Cyclo Progynova 1 x 21's (Bayer HealthCare Pharma)
Cyclo Progynova tab 21's (Bayer HealthCare Pharma)
2 mg x 28's (Svizera)$ 3.65
Ed-Val 2mg TAB / 28 (Svizera)$ 3.65
ED-VAL tab 2 mg x 28's (Svizera)$ 3.65
Ed-Val 2mg TAB / 28 (Svizera)$ 3.65
ESTROFLOW tab 2 mg x 10's (Xeno)$ 3.16
EVARIDE tab 2 mg x 28's (Intra Labs)$ 5.56

References

  1. DailyMed. "ESTRADIOL HEMIHYDRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "estradiol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "estradiol". http://www.drugbank.ca/drugs/DB00783 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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