Folacal Uses

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What is Folacal?

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Folacal (vitamin B 9) is necessary for strong blood.

Lack of Folacal may lead to anemia (weak blood). Your health care professional may treat this by prescribing Folacal for you.

Some conditions may increase your need for Folacal. These include:

In addition, infants smaller than normal, breast-fed infants, or those receiving unfortified formulas (such as evaporated milk or goat's milk) may need additional Folacal.

Increased need for Folacal should be determined by your health care professional.

Some studies have found that Folacal taken by women before they become pregnant and during early pregnancy may reduce the chances of certain birth defects (neural tube defects).

Claims that Folacal and other B vitamins are effective for preventing mental problems have not been proven. Many of these treatments involve large and expensive amounts of vitamins.

Injectable Folacal is given by or under the direction of your health care professional. Another form of Folacal is available without a prescription.

Folacal indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Folacal is used in the treatment and prevention of the folate deficiency state. It does not correct folate deficiency due to dihydrofolate reductase inhibitors. Folacal is also used in women of child-bearing potential and pregnant women to protect against neural tube defects in their offspring. It is also used for the treatment of folate-deficient megaloblastic anaemia, chronic haemolytic states such as thalassaemia major or sickle-cell anaemia.

How should I use Folacal?

Use Folacal as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Folacal.

Uses of Folacal in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Folacal is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.

Folacal supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of Folacal either through their diet or supplements to prevent infant spinal cord birth defects.

How to use Folacal

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away.

Folacal description


A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folacal is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]

Folacal dosage

Folacal Dosage

Applies to the following strength(s): 1 mg; 0.4 mg; 5 mg/mL; 0.8 mg

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Megaloblastic Anemia

1 mg orally, intramuscularly, subcutaneously or IV once a day. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized.

Usual Adult Dose for Folacal Deficiency

400 to 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Women of childbearing age, pregnant, and lactating women: 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Folacal Deficiency


0.1 mg orally, intramuscularly, subcutaneously or IV once a day.


Less than 4 years: up to 0.3 mg orally, intramuscularly, subcutaneously or IV once a day.

4 years or older: 0.4 mg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Vitamin/Mineral Supplementation

Recommended daily allowance (RDA):

Premature neonates: 50 mcg/day (15 mcg/kg/day).

Full-term neonates and infants 1 to 6 months: 25 to 35 mcg/day.


1 to 3 years: 150 mcg/day.

4 to 8 years: 200 mcg/day.

9 to 13 years: 300 mcg/day.

14 years and older: 400 mcg/day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Rarely, a dosage of 2 mg/day may be required, particularly in patients with malabsorption, alcoholism, chronic hemolysis, chronic exfoliative skin disease or who are on concomitant anticonvulsant therapy.


Folacal is removed by both hemodialysis and peritoneal dialysis. The amount removed varies with type equipment used.

Because folate may accumulate in patients with end-stage renal disease, side effects may be more likely in this patient who is undergoing dialysis. Once this patient's body stores of folate are replete, three times a week dosing may be just as beneficial as once daily dosing but should portend a lower risk of side effects.

Other Comments

The recommended daily allowance of Folacal for adult males and females ranges from 150 to 200 and 150 to 180 mcg/day, respectively.

There is a potential danger in administering Folacal to patients with undiagnosed anemia, since Folacal may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.

Severe megaloblastic anemia may require therapy for 4 to 5 weeks. Once stabilized, if dietary intake is inadequate, maintenance therapy can be started.

More about Folacal

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Folacal interactions

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What other drugs will affect Folacal?


Medications that interfere with your bodys ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and Folacal. Folacal supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, Folacal will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental Folacal should not exceed 1000 micrograms (g, sometimes mcg) per day to prevent Folacal from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between Folacal and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains Folic Acid.

Folacal side effects

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What are the possible side effects of Folacal?

Allergic sensitization has been reported following both oral and parenteral administration of Folacal.

Folacal is relatively nontoxic in man. Rare instances of allergic responses to Folacal preparations have been reported and have included erythema, skin rash, itching, general malaise, and respiratory difficulty due to bronchospasm. One patient experienced symptoms suggesting anaphylaxis following injection of the drug. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folacal daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgment. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folacal therapy.

In an uncontrolled study, orally administered Folacal was reported to increase the incidence of seizures in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. Another investigator reported decreased diphenylhydantoin serum levels in folate-deficient patients receiving diphenylhydantoin who were treated with 5 mg or 15 mg of Folacal daily.


Folacal contraindications

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What is the most important information I should know about Folacal?

Because it may mask the hematologic abnormalities while neurological damage progresses, Folacal should not be used in the therapy of patients with vitamin B12 deficiency of any cause, unless there is associated folate deficiency. The Folacal content of one tablet a day however, is unlikely to mask pernicious anemia should this condition be present. Also, pregnancy during pernicious anemia is very rare.

Active ingredient matches for Folacal:

Folic Acid

Unit description / dosage (Manufacturer)Price, USD
Capsule; Oral; Folic Acid / Calcium Folinate 0.745 mg

List of Folacal substitutes (brand and generic names):

Folac tab 5 mg 100's (North China Pharma)
Tablet; Oral; Folic Acid 5 mg (Shalina Laboratories Ltd)
Folacid 5 mg x 100's (Shalina Laboratories Ltd)
Folacid 5 mg Tablet (Shalina Laboratories Ltd)$ 0.00
Folacid cap 5 mg 100's (Shalina Laboratories Ltd)
Tablet; Oral; Folic Acid 5 mg (Mars Therapeutics & Chemicals Ltd)
Folacin 5 mg x 84's (Mars Therapeutics & Chemicals Ltd)
Folacin 5 mg x 500's (Mars Therapeutics & Chemicals Ltd)
Folacin 5 mg x 1000's (Mars Therapeutics & Chemicals Ltd)
5 mg x 10's (Mars Therapeutics & Chemicals Ltd)$ 0.19
Folacin 5mg TAB / 10 (Mars Therapeutics & Chemicals Ltd)$ 0.19
Folacin 5 mg Tablet (Mars Therapeutics & Chemicals Ltd)$ 0.01
FOLACIN tab 5 mg x 10's (Mars Therapeutics & Chemicals Ltd)$ 0.19
Folacite 400 400 mcg x 100's$ 6.27
Folacom 400 mcg x 3 x 10's (Combiphar)$ 1.77
Foladin tab 5 mg 100's (JRalph Pharma)$ 12.78
5 mg x 28's (Medi-Genix (Sterling Lab))$ 0.38
Folaid 5mg TAB / 28 (Medi-Genix (Sterling Lab))$ 0.38
Folaid 5 mg Tablet (Medi-Genix (Sterling Lab))$ 0.01
FOLAID tab 5 mg x 28's (Medi-Genix (Sterling Lab))$ 0.38
Folaid 5mg TAB / 28 (Medi-Genix (Sterling Lab))$ 0.38
Injectable; Injection; Folic Acid (Sanorell)
Tablet; Oral; Folic Acid (Sanorell)
Folart 5 mg x 100's$ 16.82
Folart 5 mg/5 mL x 60 mL$ 2.00
Folart 5 mg/5 mL x 120 mL$ 3.56
Folart 2.5 mg/1 mL x 30 mL$ 2.22
Folas 400 mcg x 10 x 10's (Landson)$ 8.07
5 mg x 10's (ATOZ)$ 0.14
Folat-5 5mg TAB / 10 (ATOZ)$ 0.14
FOLAT-5 tab 5 mg x 10's (ATOZ)$ 0.14
Folat-5 5mg TAB / 10 (ATOZ)$ 0.14
FOLATE film-coated tab 5 mg x 10's (Katg)$ 0.25


  1. DailyMed. "ASCORBIC ACID; BIOTIN; CYANOCOBALAMIN; DEXPANTHENOL; ERGOCALCIFEROL; FOLIC ACID; NIACINAMIDE; PHYTONADIONE; PYRIDOXINE HYDROCHLORIDE; RIBOFLAVIN 5'-PHOSPHATE SODIUM; THIAMINE HYDROCHLORIDE; VITAMIN A; VITAMIN E: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "folic acid". (accessed September 17, 2018).
  3. DrugBank. "folic acid". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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