Fusiwal-B Uses

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What is Fusiwal-B?

Beclomethasone is a steroid. It prevents the release of substances in the body that cause inflammation.

Beclomethasone nasal is used to treat nasal symptoms such as congestion, sneezing, and runny nose caused by seasonal or year-round allergies. The Fusiwal-B brand of this medication is also used to keep nasal polyps from coming back after surgery to remove them.

Beclomethasone may also be used for purposes not listed in this medication guide.

Fusiwal-B indications

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Maintenance treatment of asthma as prophylactic therapy in adults and children (≥5 years). For asthma patients who require systemic corticosteroid administration where adding Fusiwal-B dipropionate may reduce or eliminate the need for the systemic corticosteroids.

Fusiwal-B dipropionate is not indicated for the relief of acute bronchospasm.

Uses of Fusiwal-B in details

Fusiwal-B is used to treat runny nose, swelling and itching of the nose due to allergy (allergic rhinitis), hay fever and ulcerative colitis. Fusiwal-B reduces inflammation, swelling and irritation in nose and helps to relieve itching, sneezing and blocked or runny nose. It is also used in asthma and ulcerative colitis.

Fusiwal-B description

The dose which the patient gets through the mouthpiece of the device is 180 mcg.

Fusiwal-B contains 200 doses of finely powdered beclomethasone dipropionate mixed in a small quantity of lactose. The amount of drug received by the patient (180 mcg/dose) corresponds to that from 2 puffs of the freon-based beclomethasone inhalation aerosol with a metered dose of 100 mcg/dose. The dose to be inhaled is released from the container by pressing the device between the thumb and the forefinger. This is followed by inhalation through the device. As a result, beclomethasone dipropionate particles are transferred to their target, the lungs. Use of the Fusiwal-B does not require coordination of actuation of the dose and inhalation.

Fusiwal-B dosage

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Management of Chronic Asthma: Adults and Children >12 years: 100-400 mcg twice daily. Maximum: 1000 mcg twice daily.

Children (5-12 years): 100-200 mcg twice daily. Maximum: 200-400 mcg twice daily.

Prophylaxis of Asthma: Adults and Children >12 years: 50-200 mcg twice daily. Increase if necessary to maximum 400 mcg twice daily.

Children (5-12 years): The usual starting dose is 100 mcg twice daily. Depending on the severity of asthma, the daily dose may be increased up to 400 mcg administered in 2-4 divided doses.

When patient's symptoms remain under satisfactory control, the dose should be titrated to the lowest dose at which effective control of asthma is maintained.

Therapy in New Patients: Mild Asthma: 50-100 mcg twice daily.

Moderate Asthma: 100-200 mcg twice daily.

Severe Asthma: 200-400 mcg twice daily.

When switching a patient with well-controlled asthma from another corticosteroid inhaler, initially Fusiwal-B 100 mcg puff should be prescribed for Fusiwal-B dipropionate (CFC) or budesonide 200-250 mcg; fluticasone propionate 100 mcg.

When switching a patient with poorly-controlled asthma from another corticosteroid inhaler, initially Fusiwal-B 100 mcg puff should be prescribed for Fusiwal-B dipropionate (CFC) or budesonide or fluticasone propionate 100 mcg. The dose of Fusiwal-B should be adjusted to response.

Use in the elderly or patients with hepatic or renal impairment: There are no special dosage recommendations for use in the elderly or in patients with hepatic or renal impairment.

Fusiwal-B interactions

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What other drugs will affect Fusiwal-B?

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Due to the very low plasma concentration achieved after inhaled dosing, clinically significant drug interactions are in general unlikely. Care should be taken when co-administering with known strong CYP3A4 inhibitors (eg, ketoconazole, itraconazole, nelfinavir, ritonavir) as there is a potential for increased systemic exposure to Fusiwal-B.

Fusiwal-B side effects

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What are the possible side effects of Fusiwal-B?

The most commonly noted side effects associated with inhaled beclomethasone are mild cough or wheezing due to chemical irritation; these effects may be minimized by using an inhaled bronchodilator (e.g., albuterol or Ventolin) prior to the beclomethasone.

Oral candidiasis or thrush, a fungal infection of the mouth and throat, can occur in between 1 in 20 and 1 in 8 persons who use beclomethasone. The risk of thrush is greater with higher doses, but the risk in children is lower than in adults. Hoarseness may occur in as few as 1 in 20 or as many as 1 in 2 persons and is due to chemical irritation. A spacer device that can be attached to the inhaler and washing out the mouth with water following each use of beclomethasone reduces the amount of beclomethasone in the mouth and throat and reduces the risk of thrush and hoarseness.

Higher doses of inhaled beclomethasone (more than 1000 mcg/day) may result in more absorption into the body. This may decrease bone formation and increase bone breakdown (resorption), resulting in weak bones and a risk of fractures. Even higher doses (more than 1500 mcg/day in adults and 400 mcg/day in children) may suppress the adrenal glands and impair their ability to make natural glucocorticoid. People with such suppression (which can be identified by testing) need increased amounts of glucocorticoid orally or by the intravenous route during periods of high physical stress since higher amounts of glucocorticoids are needed by the body to fight physical stress. Patients receiving beclomethasone may develop easy bruising if enough beclomethasone is absorbed into the body from the lungs.

Fusiwal-B contraindications

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Hypersensitivity to Fusiwal-B diproprionate or to any of the excipients of Fusiwal-B.

Active ingredient matches for Fusiwal-B:

Beclometasone in India.

Beclometasone Topical/Fusidic Acid Topical

Fusidic Acid

Beclometasone dipropionate/fusidic acid in India.


Unit description / dosage (Manufacturer)Price, USD
Fusiwal-B Fusidic acid 20 mg, Beclometasone dipropionate0.25 mg. CRM / 10g$ 0.61
10g$ 0.61
5g$ 0.48
Fusiwal-B Fusidic Acid 20mg, beclometasone Dipropionate0.25mg CRM / 10g$ 0.61
Fusiwal-B Fusidic Acid 20mg, beclometasone Dipropionate0.25mg CRM / 5g$ 0.48
Fusiwal-B Fusidic acid 20 mg, Beclometasone dipropionate0.25 mg. CRM / 5g$ 0.48
FUSIWAL-B 0.025% W/W/2% W/W CREAM 1 tube / 10 GM cream each (Wallace Pharmaceuticals Pvt Ltd)$ 1.13
FUSIWAL-B 0.025% W/W/2% W/W CREAM 1 tube / 15 GM cream each (Wallace Pharmaceuticals Pvt Ltd)$ 1.45
FUSIWAL-B cream 10g (Wallace (Rivella))$ 0.61
FUSIWAL-B cream 5g (Wallace (Rivella))$ 0.48

List of Fusiwal-B substitutes (brand and generic names):

Fusiwal -B Fusidic Acid 20mg, beclometasone Dipropionate0.25mg CRM / 10g$ 0.61
Fusix-B Fusidic acid 2 % w/w, beclometasone dipropionate0.025 % w/w. CRM / 10g (Will Impex)$ 0.90
FUSIX-B cream 10g (Will Impex)$ 0.90
Fuskin 20 mg/1 g x 1 g
Fuskin 20 mg/1 g x 5 g
Fuskin 20 mg/1 g x 10 g
Fuskin 20 mg/1 g x 15 g
Fuskin 20 mg/1 g x 20 g
Fuskin 20 mg/1 g x 50 g
Fusodate 250 mg
Fuson 2%w/w CRM / 15g (Agio Pharmaceuticals Limited)$ 1.17
Fuson 2%w/w CRM / 5g (Agio Pharmaceuticals Limited)$ 0.48
Fuson 2%w/w OINT / 5g (Agio Pharmaceuticals Limited)$ 0.41
Fuson 2 % x 5 g (Agio Pharmaceuticals Limited)
2 % w/w x 15g (Agio Pharmaceuticals Limited)$ 1.17
2 % w/w x 5g (Agio Pharmaceuticals Limited)$ 0.41
Fuson 2 % x 5 g x 1's (Agio Pharmaceuticals Limited)$ 3.60
Fuson Skin 15 gm Cream (Agio Pharmaceuticals Limited)$ 1.17
Fuson Skin 5 gm Ointment (Agio Pharmaceuticals Limited)$ 0.41
FUSON 2% CREAM 1 tube / 5 GM cream each (Agio Pharmaceuticals Limited)$ 0.52
FUSON CREAM 1 tube / 15 GM cream each (Agio Pharmaceuticals Limited)$ 1.08
FUSON cream 2 % w/w x 15g (Agio Pharmaceuticals Limited)$ 1.17
FUSON cream 2 % w/w x 5g (Agio Pharmaceuticals Limited)$ 0.48
FUSON oint 2 % w/w x 5g (Agio Pharmaceuticals Limited)$ 0.41
Fuson cream 2% 5 g x 1's (Agio Pharmaceuticals Limited)
Fuson cream 2% 15 g x 1's (Agio Pharmaceuticals Limited)
Fuson oint 2% 5 g x 1's (Agio Pharmaceuticals Limited)
Fuson 2% Cream (Agio Pharmaceuticals Limited)$ 0.52
Fuson NA Cream (Agio Pharmaceuticals Limited)$ 1.08
Fuson H Skin 5 gm Cream (Agio Pharmaceuticals Limited)$ 0.46
FUSON H 1%W/W/2%W/W CREAM 1 tube / 5 GM cream each (Agio Pharmaceuticals Limited)$ 0.60
Fuson H Cream (Agio Pharmaceuticals Limited)$ 0.60
Fusotex 20 mg/1 g x 5 g
Fusotex 20 mg/1 g x 8 g
Fusotex 20 mg/1 g x 10 g
Fusotex 20 mg/1 g x 15 g
Fusotex 20 mg/1 g x 50 g
Fuster 2% CRM / 10g (Cutigen)$ 0.83
FUSTER cream 2 % x 10g (Cutigen)$ 0.83
Fusycom 5 g x 1's (Combiphar)$ 4.28
Futaderm 20 mg x 10 g (Interbat)$ 4.34

References

  1. PubChem. "fusidic acid". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "fusidic acid". http://www.drugbank.ca/drugs/DB02703 (accessed September 17, 2018).
  3. DTP/NCI. "fusidic acid: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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