Futasole Uses

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What is Futasole?

Futasole is a substance that is used to treat bacterial infections. It will not work for colds, flu, or other virus infections.

Futasole is available only with your doctor's prescription.

Futasole indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Futasole is active in vitro against Staphylococcus aureus, most coagulase-negative staphylococci, Corynebacterium species, most clostridium species. Futasole has no useful activity against enterococci or most Gram-negative bacteria (except Neisseria, Moraxella, Legionella pneumophila and Bacteroides fragilis). Futasole is active in vitro and clinically against Mycobacterium leprae but has only marginal activity against Mycobacterium tuberculosis.

One important use of Futasole clinically is its activity against methicillin-resistant Staphylococcus aureus. Many strains of MRSA remain sensitive to Futasole, but because there is a low genetic barrier to drug resistance (a single point mutation is all that is required), Futasole must never be used on its own to treat serious MRSA infection and should be combined with another antimicrobial such as rifampicin.

Futasole is often found in topical skin and eye preparations (e.g., Fucibet), a use which has been contested.

Uses of Futasole in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Futasole is used for treating various bacterial skin infections and some infections of bone, heart, lungs and eyes.

Futasole description

Futasole is a bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Futasole A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

Futasole dosage

Cream/Ointment: Apply to the affected area 2-3 times a day, generally for a period of 7 days.

Futasole ointment can be used with or without a covering dressing.

Futasole interactions

Futasole use in patients who are receiving high doses of theophylline may be associated with an increase in serum theophylline levels and potential theophylline toxicity. In case of theophylline toxicity and/or elevated serum theophylline levels, the dose of theophylline should be reduced while the patient is receiving concomitant erythromycin therapy.

Concomitant administration of erythromycin and digoxin has been reported to result in elevated digoxin serum levels. There have been reports of increased anticoagulant effects when erythromycin and oral anticoagulants were used concomitantly. Increased anticoagulation effects due to interactions of erythromycin with various oral anticoagulents may be more pronounced in the elderly.

Concurrent use of erythromycin and ergotamine or dihydroergotamine has been associated in some patients with acute ergot toxicity characterized by severe peripheral vasospasm and dysesthesia.

Futasole has been reported to decrease the clearance of triazolam and midazolam and thus may increase the pharmacologic effect of these benzodiazepines.

The use of erythromycin in patients concurrently taking drugs metabolized by the cytochrome P450 system may be associated with elevations in serum levels of these other drugs. There have been reports of interactions of erythromycin with carbamazepine, cyclosporine, tacrolimus, hexobarbital, phenytoin, alfentanil, cisapride, disopyramide, lovastatin, bromocriptine, valproate, terfenadine, and astemizole. Serum concentrations of drugs metabolized by the cytochrome P450 system should be monitored closely in patients concurrently receiving erythromycin.

Futasole has been reported to significantly alter the metabolism of nonsedating antihistamines terfenadine and astemizole when taken concomitantly. Rare cases of serious cardiovascular adverse events, including electrocardiographic QT/QTc interval prolongation, cardiac arrest, torsades de pointes, and other ventricular arrhythmias have been observed. In addition, deaths have been reported rarely with concomitant administration of terfenadine and erythromycin.

There have been postmarketing reports of drug interactions when erythromycin is coadministered with cisapride, resulting in QT prolongation, cardiac arrythmias, ventricular tachycardia, ventricular fibrulation, and torsades de pointes, most like due to inhibition of hepatic metabolism of cisapride by erythromycin. Fatalities have been reported.

Patients receiving concomitant lovastatin and erythromycin should be carefully monitored; cases of rhabdomyolysis have been reported in seriously ill patients.

Futasole side effects

See also:
What are the possible side effects of Futasole?

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Occasionally hypersensitivity reactions eg, skin rashes, weak pain and irritation may occur. If these symptoms occur, discontinue Futasole.

Futasole contraindications

Futasole is contraindicated in patients with known hypersensitivity to this antibiotic. Futasole is contraindicated in patients taking terfenadine, astemizole, or cisapride.

Topical Ery 2% Pads are contraindicated in those individuals who have shown hypersensitivity to any of its components.

Active ingredient matches for Futasole:

Fusidic Acid in Oman.

Fusidic acid or sodium fusidate in United Arab Emirates.


List of Futasole substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Futen 2 % x 1 g
Futen 2 % x 5 g
Futen 2 % x 8 g
Futen 2 % x 10 g
Futen 2 % x 15 g
Futen 2 % x 20 g
Futen 2 % x 50 g
FUTOP Cream/ Gel/ Ointment / 20mg per gm / 10gm units (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 0.94
FUTOP Cream/ Gel/ Ointment / 20mg per gm / 5gm units (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 0.59
Futop 2% w/w OINT / 5g (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 0.44
Futop 1 boä (Cosme Healthcare (CFL Pharmaceuticals Ltd))
2 % w/w x 5g (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 0.44
Futop Skin 5 gm Cream Cream (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 0.11
Futop Skin 5 gm Ointment (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 0.11
Futop Skin 10 gm Ointment (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 0.10
Futop Skin 10 gm Cream Cream (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 0.11
FUTOP 2% CREAM 1 tube / 10 GM cream each (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 1.28
FUTOP oint 20 mg x 5g (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 0.69
Futop 2% w/w OINT / 5g (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 0.44
Futop 2% Cream (Cosme Healthcare (CFL Pharmaceuticals Ltd))$ 1.28
Futop Cream Fusidic Acid 20mg, K sorbate2.7mg CRM / 10g$ 0.99
Futop Cream Fusidic Acid 20mg, K sorbate2.7mg CRM / 5g$ 0.56
Futop Ointment 20mg OINT / 10g$ 0.94
Futop Ointment 20mg OINT / 5g$ 0.99
Fuzi Skin 10 gm Cream (Adips Laboratories Ltd.)$ 0.10
Fuzi Skin 5 gm Cream (Adips Laboratories Ltd.)$ 0.13
Fuzi 20mg Cream (Adips Laboratories Ltd.)$ 1.16
FUZI / ADIPS CREAM 1 tube / 10 GM cream each (Adips Laboratories Ltd)$ 1.16
Fuzic Skin 10 gm Cream (Canbro Healthcare)$ 1.09
Germacid 2 % x 1 tube 5 g (Raza)
Germacid 2 % x 1 tube 15 g (Raza)
Gzlcon F Skin 10 gm Cream (Gedzrlvin Pharmaceuticals)$ 1.59
Hhfudic Skin 10 gm Cream (H&H Pharmaceuticals Pvt Ltd)$ 2.54
HHFUDIC CREAM 1 tube / 10 GM cream each (H&H Pharmaceuticals Pvt Ltd)$ 3.49
HHFUDIC cream 10g (H&H Pharmaceuticals Pvt Ltd)$ 2.78
Hhfudic Cream (H&H Pharmaceuticals Pvt Ltd)$ 3.67
HoeFoban 2 % x 1 tube 5 g
HoeFoban 2 % x 1 tube 15 g

References

  1. PubChem. "fusidic acid". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "fusidic acid". http://www.drugbank.ca/drugs/DB02703 (accessed September 17, 2018).
  3. DTP/NCI. "fusidic acid: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Futasole are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Futasole. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


1 consumer reported time for results

To what extent do I have to use Futasole before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 5 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Futasole. To get the time effectiveness of using Futasole drug by other patients, please click here.
Users%
5 days1
100.0%


1 consumer reported age

Users%
> 601
100.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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