Hyphoral Tablets Uses

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What is Hyphoral Tablets?

Hyphoral Tablets is used to treat infections caused by a fungus or yeast. It works by killing the fungus or yeast or preventing its growth.

Hyphoral Tablets cream is used to treat:

Hyphoral Tablets foam or gel is used to treat seborrheic dermatitis (scaly areas on your skin or scalp).

Hyphoral Tablets 1% shampoo is used to treat dandruff.

Hyphoral Tablets 2% shampoo is used to treat "sun fungus" (tinea versicolor; pityriasis versicolor).

Hyphoral Tablets may also be used for other fungus infections of the skin as determined by your doctor.

Most forms of Hyphoral Tablets are available only with your doctor's prescription. Some forms are available without a prescription. However, your doctor may have special instructions on the proper use for your medical condition.

Hyphoral Tablets indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Hyphoral Tablets is an imidazole antifungal administered topically or by mouth. It is given by mouth in chronic mucocutaneous or vaginal candidiasis, in fungal infections of the gastrointestinal tract, in dermatophyte infections of the skin and fingernails not responding to topical treatment, and in systemic infections including blastomycosis, candidiasis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis.

It has been given for the prophylaxis of fungal infections in immunocompromised patients, although fluconazole or itraconazole are usually preferred. It has been recommended that, because of its erratic absorption and slow therapeutic response, Hyphoral Tablets should not be used for the treatment of life-threatening fungal infections, including fungal meningitis, or for severe infections in immunocompromised patients. Also, because of the risk of hepatotoxicity the use of Hyphoral Tablets in nonsystemic fungal infections tends to be restricted to serious infections resistant to other treatment.

How should I use Hyphoral Tablets?

Use Hyphoral Tablets foam as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Hyphoral Tablets foam.

Uses of Hyphoral Tablets in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Fungal infections (systemic):

US labeling: Treatment of susceptible systemic fungal infections, including blastomycosis, histoplasmosis, paracoccidioidomycosis, coccidioidomycosis, and chromomycosis in patients who have failed or who are intolerant to other antifungal therapies

Limitations of use: Hyphoral Tablets should only be used when other effective antifungal therapy is not available or tolerated and the potential benefits outweigh the potential risks. Hyphoral Tablets tablets are not indicated for the treatment of onychomycosis, cutaneous dermatophyte infections, or Candida infections.

Canadian labeling: Treatment of serious or life-threatening systemic fungal infections (eg, systemic candidiasis, chronic mucocutaneous candidiasis, coccidioidomycosis, paracoccidioidomycosis, histoplasmosis, and chromomycosis) where alternate therapy is inappropriate or ineffective; may be considered for severe dermatophytoses unresponsive to other therapy

Off Label Uses

Cushing syndrome

Data from a retrospective multicenter study support the use of Hyphoral Tablets in the management of patients with Cushing disease. The study authors found the side effects of Hyphoral Tablets to be acceptable; however, close monitoring of liver enzymes is advised. Additional trials may be necessary to further define the role of Hyphoral Tablets in this condition.

Based on the Endocrine Society

Hyphoral Tablets description

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Hyphoral Tablets contains the following ingredients: D-Water, maltodextrin (corn), partially hydrolyzed sodium caseinate, lactalbumin hydrolysate, canola oil, medium-chain triglycerides (fractionated coconut oil), L-arginine, corn oil, magnesium chloride, potassium citrate, tribasic calcium phosphate, citric acid, soy lecithin, ascorbic acid, dibasic potassium phosphate, choline chloride, carrageenan, potassium chloride, taurine, L-carnitine, zinc sulfate, ferrous sulfate, α-tocopheryl acetate, niacinamide, calcium pantothenate, manganese sulfate, β-carotene, cupric sulfate, thiamine chloride HCl, pyridoxine HCl, riboflavin, vitamin A palmitate, folic acid, biotin, chromium chloride, sodium molybdate, potassium iodide, sodium selenate, phylloquinone, cyanocobalamin and vitamin D3.

Hyphoral Tablets is a ready-to-feed enteral product as a supplemental or sole-source nutrition complete and balanced nutrition for tube feeding. It is calorie dense at 1.3 cal/mL and contains a protein system of partially hydrolyzed proteins, including peptides and amino acids, to utilize the dual absorption system of the gut. Hyphoral Tablets is lactose- and gluten-free.

Caloric Distribution: See Table 1.

Analysis: See Table 2.

Hyphoral Tablets dosage

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Hyphoral Tablets Dosage

Generic name: Hyphoral Tablets 200mg

Dosage form: tablet

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

There should be laboratory as well as clinical documentation of infection prior to starting Hyphoral Tablets therapy. The usual duration of therapy for systemic infection is 6 months. Treatment should be continued until active fungal infection has subsided.

Adults

The recommended starting dose of Hyphoral Tablets® (Hyphoral Tablets) Tablets is a single daily administration of 200 mg (one tablet). If clinical responsiveness is insufficient within the expected time, the dose of Hyphoral Tablets® Tablets may be increased to 400 mg (two tablets) once daily.

Children

In small numbers of children over 2 years of age, a single daily dose of 3.3 to 6.6 mg/kg has been used. Hyphoral Tablets® Tablets have not been studied in children under 2 years of age.

More about Hyphoral Tablets (Hyphoral Tablets)

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Other formulations

Related treatment guides

Hyphoral Tablets interactions

See also:
What other drugs will affect Hyphoral Tablets?

Drugs that affect the absorption, distribution, metabolism, and excretion of Hyphoral Tablets may alter the plasma concentrations of Hyphoral Tablets. For example, gastric acid suppressants (e.g., antacids, histamine H2-blockers, proton pump inhibitors) have been shown to reduce plasma concentrations of Hyphoral Tablets.

Hyphoral Tablets is a substrate and potent inhibitor of CYP3A4. Therefore, the following drug interactions may occur when Hyphoral Tablets® is co-administered with other drugs that interact with CYP3A4.

  1. Hyphoral Tablets® may decrease the elimination of drugs metabolized by CYP3A4, thereby increasing their plasma concentrations. Increased exposure to these drugs may cause an increase or prolongation of their therapeutic and/or adverse effects. Concomitant use with Hyphoral Tablets® Tablets is contraindicated for drugs known to present a risk of serious side effects with increased exposure. For others, monitoring of plasma concentrations is advised when possible. Clinical signs and symptoms associated with these drugs should be monitored, with dosage adjusted as needed.
  2. Inducers of CYP3A4 may decrease the plasma concentrations of Hyphoral Tablets. Hyphoral Tablets® may not be effective in patients concomitantly taking one of these drugs. Therefore, administration of these drugs with Hyphoral Tablets® is not recommended.
  3. Other inhibitors of CYP3A4 may increase the plasma concentrations of Hyphoral Tablets. Patients who must take Hyphoral Tablets® concomitantly with one of these drugs should be monitored closely for signs or symptoms of increased or prolonged pharmacologic effects of Hyphoral Tablets®.

Table 1: Selected Drugs That Have Been Shown To or Are Predicted To Have Their Plasma Concentrations Altered By Hyphoral Tablets®*

Systemic exposure to these drugs is increased significantly by the addition of Hyphoral Tablets: Concomitant use with Hyphoral Tablets is contraindicated.
Alprazolam, midazolam, triazolam HMG-CoA reductase inhibitors (lovastatin, simvastatin)
Cisapride Nisoldipine
Dofetilide Pimozide
Eplerenone Quinidine
Ergot alkaloids (ergotamine, dihydroergotamine)
Systemic exposure to these drugs is increased by Hyphoral Tablets: Careful monitoring, with possible adjustment in dosage, is recommended.
Alfentanil, fentanyl, sulfentanil Indinavir, saquinavir
Amlodipine, felodipine, nicardipine, nifedipine Methylprednisolone
Bosentan Rifabutin
Buspirone Sildenafil
Busulfan Sirolimus (co-administration not recommended)
Carbamazepine Tacrolimus
Cilostazol Telithromycin
Cyclosporine Tolterodine
Digoxin Trimetrexate
Docetaxel, paclitaxel Verapamil

Oral anti-coagulants

Vinca alkaloids (vincristine, - vinblastine, vinorelbine)
* This list is not all-inclusive.

Table 2: Selected Drugs That Have Been Shown To or Are Predicted To Alter The Plasma Concentration Of Hyphoral Tablets®

Systemic exposure to Hyphoral Tablets is reduced significantly by these drugs: Concomitant use with Hyphoral Tablets is not recommended.
Carbamazepine Phenytoin
Gastric Acid Suppressants (antacids, antimuscarinics, histamine H2-blockers, proton pump inhibitors, sucralfate) Rifampin, rifabutin, isoniazid
Nevirapine
Systemic exposure to Hyphoral Tablets is increased significantly by this drug: Dose reduction of Hyphoral Tablets should be considered
Ritonavir
* This list is not all-inclusive.

Effects of Hyphoral Tablets on other drugs

Systemic exposure to the following drugs is significantly increased by co

Hyphoral Tablets side effects

See also:
What are the possible side effects of Hyphoral Tablets?

Topically applied Hyphoral Tablets appears to have a low order of toxicity and is generally well tolerated. Adverse effects have been reported in up to 5% of patients receiving Hyphoral Tablets 2% cream and have consisted principally of local reactions such as severe irritation, pruritus, and stinging. A painful allergic reaction, consisting of localized swelling and inflammation, occurred in at least one patient receiving Hyphoral Tablets 2% cream and contact dermatitis occurred in another.

In several studies evaluating the potential of topical Hyphoral Tablets for causing dermal irritation, contact sensitization, or phototoxic or photoallergenic reactions in healthy adults, topical application of Hyphoral Tablets 2% cream caused mild transient erythema in some individuals, but did not cause contact sensitization of the delayed hypersensitivity type, irritation, phototoxicity, or photocontact sensitization.

Contact dermatitis has been reported following topical application of imidazole-derivative azole antifungals (e.g., clotrimazole, econazole, miconazole, oxiconazole, sulconazole, tioconazole). Cross-sensitization appears to occur among the imidazole derivatives; however, cross-sensitivity appears to be unpredictable. The fact that patients with contact sensitivity to one imidazole-derivative azole antifungal may be sensitive to other similar drugs should be considered.

Although hepatotoxicity has occurred during treatment with oral Hyphoral Tablets, it is unlikely that this adverse effect would occur with Hyphoral Tablets 2% cream since the drug does not appear to be appreciably absorbed following topical application to skin.

Adverse effects reported in patients receiving topical Hyphoral Tablets 2% as a shampoo applied to the skin include pruritus, application site reaction, and dry skin. Adverse effects reported in patients receiving Hyphoral Tablets shampoo to the scalp include increased hair loss, irritation, abnormal hair texture, scalp pustules, dry skin, pruritus, and oiliness or dryness of the hair and scalp. In some patients with permanently waved (“permed”) hair, use of Hyphoral Tablets 2% shampoo resulted in loss of the curl.

Hyphoral Tablets contraindications

See also:
What is the most important information I should know about Hyphoral Tablets?

Drug Interactions

Coadministration of a number of CYP3A4 substrates such as dofetilide, quinidine cisapride and pimozide is contraindicated with Hyphoral Tablets Tablets. Coadministration with Hyphoral Tablets can cause elevated plasma concentrations of these drugs and may increase or prolong both therapeutic and adverse effects to such an extent that a potentially serious adverse reaction may occur. For example, increased plasma concentrations of some of these drugs can lead to QT prolongation and sometimes resulting in life-threatening ventricular tachyarrhythmias including occurrences of torsade de pointes, a potentially fatal arrhythmia.

Additionally, the following other drugs are contraindicated with Hyphoral Tablets Tablets: methadone, disopyramide, dronedarone, ergot alkaloids such as dihydroergotamine, ergometrine, ergotamine, methylergometrine, irinotecan, lurasidone, oral midazolam, alprazolam, triazolam, felodipine, nisoldipine, ranolazine, tolvaptan, eplerenone, lovastatin, simvastatin and colchicine.

Enhanced Sedation

Coadministration of Hyphoral Tablets Tablets with oral midazolam, oral triazolam or alprazolam has resulted in elevated plasma concentrations of these drugs. This may potentiate and prolong hypnotic and sedative effects, especially with repeated dosing or chronic administration of these agents. Concomitant administration of Hyphoral Tablets Tablets with oral triazolam, oral midazolam or alprazolam is contraindicated.

Myopathy

Coadministration of CYP3A4 metabolized HMG-CoA reductase inhibitors such as simvastatin, and lovastatin is contraindicated with Hyphoral Tablets Tablets.

Ergotism

Concomitant administration of ergot alkaloids such as dihydroergotamine and ergotamine with Hyphoral Tablets Tablets is contraindicated.

Liver Disease

The use of Hyphoral Tablets Tablets are contraindicated in patients with acute or chronic liver disease.

Hypersensitivity

Hyphoral Tablets Tablets are contraindicated in patients who have shown hypersensitivity to the drug.



Active ingredient matches for Hyphoral Tablets:

Ketoconazole


Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Ketoconazole

List of Hyphoral Tablets substitutes (brand and generic names):

Hyphoral 200mg Tablet (IPCA Laboratories Ltd.)$ 0.38
I-KET soap 2 % x 75g (Casca)$ 1.35
Interzol Cream 2 % x 5 g$ 1.86
Interzol Scalp Solution 1 % x 100 mL$ 4.34
Interzol Scalp Solution 2 % x 80 mL$ 5.58
Iycotic Ketoconazole 2%w/w CREAM / 20gm (Rowan Bioceuticals (P) Ltd.)$ 1.14
Iycotic Ketoconazole 2%w/v SHAMPOO / 60ml (Rowan Bioceuticals (P) Ltd.)$ 1.57
Iycotic Skin 60 ml Shampoo (Rowan Bioceuticals (P) Ltd.)$ 1.57
Iycotic Skin 20 gm Cream (Rowan Bioceuticals (P) Ltd.)$ 1.14
Iycotic 200 mg Tablet (Rowan Bioceuticals (P) Ltd.)$ 0.27
IYCOTIC 2% CREAM 1 tube / 20 GM cream each (Rowan Bioceuticals (P) Ltd.)$ 1.36
IYCOTIC 2% LOTION 1 bottle / 100 ML lotion each (Rowan Bioceuticals (P) Ltd.)$ 2.45
IYCOTIC 200 MG TABLET 1 strip / 10 tablets each (Rowan Bioceuticals (P) Ltd.)$ 2.68
IYCOTIC SHAMPOO 1 bottle / 60 ML shampoo each (Rowan Bioceuticals (P) Ltd.)$ 2.57
IYCOTIC cream 2 % x 20g (Rowan Bioceuticals (P) Ltd.)$ 1.43
IYCOTIC lotion 2 % x 100ml (Rowan Bioceuticals (P) Ltd.)$ 2.57
IYCOTIC tab 200 mg x 10's (Rowan Bioceuticals (P) Ltd.)$ 2.86
Iycotic 2% Cream (Rowan Bioceuticals (P) Ltd.)$ 1.43
Iycotic 2% Lotion (Rowan Bioceuticals (P) Ltd.)$ 2.45
Iycotic 200mg Tablet (Rowan Bioceuticals (P) Ltd.)$ 0.27
Iycotic 2% Shampoo (Rowan Bioceuticals (P) Ltd.)$ 2.57
Jacanzole 2% w/v SHAMPOO / 50ml (Sanify)$ 1.90
2 % w/v x 50ml (Sanify)$ 1.90
JACANZOLE shampoo 2 % w/v x 50ml (Sanify)$ 1.90
Jcanzole 2% w/w SHAMPOO / 50ml (Sanify)$ 1.90
2 % w/w x 50ml (Sanify)$ 1.90
JCANZOLE shampoo 2 % w/w x 50ml (Sanify)$ 1.90
Jekomac 2% w/v SHAMPOO / 50ml (Jaqson)
2 % w/v x 50ml (Jaqson)
JEKOMAC shampoo 2 % w/v x 50ml (Jaqson)
K 2 Zole Skin 70 ml Lotion (Salve Pharmaceuticals Pvt. Ltd.)$ 2.70
K To Z 2% w/v LOTION (Affy)
2 % w/v (Affy)
K TO Z lotion 2 % w/v x 60ml (Affy)
K-A-D Ketoconazole 2%w/v SHAMPOO / 50ml$ 1.11
K-Con Ketoconazole 2%w/w LOTION / 50ml
KAD Skin 50 ml Shampoo (Quzen Biotek)$ 1.11

References

  1. DailyMed. "KETOCONAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "ketoconazole". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "ketoconazole". http://www.drugbank.ca/drugs/DB01026 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Hyphoral Tablets are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Hyphoral Tablets. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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