Hyphoral Tablets is used to treat infections caused by a fungus or yeast. It works by killing the fungus or yeast or preventing its growth.
Hyphoral Tablets cream is used to treat:
Athlete's foot (tinea pedis; ringworm of the foot);
Ringworm of the body (tinea corporis);
Ringworm of the groin (tinea cruris; jock itch);
Seborrheic dermatitis;
"Sun fungus" (tinea versicolor; pityriasis versicolor); and
Yeast infection of the skin (cutaneous candidiasis).
Hyphoral Tablets foam or gel is used to treat seborrheic dermatitis (scaly areas on your skin or scalp).
Hyphoral Tablets 1% shampoo is used to treat dandruff.
Hyphoral Tablets 2% shampoo is used to treat "sun fungus" (tinea versicolor; pityriasis versicolor).
Hyphoral Tablets may also be used for other fungus infections of the skin as determined by your doctor.
Most forms of Hyphoral Tablets are available only with your doctor's prescription. Some forms are available without a prescription. However, your doctor may have special instructions on the proper use for your medical condition.
Hyphoral Tablets indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Hyphoral Tablets is an imidazole antifungal administered topically or by mouth. It is given by mouth in chronic mucocutaneous or vaginal candidiasis, in fungal infections of the gastrointestinal tract, in dermatophyte infections of the skin and fingernails not responding to topical treatment, and in systemic infections including blastomycosis, candidiasis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis.
It has been given for the prophylaxis of fungal infections in immunocompromised patients, although fluconazole or itraconazole are usually preferred. It has been recommended that, because of its erratic absorption and slow therapeutic response, Hyphoral Tablets should not be used for the treatment of life-threatening fungal infections, including fungal meningitis, or for severe infections in immunocompromised patients. Also, because of the risk of hepatotoxicity the use of Hyphoral Tablets in nonsystemic fungal infections tends to be restricted to serious infections resistant to other treatment.
How should I use Hyphoral Tablets?
Use Hyphoral Tablets foam as directed by your doctor. Check the label on the medicine for exact dosing instructions.
An extra patient leaflet is available with Hyphoral Tablets foam. Talk to your pharmacist if you have questions about this information.
Before applying the antifungal to the affected area, cleanse the skin with the cleanser unless your doctor tells you otherwise. If you are unsure how to use the cleanser, contact your doctor or pharmacist.
Wash your hands in cool water and dry well before you use Hyphoral Tablets foam. If your fingers are too warm, the antifungal will begin to melt right away when it touches your skin.
To use the antifungal, hold the can upright. Dispense the medicine into the cap or onto a cool surface. Only dispense enough medicine sufficient to cover the affected area(s). Do not dispense the medicine directly onto the affected skin or your hands because it will melt too soon. If the can seems warm or the foam seems runny, hold the can under cold running water for a few minutes.
Using your fingertips, gently massage Hyphoral Tablets foam into the affected area(s) until the foam disappears. To treat your scalp or other skin areas with hair, move your hair away so that the medicine can be applied directly to the affected skin.
After you use the antifungal, wipe any excess foam off of the container.
Wash your hands immediately after you use Hyphoral Tablets foam, unless your hands are part of the treated area.
If you miss a dose of Hyphoral Tablets foam, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Hyphoral Tablets foam.
Uses of Hyphoral Tablets in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications
Fungal infections (systemic):
US labeling: Treatment of susceptible systemic fungal infections, including blastomycosis, histoplasmosis, paracoccidioidomycosis, coccidioidomycosis, and chromomycosis in patients who have failed or who are intolerant to other antifungal therapies
Limitations of use: Hyphoral Tablets should only be used when other effective antifungal therapy is not available or tolerated and the potential benefits outweigh the potential risks. Hyphoral Tablets tablets are not indicated for the treatment of onychomycosis, cutaneous dermatophyte infections, or Candida infections.
Canadian labeling: Treatment of serious or life-threatening systemic fungal infections (eg, systemic candidiasis, chronic mucocutaneous candidiasis, coccidioidomycosis, paracoccidioidomycosis, histoplasmosis, and chromomycosis) where alternate therapy is inappropriate or ineffective; may be considered for severe dermatophytoses unresponsive to other therapy
Off Label Uses
Cushing syndrome
Data from a retrospective multicenter study support the use of Hyphoral Tablets in the management of patients with Cushing disease. The study authors found the side effects of Hyphoral Tablets to be acceptable; however, close monitoring of liver enzymes is advised. Additional trials may be necessary to further define the role of Hyphoral Tablets in this condition.
Hyphoral Tablets is a ready-to-feed enteral product as a supplemental or sole-source nutrition complete and balanced nutrition for tube feeding. It is calorie dense at 1.3 cal/mL and contains a protein system of partially hydrolyzed proteins, including peptides and amino acids, to utilize the dual absorption system of the gut. Hyphoral Tablets is lactose- and gluten-free.
Caloric Distribution: See Table 1.
Analysis: See Table 2.
Hyphoral Tablets dosage
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Hyphoral Tablets Dosage
Generic name: Hyphoral Tablets 200mg
Dosage form: tablet
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
There should be laboratory as well as clinical documentation of infection prior to starting Hyphoral Tablets therapy. The usual duration of therapy for systemic infection is 6 months. Treatment should be continued until active fungal infection has subsided.
Adults
The recommended starting dose of Hyphoral Tablets® (Hyphoral Tablets) Tablets is a single daily administration of 200 mg (one tablet). If clinical responsiveness is insufficient within the expected time, the dose of Hyphoral Tablets® Tablets may be increased to 400 mg (two tablets) once daily.
Children
In small numbers of children over 2 years of age, a single daily dose of 3.3 to 6.6 mg/kg has been used. Hyphoral Tablets® Tablets have not been studied in children under 2 years of age.
Drugs that affect the absorption, distribution, metabolism, and excretion of Hyphoral Tablets may alter the plasma concentrations of Hyphoral Tablets. For example, gastric acid suppressants (e.g., antacids, histamine H2-blockers, proton pump inhibitors) have been shown to reduce plasma concentrations of Hyphoral Tablets.
Hyphoral Tablets is a substrate and potent inhibitor of CYP3A4. Therefore, the following drug interactions may occur when Hyphoral Tablets® is co-administered with other drugs that interact with CYP3A4.
Hyphoral Tablets® may decrease the elimination of drugs metabolized by CYP3A4, thereby increasing their plasma concentrations. Increased exposure to these drugs may cause an increase or prolongation of their therapeutic and/or adverse effects. Concomitant use with Hyphoral Tablets® Tablets is contraindicated for drugs known to present a risk of serious side effects with increased exposure. For others, monitoring of plasma concentrations is advised when possible. Clinical signs and symptoms associated with these drugs should be monitored, with dosage adjusted as needed.
Inducers of CYP3A4 may decrease the plasma concentrations of Hyphoral Tablets. Hyphoral Tablets® may not be effective in patients concomitantly taking one of these drugs. Therefore, administration of these drugs with Hyphoral Tablets® is not recommended.
Other inhibitors of CYP3A4 may increase the plasma concentrations of Hyphoral Tablets. Patients who must take Hyphoral Tablets® concomitantly with one of these drugs should be monitored closely for signs or symptoms of increased or prolonged pharmacologic effects of Hyphoral Tablets®.
Table 1: Selected Drugs That Have Been Shown To or Are Predicted To Have Their Plasma Concentrations Altered By Hyphoral Tablets®*
Systemic exposure to these drugs is increased significantly by the addition of Hyphoral Tablets: Concomitant use with Hyphoral Tablets is contraindicated.
Topically applied Hyphoral Tablets appears to have a low order of toxicity and is generally well tolerated. Adverse effects have been reported in up to 5% of patients receiving Hyphoral Tablets 2% cream and have consisted principally of local reactions such as severe irritation, pruritus, and stinging. A painful allergic reaction, consisting of localized swelling and inflammation, occurred in at least one patient receiving Hyphoral Tablets 2% cream and contact dermatitis occurred in another.
In several studies evaluating the potential of topical Hyphoral Tablets for causing dermal irritation, contact sensitization, or phototoxic or photoallergenic reactions in healthy adults, topical application of Hyphoral Tablets 2% cream caused mild transient erythema in some individuals, but did not cause contact sensitization of the delayed hypersensitivity type, irritation, phototoxicity, or photocontact sensitization.
Contact dermatitis has been reported following topical application of imidazole-derivative azole antifungals (e.g., clotrimazole, econazole, miconazole, oxiconazole, sulconazole, tioconazole). Cross-sensitization appears to occur among the imidazole derivatives; however, cross-sensitivity appears to be unpredictable. The fact that patients with contact sensitivity to one imidazole-derivative azole antifungal may be sensitive to other similar drugs should be considered.
Although hepatotoxicity has occurred during treatment with oral Hyphoral Tablets, it is unlikely that this adverse effect would occur with Hyphoral Tablets 2% cream since the drug does not appear to be appreciably absorbed following topical application to skin.
Adverse effects reported in patients receiving topical Hyphoral Tablets 2% as a shampoo applied to the skin include pruritus, application site reaction, and dry skin. Adverse effects reported in patients receiving Hyphoral Tablets shampoo to the scalp include increased hair loss, irritation, abnormal hair texture, scalp pustules, dry skin, pruritus, and oiliness or dryness of the hair and scalp. In some patients with permanently waved (“permed”) hair, use of Hyphoral Tablets 2% shampoo resulted in loss of the curl.
Coadministration of a number of CYP3A4 substrates such as dofetilide, quinidine cisapride and pimozide is contraindicated with Hyphoral Tablets Tablets. Coadministration with Hyphoral Tablets can cause elevated plasma concentrations of these drugs and may increase or prolong both therapeutic and adverse effects to such an extent that a potentially serious adverse reaction may occur. For example, increased plasma concentrations of some of these drugs can lead to QT prolongation and sometimes resulting in life-threatening ventricular tachyarrhythmias including occurrences of torsade de pointes, a potentially fatal arrhythmia.
Additionally, the following other drugs are contraindicated with Hyphoral Tablets Tablets: methadone, disopyramide, dronedarone, ergot alkaloids such as dihydroergotamine, ergometrine, ergotamine, methylergometrine, irinotecan, lurasidone, oral midazolam, alprazolam, triazolam, felodipine, nisoldipine, ranolazine, tolvaptan, eplerenone, lovastatin, simvastatin and colchicine.
Enhanced Sedation
Coadministration of Hyphoral Tablets Tablets with oral midazolam, oral triazolam or alprazolam has resulted in elevated plasma concentrations of these drugs. This may potentiate and prolong hypnotic and sedative effects, especially with repeated dosing or chronic administration of these agents. Concomitant administration of Hyphoral Tablets Tablets with oral triazolam, oral midazolam or alprazolam is contraindicated.
Myopathy
Coadministration of CYP3A4 metabolized HMG-CoA reductase inhibitors such as simvastatin, and lovastatin is contraindicated with Hyphoral Tablets Tablets.
Ergotism
Concomitant administration of ergot alkaloids such as dihydroergotamine and ergotamine with Hyphoral Tablets Tablets is contraindicated.
Liver Disease
The use of Hyphoral Tablets Tablets are contraindicated in patients with acute or chronic liver disease.
Hypersensitivity
Hyphoral Tablets Tablets are contraindicated in patients who have shown hypersensitivity to the drug.
DailyMed. "KETOCONAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
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1 consumer reported age
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%
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1
100.0%
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