Imipenem Dosage

• Dosage of Imipenem in details
• Imipenem interactions
• Imipenem reviews

Dosage of Imipenem in details

Intravenous

Susceptible infections

Adult: Combined with Imipenem: (as anhydrous Imipenem) 1-2 g daily in divided doses every 6-8 hr, given via IV infusion. Doses 250 or 500 mg are infused over 20-30 min, and doses of 750 mg or 1 g over 40-60 min. Max: 4 g/day or 50 mg/kg.

Child: >40 kg: same as adult dose. Child >3 mth and <40 kg: 15-25 mg/kg every 6 hr by IV infusion. Doses up to 90 mg/kg may be given to older children with cystic fibrosis. Neonates and infants <3 mth: 4 wk-3 mth, 25 mg/kg every 6 hr; 1-4 wk, 25 mg/kg every 8 hr; up to 1 wk, 25 mg/kg every 12 hr. Max: >40 kg: 4 g/day or 50 mg/kg; <40 kg: 2 g/day.

Renal impairment: Max doses based on CrCl.

CrCl (ml/min)	Dosage Recommendation
31-70	500 mg every 6-8 hr.
21-30	500 mg every 8-12 hr.
6-20	250 mg or 3.5 mg/kg (whichever is lower) every 12 hr.
≤5	Only give if haemodialysis is started within 48 hr.

Intravenous

Prophylaxis of surgical infections

Adult: 1 g may be given on induction of anaesthesia, followed by 1 g 3 hr later, with additional doses of 500 mg at 8 and 16 hr after induction if necessary.

Intramuscular

Mild to moderate susceptible infections

Adult: 500 or 750 mg every 12 hr.

Intramuscular

Uncomplicated gonorrhoea

Adult: 500 mg as a single dose.

Imipenem interactions

Increased risk of seizures when used with ganciclovir. Ciclosporin may increase neurotoxicity of ifosfamide; ifosfamide may also raise serum levels of ciclosporin. Serum levels may be increased by uricosuric agents. May reduce efficacy of valproic acid; monitor.

References

1. DailyMed. "CILASTATIN SODIUM; IMIPENEM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. DailyMed. "CILASTATIN SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
3. FDA/SPL Indexing Data. "Q20IM7HE75: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Imipenem are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Imipenem. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

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Information checked by Dr. Sachin Kumar, MD Pharmacology