Imipenem Uses

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Imipenem indications

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Intravenous

Susceptible infections

Adult: Combined with Imipenem: (as anhydrous Imipenem) 1-2 g daily in divided doses every 6-8 hr, given via IV infusion. Doses 250 or 500 mg are infused over 20-30 min, and doses of 750 mg or 1 g over 40-60 min. Max: 4 g/day or 50 mg/kg.

Child: >40 kg: same as adult dose. Child >3 mth and <40 kg: 15-25 mg/kg every 6 hr by IV infusion. Doses up to 90 mg/kg may be given to older children with cystic fibrosis. Neonates and infants <3 mth: 4 wk-3 mth, 25 mg/kg every 6 hr; 1-4 wk, 25 mg/kg every 8 hr; up to 1 wk, 25 mg/kg every 12 hr. Max: >40 kg: 4 g/day or 50 mg/kg; <40 kg: 2 g/day.

Renal impairment: Max doses based on CrCl.

CrCl (ml/min)Dosage Recommendation
31-70500 mg every 6-8 hr.
21-30500 mg every 8-12 hr.
6-20250 mg or 3.5 mg/kg (whichever is lower) every 12 hr.
≤5Only give if haemodialysis is started within 48 hr.

Intravenous

Prophylaxis of surgical infections

Adult: 1 g may be given on induction of anaesthesia, followed by 1 g 3 hr later, with additional doses of 500 mg at 8 and 16 hr after induction if necessary.

Intramuscular

Mild to moderate susceptible infections

Adult: 500 or 750 mg every 12 hr.

Intramuscular

Uncomplicated gonorrhoea

Adult: 500 mg as a single dose.

Uses of Imipenem in details

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Imipenem in combination with Imipenem (inhibitor of enzyme dehydropeptidase) is used to treat bacterial infections of lung (pneumonia), urinary tract, abdomen, blood, skin and soft tissue. It is also used to treat infections during or after delivery. It may be used in the management of fever of patients with reduced immunity due to low white blood cells (neutropenia).

Imipenem description

Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with Imipenem, a renal dipeptidase inhibitor. [PubChem]

Imipenem dosage

Intravenous

Susceptible infections

Adult: Combined with Imipenem: (as anhydrous Imipenem) 1-2 g daily in divided doses every 6-8 hr, given via IV infusion. Doses 250 or 500 mg are infused over 20-30 min, and doses of 750 mg or 1 g over 40-60 min. Max: 4 g/day or 50 mg/kg.

Child: >40 kg: same as adult dose. Child >3 mth and <40 kg: 15-25 mg/kg every 6 hr by IV infusion. Doses up to 90 mg/kg may be given to older children with cystic fibrosis. Neonates and infants <3 mth: 4 wk-3 mth, 25 mg/kg every 6 hr; 1-4 wk, 25 mg/kg every 8 hr; up to 1 wk, 25 mg/kg every 12 hr. Max: >40 kg: 4 g/day or 50 mg/kg; <40 kg: 2 g/day.

Renal impairment: Max doses based on CrCl.

CrCl (ml/min)Dosage Recommendation
31-70500 mg every 6-8 hr.
21-30500 mg every 8-12 hr.
6-20250 mg or 3.5 mg/kg (whichever is lower) every 12 hr.
≤5Only give if haemodialysis is started within 48 hr.

Intravenous

Prophylaxis of surgical infections

Adult: 1 g may be given on induction of anaesthesia, followed by 1 g 3 hr later, with additional doses of 500 mg at 8 and 16 hr after induction if necessary.

Intramuscular

Mild to moderate susceptible infections

Adult: 500 or 750 mg every 12 hr.

Intramuscular

Uncomplicated gonorrhoea

Adult: 500 mg as a single dose.

Imipenem interactions

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Increased risk of seizures when used with ganciclovir. Ciclosporin may increase neurotoxicity of ifosfamide; ifosfamide may also raise serum levels of ciclosporin. Serum levels may be increased by uricosuric agents. May reduce efficacy of valproic acid; monitor.

Imipenem side effects

Skin rashes, urticaria, eosinophilia, fever, nausea, vomiting, diarrhoea, tooth or tongue discoloration, and altered taste. Erythema multiforme, exfoliative dermatitis. Pain and thrombophlebitis may occur at the inj site.

Potentially Fatal: Severe anaphylactic reactions. Stevens-Johnson syndrome and toxic epidermal necrolysis.

Imipenem contraindications

Hypersensitivity.

Active ingredient matches for Imipenem:

Imipenem


List of Imipenem substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
CILANE MONO 500MG INJECTION 1 vial / 1 injection each (Ranbaxy Laboratories Ltd)$ 15.31
Cilapen 250 mg x 1's (Olcare)
Cilapen 500 mg x 1's (Olcare)
Cilapen Cilastatin 500 mg, imipenem500 mg INJ / 1 (Olcare)$ 15.06
Cilaxter 500 Injection (Alkem Laboratories Ltd)$ 0.01
I Nem Inj 500+500 Injection (Glenmark Pharmaceuticals Ltd.)$ 0.01
IC2 250MG INJECTION 1 vial / 1 injection each (Unimark Remedies Ltd)$ 11.30
IC2 500MG INJECTION 1 vial / 1 injection each (Unimark Remedies Ltd)$ 15.60
IC2 500mg Injection (Unimark Remedies Ltd)$ 15.60
IMC 250+250 Injection (Uniword Marketing (P) Ltd)$ 0.01
IMCI 500MG INJECTION 1 vial / 1 ML injection each (Parenteral Drugs India Ltd)$ 12.51
Ime Cila 250+250 Injection (Abbott Healthcare Pvt Ltd (AHPL))$ 8.46
Ime Cila 500+500 Injection (Abbott Healthcare Pvt Ltd (AHPL))$ 0.01
IME CILA 500MG/500MG INJECTION 1 vial / 1 injection each (Abbott Healthcare Pvt Ltd (AHPL))$ 19.46
Imilastin 500+500 Injection (Samarth Pharma Pvt. Ltd.)$ 0.01
IMILASTIN 500MG/500MG INJECTION 1 vial / 1 injection each (Samarth Pharma Pvt. Ltd.)$ 6.78
Imilastin 500 mg/500 mg Injection (Samarth Pharma Pvt. Ltd.)$ 6.78
Implatin 250+250 Injection (Mickle Pharma)$ 8.13
Sanam 250+250 Injection (Stellar Life Sciences)$ 0.01
VE IC 500+500 Injection (Biovista Lifesciences)$ 0.01
VE IC 250+250 Injection (Biovista Lifesciences)$ 8.07
Vocef 250+250 Injection (Vokin Biotech Pvt. Ltd.)$ 0.01
Vocef 500+500 Injection (Vokin Biotech Pvt. Ltd.)$ 0.02

References

  1. DailyMed. "CILASTATIN SODIUM; IMIPENEM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "CILASTATIN SODIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "Cilastatin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Imipenem are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Imipenem. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


1 consumer reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Imipenem drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Not expensive1
100.0%


1 consumer reported time for results

To what extent do I have to use Imipenem before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 2 weeks and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Imipenem. To get the time effectiveness of using Imipenem drug by other patients, please click here.
Users%
2 weeks1
100.0%


1 consumer reported age

Users%
46-601
100.0%


Consumer reviews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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