• Implanon NXT 68mg indications
• Uses of Implanon NXT 68mg in details
• Implanon NXT 68mg description
• Implanon NXT 68mg dosage
• Implanon NXT 68mg interactions
• Implanon NXT 68mg side effects
• Implanon NXT 68mg contraindications

What is Implanon NXT 68mg?

Implanon NXT 68mg (Implanon NXT 68mg) is a hormone implant that prevents ovulation (the release of an egg from an ovary). This medication also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.

Implanon NXT 68mg is radiopaque implant used as contraception to prevent pregnancy. Implanon NXT 68mg is contained in a small plastic rod that is implanted into the skin of your upper arm. The medicine is released slowly into the body.

The Implanon NXT 68mg rod can remain in place and provide continuous contraception for up to 3 years.

Implanon NXT 68mg implants contain a small amount of barium sulfate so that the implant can be seen by X-ray.

Implanon NXT 68mg indications

Subdermal

Contraception

Adult: Each implant contains 68 mg of Implanon NXT 68mg: 1 implant is inserted during the 1st 5 days of the menstrual cycle; remove within 3 yr of insertion.

Vaginal

Contraception

Adult: Each vaginal ring delivers 120 mcg of etonorgestrel and 15 mcg of ethinylestradiol daily. Insert one ring into the vagina on the 1st day of menstruation. Leave the ring in place continuously for 3 wk. Remove it after 3 wk for the 1 wk break during which breakthrough bleeding will occur. Insert a new ring 1 wk after removal of the previous ring.

How should I use Implanon NXT 68mg?

Implanon NXT 68mg is inserted through a needle (under local anesthesia) into the skin of your upper arm, just inside and above the elbow. After the implant is inserted, your arm will be covered with 2 bandages. Remove the top bandage after 24 hours, but leave the smaller bandage on for 3 to 5 days. Keep the area clean and dry.

The timing of when you will receive the Implanon NXT 68mg implant depends on whether you were using birth control before, and what type it was.

You should be able to feel the implant under your skin. Tell your doctor if you cannot feel the implant at any time while it is in place.

Implanon NXT 68mg can remain in place for up to 3 years. If the implant is placed correctly, you will not need to use back-up birth control. Follow your doctor's instructions.

You may have irregular and unpredictable periods while using the Implanon NXT 68mg implant. Tell your doctor if your periods are very heavy or long-lasting, or if you miss a period (you may be pregnant).

If you need surgery or medical tests or if you will be on bed rest, you may need to have your Implanon NXT 68mg implant removed for a short time. Any doctor or surgeon who treats you should know that you have an Implanon NXT 68mg implant.

Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using Implanon NXT 68mg.

The Implanon NXT 68mg implant must be removed by the end of the third year after it was inserted and may be replaced at that time with a new implant. After the implant is removed, your ability to get pregnant will return quickly. If the implant is not replaced with a new one, start using another form of birth control right away if you wish to prevent pregnancy.

Call your doctor at once if it feels like the implant may be bent or broken while it is in your arm.

Uses of Implanon NXT 68mg in details

Use: Labeled Indications

Contraception: Prevention of pregnancy

Implanon NXT 68mg description

Each radiopaque implant contains Etonogestrel 68 mg. The release rate is approximately 60-70 mcg/day in week 5-6 and has decreased to approximately 35-45 mcg/day at the end of the 1st year to approximately 30-40 mcg/day at the end of the 2nd year and to approximately 25-30 mcg/day at the end of the 3rd year. The innovative applicator is designed to be operated with 1 hand and help facilitate correct subdermal insertion of implant. Implanon NXT 68mg also contains the following excipients: Core: Ethylene vinylacetate copolymer (28% vinyl acetate, 43 mg), barium sulfate 15 mg. Skin: Ethylene vinylacetate, copolymer (14% vinyl acetate, 15 mg).

Impanon NXT is a progestagen-only, flexible implant preloaded in a sterile, ready-for-use, disposable applicator.

Implanon NXT 68mg dosage

Implanon NXT 68mg Dosage

Generic name: Implanon NXT 68mg 68mg

Dosage form: implant

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

The efficacy of Implanon NXT 68mg does not depend on daily, weekly or monthly administration.

All healthcare providers should receive instruction and training prior to performing insertion and/or removal of Implanon NXT 68mg.

​A single Implanon NXT 68mg implant is inserted subdermally in the upper arm. To reduce the risk of neural or vascular injury, the implant should be inserted at the inner side of the non-dominant upper arm about 8-10 cm (3-4 inches) above the medial epicondyle of the humerus. The implant should be inserted subdermally just under the skin, avoiding the sulcus (groove) between the biceps and triceps muscles and the large blood vessels and nerves that lie there in the neurovascular bundle deeper in the subcutaneous tissues. An implant inserted more deeply than subdermally (deep insertion) may not be palpable and the localization and/or removal can be difficult or impossible. Implanon NXT 68mg must be inserted by the expiration date stated on the packaging. Implanon NXT 68mg is a long-acting (up to 3 years), reversible, hormonal contraceptive method. The implant must be removed by the end of the third year and may be replaced by a new implant at the time of removal, if continued contraceptive protection is desired.

Initiating Contraception with Implanon NXT 68mg

IMPORTANT: Rule out pregnancy before inserting the implant.

Timing of insertion depends on the woman's recent contraceptive history, as follows:

• No preceding hormonal contraceptive use in the past month

  Implanon NXT 68mg should be inserted between Day 1 (first day of menstrual bleeding) and Day 5 of the menstrual cycle, even if the woman is still bleeding.

  If inserted as recommended, back-up contraception is not necessary. If deviating from the recommended timing of insertion, the woman should be advised to use a barrier method until 7 days after insertion. If intercourse has already occurred, pregnancy should be excluded.

• Switching contraceptive method to Implanon NXT 68mg

  Combination hormonal contraceptives:

  Implanon NXT 68mg should preferably be inserted on the day after the last active tablet of the previous combined oral contraceptive or on the day of the removal of the vaginal ring or transdermal patch. At the latest, Implanon NXT 68mg should be inserted on the day following the usual tablet-free, ring-free, patch-free or placebo tablet interval of the previous combined hormonal contraceptive.

  If inserted as recommended, back-up contraception is not necessary. If deviating from the recommended timing of insertion, the woman should be advised to use a barrier method until 7 days after insertion. If intercourse has already occurred, pregnancy should be excluded.

  Progestin-only contraceptives:

  There are several types of progestin-only methods. Implanon NXT 68mg should be inserted as follows:

  • Injectable Contraceptives: Insert Implanon NXT 68mg on the day the next injection is due.

  • Minipill: A woman may switch to Implanon NXT 68mg on any day of the month. Implanon NXT 68mg should be inserted within 24 hours after taking the last tablet.

  • Contraceptive implant or intrauterine system (IUS): Insert Implanon NXT 68mg on the same day as the previous contraceptive implant or IUS is removed.

  If inserted as recommended, back-up contraception is not necessary. If deviating from the recommended timing of insertion, the woman should be advised to use a barrier method until 7 days after insertion. If intercourse has already occurred, pregnancy should be excluded.

• Following abortion or miscarriage
  • First Trimester: Implanon NXT 68mg should be inserted within 5 days following a first trimester abortion or miscarriage.

  • Second Trimester: Insert Implanon NXT 68mg between 21 to 28 days following second trimester abortion or miscarriage.

  If inserted as recommended, back-up contraception is not necessary. If deviating from the recommended timing of insertion, the woman should be advised to use a barrier method until 7 days after insertion. If intercourse has already occurred, pregnancy should be excluded.

• Postpartum
  • Not Breastfeeding: Implanon NXT 68mg should be inserted between 21 to 28 days postpartum. If inserted as recommended, back-up contraception is not necessary. If deviating from the recommended timing of insertion, the woman should be advised to use a barrier method until 7 days after insertion. If intercourse has already occurred, pregnancy should be excluded.

  • Breastfeeding: Implanon NXT 68mg should be inserted after the fourth postpartum week. The woman should be advised to use a barrier method until 7 days after insertion. If intercourse has already occurred, pregnancy should be excluded.

Insertion of Implanon NXT 68mg

The basis for successful use and subsequent removal of Implanon NXT 68mg is a correct and carefully performed subdermal insertion of the single, rod-shaped implant in accordance with the instructions. Both the healthcare provider and the woman should be able to feel the implant under the skin after placement.

All healthcare providers performing insertions and/or removals of Implanon NXT 68mg should receive instructions and training prior to inserting or removing the implant. Information concerning the insertion and removal of Implanon NXT 68mg will be sent upon request free of charge [1-877-Implanon NXT 68mg (1-877-467-5266)].

Preparation

Prior to inserting Implanon NXT 68mg carefully read the instructions for insertion as well as the full prescribing information.

Before insertion of Implanon NXT 68mg, the healthcare provider should confirm that:

• The woman is not pregnant nor has any other contraindication for the use of Implanon NXT 68mg.
• The woman has had a medical history and physical examination, including a gynecologic examination, performed.
• The woman understands the benefits and risks of Implanon NXT 68mg.
• The woman has received a copy of the Patient Labeling included in packaging.
• The woman has reviewed and completed a consent form to be maintained with the woman's chart.
• The woman does not have allergies to the antiseptic and anesthetic to be used during insertion.

Insert Implanon NXT 68mg under aseptic conditions.

The following equipment is needed for the implant insertion:

• An examination table for the woman to lie on
• Sterile surgical drapes, sterile gloves, antiseptic solution, sterile marker (optional)
• Local anesthetic, needles, and syringe
• Sterile gauze, adhesive bandage, pressure bandage

An applicator and its parts are shown below (Figures 1a and 1b).

Figure 1a (Not to scale)

Figure 1b

Grooved tip of obturator (enlarged)

The procedure used for Implanon NXT 68mg insertion is opposite from that of an injection. The obturator keeps Implanon NXT 68mg in place while the cannula is retracted. The obturator must remain fixed in place while the cannula with needle is retracted from the arm. Do not push the obturator.

Insertion Procedure

Step 1. Have the woman lie on her back on the examination table with her non-dominant arm flexed at the elbow and externally rotated so that her wrist is parallel to her ear or her hand is positioned next to her head (Figure 2).

Figure 2

​Step 2. Identify the insertion site, which is at the inner side of the non-dominant upper arm about 8-10 cm (3-4 inches) above the medial epicondyle of the humerus, avoiding the sulcus (groove) between the biceps and triceps muscles and the large blood vessels and nerves that lie there in the neurovascular bundle deeper in the subcutaneous tissue (Figure 3). The implant should be inserted subdermally just under the skin.

Step 3. Make two marks with a sterile marker: first, mark the spot where the Implanon NXT 68mg implant will be inserted, and second, mark a spot a few centimeters proximal to the first mark (Figure 3). This second mark will later serve as a direction guide during insertion.

Figure 3

Step 4. Clean the insertion site with an antiseptic solution.

Step 5. Anesthetize the insertion area (for example, with anesthetic spray or by injecting 2 mL of 1% lidocaine just under the skin along the planned insertion tunnel).

Step 6. Remove the sterile pre-loaded disposable Implanon NXT 68mg applicator carrying the implant from its blister. Keep the Implanon NXT 68mg needle and rod sterile. The applicator should not be used if sterility is in question. If contamination occurs, use a new package of Implanon NXT 68mg with a new sterile applicator.

Step 7. Keep the shield on the needle and look for the Implanon NXT 68mg rod, seen as a white cylinder inside the needle tip.

Step 8. If you don't see the Implanon NXT 68mg rod, tap the top of the needle shield against a firm surface to bring the implant into the needle tip.

Step 9. Following visual confirmation, lower the Implanon NXT 68mg rod back into the needle by tapping it back into the needle tip. Then remove the needle shield, while holding the applicator upright.

Step 10. Note that Implanon NXT 68mg can fall out of the needle. Therefore, after you remove the needle shield, keep the applicator in the upright position until the moment of insertion

Step 11. With your free hand, stretch the skin around the insertion site with thumb and index finger (Figure 4).

Figure 4

Step 12. At a slight angle (not greater than 20°), insert only the tip of the needle with the beveled side up into the insertion site (Figure 5).

Figure 5

Step 13. Lower the applicator to a horizontal position. Lift the skin up with the tip of the needle, but keep the needle in the subdermal connective tissue (Figure 6).

Figure 6

Step 14. While "tenting" (lifting) the skin, gently insert the needle to its full length. Keep the needle parallel to the surface of the skin during insertion (Figure 7).

Figure 7

​Step 15. If Implanon NXT 68mg is placed deeply, the removal process can be difficult or impossible. If the needle is not inserted to its full length, the implant may protrude from the insertion site and fall out.

Step 16. Break the seal of the applicator by pressing the obturator support (Figure 8).

Figure 8

Step 17. Turn the obturator 90° in either direction with respect to the needle (Figure 9).

Figure 9

Step 18. While holding the obturator fixed in place on the arm, fully retract the cannula (Figure 10). Note: This procedure is opposite from an injection. Do not push the obturator. By holding the obturator fixed in place on the arm and fully retracting the cannula, the implant will be left in its correct subdermal position. Do not simultaneously retract the obturator and cannula from the patient's arm.

Figure 10

In this figure, the right hand is holding the obturator in place while the left hand is retracting the cannula.

Step 19. Confirm that the implant has been inserted by checking the tip of the needle for the absence of the implant. After insertion of the implant, the grooved tip of the obturator will be visible inside the needle (Figure 11).

Figure 11

​Step 20. Always verify the presence of the implant in the woman's arm immediately after insertion by palpation. By palpating both ends of the implant, you should be able to confirm the presence of the 4-cm rod (Figure 12). See section below "If the rod is not palpable".

Figure 12

​Step 21. Place a small adhesive bandage over the insertion site. Request that the woman palpate the implant.

​Step 22. Apply a pressure bandage with sterile gauze to minimize bruising. The woman may remove the pressure bandage in 24 hours and the small bandage over the insertion site in 3 to 5 days.

​Step 23. Complete the USER CARD and give it to the woman to keep. Also, complete the PATIENT CHART LABEL and affix it to the woman's medical record.

​Step 24. The applicator is for single use only and should be disposed in accordance with the Center for Disease Control and Prevention guidelines for handling of hazardous waste.

​If the rod is not palpable:

​If you cannot feel the implant or are in doubt of its presence, the implant may not have been inserted or it may have been inserted deeply:

• Check the tip of the needle for the absence of the implant. After insertion of the implant, the grooved tip of the obturator will be visible inside the needle.
• Use other methods to confirm the presence of the implant. Suitable methods to locate are: ultrasound (US) with a high-frequency linear array transducer (10 MHz or greater) or magnetic resonance imaging (MRI). Please note that the Implanon NXT 68mg rod is not radiopaque and cannot be seen by X-ray or CT scan. If ultrasound and MRI fail, call 1-877-Implanon NXT 68mg (1-877-467-5266) for information on the procedure for measuring Implanon NXT 68mg blood levels.

Until the presence of the implant has been verified, the woman should be advised to use a non-hormonal contraceptive method, such as condoms.

​Once the non-palpable implant has been located, removal is recommended.

Removal of Implanon NXT 68mg

Preparation

​Before initiating the removal procedure, the healthcare provider should carefully read the instructions for removal and consult the USER CARD and/or the PATIENT CHART LABEL for the location of the implant. The exact location of the implant in the arm should be verified by palpation.

​Procedure for Removal of an Implant that is Palpable

Before removal of the implant, the healthcare provider should confirm that:

• The woman does not have allergies to the antiseptic or anesthetic to be used.

Remove the implant under aseptic conditions.

The following equipment is needed for removal of the implant:

• An examination table for the woman to lie on
• Sterile surgical drapes, sterile gloves, antiseptic solution, sterile marker (optional)
• Local anesthetic, needles, and syringe
• Sterile scalpel, forceps (straight and curved mosquito)
• Skin closure, sterile gauze, adhesive bandage and pressure bandages

Removal Procedure

Step 1. Clean the site where the incision will be made and apply an antiseptic. Locate the implant by palpation and mark the distal end (end closest to the elbow), for example, with a sterile marker (Figure 13).

Figure 13

Step 2. Anesthetize the arm, for example, with 0.5 to 1 mL 1% lidocaine at the marked site where the incision will be made (Figure 14). Be sure to inject the local anesthetic under the implant to keep it close to the skin surface.

Figure 14

Step 3. Push down the proximal end of the implant (Figure 15) to stabilize it; a bulge may appear indicating the distal end of the implant. Starting at the distal tip of the implant, make a longitudinal incision of 2 mm towards the elbow.

Figure 15

Step 4. Gently push the implant towards the incision until the tip is visible. Grasp the implant with forceps (preferably curved mosquito forceps) and gently remove the implant (Figure 16).

Figure 16

Step 5. If the implant is encapsulated, make an incision into the tissue sheath and then remove the implant with the forceps (Figures 17 and 18).

Figure 17	Figure 18

Step 6. If the tip of the implant does not become visible in the incision, gently insert a forceps into the incision (Figure 19). Flip the forceps over into your other hand (Figure 20).

Figure 19	Figure 20

Step 7. With a second pair of forceps carefully dissect the tissue around the implant and grasp the implant (Figure 21). The implant can then be removed.

Figure 21

​Step 8. Confirm that the entire implant, which is 4 cm long, has been removed by measuring its length. There have been reports of broken implants while in the patient's arm. In some cases, difficult removal of the broken implant has been reported. If a partial implant (less than 4 cm) is removed, the remaining piece should be removed by following the instructions in section 2.3. If the woman would like to continue using Implanon NXT 68mg, a new implant may be inserted immediately after the old implant is removed using the same incision.

Step 9. After removing the implant, close the incision with a steri-strip and apply an adhesive bandage.

Step 10. Apply a pressure bandage with sterile gauze to minimize bruising. The woman may remove the pressure bandage in 24 hours and the small bandage in 3 to 5 days.

​Localization and Removal of a Non-Palpable Implant

​There have been reports of migration of the implant; usually this involves minor movement relative to the original position, but may lead to the implant not being palpable in the location in which it was placed. An implant that has been deeply inserted or has migrated may not be palpable and therefore imaging procedures, as described below, may be required for localization.

​A non-palpable implant should always be located prior to attempting removal. Suitable methods for localization include ultrasound with a high-frequency linear array transducer (10 MHz or greater) or magnetic resonance imaging. Once the implant has been localized in the arm, the implant should be removed according to the instructions in Dosage and Administration (2.3), Procedure for Removal of an Implant that is Palpable, and the use of ultrasound guidance during the removal should be considered.

​If the implant cannot be found in the arm after comprehensive localization attempts, consult a radiologist familiar with applying advanced imaging techniques to the chest, as events of migration to the pulmonary vasculature have been reported. If the implant is located in the chest, surgical or endovascular procedures may be needed for removal; healthcare providers familiar with the anatomy of the chest should be consulted.

​If at any time these imaging methods fail to locate the implant, Implanon NXT 68mg blood level determination can be used for verification of the presence of the implant. For details on Implanon NXT 68mg blood level determination, call 1-877-Implanon NXT 68mg (1-877-467-5266) for further instructions.

​If the implant migrates within the arm, removal may require a minor surgical procedure with a larger incision or a surgical procedure in an operating room. Removal of deeply inserted implants should be conducted with caution in order to prevent injury to deeper neural or vascular structures in the arm and be performed by healthcare providers familiar with the anatomy of the arm.

​Exploratory surgery without knowledge of the exact location of the implant is strongly discouraged.

Replacing Implanon NXT 68mg

Immediate replacement can be done after removal of the previous implant and is similar to the insertion procedure described in section 2.2 Insertion of Implanon NXT 68mg.

The new implant may be inserted in the same arm, and through the same incision from which the previous implant was removed. If the same incision is being used to insert a new implant, anesthetize the insertion site [for example, 2 mL lidocaine (1%)] applying it just under the skin along the 'insertion canal.'

Follow the subsequent steps in the insertion instructions.

More about Implanon NXT 68mg (Implanon NXT 68mg)

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• Implanon NXT 68mg (Advanced Reading)

• Other brands: Implanon NXT 68mg

Professional resources

• Implanon NXT 68mg (FDA)

Related treatment guides

• Birth Control

Implanon NXT 68mg interactions

See also:
What other drugs will affect Implanon NXT 68mg?

Influence of Other Medicinal Products on Implanon NXT 68mg: Interactions between hormonal contraceptives and other medicinal products may lead to breakthrough bleeding and/or contraceptive failure. No specific interaction studies have been performed with Implanon NXT 68mg. The following interactions have been reported in the literature (mainly with combined contraceptives but occasionally also with progestogen-only contraceptives).

Hepatic Metabolism: Interactions can occur with medicinal products that induce microsomal enzymes, specifically cytochrome P-450 enzymes, which can result in increased clearance of sex hormones (eg, phenytoin, barbiturates, primidone, carbamazepine, rifampicin and possibly also oxcarbazepine, rifabutin, topiramate, felbamate, ritonavir, nelfinavir, nevirapine, griseofulvin and the herbal remedy St. John's wort).

Also human immunodeficiency virus HIV protease (eg, ritonavir, nelfinavir) and non-nucleoside reverse transcriptase inhibitors (eg, nevirapine, efavirenz) and combinations of them have been reported to potentially affect hepatic metabolism.

Women on treatment with any of these drugs should temporarily use a barrier method in addition to Implanon NXT 68mg. With microsomal enzyme-inducing drugs, the barrier method should be used during the time of concomitant drug administration and for 28 days after their discontinuation.

In women on long-term treatment with hepatic enzyme-inducing drugs, it is recommended to remove Implanon NXT 68mg and to prescribe a non-hormonal method.

Increase in plasma hormone levels associated with co-administered drugs: Drugs (eg, ketoconazole) that inhibit microsomal enzymes eg, CYP3A4 may increase plasma hormone levels.

Influence of Implanon NXT 68mg on Other Medicinal Products: Hormonal contraceptives may interfere with the metabolism of other drugs. Accordingly, plasma and tissue concentrations either increase (eg, cyclosporine) or decrease (eg, lamotrigine).

Note: The prescribing information of concomitant medications should be consulted to identify potential interactions.

Laboratory Test: Data obtained with combined oral contraceptives have shown that contraceptive steroids may influence the results of certain laboratory tests, including biochemical parameters of the liver, thyroid, adrenal and renal function, serum levels of (carrier) proteins eg, corticosteroid-binding globulin and lipid/lipoprotein fractions, parameters of carbohydrate metabolism and parameters of coagulation and fibrinolysis. The changes generally remain within the normal range. To what extent this also applies to progestagen-only contraceptives is not known.

Implanon NXT 68mg side effects

See also:
What are the possible side effects of Implanon NXT 68mg?

During the use of Implanon NXT 68mg, women are likely to have changes in their vaginal bleeding patterns which are often unpredictable. These may inlcude changes in bleeding frequency (absent, less, more frequent or continuous), intensity (reduced or increased) or duration. Ammenorhoea was reported in about 1 of 5 women while another 1 of 5 women reported frequent and/or prolonged bleeding. Occasionally, heavy bleeding has been reported. In clinical trials, bleeding changes were the most common reason for stopping treatment with Implanon NXT 68mg (about 11%). Dysmenorrhoea tends to improve while using Implanon NXT 68mg. The bleeding pattern experienced during the first 3 months is broadly predictive of future bleeding patterns for many women.

Possibly related undesirable effects reported in clinical trials with Implanon NXT 68mg have been listed in the following table. An association has been neither confirmed nor refuted.

In rare cases, a clinically relevant rise in blood pressure has been observed during the use of Implanon NXT 68mg. Urticaria and (aggravation of) angioedema and/or aggravation of hereditary angioedema may occur. Insertion or removal of Implanon NXT 68mg may cause some bruising, slight local irritation, pain or itching. Occasionally, fibrosis at the injection site may occur or a scar may be formed or an abscess may develop. In rare cases, paresthesia or paresthesia-like events may occur. Expulsion or migration of Implanon NXT 68mg may be possible. Minor surgical intervention might be necessary when removing Implanon NXT 68mg.

On rare occasions, ectopic pregnancies have been reported.

In women using (combined oral) contraceptives, a number of (serious) undesirable effects have been reported. These include venous thromboembolic disorders, arterial thromboembolic disorders, hypertension, hormone-dependent tumours (eg, liver tumours, breast cancer) and chloasma.

Implanon NXT 68mg contraindications

See also:
What is the most important information I should know about Implanon NXT 68mg?

Hypersensitivity to Implanon NXT 68mg or to any of the excipients of Implanon NXT 68mg.

Progestagen-only contraceptives should not be used in the presence of active venous thromboembolic disorder, known or suspected sex steroid-sensitive malignancies, presence or history of severe hepatic disease as long as liver function values have not returned to normal, undiagnosed vaginal bleeding, and known or suspected pregnancy. Should any of the conditions appear for the 1st time during the use of Implanon NXT 68mg immediately discontinue use.

Use in pregnancy & lactation: Implanon NXT 68mg is not indicated during pregnancy. If pregnancy occurs during use of Implanon NXT 68mg, the implant should be removed. Animal studies have shown that very high doses of progestogenic substances may cause masculinisation of female fetuses. Extensive epidemiological studies have revealed neither an increased risk of birth defects in children born to women who used oral contraceptives (OCs) prior to pregnancy nor of a teratogenic effect when OCs were inadvertently used during pregnancy. Although this probably applies to all OCs, it is not clear whether this is also the case for Implanon NXT 68mg. Pharmacovigilance data with various Implanon NXT 68mg- and desogestrel-containing products (Implanon NXT 68mg is a metabolite of desogestrel) do not indicate an increased risk.

Clinical data indicate that Implanon NXT 68mg does not influence the production or the quality (protein, lactose or fat concentrations) of breast milk. However, small amounts of Implanon NXT 68mg are excreted in breast milk. Based on an average daily milk ingestion of 150 mL/kg, the mean daily infant Implanon NXT 68mg-dose calculated after 1 month of Implanon NXT 68mg release is approximately 27 ng/kg/day. This corresponds to approximately 2.2% of the weight-adjusted maternal daily dose and to approximately 0.2% of the estimated absolute maternal daily dose. Subsequently the milk Implanon NXT 68mg concentration decreases with time during the lactation period.

Long-term data are available on 38 children, whose mothers had an implant inserted during the 4th-8th week postpartum. They were breastfed for a mean duration of 14 months and followed-up to 36 months of age. Evaluation of growth and physical, and psychomotor development did not indicate any differences in comparison to nursing infants whose mothers used an intrauterine device (n=33). Nevertheless, development and growth of the child should be carefully followed. Based on the available data, Implanon NXT 68mg may be used during lactation and should be inserted after the 4th postpartum week.

Active ingredient matches for Implanon NXT 68mg:

Etonogestrel in Austria, Luxembourg.

List of Implanon NXT 68mg substitutes (brand and generic names)	Sort by popularity
Unit description / dosage (Manufacturer)	Price, USD
Etonogestrel (Australia, Austria, Belgium, Bulgaria, Canada, Chile, Colombia, Croatia (Hrvatska), Czech Republic, Denmark, Estonia, Finland, France, Georgia, Germany, Greece, Hungary, Iceland, Ireland, Israel, Italy, Latvia, Lithuania, Malta, Mexico, Netherlands, Norway, Oman, Peru, Poland, Portugal, Romania, Russian Federation, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Taiwan, Turkey, United Kingdom, United States)
Implanon 68 mg implant	$ 714.34
Implanon 68 mg implant	$ 714.34
etonogestrel implant
Implanon (Australia, Austria, Bahrain, Belgium, Brazil, Chile, Cyprus, Czech Republic, Denmark, Egypt, Finland, France, Germany, Hungary, Iceland, Indonesia, Iran, Iraq, Ireland, Jordan, Kuwait, Lebanon, Libya, Luxembourg, Malta, Mexico, Netherlands, Norway, Oman, Peru, Portugal, Qatar, Saudi Arabia, Singapore, Spain, Sudan, Sweden, Switzerland, Syria, Thailand, Tunisia, Turkey, United Arab Emirates, United Kingdom, United States, Venezuela, Yemen)
Implant; Implantation; Etonogestrel 68 mg (MSD)
Implanon 68 mg x 1's (MSD)
Implanon / Gold Circle/Limas 68 mg x 1's (MSD)	$ 75.39
Implanon 1 que (MSD)
Implanon 68 mg x 1 que (MSD)
Implanon implant 68 mg 1's (MSD)
Implanon implant 68 mg/1 (MSD)
Implanon (Merck Sharp & Dohme (China)
Implanon 68mg (Oman)
Implanon NKST (Russian Federation)
Implanon NXT (Germany, Switzerland)
Implanon NXT 68 mg x 1's (MSD)
Implanon NXT implant 68 mg 1's (MSD)
Implanon NXT rod implant 68 mg 1's (MSD)
Implanon/Implanon NXT (Myanmar)
Nexplanon (France, Malta, Norway, Sweden, United Kingdom, United States)
Nexplanon implant 68 mg/1 (Organon USA Inc. (US))
Nexplanon implant

References

1. DailyMed. "ETONOGESTREL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "ETONOGESTREL". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "ETONOGESTREL". http://www.drugbank.ca/drugs/DB00294 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Implanon NXT 68mg are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Implanon NXT 68mg. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology