Jaimiess Uses

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What is Jaimiess?

See also: Mirena

Jaimiess is a combination birth control pill containing female hormones that prevent ovulation (the release of an egg from an ovary). Jaimiess also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.

Jaimiess is used as contraception to prevent pregnancy. There are many brands and forms of this medicine available. Not all brands are listed on this leaflet.

Jaimiess may also be used for purposes not listed in this medication guide.

Jaimiess indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Jaimiess is indicated for the prevention of pregnancy in women who elect to use oral contraceptives as a method of contraception.

Oral contraceptives are highly effective for pregnancy prevention. Table 2 lists the typical unintended pregnancy rates for users of combination oral contraceptives and other methods of contraception. The efficacy of these contraceptive methods, except sterilization, the IUD, and implants, depend upon the reliability with which they are used. Correct and consistent use of methods can result in lower failure rates.

Table 2: Percentage of Women Experiencing an Unintended Pregnancy During The First Year of Typical Use and The First Year of Perfect Use of Contraception and The Percentage Continuing Use at The End of the First Year. United States.
% of Women Experiencing an Unintended Pregnancy

within the First Year of Use

% of Women

Continuing Use at

One Year3

Method (1) Typical Use1 (2) Perfect Use2 (3) (4)
Chance4 85 85
Spermicides5 26 6 40
Periodic abstinence 25 63
Calendar 9
Ovulation Method 3
Sympto-Thermal6 2
Post-Ovulation 1
Cap7
Parous Women 40 26 42
Nulliparous Women 20 9 56
Sponge
Parous Women 40 20 42
Nulliparous Women 20 9 56
Diaphragm7 20 6 56
Withdrawal 19 4
Condom8
Female (RealityTM) 21 5 56
Male 14 3 61
Pill 5 71
Progestin only 0.5
Combined 0.1
IUD
Progesterone T 2.0 1.5 81
Copper T380A 0.8 0.6 78
LNg 20 0.1 0.1 81
Depo-Provera® 0.3 0.3 70
Levonorgestrel (Jaimiess)

Implants (Norplant®)

0.05 0.05 88
Female Sterilization 0.5 0.5 100
Male Sterilization 0.15 0.10 100

Emergency Contraceptive Pills: The FDA has concluded that certain combined oral contraceptives containing Ethinyl estradiol (Jaimiess) and norgestrel or Levonorgestrel (Jaimiess) are safe and effective for use as postcoital emergency contraception. Treatment initiated within 72 hours after unprotected intercourse reduces the risk of pregnancy by at least 75%.9

Lactation Amenorrhea Method: LAM is a highly effective, temporary method of contraception.10

Source: Trussell J. Contraceptive efficacy. In: Hatcher RA, Trussell J, Stewart F, Cates W, Stewart GK, Kowel D, Guest F. Contraceptive Technology: Seventeenth Revised Edition. New York NY: Irvington Publishers; 1998.

  1. Among typical couples who initiate use of a method (not necessarily for the first time), the percentage who experience an accidental pregnancy during the first year if they do not stop use for any other reason.
  2. Among couples who initiate use of a method (not necessarily for the first time) and who use it perfectly (both consistently and correctly), the percentage who experience an accidental pregnancy during the first year if they do not stop use for any other reason.
  3. Among couples attempting to avoid pregnancy, the percentage who continue to use a method for one year.
  4. The percents becoming pregnant in columns (2) and (3) are based on data from populations where contraception is not used and from women who cease using contraception in order to become pregnant. Among such populations, about 89% become pregnant within one year. This estimate was lowered slightly (to 85%) to represent the percent who would become pregnant within one year among women now relying on reversible methods of contraception if they abandoned contraception altogether.
  5. Foams, creams, gels, vaginal suppositories, and vaginal film.
  6. Cervical mucus (ovulation) method supplemented by calendar in the pre-ovulatory and basal body temperature in the post-ovulatory phases.
  7. With spermicidal cream or jelly.
  8. Without spermicides.
  9. The treatment schedule is one dose within 72 hours after unprotected intercourse, and a second dose 12 hours after the first dose. The FDA has declared the following dosage regimens of oral contraceptives to be safe and effective for emergency contraception: for tablets containing 50 mcg of Ethinyl estradiol (Jaimiess) and 500 mcg of norgestrel 1 dose is 2 tablets; for tablets containing 20 mcg of Ethinyl estradiol (Jaimiess) and 100 mcg of Levonorgestrel (Jaimiess) 1 dose is 5 tablets; for tablets containing 30 mcg of Ethinyl estradiol (Jaimiess) and 150 mcg of Levonorgestrel (Jaimiess) 1 dose is 4 tablets.
  10. However, to maintain effective protection against pregnancy, another method of contraception must be used as soon as menstruation resumes, the frequency or duration of breastfeeds is reduced, bottle feeds are introduced, or the baby reaches 6 months of age.

Clinical Studies

The efficacy and safety of Jaimiess were studied in 2 one-year clinical trials of subjects age 18-49. There were no exclusions for body mass index (BMI), weight, or bleeding history.

The primary efficacy and safety study (313-NA) was a one-year open-label clinical trial that treated 2,134 subjects in North America. Of these subjects 1,213 (56.8%) discontinued prematurely, including 102 (4.8%) discontinued by the Sponsor for early study closure. The mean weight of subjects in this study was 70.38 kg. The efficacy of Jaimiess was assessed by the number of pregnancies that occurred after the onset of treatment and within 14 days of the last dose. Among subjects 35 years or less, there were 23 pregnancies (4 of these occurred during the interval 1 to 14 days after the last day of pill use) during 12,572 28-day pill packs of use. The resulting total Pearl Index was 2.38 (95% CI: 1.51, 3.57) and the one-year life table pregnancy rate was 2.39 (95% CI: 1.57, 3.62). Pill pack cycles during which subjects used back-up contraception or were not sexually active were not included in these calculations. Among women 35 years or less who took the pills completely as directed, there were 15 pregnancies (method failures) resulting in a Pearl Index of 1.55 (95% CI: 0.87, 2.56) and the one-year life table pregnancy rate was 1.59 (95% CI: 0.95-2.67).

In a second supportive study conducted in Europe (315-EU), 641 subjects were randomized to Jaimiess (n=323) or the cyclic comparator of 100 mcg Levonorgestrel (Jaimiess) and 20 mcg Ethinyl estradiol (Jaimiess) (n=318). The mean weight of subjects in this study was 63.86 kg. The efficacy analysis among women 35 years or less included 2,756 Jaimiess pill packs and 2,886 cyclic comparator pill packs. There was one pregnancy in the Jaimiess group that occurred within 14 days following the last dose. There were three pregnancies in the cyclic comparator group.

Inhibition of Menses (Bleeding Profile)

The bleeding profile for subjects in Study 313-NA also was assessed. Women with a history of unscheduled bleeding and/or spotting were not excluded from the study.

In those subjects who provided complete bleeding data, the percentage of patients who were amenorrheic in a given cycle and remained amenorrheic through cycle 13 (cumulative amenorrhea rate) was determined (Figure 2).

Figure 2: Percentage of Subjects with Cumulative Amenorrhea for Each Pill Pack through Pill Pack 13

When prescribing Jaimiess, the convenience of having no scheduled menstrual bleeding should be weighed against the inconvenience of unscheduled bleeding and spotting.

How should I use Jaimiess?

Use Jaimiess as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Jaimiess.

Uses of Jaimiess in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This combination hormone medication is used to prevent pregnancy. It contains 2 hormones: a progestin (Levonorgestrel (Jaimiess)) and an estrogen (Ethinyl estradiol (Jaimiess)). It works mainly by preventing the release of an egg (ovulation) during your menstrual cycle. It also makes vaginal fluid thicker to help prevent sperm from reaching an egg (fertilization) and changes the lining of the uterus (womb) to prevent attachment of a fertilized egg. If a fertilized egg does not attach to the uterus, it passes out of the body.

Besides preventing pregnancy, birth control pills may make your periods more regular, decrease blood loss and painful periods, decrease your risk of ovarian cysts, and also treat acne.

Using this medication does not protect you or your partner against sexually transmitted diseases (such as HIV, gonorrhea, chlamydia).

How to use Jaimiess

Read the Patient Information Leaflet provided by your pharmacist before you start using this product and each time you get a refill. The leaflet contains very important information on when to take your pills and what to do if you miss a dose. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once daily. Pick a time of day that is easy for you to remember, and take your pill at the same time each day.

It is very important to continue taking this medication exactly as prescribed by your doctor. Follow the package instructions to find the first tablet, start with the first tablet in the pack, and take them in the correct order. Do not skip any doses. Pregnancy is more likely if you miss pills, start a new pack late, or take your pill at a different time of the day than usual.

Taking this medication after your evening meal or at bedtime may help if you have stomach upset or nausea with the medication. You may choose to take this medication at another time of day that is easier for you to remember. No matter what dosing schedule you use, it is very important that you take this medication at the same time each day, 24 hours apart. Ask your doctor or pharmacist if you have any questions.

Begin taking this medication on the first Sunday following the beginning of your menstrual period. If your period begins on a Sunday, begin taking this medication on that day. Your pill pack contains 84 estrogen/progestin pills and 7 estrogen-only pills. Take one estrogen/progestin pill daily for 84 days in a row. The day after you finish all the combination pills, start taking one estrogen-only pill daily for 7 days in a row. You should have your period during the week you are taking the estrogen-only pills. The day after you take the last estrogen-only pill, start a new pack whether or not you have your period. If you do not get your period, consult your doctor.

If this is the first time you are using this medication, use an additional form of non-hormonal birth control (such as condoms, spermicide) for the first 7 days to prevent pregnancy until the medication has enough time to work. If you start on the first day of your period, you do not need to use back-up birth control the first week.

Ask your doctor or pharmacist about how to switch from other forms of hormonal birth control (such as patch, other birth control pills) to this product. If any information is unclear, consult the Patient Information Leaflet or your doctor or pharmacist.

Jaimiess description

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Each tablet contains Levonorgestrel (Jaimiess) 150μg and Ethinyl estradiol (Jaimiess) 30 μg.

Ethinyl estradiol (Jaimiess) is 19-nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17-diol.

Levonorgestrel (Jaimiess) is (-)-13-ethyl-17-hydroxy-18,19-dinor-17α-pregna-4-en-20-yn-3-one.

Ethinyl estradiol (Jaimiess) is a white to creamy white, odorless, crystalline powder. It is insoluble in water and soluble in alcohol, chloroform, ether, vegetable oils and aqueous solutions of alkali hydroxides.

Levonorgestrel (Jaimiess) is a white, crystalline powder that is very slightly soluble in water, slightly soluble in alcohol and acetone and soluble in chloroform.

Jaimiess dosage

Jaimiess Dosage

Generic name: Ethinyl estradiol (Jaimiess) 0.01mg; Ethinyl estradiol (Jaimiess) 0.03mg, Levonorgestrel (Jaimiess) 0.15mg

Dosage form: tablets

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The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Take one tablet by mouth at the same time every day. The dosage of Jaimiess tablets is one white tablet containing Levonorgestrel (Jaimiess) and Ethinyl estradiol (Jaimiess) daily for 84 consecutive days, followed by one light blue Ethinyl estradiol (Jaimiess) tablet for 7 days. To achieve maximum contraceptive effectiveness, Jaimiess tablets must be taken exactly as directed and at intervals not exceeding 24 hours.

Instruct the patient to begin taking Jaimiess tablets on the first Sunday after the onset of menstruation. If menstruation begins on a Sunday, the first white tablet is taken that day. One white tablet should be taken daily for 84 consecutive days, followed by one light blue tablet for 7 consecutive days. A non-hormonal back-up method of contraception (such as condoms or spermicide) should be used until a white tablet has been taken daily for 7 consecutive days. A scheduled period should occur during the 7 days that the light blue tablets are taken.

Begin the next and all subsequent 91-day cycles without interruption on the same day of the week (Sunday) on which the patient began her first dose of Jaimiess tablets, following the same schedule: 84 days taking a white tablet followed by 7 days taking a blue tablet. If the patient does not immediately start her next pill pack, she should protect herself from pregnancy by using a non-hormonal back-up method of contraception until she has taken a white tablet daily for 7 consecutive days. If unscheduled spotting or bleeding occurs, instruct the patient to continue on the same regimen. If the bleeding is persistent or prolonged, advise the patient to consult her healthcare provider.

For patient instructions regarding missed pills, see FDA-Approved Patient Labeling.

For postpartum women who are not breastfeeding, start Jaimiess tablets no earlier than four to six weeks postpartum due to increased risk of thromboembolism. If the patient starts on Jaimiess tablets postpartum and has not yet had a period, evaluate for possible pregnancy, and instruct her to use an additional method of contraception until she has taken a white tablet for 7 consecutive days.

More about Jaimiess (Ethinyl estradiol (Jaimiess) / Levonorgestrel (Jaimiess))

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Jaimiess interactions

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What other drugs will affect Jaimiess?

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Interactions between Ethinyl estradiol (Jaimiess) and other substances may lead to decreased or increased serum Ethinyl estradiol (Jaimiess) concentrations, respectively.

Decreased Ethinyl estradiol (Jaimiess) serum concentrations may cause an increased incidence of breakthrough bleeding and menstrual irregularities and may possibly reduce efficacy of the COC.

During concomitant use of Ethinyl estradiol (Jaimiess)-containing products and substances that may lead to decreased Ethinyl estradiol (Jaimiess) serum concentrations, it is recommended that a nonhormonal back-up method of birth control (eg, condoms and spermicide) be used in addition to the regular intake of Jaimiess. In the case of prolonged use of such substances, COCs should not be considered the primary contraceptive.

After discontinuation of substances that may lead to decreased Ethinyl estradiol (Jaimiess) serum concentrations, use of a nonhormonal back-up method is recommended for at least 7 days. Longer use of a back-up method is advisable after discontinuation of substances that have lead to induction of hepatic microsomal enzymes, resulting in decreased Ethinyl estradiol (Jaimiess) serum concentrations. It may sometimes take several weeks until enzyme induction has completely subsided, depending on dosage, duration of use and rate of elimination of the inducing substance.

Substances That May Decrease Serum Ethinyl estradiol (Jaimiess) Concentrations: Any substance that reduces gastrointestinal tract transit time and, therefore, Ethinyl estradiol (Jaimiess) absorption.

Substances that induce hepatic microsomal enzymes eg, rifampicin, rifabutin, barbiturates, primidone, phenylbutazone, phenytoin, dexamethasone, griseofulvin, topiramate, some protease inhibitors, modafinil. Hypericum perforatum, also known as St. John's wort and ritonavir (possibly by induction of hepatic microsomal enzymes). Certain antibiotics (eg, ampicillin and other penicillins, tetracyclines), by a decrease of enterohepatic circulation of estrogens.

Substances That May Increase Serum Ethinyl estradiol (Jaimiess) Concentrations: Atorvastatin. Competitive inhibitors for sulfation in the gastrointestinal wall eg, as ascorbic acid (vitamin C) and paracetamol (acetaminophen). Substances that inhibit cytochrome P450 3A4 isoenzymes eg, indinavir, fluconazole and troleandomycin.

Troleandomycin may increase the risk of intrahepatic cholestasis during co-administration with COCs.

Ethinyl estradiol (Jaimiess) may interfere with the metabolism of other drugs by inhibiting hepatic microsomal enzymes, or by inducing hepatic drug conjugation, particularly glucuronidation. Accordingly, plasma and tissue concentrations may either be increased (eg, cyclosporine, theophylline, corticosteroids) or decreased (eg, lamotrigine).

In patients treated with flunarizine, use of oral contraceptives has been reported to increase the risk of galactorrhea.

The prescribing information of concomitant medications should be consulted to identify potential interactions.

Although ritonavir is an inhibitor of cytochrome P450 3A4, treatment with ritonavir has been shown to decrease Ethinyl estradiol (Jaimiess) serum concentrations.

Effects on Laboratory Parameters: The use of COCs may cause certain physiologic changes which may be reflected in the results of certain laboratory tests, including biochemical parameters of liver function (including a decrease in bilirubin and alkaline phosphatase, thyroid function (increased total T3 and T4 due to increased TBG, decreased free T3 resin uptake), adrenal function [increased plasma cortisol and cortisol binding globulin, decreased dehydroepiandrosterone sulfate (DHEAS)] and renal function (increased plasma creatinine and creatinine clearance); plasma levels of (carrier) proteins eg, corticosteroid-binding globulin and lipid/lipoprotein fractions; parameters of carbohydrate metabolism; parameters of coagulation and fibrinolysis; decreased serum folate levels.

Jaimiess side effects

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What are the possible side effects of Jaimiess?

The following serious adverse reactions with the use of COCs are discussed elsewhere in the labeling:

Adverse reactions commonly reported by COC users are:

Clinical Trial Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to the rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

The clinical trial that evaluated the safety and efficacy of Jaimiess was a 12-month, randomized, multicenter, open-label study, which enrolled women aged 18 to 40, of whom 456 took at least one dose of Jaimiess (345.14 woman-years of exposure).

Adverse Reactions Leading to Study Discontinuation: 14.9% of the women discontinued from the clinical trial due to an adverse reaction; the most common adverse reactions (≥ 1% of women) leading to discontinuation in the Jaimiess group were menorrhagia (5.7%), mood swings (1.9%), weight/appetite increase (1.5%), and acne (1.3%).

Common Adverse Reactions (≥ 2% of women): headache (20.6%), menorrhagia (11.6%), nausea (7.5%), dysmenorrhea (5.7%), acne (4.6%), migraine (4.4%), breast tenderness (3.5%), weight increased (3.1%), and depression (2.1%).

Serious Adverse Reactions: pulmonary embolus, cholecystitis.

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of Jaimiess. Because these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Gastrointestinal disorders: abdominal distension, vomiting

General disorders and administration site conditions: chest pain, fatigue, malaise, edema peripheral, pain

Immune system disorder: hypersensitivity reactions, including itching, rash, and angioedema

Investigations: blood pressure increased

Musculoskeletal and connective tissue disorders: muscle spasms, pain in extremity

Nervous system disorders: dizziness, loss of consciousness

Psychiatric disorders: insomnia

Reproductive and breast disorders: dysmenorrhea

Skin and subcutaneous tissue disorders: alopecia

Vascular disorders: thrombosis, pulmonary embolism, pulmonary thrombosis

Jaimiess contraindications

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What is the most important information I should know about Jaimiess?

Do not prescribe Jaimiess to women who are known to have the following conditions:

A high risk of arterial or venous thrombotic disease. Examples include women who are known to:
o
Smoke, if over age 35.
o
Have deep vein thrombosis or pulmonary embolism, now or in the past.
o
Have inherited or acquired hypercoagulopathies.
o
Have cerebrovascular disease.
o
Have coronary artery disease.
o
Have thrombogenic valvular or thrombogenic rhythm diseases of the heart (for example, subacute bacterial endocarditis with valvular disease, or atrial fibrillation).
o
Have uncontrolled hypertension.
o
Have diabetes mellitus with vascular disease.
o
Have headaches with focal neurological symptoms or have migraine headaches with aura.
Women over age 35 with any migraine headaches.
Liver tumors, benign or malignant, or liver disease
Undiagnosed abnormal uterine bleeding.
Pregnancy, because there is no reason to use COCs during pregnancy.
Breast cancer or other estrogen- or progestin-sensitive cancer, now or in the past.
Hypersensitivity to any of the components.
Use of Hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to the potential for ALT elevations



Active ingredient matches for Jaimiess:

Ethinyl estradiol/levonorgestrel

01mg/03mg; ETHINYL ESTRADIOL 0/15mg/ethinyl estradiol/ETHINYL ESTRADIOL 0/levonorgestrel/LEVONORGESTREL 0


List of Jaimiess substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral-21; Ethinyl Estradiol 0.02 mg; Levonorgestrel 0.1 mg (Barr)
Tablet; Oral-28; Ethinyl Estradiol 0.02 mg; Levonorgestrel 0.1 mg (Barr)
Tablet; Oral-21; Ethinyl Estradiol 0.02 mg; Levonorgestrel 0.1 mg (Berlex)
Tablet; Oral-28; Ethinyl Estradiol 0.02 mg; Levonorgestrel 0.1 mg (Berlex)
Tablet; Oral; Ethinyl Estradiol 0.03 mg; Levonorgestrel 0.15 mg
Tablet; Oral-28; Ethinyl Estradiol 0.02 mg; Levonorgestrel 0.1 mg
Tablet; Oral-21; Ethinyl Estradiol 0.02 mg; Levonorgestrel 0.1 mg
Tablet; Oral-21; Ethinyl Estradiol 0.03 mg; Levonorgestrel 0.15 mg (Watson)
Tablet; Oral-28; Ethinyl Estradiol 0.03 mg; Levonorgestrel 0.15 mg (Watson)
LEVORA 0.03MG/0.15MG TABLET 1 strip / 10 tablets each (Watson)$ 0.40
Levora Tablet (Watson)$ 0.04
Tablet; Oral; Ethinyl Estradiol 0.02 mg; Ethinyl Estradiol 0.01 mg; Levonorgestrel 0.1 mg
Tablet; Oral; Ethinyl Estradiol; Levonorgestrel (Watson)
Tablet; Oral; Ethinyl Estradiol 0.09 mg; Levonorgestrel 0.02 mg (Wyeth)
LYNA TABLET 1 strip / 21 tablets each (West-Coast Pharmaceutical Works Ltd)$ 0.87
MALA D TABLET 1 strip / 28 tablets each (Deys Medical)$ 0.04
Mala D Tablet (Deys Medical)$ 0.00
Tablet, Sugar-Coated; Oral; Ethinyl Estradiol 0.03 mg; Levonorgestrel 0.15 mg (Schering)
Tablet, Sugar-Coated; Oral; Ethinyl Estradiol 0.03 mg; Levonorgestrel 0.15 mg
Tablet, Sugar-Coated; Oral; Ethinyl Estradiol 0.03 mg; Levonorgestrel 0.125 mg
Dragee; Oral; Ethinyl Estradiol 0.02 mg; Levonorgestrel 0.1 mg
Dragee; Oral; Ethinyl Estradiol 0.02 mg; Levonorgestrel 0.1 mg
6 Blue Dragee; Oral; Ethinyl Estradiol 0.03 mg; Levonorgestrel 0.05 mg / 5 Yellow Dragee; Oral; Ethinyl Estradiol 0.04 mg; Levonorgestrel 0.075 mg / 10 Red Dragee; Oral; Ethinyl Estradiol 0.03 mg; Levonorgestrel 0.125 mg (Gynopharm)
Dragee; Oral; Ethinyl Estradiol; Levonorgestrel (Wyeth)

References

  1. DailyMed. "ETHINYL ESTRADIOL; NORETHINDRONE ACETATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "ESTRADIOL; LEVONORGESTREL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "ethinyl estradiol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

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