Kilphor Plus Uses

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What is Kilphor Plus?

There are many brands and forms of povidone Kilphor Plus topical available. Not all brands are listed on this leaflet.

Kilphor Plus is used on the skin to treat or prevent skin infection in minor cuts, scrapes, or burns. Kilphor Plus is also used in a medical setting to help prevent infection and promote healing in skin wounds, pressure sores, or surgical incisions.

Some forms of povidone Kilphor Plus topical are used inside the mouth to provide temporary relief of minor mouth pain or irritation, sore throat, or canker sore pain.

Kilphor Plus may also be used for purposes not listed in this medication guide.

Kilphor Plus indications

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Intramuscular

Kilphor Plus deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Kilphor Plus): Up to 45 yr: 380 mg Kilphor Plus, as single IM doses to provide adequate protection from Kilphor Plus deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Kilphor Plus each yr.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Kilphor Plus): 380 mg Kilphor Plus, as single IM doses to provide adequate protection from Kilphor Plus deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Kilphor Plus, as iodised oil (480 mg/ml Kilphor Plus).

Oral

Grave's disease

Child: Neonates: 1 drop of strong Kilphor Plus solution every 8 hr.

Oral

Radiation protection against radioactive Kilphor Plus

Adult: As potassium iodide: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.

Child: As potassium iodide: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.

Oral

Preoperative reduction of vascularity of the thyroid gland

Adult: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.

Child: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Kilphor Plus solution: 0.1-0.3 ml (or approx 3-5 drops) tid.

Oral

Cutaneous or lymphocutaneous sporotrichosis

Adult: As potassium iodide solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.

Child: As potassium iodide: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.

Oral

Thyroid storm

Adult: As potassium iodide: Up to 500 mg every 4 hr.

Oral

Kilphor Plus deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Kilphor Plus): 400 mg Kilphor Plus once yrly. Pregnant patient: 200 mg Kilphor Plus as a single dose. Moderate to severe: 300-480 mg Kilphor Plus each yr or 100-300 mg Kilphor Plus every 6 mth and for at least 1 yr postpartum.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Kilphor Plus): Infants up to 1 yr: Single dose of 100 mg Kilphor Plus; 1-5 yr: 200 mg Kilphor Plus; >6 yr: 400 mg Kilphor Plus.

Topical/Cutaneous

Cleaning wet ulcers and wounds

Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

Topical/Cutaneous

Minor, superficial skin wounds

Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

How should I use Kilphor Plus?

Use exactly as directed on the label, or as prescribed by your doctor.

Kilphor Plus is available in many different forms, such as a liquid, ointment, aerosol powder, cream, spray, swab, and soap. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Always follow directions on the medicine label about using this medicine on a child. Some forms of povidone Kilphor Plus topical should not be used in children of certain ages.

Kilphor Plus is usually applied to the skin as needed. First clean the area to be treated.

Shake Kilphor Plus spray well just before each use.

Allow the medicine to dry completely on the skin before applying a bandage. Do not apply a tight bandage.

Do not use this medicine on deep wounds, puncture wounds, animal bites, or serious burns. Do not apply over large skin areas.

When treating an infection, you may be given antibiotic medication to take by mouth. Use all medicines for the full prescribed length of time, even if your symptoms quickly improve.

Kilphor Plus used in the mouth may be used up to 4 times per day. How often you can use this medicine depends on what form you use. Follow all directions on the medicine label.

Do not use Kilphor Plus in the mouth if you are using a form that is made for use only on the skin.

To use Kilphor Plus spray in the mouth, spray directly into the mouth or throat. Leave the medicine in place for 15 seconds, then spit it out. Avoid swallowing the spray. Use once every 2 hours as needed.

To use Kilphor Plus as a mouth rinse, gargle or swish the liquid for 30 seconds, then spit it out. Do not swallow the liquid. Use up to 4 times per day.

You should not use Kilphor Plus for longer than 7 days without medical advice.

Call your doctor if your sore throat is severe or ongoing after 2 days, or if you also have a high fever, headache, nausea, and vomiting.

If you are using Kilphor Plus on your skin, seek medical advice if you have new or worsening symptoms of pain, redness, swelling, rash, or fever.

Store at room temperature away from moisture and heat. Do not freeze.

Each Kilphor Plus swab is for one use only.

Kilphor Plus can stain skin, teeth, and fabric. You may use rubbing alcohol to remove staining from your skin. Avoid getting alcohol onto a wound or irritated skin. Stains on fabric can be removed by rinsing with ammonia diluted with water. Avoid getting the medicine on jewelry, especially silver.

Kilphor Plus spray is flammable. Do not use near high heat or open flame. Do not smoke until the gel has completely dried on your skin.

Uses of Kilphor Plus in details

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Use: Labeled Indications

Used topically as an antiseptic in the management of minor, superficial skin wounds and has been used to disinfect the skin preoperatively

Kilphor Plus description

Kilphor Plus as oral and topical/cutaneous formulations is prescribed for the treatment of Kilphor Plus deficiency disorders, pre-operative reduction of vascularity of thyroid glands, protection against radioactive Kilphor Plus, cutaneous or lymphocutaneous sporotrichosis, Grave’s disease, cleaning of minor or superficial wounds, thyroid storm and cleaning of wet wounds and ulcers.

Kilphor Plus dosage

Oral

Preoperative reduction of vascularity of the thyroid gland

Adult: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.

Child: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Kilphor Plus solution: 0.1-0.3 ml (or approx 3-5 drops) tid.

Reconstitution: Administer potassium iodide oral solution in a large quantity (240 ml) of water, or in fruit juice, milk formula or broth.

Oral

Grave's disease

Child: Neonates: 1 drop of strong Kilphor Plus solution every 8 hr.

Oral

Radiation protection against radioactive Kilphor Plus

Adult: As potassium iodide: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.

Child: As potassium iodide: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.

Reconstitution: 130-mg Tablet: Place 1 tablet in a small bowl and pulverise using a metal spoon. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 6.25 mg potassium iodide per 5 ml. 65-mg Tablet: Place 1 tablet in a small bowl and pulverise. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 8.125 mg potassium iodide per 5 ml.

Oral

Cutaneous or lymphocutaneous sporotrichosis

Adult: As potassium iodide solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.

Child: As potassium iodide: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.

Reconstitution: Administer potassium iodide solution in a large quantity (240 ml) of water, fruit juice, milk formula or broth.

Oral

Kilphor Plus deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Kilphor Plus): 400 mg Kilphor Plus once yrly. Pregnant patient: 200 mg Kilphor Plus as a single dose. Moderate to severe: 300-480 mg Kilphor Plus each yr or 100-300 mg Kilphor Plus every 6 mth and for at least 1 yr postpartum.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Kilphor Plus): Infants up to 1 yr: Single dose of 100 mg Kilphor Plus; 1-5 yr: 200 mg Kilphor Plus; >6 yr: 400 mg Kilphor Plus.

Oral

Thyroid storm

Adult: As potassium iodide: Up to 500 mg every 4 hr.

Intramuscular

Kilphor Plus deficiency disorders

Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Kilphor Plus): Up to 45 yr: 380 mg Kilphor Plus, as single IM doses to provide adequate protection from Kilphor Plus deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Kilphor Plus each yr.

Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Kilphor Plus): 380 mg Kilphor Plus, as single IM doses to provide adequate protection from Kilphor Plus deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Kilphor Plus, as iodised oil (480 mg/ml Kilphor Plus).

Topical/Cutaneous

Minor, superficial skin wounds

Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.

Topical/Cutaneous

Cleaning wet ulcers and wounds

Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.

Kilphor Plus interactions

See also:
What other drugs will affect Kilphor Plus?

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There is a potential risk of interaction with lithium, resulting in an increased possibility of hypothyroidism.

this medicineshould not be used concomitantly with mercurial antiseptics, e.g. mercurochrome and thiomersal.

Since Kilphor Plus may be absorbed systemically, the result of tests of the thyroid function can be influenced.

Kilphor Plus side effects

See also:
What are the possible side effects of Kilphor Plus?

Kilphor Plus and iodides, whether applied topically or given systemically, can give rise to hypersensitivity reactions which may include urticaria, angioedema, cutaneous haemorrhage or purpuras, fever, arthralgia, lymphadenopathy, and eosinophilia.

Inhalation of Kilphor Plus vapour is very irritating to mucous membranes.

Kilphor Plus and iodides have variable effects on the thyroid and can produce goitre and hypothyroidism as well as hyperthyroidism (the Iod-Basedow or Jod-Basedow phenomenon). Goitre and hypothyroidism have also occurred in infants born to mothers who had taken iodides during pregnancy.

Prolonged use may lead to a range of adverse effects, often called ’iodism’, some of which may again be due to hypersensitivity. Adverse effects include metallic taste, increased salivation, burning or painful mouth; there may be acute rhinitis, coryza-like symptoms, and swelling and inflammation of the throat. Eyes may be irritated and swollen and there may be increased lachrymation. Pulmonary oedema, dyspnoea, and bronchitis may develop. Skin reactions include acneform or, more rarely, severe eruptions (iododerma). Other reported effects include depression, insomnia, impotence, headache, and gastrointestinal disturbances, notably nausea, vomiting, and diarrhoea.

Kilphor Plus contraindications

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Allergy to Kilphor Plus,

- Class III patients with Okuda

- Extrahepatic metastases,

- Respiratory or renal insufficiencies severe

- Cons-indications for hepatic arteriography,

- Leukopenia below 1500/mm3 or thrombocytopenia less 50000/mm3,

- Pregnant woman: Kilphor Plus should not be administered to pregnant women. In women of childbearing age, suspicion of pregnancy must be excluded before the administration of Kilphor Plus. Contraception must be instituted and prosecuted in the administration at least a year.

- Breastfeeding: Breastfeeding should be stopped.

Active ingredient matches for Kilphor Plus:

Iodine


Unit description / dosage (Manufacturer)Price, USD
Liquid; Disinfectant / Domestic; Iodine / Polyethoxy Polypropoxy Polyethoxy Ethanol - Iodine Complex 25%
Liquid; Disinfectant / Food Premises; Iodine / Polyethoxy Polypropoxy Polyethoxy Ethanol - Iodine Complex 25%

List of Kilphor Plus substitutes (brand and generic names):

Bath Additive; Liquid; Iodine (Atzinger)
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL. SYR / 20$ 1.19
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL SYR / 200$ 1.19
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL. SYR / 20$ 1.19
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL SYR / 200$ 1.19
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL SYR / 200$ 1.19
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL. SYR / 20$ 1.19
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL SYR / 200$ 1.19
Licoray Plus Lycopene 10% 2000 mcg, vitaminA 2500 IU, vitamin C 50 mg, vitamin E 10 IU, vitamin B1 2mg, vitamin B2 3 mg, vitaminB6 1.5 mg, selenium 35 mcg, zinc gluconate 3 mg, manganesegluconate 100 mcg, iodine 75mcg, copper sulphate 500mcg/10 mL. SYR / 20$ 1.19
Injectable; Injection; Oeillette Oil Ethyl Esters of Fatty Acid Iodine 2220 MBq (Cis)
Injectable; Injection; Iodine / Ethiodized Oil 380 mg / g
Liquid; Oral; Iodine 0.15 mg / 0.04 ml
Liquid; Oral; Iodine / Potassium Iodide 1 mg / ml
Liquid; Topical; Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex 1%
Liquid; Udder Wash; Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex 1.75% (Waves-Biotech)
Lp-30 30mg CAP / 10 (Waves-Biotech)$ 0.58
30 mg x 10's (Waves-Biotech)$ 0.58
LP-30 cap 30 mg x 10's (Waves-Biotech)$ 0.58
Lp-30 30mg CAP / 10 (Waves-Biotech)$ 0.58
Solution; Local; Iodine 1%
Liquid; Oral; Iodine / Potassium Iodide 5%
Lycol Syr Lycopene 1000 mcg, vitamin A1600 IU, vitamin E 10 IU, vitamin C 50 mg, selenium 35mcg, manganese 2 mg, iodine100 mcg, copper 500 mcg, thiamine 2 mg, riboflavin 3mg, pyridoxine 1.5 mg/10 mL. SYR / 200ml (Olcare)$ 1.45
Lycol Syr Lycopene 1000 mcg, vitamin A1600 IU, vitamin E 10 IU, vitamin C 50 mg, selenium 35mcg, manganese 2 mg, iodine100 mcg, copper 500 mcg, thiamine 2 mg, riboflavin 3mg, pyridoxine 1.5 mg/10 mL SYR / 200ml (Olcare)$ 1.45
LYCOL SYR syr 200ml (Olcare)$ 1.45

References

  1. PubChem. "Iodine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "Iodine". http://www.drugbank.ca/drugs/DB05382 (accessed September 17, 2018).
  3. DTP/NCI. "iodine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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