Kwellada Uses

How do you administer this medicine?
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What is Kwellada?

Treating head lice.

Kwellada cream rinse is a scabicide. It works by killing lice, although this process is not fully understood. It may attack the nervous system of adult lice or interfere with the development of the eggs they produce.

Kwellada indications

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Kwellada Cream, 5% is indicated for the treatment of infestation with Sarcoptesscabiei(scabies).

How should I use Kwellada?

Use Kwellada lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Kwellada lotion.

Uses of Kwellada in details

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Kwellada is used to treat scabies (itchy and highly contagious skin infestation by itch mite sarcoptes scabiei), infestation by head lice (head paediculosis) and pubic infestation (paediculosis pubis).

Kwellada description

Kwellada is an epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.

Kwellada dosage

Usual Adult Dose for Scabies

Kwellada topical 5% cream:

Thoroughly massage into the skin from the neck to the soles of the feet. The cream should be removed by washing (shower or bath) after 8 to 14 hours.

Usual Adult Dose for Lice

Kwellada topical 1% kit:

Apply lotion/creme rinse to shampooed and towel-dried hair until hair and scalp are saturated (especially behind the ears and on the nape of the neck). Leave on hair for 10 minutes and rinse with water. Use comb and/or gloves provided to remove remaining nits.

Kwellada topical 1% solution:

Apply to shampooed and towel-dried hair until hair and scalp are saturated (especially behind the ears and on the nape of the neck). Leave on hair for 10 minutes and rinse with water.

Usual Pediatric Dose for Scabies

Kwellada topical 5% cream

Infants: Thoroughly massage along the hairline, neck, temple, and forehead. The cream should be removed by washing after 8 to 14 hours.

Usual Pediatric Dose for Lice

Kwellada topical 1% kit:

2 months or older: Apply lotion/creme rinse to shampooed and towel-dried hair until hair and scalp are saturated (especially behind the ears and on the nape of the neck). Leave on hair for 10 minutes and rinse with water. Use comb and/or gloves provided to remove remaining nits.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

For external use only. Avoid contact with the eyes and mucous membranes. If contact occurs, wash the area thoroughly with water.

Usually 30 grams of Kwellada cream is sufficient for an average adult.

Scabies rarely infest the scalp of adults, although the hairline, neck, temple, and forehead may be infested in geriatric patients and infants.

One application is generally curative. A second treatment of Kwellada lotion may be given for patients that present with live lice 7 days after the initial treatment.

Patients may experience persistent pruritus after treatment for scabies. Demonstrable living mites after 14 days indicate retreatment is necessary.

Safety and efficacy in children under the age of 2 months have not been established.

Dialysis

Data not available

Other Comments

Concomitant treatment of individuals in the household is recommended to avoid reinfestation. Thorough cleaning of all clothing and bedding is required once treatment has begun.

For proper head lice management, nits should be removed with a nit comb.

Kwellada interactions

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Bile acid sequestering agents such as cholestyramine and colestipol may interfere with the action of Ursodiol by reducing its absorption. Aluminum-based antacids have been shown to adsorb bile acids in vitro and may be expected to interfere with Ursodiol in the same manner as the bile acid sequestering agents. Estrogens, oral contraceptives, and clofibrate (and perhaps other lipid-lowering drugs) increase hepatic cholesterol secretion, and encourage cholesterol gallstone formation and hence may counteract the effectiveness of Ursodiol.

Kwellada side effects

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What are the possible side effects of Kwellada?

In clinical trials, generally mild and transient burning and stinging followed application with Kwellada cream, 5% in 10% of patients and was associated with the severity of infestation. Pruritus was reported in 7% of patients at various times post-application. Erythema, numbness, tingling, and rash were reported in 1 to 2% or less of patients. Other adverse events reported since marketing Kwellada cream, 5% include: headache, fever, dizziness, abdominal pain, diarrhea and nausea and/or vomiting. Although extremely uncommon and not expected when used as directed, rare occurrences of seizure have been reported. None have been medically confirmed as associated with Kwellada Cream, 5% treatment.

Kwellada contraindications

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What is the most important information I should know about Kwellada?

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Kwellada Lotion is contraindicated for premature neonates because their skin may be more permeable than full term infants and their liver enzymes may not be sufficiently developed. It is also contraindicated for patients with Norwegian (crusted) scabies due to possible increased absorption. It is also contraindicated for patients with known seizure disorders and for individuals with a known sensitivity to the product or any of its components.

Active ingredient matches for Kwellada:

Permethrin in Canada, Turkey.

Lindane in Canada.


Unit description / dosage (Manufacturer)Price, USD
Lotion; Topical; Lindane 1%
Shampoo; Topical; Lindane 1%

List of Kwellada substitutes (brand and generic names):

Kwellada Lotion 1% lotion 1 % (Reed & Carnrick, Division Of Block Drug Company (Canada) Ltd.)
Liquid; Topical; Permethrin 1%
Kwellada-P CRème Rinse liquid 1.0 % (Medtech Products Inc (Canada))
Lotion; Topical; Permethrin 5%
Kwellada-P Lotion lotion 5 % (Medtech Products Inc (Canada))
Le-scab - TAB / 10
Lescab - LOTION / 60ml
Lexilice 5%w/w CREAM / 30gm
Lexilice - SOAP / 75gm
Licenil 5%w/v CREAM / 10gm (Shinto Biotec)
Licenil 5% SOAP / 75gm (Shinto Biotec)
LICENIL soap 5 % x 75g (Shinto Biotec)$ 0.80
LICENIL lotion 5 % x 60ml (Shinto Biotec)$ 0.96
Lotion; Topical; Lindane 1%
Shampoo; Topical; Lindane 1%
Lindane 1% Lotion 60ml Bottle$ 142.33
Lindane 1% Shampoo 60ml Bottle$ 142.33
Lindane 1% lotion$ 5.16

References

  1. DailyMed. "PERMETHRIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "LINDANE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "lindane". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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