What is Lo / Ovral-28?
Ethinyl estradiol (Lo / Ovral-28) and Norgestrel (Lo / Lo / Ovral-28-28) combination is used to prevent pregnancy. It works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization (pregnancy) is prevented.
No contraceptive method is 100 percent effective. Birth control methods such as having surgery to become sterile or not having sex are more effective than birth control pills. Discuss your options for birth control with your doctor.
Lo / Ovral-28 (Lo / Lo / Ovral-28-28) will not prevent HIV infection or other sexually transmitted diseases. It will not help as emergency contraception, such as after unprotected sexual contact.
Lo / Ovral-28 (Lo / Lo / Ovral-28-28) is available only with your doctor's prescription.
Lo / Ovral-28 indications
Low-Lo / Ovral-28® (Norgestrel (Lo / Lo / Ovral-28-28) and Ethinyl estradiol (Lo / Ovral-28) tablets USP, 0.3 mg/0.03 mg) is indicated for the prevention of pregnancy in women who elect to use this product as a method of contraception.
Oral contraceptives are highly effective. Table I lists the typical accidental pregnancy rates for users of combination oral contraceptives and other methods of contraception.1 The efficacy of these contraceptive methods, except sterilization, depends upon the reliability with which they are used. Correct and consistent use of methods can result in lower failure rates.
TABLE I: PERCENTAGE OF WOMEN EXPERIENCING AN UNINTENDED PREGNANCY DURING THE FIRST YEAR OF A CONTRACEPTIVE METHOD
| Method | Perfect use | Average use |
| Levonorgestrel implants | 0.05 | 0.05 |
| Male sterilization | 0.1 | 0.15 |
| Female sterilization | 0.5 | 0.5 |
| Depo-Provera® (injectable progestogen) | 0.3 | 0.3 |
Oral contraceptive | 5 | |
| Combined | 0.1 | NA |
| Progestin only | 0.5 | NA |
| IUD | ||
| Progesterone | 1.5 | 2 |
| Copper T 380A | 0.6 | 0.8 |
| Condom (male) without spermicide | 3 | 14 |
| (female) without spermicide | 5 | 21 |
| Cervical cap | ||
| Never given birth | 9 | 20 |
| Given birth | 26 | 40 |
| Vaginal sponge | ||
| Never given birth | 9 | 20 |
| Given birth | 20 | 40 |
| Diaphragm with spermicidal cream or jelly | 6 | 20 |
| Spermicides alone (foam, creams, jellies, and vaginal suppositories) | 6 | 26 |
| Periodic abstinence (all methods) | 1-9* | 25 |
| Withdrawal | 4 | 19 |
| No contraception (planned pregnancy) | 85 | 85 |
| NA- not available *Depending on method (calender, ovulation symptothermal, post-ovulation) Adapted from Hatcher RA et al, Contraceptive Technology: 17 th Revised Edition. NY, NY: Ardent Medi, Inc., 1998 |
How should I use Lo / Ovral-28?
Use Lo / Ovral-28 as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Lo / Ovral-28 by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Begin taking Lo / Ovral-28 on the first Sunday following the start of your period, unless otherwise directed by your doctor. If your period begins on a Sunday, begin taking Lo / Ovral-28 on that day. Try to take Lo / Ovral-28 at the same time every day, not more than 24 hours apart. After taking the last pill in the pack, start taking the first pill from a new pack the very next day.
- Lo / Ovral-28 works best if it is taken at the same time each day. Do not skip doses.
- If you miss 1 dose of Lo / Ovral-28, take it as soon as you remember. Take your next dose at the regular time. This means you may take 2 doses on the same day. If you miss more than 1 dose of Lo / Ovral-28, read the extra patient information leaflet that comes with Lo / Ovral-28 or contact your doctor for instructions. If you miss 1 or more doses of Lo / Ovral-28, you must use a backup form of birth control for 7 days after you start to take it again. If you are not sure about how to handle miss doses, use an extra form of birth control (eg, condoms) and talk with your doctor.
Ask your health care provider any questions you may have about how to use Lo / Ovral-28.
Lo / Ovral-28 description
A synthetic progestational hormone with actions similar to those of progesterone and about twice as potent as its racemic or (+-)-isomer (Norgestrel (Lo / Lo / Ovral-28-28)). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.
Lo / Ovral-28 dosage
Low-Lo / Ovral-28 Dosage
Generic name: Ethinyl estradiol (Lo / Ovral-28) 0.03mg, Norgestrel (Lo / Lo / Ovral-28-28) 0.3mg;
Dosage form: tablets
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
To achieve maximum contraceptive effectiveness, oral contraceptives must be taken exactly as directed and at intervals not exceeding 24 hours.
28-Day Schedule
For a DAY 1 START, count the first day of menstrual flow as Day 1 and the first tablet (white) is then taken on Day 1. For a SUNDAY START when menstrual flow begins on or before Sunday, the first tablet (white) is taken on that day. With either a DAY 1 START or SUNDAY START, 1 tablet (white) is taken each day at the same time for 21 days. Then the peach tablets are taken for 7 days, whether bleeding has stopped or not. After all 28 tablets have been taken, whether bleeding has stopped or not, the same dosage schedule is repeated beginning on the following day.
More about Low-Lo / Ovral-28-21 (Ethinyl estradiol (Lo / Ovral-28) / Norgestrel (Lo / Lo / Ovral-28-28))
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Espanol
- 3 Reviews - Add your own review/rating
Consumer resources
- Low-Lo / Ovral-28
- Other brands: Lo / Ovral-28, Lo/Lo / Ovral-28
Professional resources
- Low-Lo / Ovral-28 (FDA)
Other formulations
- Lo / Ovral-28
- Lo / Ovral-28-28
Related treatment guides
- Abnormal Uterine Bleeding
- Birth Control
- Endometriosis
- Gonadotropin Inhibition
Lo / Ovral-28 interactions
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What other drugs will affect Lo / Ovral-28?
This medication alters the bioavailability of any drug, absorption depends on pH (ketoconazole, iron salts, etc.). Lo / Ovral-28 Scoshia Remedy slows down the elimination of drugs metabolized in the liver by microsomal oxidation (warfarin, diazepam, phenytoin, etc.).
Lo / Ovral-28 Scoshia Remedy enhances the action of coumarin and diphenine, does not change - NSAIDs. This drug increases (relative) the concentration of clarithromycin in the blood; may increases the leukopenic and thrombocytopenic effects of depressants hematopoiesis drugs. Substance for intravenous infusion is compatible only with saline and dextrose (using other solvents may decrease the stability of omeprazole due to changes in pH of infusion medium).
Lo / Ovral-28 side effects
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What are the possible side effects of Lo / Ovral-28?
Applies to Ethinyl estradiol (Lo / Ovral-28) / Norgestrel (Lo / Lo / Ovral-28-28): tablets
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Acne; breast tenderness or enlargement; changes in appetite; changes in weight; dizziness; headache; mild hair loss; nausea; nervousness; stomach cramps or bloating; vaginal spotting or breakthrough bleeding.
Seek medical attention right away if any of these SEVERE side effects occur while taking Ethinyl estradiol (Lo / Ovral-28) / Norgestrel (Lo / Lo / Ovral-28-28):
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue, unusual hoarseness); absent menstrual period; breast discharge; breast lumps; calf or leg pain, swelling, or tenderness; change in the amount of urine produced; chest pain or heaviness; confusion; coughing of blood; dark urine; fainting; mental or mood changes (eg, depression); migraines; numbness of an arm or leg; one-sided weakness; pale stools; persistent, severe, or recurring headache or dizziness; persistent vaginal spotting; severe pain or tenderness in the stomach; shortness of breath; slurred speech; sudden severe headache or vomiting; swelling of the fingers, hands, legs, or ankles; unusual or severe vaginal bleeding; unusual tiredness or weakness; vaginal irritation, discharge, or change in secretions; vision changes (eg, sudden vision loss, double vision); yellowing of the skin or eyes (with or without fever).
Lo / Ovral-28 contraindications
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What is the most important information I should know about Lo / Ovral-28?
Combination oral contraceptives should not be used in women with any of the following conditions: - Thrombophlebitis or thromboembolic disorders - A past history of deep-vein thrombophlebitis or thromboembolic disorders - Cerebral-vascular or coronary-artery disease (current or history) - Thrombogenic valvulopathies - Thrombogenic rhythm disorders - Major surgery with prolonged immobilization - Diabetes with vascular involvement - Headaches with focal neurological symptoms - Uncontrolled hypertension Known or suspected carcinoma of the breast or personal history of breast cancer - Carcinoma of the endometrium or other known or suspected estrogen-dependent neoplasia - Undiagnosed abnormal genital bleeding - Cholestatic jaundice of pregnancy or jaundice with prior pill use - Hepatic adenomas or carcinomas, or active liver disease, as long as liver function has not returned to normal - Known or suspected pregnancy - Hypersensitivity to any of the components of Lo/Lo / Ovral-28
Active ingredient matches for Lo / Ovral-28:
List of Lo / Ovral-28 substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Lo Ovral 28 | |
| Lo-Femenal | |
| Tablet; Oral; Ethinyl Estradiol 0.03 mg; Norgestrel 0.3 mg | |
| Lo-Femenal 21 | |
| Tablet; Oral; Ethinyl Estradiol 0.03 mg; Norgestrel 0.3 mg | |
| Lo/ Ovral | |
| Lo/ Ovral | |
| Lo/Ovral | |
| Lo/Ovral-28 | |
| Low-Ogestrel | |
| Tablet; Oral-21; Ethinyl Estradiol 0.03 mg; Norgestrel 0.3 mg | |
| Tablet; Oral-28; Ethinyl Estradiol 0.03 mg; Norgestrel 0.3 mg | |
| Low-Ogestrel-21 | |
| Low-Ogestrel-28 | |
| Norgestrel/ ethinyl estradiol | |
| Norgestrel/Ethinyl Estradiol (Philippines) | |
| Ogestrel | |
| Tablet; Oral-21; Ethinyl Estradiol 0.05 mg; Norgestrel 0.5 mg (Scoshia Remedy Inc.) | |
| Tablet; Oral-28; Ethinyl Estradiol 0.05 mg; Norgestrel 0.5 mg (Scoshia Remedy Inc.) | |
| 20 mg x 300's (Scoshia Remedy Inc.) | $ 13.01 |
| Ogestrel 20mg CAP / 20x15 (Scoshia Remedy Inc.) | $ 13.01 |
| Ogestrel 20 mg Capsule (Scoshia Remedy Inc.) | $ 0.04 |
| OGESTREL cap 20 mg x 10's (Scoshia Remedy Inc.) | $ 0.43 |
| Ogestrel 0.5 / 50 | |
| Ogestrel-28 | |
| Ovral (Ethiopia, India, Peru, South Africa) | |
| Tablet; Oral-21; Ethinyl Estradiol 0.05 mg; Norgestrel 0.25 mg (Wyeth Ltd.) | |
| Tablet; Oral-21; Ethinyl Estradiol 0.05 mg; Norgestrel 0.5 mg (Wyeth Ltd.) | |
| Tablet; Oral-28; Ethinyl Estradiol 0.05 mg; Norgestrel 0.25 mg (Wyeth Ltd.) | |
| Tablet; Oral-28; Ethinyl Estradiol 0.05 mg; Norgestrel 0.5 mg (Wyeth Ltd.) | |
| OVRAL Capsule/ Tablet / 0.05mg - 0.25mg / 21 units (Wyeth Ltd.) | $ 0.60 |
| Ovral Levonorgestrel 0.25mg, EthinylEstradiol 0.05mg TAB / 21 (Wyeth Ltd.) | $ 0.45 |
| 21's (Wyeth Ltd.) | $ 0.45 |
| Ovral Levonorgestrel 0.25 mg, Ethinyl estradiol 0.05 mg. TAB / 21 (Wyeth Ltd.) | $ 0.45 |
| Ovral 0.25+0.05 Tablet (Wyeth Ltd.) | $ 0.03 |
| OVRAL TABLET 1 strip / 21 tablets each (Wyeth Ltd.) | $ 0.85 |
| OVRAL tab 21's (Wyeth Ltd.) | $ 0.45 |
| Ovral Tablet (Wyeth Ltd.) | $ 0.04 |
| Ovral 28 | |
| Tablet; Oral-21; Ethinyl Estradiol 0.05 mg; Norgestrel 0.25 mg | |
| Tablet; Oral-21; Ethinyl Estradiol 0.05 mg; Norgestrel 0.5 mg | |
| Tablet; Oral-28; Ethinyl Estradiol 0.05 mg; Norgestrel 0.25 mg | |
| Tablet; Oral-28; Ethinyl Estradiol 0.05 mg; Norgestrel 0.5 mg | |
| Ovral-21 | |
| Ovral-28 | |
| Primovlar (Brazil) | |
| Schering PC4 (United Kingdom) | |
See 55 substitutes for Lo / Ovral-28 | |
References
- DailyMed. "ETHINYL ESTRADIOL; NORETHINDRONE ACETATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "ETHINYL ESTRADIOL; NORGESTREL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "ethinyl estradiol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Lo / Ovral-28 are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lo / Ovral-28. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
