Mecobalamin indications
Pernicious anemia, both uncomplicated and accompanied by nervous system involvement.
Dietary deficiency of Vitamin B12, occurring in strict vegetarians and in their breast-fed infants. (Isolated vitamin B12 deficiency is very rare).
Malabsorption of vitamin B12, resulting from structural or functional damage to the stomach, where intrinsic factor is secreted or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency.
Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency.
Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc.
Competition for Vitamin B12 by intestinal parasites or bacteria.
The fish tapeworm (Diphyilobothrium latum) absorbs huge quantities of vitamin B12 and infested patients often have associated gastric atrophy. The blind-loop syndrome may produce deficiency of Vitamin B12 or folate.
Inadequate utilization of vitamin B12. This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.
For the Schilling Test.
Mecobalamin description
Mecobalamin also contains the following inactive ingredients: Lactose, maize starch, microcrystalline cellulose, povidone (K-30), purified talc, anhydrous colloidal silica, hypromellose, macrogol, titanium dioxide, isopropyl alcohol, dicholoromethane, red iron oxide and yellow iron oxide.
Mecobalamin dosage
Mecobalamin-500: The daily dose is 1 tab 3 times daily.
Mecobalamin-1500: The daily dose is 1 tab once daily. The dosage should be adjusted according to age of patient and severity of symptoms.
Mecobalamin interactions
Antibiotics: The use of antibiotics may alter the intestinal microflora and may decrease the possible contribution of Mecobalamin by certain inhabitants of the microflora (eg, Lactobacillus spp) to the body's requirement for the vitamin. This may particularly be a problem for vegetarians. Garlic, onions, leeks, bananas, asparagus and artichokes, among other vegetables and fruits, contain inulins which promote the growth of certain colonic bacteria including Lactobacillus spp. Cholestyramine:
Colchicine: Colchicine may cause decreased absorption of Mecobalamin. Colestipol:
H2-Blockers (Cimetidine, Famotidine, Nizatidine, Ranitidine): Chronic use of H2-blockers may result to decreased absorption of Mecobalamin. They are unlikely to affect the absorption of supplemental B12.
Metformin: Metformin may decrease the absorption of Mecobalamin. This possible effect may be reversed with oral calcium supplementation.
Nitrous Oxide: Inhalation of the anesthetic agent nitrous oxide (not to be confused with nitric oxide) can produce a functional deficiency. Nitrous oxide forms a complex with cobalt in Mecobalamin, the cofactor for methionine synthase, resulting in inactivation of the enzyme.
Para-Amino Salicylic Acid: Chronic use of the anti-tuberculosis drug may decrease the absorption of Mecobalamin.
Potassium Chloride: It has been reported that potassium chloride may decrease the absorption of Mecobalamin.
Proton Pump Inhibitors (Lansoprazole, Omeprazole, Pantoprazole, Rabeprazole): Chronic use of proton pump inhibitors may result in decreased absorption, naturally found in food sources.
Mecobalamin side effects
water weight gain, edema, increase in BUN, and dilutional hyponatremia. Asterixis was reported to have worsened in one patient during infusion of this medicine.
Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.
Symptoms may result from an excess or deficit of one or more of the ions present in the solution; therefore, frequent monitoring of electrolyte levels is essential.
Phosphorus deficiency may lead to impaired tissue oxygenation and acute hemolytic anemia. Relative to calcium, excessive phosphorus intake can precipitate hypocalcemia with cramps, tetany and muscular hyperexcitability.
If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.
Mecobalamin contraindications
Hypersensitivity to Mecobalamin or other vit B12-containing, cobalamin products or cobalt.
Active ingredient matches for Mecobalamin:
Mecobalamin
| Unit description / dosage (Manufacturer) | Price, USD |
| Mecobalamin / Tsuruhara 500 mcg x 1000's | |
| Mecobalamin / Tsuruhara 500 mcg/1 mL x 1 mL | |
| Mecobalamin / Astar 500 mcg/1 mL x 1 mL | |
| Mecobalamin / Astar 500 mcg/1 mL x 2 mL | |
| Mecobalamin / Astar 500 mcg/1 mL x 5 mL | |
| Mecobalamin / Towa 500 mcg | |
List of Mecobalamin substitutes (brand and generic names): | |
| Mecobal-OD (India) | |
| MECOBAL-OD tab 1500 mcg x 10's (Rapross) | $ 0.83 |
| Mecobalamin Daiko (Japan) | |
| Mecobalamin DK (Japan) | |
| Mecobalamin JG (Japan) | |
| Mecobalamin NP (Japan) | |
| Mecobalamin Towa (Taiwan) | |
| Mecobalamin Towa Yakuhin (Japan) | |
| Mecobalamin Tsuruhara (Japan) | |
| Mecobalamin YD (Japan) | |
| Mecobalamin-Daito (Thailand) | |
| Mecobalamin-Daito 500 mcg x 100's (Daito) | |
| Mecobalamin-Daito 500 mcg x 500's (Daito) | |
| Mecobalamin-Daito tab 500 mcg 100's (Daito) | |
| Mecobalamin-Daito tab 500 mcg 500's (Daito) | |
| Mecobalamine (Japan) | |
| Mecobamide (Japan) | |
| Mecobest (India) | |
| Mecobest 500 mcg INJ / 1ml (Lupin (Lupinova)) | |
| 500 mcg x 1ml (Lupin (Lupinova)) | |
| MECOBEST inj 500 mcg x 1ml (Lupin (Lupinova)) | |
| Mecobex Tab (India) | |
| Mecobex Tab Mecobalamin 500 mcg, Thiaminemononitrate 10 mg, pyridoxinehydrochloride 3 mg, folic acid0.75 mg. TAB / 200 (Burgeon) | $ 3.61 |
| 200's (Burgeon) | $ 3.61 |
| MECOBEX TAB tab 10's (Burgeon) | $ 0.18 |
| Mecobil-P (India) | |
| Mecobil-P Pregabalin 75 mg, Mecobalamin500 mcg. CAP / 10 (Vilberry) | $ 0.96 |
| 10's (Vilberry) | $ 0.96 |
| MECOBIL-P cap 10's (Vilberry) | $ 0.96 |
| Mecobin (Thailand) | |
| Mecobin 0.5 mg x 10's (Unison) | |
| Mecobin 0.5 mg x 3 x 10's (Unison) | |
| Mecobin 0.5 mg x 50 x 10's (Unison) | |
| Mecobin FC tab 0.5 mg 10's (Unison) | |
| Mecobin FC tab 0.5 mg 25 x 10's (Unison) | |
| Mecocob (India) | |
| Mecocob 1500 mcg INJ / 2ml (Skyways) | $ 0.40 |
| MECOCOB inj 1500 mcg x 2ml (Skyways) | $ 0.40 |
| Mecocob-G (India) | |
| Mecocob-G Mecobalamin 500 mcg, gabapentin 300 mg. TAB / 10x10 (Skyways) | $ 14.46 |
| MECOCOB-G tab 10's (Skyways) | $ 1.45 |
| Mecocob-M (India) | |
| Mecocob-M Mecobalamin 1000 mcg, pyridoxine hydrochloride 100mg, nicotinamide 100 mg. INJ / 2ml (Skyways) | $ 0.46 |
| MECOCOB-M inj 2ml (Skyways) | $ 0.46 |
| Mecocob-P (India) | |
| Mecocob-P Mecobalamin 750 mcg, pregabalin 75 mg. CAP / 10x10 (Skyways) | $ 12.65 |
| MECOCOB-P cap 10's (Skyways) | $ 1.27 |
| Mecoday-G (India) | |
| Mecoday-G Methylcobalamin 500 mcg, Gabapentin 300 mg. TAB / 10 (Invision (Idalis)) | $ 1.17 |
| 10's (Invision (Idalis)) | $ 1.17 |
| MECODAY-G tab 10's (Invision (Idalis)) | $ 1.17 |
| Mecoday-PG (India) | |
| Mecoday-PG Pregabalin 75 mg, Methylcobalamin 750 mg. CAP / 10 (Invision (Idalis)) | $ 1.33 |
| 10's (Invision (Idalis)) | $ 1.33 |
See 2610 substitutes for Mecobalamin | |
Reviews
The results of a survey conducted on ndrugs.com for Mecobalamin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Mecobalamin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported useful
Was the Mecobalamin drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
| Users | % | ||
|---|---|---|---|
| Useful | 1 | 100.0% | |
Consumer reported price estimates
No survey data has been collected yet5 consumers reported time for results
To what extent do I have to use Mecobalamin before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 2 weeks and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Mecobalamin. To get the time effectiveness of using Mecobalamin drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 2 weeks | 2 | 40.0% | |
| > 3 month | 1 | 20.0% | |
| 5 days | 1 | 20.0% | |
| 3 month | 1 | 20.0% | |
14 consumers reported age
| Users | % | ||
|---|---|---|---|
| 46-60 | 4 | 28.6% | |
| 30-45 | 4 | 28.6% | |
| 16-29 | 3 | 21.4% | |
| > 60 | 1 | 7.1% | |
| 6-15 | 1 | 7.1% | |
| < 1 | 1 | 7.1% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
