What is Metadyne?
There are many brands and forms of povidone Metadyne topical available. Not all brands are listed on this leaflet.
Metadyne is used on the skin to treat or prevent skin infection in minor cuts, scrapes, or burns. Metadyne is also used in a medical setting to help prevent infection and promote healing in skin wounds, pressure sores, or surgical incisions.
Some forms of povidone Metadyne topical are used inside the mouth to provide temporary relief of minor mouth pain or irritation, sore throat, or canker sore pain.
Metadyne may also be used for purposes not listed in this medication guide.
Metadyne indications
Intramuscular
Metadyne deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Metadyne): Up to 45 yr: 380 mg Metadyne, as single IM doses to provide adequate protection from Metadyne deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Metadyne each yr.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Metadyne): 380 mg Metadyne, as single IM doses to provide adequate protection from Metadyne deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Metadyne, as iodised oil (480 mg/ml Metadyne).
Oral
Grave's disease
Child: Neonates: 1 drop of strong Metadyne solution every 8 hr.
Oral
Radiation protection against radioactive Metadyne
Adult: As potassium iodide: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.
Child: As potassium iodide: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.
Oral
Preoperative reduction of vascularity of the thyroid gland
Adult: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.
Child: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Metadyne solution: 0.1-0.3 ml (or approx 3-5 drops) tid.
Oral
Cutaneous or lymphocutaneous sporotrichosis
Adult: As potassium iodide solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.
Child: As potassium iodide: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.
Oral
Thyroid storm
Adult: As potassium iodide: Up to 500 mg every 4 hr.
Oral
Metadyne deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Metadyne): 400 mg Metadyne once yrly. Pregnant patient: 200 mg Metadyne as a single dose. Moderate to severe: 300-480 mg Metadyne each yr or 100-300 mg Metadyne every 6 mth and for at least 1 yr postpartum.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Metadyne): Infants up to 1 yr: Single dose of 100 mg Metadyne; 1-5 yr: 200 mg Metadyne; >6 yr: 400 mg Metadyne.
Topical/Cutaneous
Cleaning wet ulcers and wounds
Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
Topical/Cutaneous
Minor, superficial skin wounds
Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
How should I use Metadyne?
Use exactly as directed on the label, or as prescribed by your doctor.
Metadyne is available in many different forms, such as a liquid, ointment, aerosol powder, cream, spray, swab, and soap. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Always follow directions on the medicine label about using this medicine on a child. Some forms of povidone Metadyne topical should not be used in children of certain ages.
Metadyne is usually applied to the skin as needed. First clean the area to be treated.
Shake Metadyne spray well just before each use.
Allow the medicine to dry completely on the skin before applying a bandage. Do not apply a tight bandage.
Do not use this medicine on deep wounds, puncture wounds, animal bites, or serious burns. Do not apply over large skin areas.
When treating an infection, you may be given antibiotic medication to take by mouth. Use all medicines for the full prescribed length of time, even if your symptoms quickly improve.
Metadyne used in the mouth may be used up to 4 times per day. How often you can use this medicine depends on what form you use. Follow all directions on the medicine label.
Do not use Metadyne in the mouth if you are using a form that is made for use only on the skin.
To use Metadyne spray in the mouth, spray directly into the mouth or throat. Leave the medicine in place for 15 seconds, then spit it out. Avoid swallowing the spray. Use once every 2 hours as needed.
To use Metadyne as a mouth rinse, gargle or swish the liquid for 30 seconds, then spit it out. Do not swallow the liquid. Use up to 4 times per day.
You should not use Metadyne for longer than 7 days without medical advice.
Call your doctor if your sore throat is severe or ongoing after 2 days, or if you also have a high fever, headache, nausea, and vomiting.
If you are using Metadyne on your skin, seek medical advice if you have new or worsening symptoms of pain, redness, swelling, rash, or fever.
Store at room temperature away from moisture and heat. Do not freeze.
Each Metadyne swab is for one use only.
Metadyne can stain skin, teeth, and fabric. You may use rubbing alcohol to remove staining from your skin. Avoid getting alcohol onto a wound or irritated skin. Stains on fabric can be removed by rinsing with ammonia diluted with water. Avoid getting the medicine on jewelry, especially silver.
Metadyne spray is flammable. Do not use near high heat or open flame. Do not smoke until the gel has completely dried on your skin.
Uses of Metadyne in details
Use: Labeled Indications
Used topically as an antiseptic in the management of minor, superficial skin wounds and has been used to disinfect the skin preoperatively
Metadyne description
Metadyne as oral and topical/cutaneous formulations is prescribed for the treatment of Metadyne deficiency disorders, pre-operative reduction of vascularity of thyroid glands, protection against radioactive Metadyne, cutaneous or lymphocutaneous sporotrichosis, Grave’s disease, cleaning of minor or superficial wounds, thyroid storm and cleaning of wet wounds and ulcers.
Metadyne dosage
Oral
Preoperative reduction of vascularity of the thyroid gland
Adult: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.
Child: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Metadyne solution: 0.1-0.3 ml (or approx 3-5 drops) tid.
Reconstitution: Administer potassium iodide oral solution in a large quantity (240 ml) of water, or in fruit juice, milk formula or broth.
Oral
Grave's disease
Child: Neonates: 1 drop of strong Metadyne solution every 8 hr.
Oral
Radiation protection against radioactive Metadyne
Adult: As potassium iodide: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.
Child: As potassium iodide: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.
Reconstitution: 130-mg Tablet: Place 1 tablet in a small bowl and pulverise using a metal spoon. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 6.25 mg potassium iodide per 5 ml. 65-mg Tablet: Place 1 tablet in a small bowl and pulverise. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 8.125 mg potassium iodide per 5 ml.
Oral
Cutaneous or lymphocutaneous sporotrichosis
Adult: As potassium iodide solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.
Child: As potassium iodide: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.
Reconstitution: Administer potassium iodide solution in a large quantity (240 ml) of water, fruit juice, milk formula or broth.
Oral
Metadyne deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Metadyne): 400 mg Metadyne once yrly. Pregnant patient: 200 mg Metadyne as a single dose. Moderate to severe: 300-480 mg Metadyne each yr or 100-300 mg Metadyne every 6 mth and for at least 1 yr postpartum.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Metadyne): Infants up to 1 yr: Single dose of 100 mg Metadyne; 1-5 yr: 200 mg Metadyne; >6 yr: 400 mg Metadyne.
Oral
Thyroid storm
Adult: As potassium iodide: Up to 500 mg every 4 hr.
Intramuscular
Metadyne deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Metadyne): Up to 45 yr: 380 mg Metadyne, as single IM doses to provide adequate protection from Metadyne deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Metadyne each yr.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Metadyne): 380 mg Metadyne, as single IM doses to provide adequate protection from Metadyne deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Metadyne, as iodised oil (480 mg/ml Metadyne).
Topical/Cutaneous
Minor, superficial skin wounds
Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
Topical/Cutaneous
Cleaning wet ulcers and wounds
Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
Metadyne interactions
See also:
What other drugs will affect Metadyne?
There is a potential risk of interaction with lithium, resulting in an increased possibility of hypothyroidism.
this medicineshould not be used concomitantly with mercurial antiseptics, e.g. mercurochrome and thiomersal.
Since Metadyne may be absorbed systemically, the result of tests of the thyroid function can be influenced.
Metadyne side effects
See also:
What are the possible side effects of Metadyne?
Metadyne and iodides, whether applied topically or given systemically, can give rise to hypersensitivity reactions which may include urticaria, angioedema, cutaneous haemorrhage or purpuras, fever, arthralgia, lymphadenopathy, and eosinophilia.
Inhalation of Metadyne vapour is very irritating to mucous membranes.
Metadyne and iodides have variable effects on the thyroid and can produce goitre and hypothyroidism as well as hyperthyroidism (the Iod-Basedow or Jod-Basedow phenomenon). Goitre and hypothyroidism have also occurred in infants born to mothers who had taken iodides during pregnancy.
Prolonged use may lead to a range of adverse effects, often called ’iodism’, some of which may again be due to hypersensitivity. Adverse effects include metallic taste, increased salivation, burning or painful mouth; there may be acute rhinitis, coryza-like symptoms, and swelling and inflammation of the throat. Eyes may be irritated and swollen and there may be increased lachrymation. Pulmonary oedema, dyspnoea, and bronchitis may develop. Skin reactions include acneform or, more rarely, severe eruptions (iododerma). Other reported effects include depression, insomnia, impotence, headache, and gastrointestinal disturbances, notably nausea, vomiting, and diarrhoea.
Metadyne contraindications
Allergy to Metadyne,
- Class III patients with Okuda
- Extrahepatic metastases,
- Respiratory or renal insufficiencies severe
- Cons-indications for hepatic arteriography,
- Leukopenia below 1500/mm3 or thrombocytopenia less 50000/mm3,
- Pregnant woman: Metadyne should not be administered to pregnant women. In women of childbearing age, suspicion of pregnancy must be excluded before the administration of Metadyne. Contraception must be instituted and prosecuted in the administration at least a year.
- Breastfeeding: Breastfeeding should be stopped.
Active ingredient matches for Metadyne:
Iodine in Canada.
Povidone-iodine in Canada.
| Unit description / dosage (Manufacturer) | Price, USD |
| Liquid; Topical; Iodine / Povidone-Iodine 1% | |
List of Metadyne substitutes (brand and generic names): | |
| Mercuchrom-Jod (Germany) | |
| Microdine (India) | |
| Microdine 5% w/w OINT / 15g (Centaur) | $ 0.30 |
| 5 % w/w x 15g (Centaur) | $ 0.30 |
| MICRODINE 5% SOLUTION 1 bottle / 100 ML solution each (Centaur) | $ 0.61 |
| MICRODINE oint 5 % w/w x 15g (Centaur) | $ 0.30 |
| Microdine 5% Solution (Centaur) | $ 0.61 |
| Microshield PVP (India, Japan) | |
| MICROSHIELD PVP Liquid / 0.075 / 100ml units (Johnson & johnson) | $ 0.59 |
| MICROSHIELD PVP Liquid / 0.075 / 500ml units (Johnson & johnson) | $ 2.53 |
| Microshield PVP 7.5% w/v T-SOLN / 100ml (Johnson & johnson) | $ 0.81 |
| Microshield PVP 7.5% w/v T-SOLN / 500ml (Johnson & johnson) | $ 2.53 |
| MICROSHIELD PVP 10% SOLUTION 1 bottle / 100 ML solution each (Johnson & johnson) | $ 1.13 |
| MICROSHIELD PVP 10% SOLUTION 1 bottle / 500 ML solution each (Johnson & johnson) | $ 4.90 |
| Microshield PVP-S (India) | |
| Microshield PVP-S 10% w/v Povidone Iodine T-SOLN / 100ml (J & J) | $ 0.67 |
| Microshield PVP-S 10% w/v Povidone Iodine T-SOLN / 500ml (J & J) | $ 2.73 |
| 10 % w/v x 100ml (J & J) | $ 0.67 |
| 10 % w/v x 500ml (J & J) | $ 2.73 |
| MICROSHIELD PVP-S topical soln 10 % w/v x 100ml (J & J) | $ 0.67 |
| MICROSHIELD PVP-S topical soln 10 % w/v x 500ml (J & J) | $ 2.73 |
| Mikroplex Jod (Germany) | |
| Milbidine (South Africa) | |
| Milk-Line Teat Plus (United Kingdom) | |
| Mini Benadin 10% (Egypt) | |
| Minidine (Australia) | |
| Minims Povidon Jodium 5% (Netherlands) | |
| Minims Povidone Iodine (United Kingdom) | |
| Minims Povidone Iodine 5% (United Kingdom) | |
| Modyne | |
| Solution; Disinfectant / Barn; Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex 1.75% | |
| Molexdine (Indonesia) | |
| Molexdine 10 % x 15 mL x 1's (Molex ayus) | $ 0.31 |
| Molexdine 10 % x 60 mL x 1's (Molex ayus) | $ 0.90 |
| Molexdine 10 % x 1 L x 1's (Molex ayus) | $ 10.54 |
| Molexdine 10 % x 5 L x 1's (Molex ayus) | $ 43.40 |
| Molexdine Mouthwash (Indonesia) | |
| Molexdine Mouthwash 1 % x 190 mL x 1's | $ 0.74 |
| Monarch Full Dip Teat Dip | |
| Liquid; Teat-Dip; Iodine / Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex Complex 1% | |
| Monarch Low Acid Udder Wash | |
| Liquid; Udder Wash; Iodine / Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex Complex 1.75% | |
| Monarch Mon O Dine | |
| Liquid; Udder Wash; Iodine / Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex Complex 1.75% | |
| Movidone (Thailand) | |
| MS Cow Udder Brown (Netherlands) | |
| MS Jodium Bruin (Netherlands) | |
| MS Uddercare Brown (Netherlands) | |
| Mugisept (Indonesia) | |
| Mugisept 100 mg/1 mL x 5 mL x 1's (Mugi) | $ 0.21 |
| Mugisept 100 mg/1 mL x 1 L x 1's (Mugi) | $ 9.30 |
| Mugisept 100 mg/1 mL x 4.5 L x 1's (Mugi) | $ 38.44 |
See 1708 substitutes for Metadyne | |
References
- PubChem. "Iodine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Iodine". http://www.drugbank.ca/drugs/DB05382 (accessed September 17, 2018).
- DTP/NCI. "iodine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Metadyne are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Metadyne. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
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Information checked by Dr. Sachin Kumar, MD Pharmacology
