What is Microcept?
Microcept is a female hormone. This hormone can cause changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.
Microcept intrauterine system is a plastic device that contains the hormone Microcept. This device is placed in the uterus where it slowly releases the hormone to prevent pregnancy for up to 5 years. Microcept intrauterine system is meant for use in a woman who has had at least one child and is in a stable sexual relationship with someone who has no other sexual partners.
Microcept intrauterine system is also used in women who have heavy menstrual bleeding and choose to use an intrauterine form of birth control.
Microcept is a progestin hormone and does not contain estrogen. The intrauterine device releases Microcept into the uterus, but only small amounts of the hormone reach your blood stream.
Microcept intrauterine system may also be used for other purposes not listed in this medication guide.
Microcept indications
Microcept® (Microcept implants (unavailable in us)) implants are indicated for the prevention of pregnancy and are a long-term (up to 5 years) reversible method of contraception. Both implants must be removed by the end of the fifth year. New implants may be inserted at that time if continuing contraceptive protection is desired. Following removal, fertility rates return to levels comparable to those in a population of similar women using no method of contraception.
Eight (8) pregnancies occurred within 5 years of Microcept® (Microcept implants (unavailable in us)) placement in multicenter clinical trials involving 1393 women. One of the eight pregnancies was ectopic. The following table shows pregnancy rate as Pearl Indices for each year.
Pearl Indices (Pregnancies per 100 woman-years) by Year for Microcept (Microcept implants (unavailable in us))
| Year 1 | Year 2 | Year 3 | Year 4 | Year 5 | |
| Annual Pearl Index | 0.08 | 0.09 | 0.11 | 0.00 | 0.84 |
| 95% CI | (0.00,0.43) | (0.00, 0.50) | (0.00, 0.61) | (0.00, 0.50) | (0.27, 1.95) |
| Cumulative Pearl Index | 0.08 | 0.08 | 0.09 | 0.07 | 0.17 |
| 95% CI | (0.00, 0.43) | (0.01, 0.30) | (0.02, 0.26) | (0.01, 0.22) | (0.07, 0.34) |
Microcept (Microcept implants (unavailable in us)) is likely to be less effective in obese women. Mean serum Microcept levels decrease as weight increases, and the risk of pregnancy increases as serum Microcept levels decrease.
Typically, pregnancy rates with contraceptive methods are reported only for the first year of use, as shown in Table 2. The efficacy of these contraceptive methods, except for Microcept®, the intrauterine device (IUD), and sterilization, depends in part on the reliability of use. The efficacy of Microcept® (Microcept implants (unavailable in us)) implants does not depend on patient compliance. However, no contraceptive method is 100% effective.
TABLE 2: Percentage of Women Experiencing an Unintended Pregnancy During the First Year of Use of a Contraceptive Method
| Method | Typical Use | Perfect Use |
| Chance | 85 | 85 |
| Spermicides | 26 | 6 |
| Periodic Abstinence | 25 | |
| Calendar | 9 | |
| Ovulation | 3 | |
| Symptothermal | 2 | |
| Post-ovulation | 1 | |
| Cap | ||
| Parous women | 40 | 26 |
| Nulliparous women | 20 | 9 |
| Sponge | ||
| Parous women | 40 | 20 |
| Nulliparous women | 20 | 9 |
| Diaphragm | 20 | 6 |
| Withdrawal | 19 | 4 |
| Condom | ||
| Female (Reality) | 21 | 5 |
| Male | 14 | 3 |
| Pill | 5 | |
| Progestin only | 0.5 | |
| Combined | 0.1 | |
| IUD | ||
| Progesterone | 2.0 | 1.5 |
| Copper T 380A | 0.8 | 0.6 |
| LNg 20 | 0.1 | 0.1 |
| Depo-Provera | 0.3 | 0.3 |
| Microcept® and Microcept® 2 | 0.05 | 0.05 |
| Female sterilization | 0.5 | 0.5 |
| Male sterilization | 0.15 | 0.1 |
| From Hatcher RA et al., Contraceptive Technology, 17th Revised Edition. New York, NY: Irvington Publishers, 1998. Table 9-2 |
The gross cumulative rates of discontinuation and continuation in clinical trials of Microcept® (Microcept implants (unavailable in us)) are summarized in Table 3.
TABLE 3: Discontinuation and Continuation Rates (Cumulative Rates per 100 Users, n=1393)
| Year | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Reasons for discontinuing | 1 | 3 | 5 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pregnancy | 0.1
How should I use Microcept?Use Microcept as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Microcept. Uses of Microcept in detailssponsored
Microcept, is an emergency hormonal contraceptive used to help prevent a pregnancy when taken within 72 hours (3 days) of having had unprotected sex or if usual method of contraception has failed. It is also i available as a T-shaped intrauterine delivery system (IUD) which is used for the prevention of pregnancy (contraception) for up to three years. Microcept descriptionA synthetic progestational hormone with actions similar to those of progesterone and about twice as potent as its racemic or (+-)-isomer (norgestrel). It is used for contraception, control of menstrual disorders, and treatment of endometriosis. It is usually supplied in a racemic mixture (Norgestrel, 6533-00-2). Only the Microcept isomer is active. Microcept is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Triphasil, and Min-Ovral. Microcept dosageMicrocept DosageGeneric name: Microcept 0.75mg Dosage form: tablet See also:
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Take one tablet of Microcept orally as soon as possible within 72 hours after unprotected intercourse or a known or suspected contraceptive failure. Efficacy is better if the tablet is taken as soon as possible after unprotected intercourse. The second tablet should be taken 12 hours after the first dose. Microcept can be used at any time during the menstrual cycle. If vomiting occurs within two hours of taking either dose of medication, consideration should be given to repeating the dose.
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Microcept interactionsSee also: sponsored
Microcept® (Microcept implants (unavailable in us)) implants are not recommended for women who require chronic use of phenytoin, phenobarbital, carbamazepine or oxcarbazepine because Microcept® (Microcept implants (unavailable in us)) is likely to be less effective for these women. Although the large clinical trials of Microcept® and of Microcept® (Microcept implants (unavailable in us)) implants excluded women with epilepsy, there are published studies showing decreased Microcept concentrations in women taking these antiepileptic drugs along with Microcept-containing contraceptives. These drugs may increase the metabolism of Microcept through induction of microsomal liver enzymes. For women receiving long-term therapy with hepatic enzyme inducers, a different method of contraception should be considered. Women on short-term therapy with hepatic enzyme inducers should consider using a back-up method of contraception (such as condoms or spermicides) for the duration of therapy. Rifampicin is known to decrease the effectiveness of combination oral contraceptives; its effect on Microcept concentrations has not been established. Data from clinical trials of Microcept® implants, however, indicate low serum concentrations and subsequent pregnancy in one woman using rifampicin. Herbal products containing St. John's Wort (hypericum perforatum) may induce hepatic enzymes (cytochrome P450) and may reduce the effectiveness of contraceptive steroids. Laboratory Test InteractionsCertain endocrine tests may be affected by Microcept® (Microcept implants (unavailable in us)) use:
Microcept side effectsSee also: sponsored
The following adverse reactions have been associated with the Microcept (Microcept implants (unavailable in us)) SYSTEM during the first year of use in clinical trials:
In addition, removal difficulties affecting subjects (including multiple incisions, capsule fragments remaining, pain, multiple visits, deep placement, lengthy removal procedure, or other) have been reported with a frequency of 6.2%, which is based on 849 removals occurring through 5 years of use. See “WARNINGS” and “PRECAUTIONS.” Clinical studies comparing Microcept (Microcept implants (unavailable in us)) SYSTEM users with other contraceptive method users suggest that the following adverse reactions occurring during the first year are probably associated with Microcept (Microcept implants (unavailable in us)) SYSTEM use. These adverse reactions have also been reported post-marketing:
In addition, the following adverse reactions have been reported in clinical trials with a frequency of 5% or greater during the first year and are possibly related to Microcept (Microcept implants (unavailable in us)) SYSTEM use:
The following adverse reactions have been reported post-marketing with an incidence of less than 1% and are possibly related to Microcept (Microcept implants (unavailable in us)) SYSTEM use: Arm pain Gallbladder disease Hypertension Idiopathic intracranial hypertension (IIH) (pseudotumor cerebri, benign intracranial hypertension) Insertion/removal site reactions including abscess, cellulitis; blistering; bruising; edema; excessive scarring; hyperpigmentation; induration; nerve injury; numbness; sloughing; tingling; ulcerations Migraine headaches Ovarian cysts Phlebitis The following adverse reactions have been reported post-marketing and a causal relationship to the Microcept (Microcept implants (unavailable in us)) SYSTEM has not been established: Asthenia (fatigue/weakness) Breast cancer Congenital anomalies Deep vein thrombosis Dysmenorrhea Emotional lability and depression, sometimes severe Myocardial infarction Pulmonary embolism Stroke Superficial venous thrombosis Thrombotic thrombocytopenic purpura (TTP) Urticaria, pruritus Vaginal bleeding, heavy Visual disturbances Weight gain of more than 10 pounds Microcept contraindicationsSee also: You should not use this medication if you have abnormal vaginal bleeding, an uncontrolled pelvic infection, a condition that affects the shape of the uterus, past or present breast cancer, a liver problem, cervical or uterine cancer, a weak immune system, if you have recently had a serious pelvic infection following a pregnancy or abortion, or if you already have an intrauterine device (IUD) in place. You also should not use this medication if you have a history of pelvic inflammatory disease (unless you have had a normal pregnancy after the infection was treated and cleared), a recent abnormal Pap smear that has not yet been diagnosed or treated, or if you do not have an exclusive sexual partner. Before using the Microcept intrauterine device, tell your doctor if you have diabetes, a bleeding or blood-clotting disorder, a vaginal infection, pelvic infection, or sexually transmitted disease, high blood pressure, heart disease, or a heart valve disorder. Serious side effects of the intrauterine system include severe cramps or pelvic pain, heavy or ongoing vaginal bleeding, unusual vaginal discharge, pale skin, easy bruising or bleeding, fever, chills, sudden numbness or weakness, severe headaches, or jaundice (yellowing of the skin or eyes). Only your doctor should remove the Microcept intrauterine system. Do not attempt to remove the device yourself.
Active ingredient matches for Microcept:Levonorgestrel in Egypt.
References
ReviewsThe results of a survey conducted on ndrugs.com for Microcept are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Microcept. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reportsConsumer reported usefulNo survey data has been collected yet1 consumer reported price estimatesWas the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Microcept drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Consumer reported time for resultsNo survey data has been collected yet3 consumers reported age
Consumer reviews
Information checked by Dr. Sachin Kumar, MD Pharmacology More about MicroceptClinician Information
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