What is Mirtax?
Mirtax (Mirtax) is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain.
Mirtax is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.
Mirtax may also be used for other purposes not listed in this medication guide.
Mirtax indications
Mirtax® (Mirtax hydrochloride extended-release capsules) is indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. Improvement is manifested by relief of muscle spasm and its associated signs and symptoms, namely, pain, tenderness, and limitation of motion.
Limitations of Use:
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- Mirtax should be used only for short periods (up to two or three weeks) because adequate evidence of effectiveness for more prolonged use is not available and because muscle spasm associated with acute, painful musculoskeletal conditions is generally of short duration and specific therapy for longer periods is seldom warranted.
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- Mirtax has not been found effective in the treatment of spasticity associated with cerebral or spinal cord disease or in children with cerebral palsy.
How should I use Mirtax?
Use Mirtax extended-release capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Mirtax extended-release capsules by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Swallow Mirtax extended-release capsules whole. Do not break, crush, or chew before swallowing.
- Mirtax extended-release capsules works best if it is taken at the same time each day.
- Do not suddenly stop taking Mirtax extended-release capsules without checking with your doctor.
- If you miss a dose of Mirtax extended-release capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Mirtax extended-release capsules.
Uses of Mirtax in details
Mirtax is used along with physical therapy and rest to relieve pain, stiffness or discomfort caused by muscle injury.
Mirtax description
Mirtax is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Mirtax acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord. It is structurally similar to Amitriptyline, differing by only one double bond.
Mirtax dosage
Mirtax Dosage
Generic name: Mirtax HYDROCHLORIDE 15mg
Dosage form: capsule, extended release
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
The recommended adult dose for most patients is one (1) Mirtax 15 mg capsule taken once daily. Some patients may require up to 30 mg/day, given as one (1) Mirtax 30 mg capsule taken once daily or as two (2) Mirtax 15 mg capsules taken once daily.
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- It is recommended that doses be taken at approximately the same time each day.
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- Use of Mirtax for periods longer than two or three weeks is not recommended.
Instruct patients to swallow Mirtax capsules intact. Alternatively, the contents of the Mirtax capsule may be sprinkled over applesauce and then swallowed. This method is appropriate only for patients able to reliably swallow the applesauce without chewing. Other foods have not been tested and should not be substituted for applesauce. Instruct the patient to:
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- Sprinkle the contents of the capsule onto a tablespoon of applesauce and consume immediately without chewing.
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- Rinse the mouth to ensure all of the contents have been swallowed.
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- Discard any unused portion of the Mirtax capsules after the contents have been sprinkled on applesauce.
More about Mirtax (Mirtax)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Espanol
- 42 Reviews - Add your own review/rating
- Generic Availability
Consumer resources
- Mirtax extended-release capsules
- Mirtax
- Mirtax (Advanced Reading)
- Other brands: Mirtax, Fexmid, Comfort Pac with Mirtax
Professional resources
- Mirtax (FDA)
- Mirtax (AHFS Monograph)
Related treatment guides
- Muscle Spasm
- Sciatica
Mirtax interactions
See also:
What other drugs will affect Mirtax?
Based on its structural similarity to tricyclic antidepressants, Mirtax may have life-threatening interactions with MAO inhibitors, may enhance the effects of alcohol, barbiturates, and other CNS depressants, may enhance the seizure risk in patients taking tramadol, or may block the antihypertensive action of guanethidine and similarly acting compounds.
Postmarketing cases of serotonin syndrome have been reported during combined use of Mirtax and other drugs, such as SSRIs, SNRIs, TCAs, tramadol, bupropion, meperidine, verapamil, or MAO inhibitors.
Drug Abuse And Dependence
Dependence
Pharmacologic similarities among the tricyclic drugs require that certain withdrawal symptoms be considered when Mirtax is administered, even though they have not been reported to occur with this drug. Abrupt cessation of treatment after prolonged administration rarely may produce nausea, headache, and malaise. These are not indicative of addiction.
Mirtax side effects
See also:
What are the possible side effects of Mirtax?
Most Common Adverse Reactions in the Mirtax Clinical Trials
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
The data described below reflect exposure to Mirtax in 253 patients in 2 clinical trials. Mirtax was studied in two double-blind, parallel-group, placebo-controlled, active-controlled trials of identical design. The study population was composed of patients with muscle spasms associated with acute painful musculoskeletal conditions. Patients received 15 mg or 30 mg of Mirtax taken orally once daily, Mirtax immediate-release (IR) 10 mg three times a day, or placebo for 14 days.
The most common adverse reactions (incidence ≥ 3% in any treatment group and greater than placebo) were dry mouth, dizziness, fatigue, constipation, nausea, dyspepsia, and somnolence.
Table 1: Incidence of the Most Common Adverse Reactions Occurring in ≥ 3% of Patients in any Treatment Group* and Greater Than Placebo in the Two Phase 3, Double-Blind Mirtax Trials
| Placebo N=128 | Mirtax 15 mg N=127 | Mirtax 30 mg N=126 | |
| Dry mouth | 2% | 6% | 14% |
| Dizziness | 2% | 3% | 6% |
| Fatigue | 2% | 3% | 3% |
| Constipation | 0% | 1% | 3% |
| Somnolence | 0% | 1% | 2% |
| Nausea | 1% | 3% | 3% |
| Dyspepsia | 1% | 0% | 4% |
| *Mirtax 15 mg QD, Mirtax 30 mg QD, or Mirtax IR tablets TID |
Additional Adverse Reactions from Clinical Studies and Postmarketing Experience
The following adverse reactions have been reported in clinical studies or postmarketing experience with Mirtax, Mirtax IR, or tricyclic drugs. Because some of these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
In a postmarketing surveillance program of Mirtax IR, the adverse reactions reported most frequently were drowsiness, dry mouth, and dizziness and adverse reactions reported in 1% to 3% of the patients were: fatigue/tiredness, asthenia, nausea, constipation, dyspepsia, unpleasant taste, blurred vision, headache, nervousness, and confusion.
The following adverse reactions have been reported in postmarketing experience (Mirtax or Mirtax IR), in clinical studies of Mirtax IR (incidence < 1%), or in postmarketing experience with other tricyclic drugs:
Body as a Whole: Syncope; malaise; chest pain; edema.
Cardiovascular: Tachycardia; arrhythmia; vasodilatation; palpitation; hypotension; hypertension; myocardial infarction; heart block; stroke.
Digestive: Vomiting; anorexia; diarrhea; gastrointestinal pain; gastritis; thirst; flatulence; edema of the tongue; abnormal liver function and rare reports of hepatitis, jaundice, and cholestasis; paralytic ileus, tongue discoloration; stomatitis; parotid swelling.
Endocrine: Inappropriate ADH syndrome.
Hematologic and Lymphatic: Purpura; bone marrow depression; leukopenia; eosinophilia; thrombocytopenia.
Hypersensitivity: Anaphylaxis; angioedema; pruritus; facial edema; urticaria; rash.
Metabolic, Nutritional and Immune: Elevation and lowering of blood sugar levels; weight gain or loss.
Musculoskeletal: Local weakness; myalgia.
Nervous System and Psychiatric: Seizures, ataxia; vertigo; dysarthria; tremors; hypertonia; convulsions; muscle twitching; disorientation; insomnia; depressed mood; abnormal sensations; anxiety; agitation; psychosis, abnormal thinking and dreaming; hallucinations; excitement; paresthesia; diplopia; serotonin syndrome; neuroleptic malignant syndrome; decreased or increased libido; abnormal gait; delusions; aggressive behavior; paranoia; peripheral neuropathy; Bell's palsy; alteration in EEG patterns; extrapyramidal symptoms.
Respiratory: Dyspnea.
Skin: Sweating; photosensitization; alopecia.
Special Senses: Ageusia; tinnitus.
Urogenital: Urinary frequency and/or retention; impaired urination; dilatation of urinary tract; impotence; testicular swelling; gynecomastia; breast enlargement; galactorrhea.
Mirtax contraindications
See also:
What is the most important information I should know about Mirtax?
Do not take Mirtax if you have used an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam) within the past 14 days. Serious, life-threatening side effects can occur if you take Mirtax before the MAO inhibitor has cleared from your body.
You should not take Mirtax if you have recently had a heart attack, or if you have a heart rhythm disorder, congestive heart failure, heart block, or an overactive thyroid.
Mirtax can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Avoid drinking alcohol, which can increase some of the side effects of Mirtax.
Active ingredient matches for Mirtax:
Cyclobenzaprine in Brazil, South Korea.
Mirtazapine in South Korea.
List of Mirtax substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Mirtawin (Czech Republic) | |
| Tablet, Film-Coated; Oral; Mirtazapine 45 mg | |
| Mirtax ODT (South Korea) | |
| Mirtaz (India, Ireland, Peru) | |
| Mirtaz Capsule/ Tablet / 15mg / 10 units (Sun) | $ 0.86 |
| Mirtaz Capsule/ Tablet / 30mg / 10 units (Sun) | $ 1.67 |
| Mirtaz Capsule/ Tablet / 7.5mg / 10 units (Sun) | $ 0.53 |
| 7.5 mg x 10's (Sun) | $ 0.55 |
| 15 mg x 10's (Sun) | $ 0.88 |
| 30 mg x 10's (Sun) | $ 1.39 |
| Mirtaz 7.5mg TAB / 10 (Sun) | $ 0.55 |
| Mirtaz 15mg TAB / 10 (Sun) | $ 0.88 |
| Mirtaz 30mg TAB / 10 (Sun) | $ 1.39 |
| Mirtaz 15 mg x 10 Blister x 10 Tablet (Sun) | |
| Mirtaz 30 mg x 3 Blister x 10 Tablet (Sun) | |
| MIRTAZ 15 TABLET 1 strip / 10 tablets each (Sun) | $ 0.99 |
| MIRTAZ 30 TABLET 1 strip / 10 tablets each (Sun) | $ 1.99 |
| MIRTAZ 7.5 TABLET 1 strip / 10 tablets each (Sun) | $ 0.70 |
| MIRTAZ MD 30 TABLET 1 strip / 10 tablets each (Sun) | $ 1.84 |
| MIRTAZ MD 7.5 TABLET 1 strip / 10 tablets each (Sun) | $ 0.65 |
| MIRTAZ tab 7.5 mg x 10's (Sun) | $ 0.58 |
| MIRTAZ tab 15 mg x 10's (Sun) | $ 0.89 |
| MIRTAZ tab 30 mg x 10's (Sun) | $ 1.39 |
| Mirtaz 15mg Tablet (Sun) | $ 0.11 |
| Mirtaz 30mg Tablet (Sun) | $ 0.20 |
| Mirtaz 7.5mg Tablet (Sun) | $ 0.08 |
| Mirtazafer (Greece) | |
| Mirtazap-Mepha (Switzerland) | |
| Mirtazap-Mepha oro (Switzerland) | |
| Mirtazapin (Romania) | |
| Tablet, Film-Coated; Oral; Mirtazapine 30 mg (Aurobindo pharma) | |
| Tablet, Film-Coated; Oral; Mirtazapine 45 mg (Aurobindo pharma) | |
| Mirtazapin +pharma (Czech Republic) | |
| Mirtazapin - 1 A Pharma (Germany) | |
| Mirtazapin AAA-Pharma (Germany) | |
| Mirtazapin AB (Belgium) | |
| Mirtazapin AbZ (Germany) | |
| Mirtazapin Actavis (Austria, Czech Republic, Denmark, Estonia, Finland, Latvia, Lithuania, Sweden, Switzerland) | |
| Mirtazapin Actavis 15 mg (Austria) | |
| Mirtazapin Actavis 30 mg (Austria) | |
| Mirtazapin Actavis 45 mg (Austria) | |
| Mirtazapin AL (Germany) | |
| Mirtazapin Almus (Germany) | |
| Mirtazapin Alternova (Austria, Denmark, Sweden) | |
| Mirtazapin Alternova 30 mg (Austria) | |
See 1058 substitutes for Mirtax | |
References
- DailyMed. "MIRTAZAPINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "mirtazapine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "cyclobenzaprine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Mirtax are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Mirtax. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
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Information checked by Dr. Sachin Kumar, MD Pharmacology
