Neo Rheumacyl Uses

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Neo Rheumacyl indications

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Articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), degenerative and chronic inflammatory diseases of musculoskeletal system (osteochondrosis, osteoarthritis, periartropatii), post-traumatic inflammation of soft tissue and musculoskeletal system (sprains, bruises). Pain in the spine, neuralgia, myalgia, arthralgia, pain and inflammation after surgery or injury, pain in gout, migraine, algomenorrhea, pain with Bursitis, proctitis, colic (biliary and renal), pain in infectious and inflammatory diseases of ENT organs.

For local use: the inhibition of miosis during surgery for cataract prevention of cystoid macular edema associated with removal and lens implantation, inflammatory eye non-infectious nature, post-traumatic inflammation in penetrating and nonpenetrating wound of the eyeball.

Neo Rheumacyl description

Neo Rheumacyl: Each tablet contains Ibuprofen (Neo Rheumacyl) 300 mg and Paracetamol (Neo Rheumacyl) 325 mg.

Neo Rheumacyl Kid: Each dispersible tablet contains Ibuprofen (Neo Rheumacyl) 100 mg and Paracetamol (Neo Rheumacyl) 125 mg. Colour: Tartrazine.

Neo Rheumacyl Forte: Each tablet contains Ibuprofen (Neo Rheumacyl) 400 mg and Paracetamol (Neo Rheumacyl) 500 mg.

Neo Rheumacyl dosage

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For oral use for adult single dose is 25-50 mg 2-3 times / 24 h. Frequency of admission depends on the dosage form employed, the severity of the disease and is 1-3 times / 24 h, rectally - 1 times / 24 h, for the treatment of acute conditions or the exacerbation of chronic edema use intramuscular in dose of 75 mg.

For children older than 6 years and adolescents daily dose is 2 mg / kg.

Topical applied at a dose of 2-4 g (depending on the size of painful area) on the affected area 3-4 times / 24 h.

When used in ophthalmology frequency and duration of administration are determined individually.

The maximum oral daily dose for adults is 150 mg.

Neo Rheumacyl interactions

Concurrent use of Phenobarbital, Phenytoin, rifampin or ephedrine may enhance the metabolism of corticosteroids, reducing their therapeutic effects.

Patients receiving both a corticosteroid an estrogen should be observed for excessive corticosteroid effects.

Concurrent use of corticosteroids with potassium-depleting diuretics may enhance

Hypokalemia with cardiac glycosides may enhance the possibility of arrhythmias or digitalis toxicity associated with hypokalemia. Corticosteroids may enhance the potassium depletion caused by amphotericin B. In all patients taking any of these drug therapy combinations, serum electrolyte determinations, particularly potassium levels should be monitored closely.

Concurrent use of corticosteroids with coumarin-type anticoagulants may increase or decrease the anticoagulant effects possibly requiring adjustment in dosage.

Combined effects of non-steroidal anti-inflammatory drugs or alcohol with glucocorticosteroids may result in an increased occurrence or increased severity of gastrointestinal ulceration.

Corticosteroids may decrease blood salicylate concentrations. Acetylsalicylic acid should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia.

Dosage adjustments of an antidiabetic drug may be necessary when corticosteroids are given to diabetics.

Concomitant glucocorticosteroid therapy may inhibit the response to somatotropin.

Laboratory test interactions: corticosteroids may affect the nitroblue tetrazolium test for bacterial infection and produce false negative results.

Neo Rheumacyl side effects

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Ibuprofen (Neo Rheumacyl): Cardiovascular System: Tachycardia, flushing, increase in blood pressure.

Central Nervous System: Confusion, hallucinations, mental depression, peripheral neuropathy, tinnitus, drowsiness, insomnia.

Gastrointestinal System: Epigastric pain or discomfort, gastritis, hematemesis, GI perforation, GI ulceration.

Dermatological: Allergic dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Renal: Hematuria, cystitis, renal impairment or failure, polyuria, fluid retention/oedema, acute renal failure, interstitial nephritis, nephrotic syndrome.

Hematological: Agranulocytosis, anaemia, aplastic anaemia, eosinophilia, hemolytic anaemia, leukopenia, thrombocytopenia.

Hypersensitivity Reactions: Anginitis, angioedema, bronchospastic allergic reactions, allergic rhinitis, serum sickness-like reaction, systemic lupus erythematosus, aseptic meningitis.

Ophthalmic:

Amblyopia, blurred or double vision, conjunctivitis, dry irritated or swollen eyes, scotoma.

Oral:

Aphthous stomatitis, gingival ulcerations.

Ear, Nose and Throat: Decreased hearing or any change in hearing, epistaxis.

Hepatic Effect: Hepatitis.

Pancreatic Effect: Pancreatitis.

Paracetamol (Neo Rheumacyl): Gastrointestinal System: Nausea, vomiting, stomach pain or cramps, diarrhoea, loss of appetite, hepatotoxicity, hepatic failure, hepatic encephalopathy, GIT bleeding, pancreatitis.

Central Nervous System: Convulsions, respiratory depression, cerebral oedema, coma.

Haematological: Leucopenia, thrombocytopenia, neutropenia, pancytopenia, agranulocytosis, disseminated intravascular coagulation.

Metabolic: Hypoglycaemia, metabolic acidosis.

Cardiovascular System: Cardiac arrhythmias, cardiovascular collapse.

Renal System: Renal tubular necrosis, renal failure.

Dermatological: Skin rashes and other allergic reactions. The rash is usually erythematous or urticarial but sometimes more serious and may be accompanied by fever and mucosal lesions.

Neo Rheumacyl contraindications

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Neo Rheumacyl is contraindicated in patients with the following conditions: History of severe allergic reaction eg, anaphylaxis or angioedema induced by aspirin or other NSAIDs. Because of the possibility of cross-sensitivity due to structural relationships which exist among non-steroidal anti-inflammatory medicines, acute allergic reactions are likely to occur in patients who have exhibited allergic reactions to these compounds.

Patients sensitive to any of the ingredients.

Aspirin-induced nasal polyps associated with bronchospasm (high risk of severe allergic reactions because of cross-sensitivity).

Active peptic ulceration.

Severe renal function impairment.

Active ingredient matches for Neo Rheumacyl:

Ibuprofen/Paracetamol in Indonesia.


Unit description / dosage (Manufacturer)Price, USD
NEO rheumacyl 1 x 20's$ 0.67

List of Neo Rheumacyl substitutes (brand and generic names):

Napharsane 5 Blister x 20 Tablet
New Artifen Plus Ibuprofen 400mg, Paracetamol400mg TAB / 10 (Aglowmed Ltd)$ 0.16
New Artifen Plus Ibuprofen 100mg, Paracetamol125mg/5mL SUSP / 60ml (Aglowmed Ltd)$ 0.13
10's (Aglowmed Ltd)$ 0.16
60ml (Aglowmed Ltd)$ 0.13
New Artifen Plus 400+400 Tablet (Aglowmed Ltd)$ 0.02
New Artifen Plus 60 ml Suspension (Aglowmed Ltd)$ 0.01
NEW ARTIFEN PLUS 400MG/400MG TABLET 1 strip / 10 tablets each (Aglowmed Ltd)$ 0.81
New Artifen Plus Tablet (Aglowmed Ltd)$ 0.08
Nimucet-Flam Paracetamol 162.5 mg, Ibuprofen 100 mg/5 mL SUSP / 60ml (Intas)$ 0.17
Nimucet-Flam Paracetamol 162.5 mg, ibuprofen 100 mg/5 mL. O-SUSP / 60ml (Intas)$ 0.17
NIMUCET-FLAM oral susp 60ml (Intas)$ 0.17
NORSWELL PLUS TABLET 1 strip / 10 tablets each (Zydus Cadila)$ 0.09
NOVAFLAM SYRUP 1 bottle / 60 ML syrup each (Synchem Lab)$ 0.25
NOVOGESIC Capsule/ Tablet / 100mg / 10 units (Glenmark Pharmaceuticals Ltd.)$ 0.22
Novogesic 100 mg Tablet (Glenmark Pharmaceuticals Ltd.)$ 0.02
Novogesic 60 ml Suspension (Glenmark Pharmaceuticals Ltd.)$ 0.01
NOVOGESIC 100MG TABLET 1 strip / 10 tablets each (Glenmark Pharmaceuticals Ltd.)$ 0.52
Novogesic 100mg Tablet (Glenmark Pharmaceuticals Ltd.)$ 0.05
10's (Dabur)$ 0.11
50ml (Dabur)$ 0.11
60ml (Dabur)$ 0.13
Nuren-Ace Ibuprofen 400 mg, paracetamol325 mg TAB / 10 (Dabur)$ 0.11
Nuren-Ace Ibuprofen 100 mg, paracetamol125 mg/5 mL. SUSP / 50ml (Dabur)$ 0.11
Nuren-Ace Ibuprofen 100 mg, paracetamol125 mg/5 mL. SUSP / 60ml (Dabur)$ 0.13
Nuren-Ace Ibuprofen 400 mg, Paracetamol325 mg. TAB / 10 (Dabur)$ 0.11
NUREN-ACE tab 10's (Dabur)$ 0.11
NUREN-ACE oral susp 50ml (Dabur)$ 0.11
NUREN-ACE oral susp 60ml (Dabur)$ 0.13
Nuren-Ace Ibuprofen 400 mg, paracetamol325 mg TAB / 10 (Dabur)$ 0.11
Nuren-Ace Ibuprofen 100 mg, paracetamol125 mg/5 mL. SUSP / 50ml (Dabur)$ 0.11
Nuren-Ace Ibuprofen 100 mg, paracetamol125 mg/5 mL. SUSP / 60ml (Dabur)$ 0.13
Nuren-Ace Ibuprofen 400 mg, Paracetamol325 mg. TAB / 10 (Dabur)$ 0.11
O-Dox Ibuprofen400mgDextropropoxyphene HCl32mg TAB / 10$ 0.54
O-Dox Ibuprofen400mg Dextropropoxyphene HCl32mg TAB / 10$ 0.54
Oncodin Ibuprofen 400mg, acetaminophen500mg, Codiene Phosphate 30mg TAB / 10 (Baxter (India) Pvt. Ltd.)$ 0.72
Oncodin 400+500+30 Tablet (Baxter (India) Pvt. Ltd.)$ 0.07
Oncodin Ibuprofen 400mg, acetaminophen500mg, Codiene Phosphate 30mg TAB / 10 (Baxter (India) Pvt. Ltd.)$ 0.72
Ospidyne Codeine Phosphate 30mg, Ibuprofen 400mg, Paracetamol325mg TAB / 10 (Osper Pharmaceutics Pvt. Ltd.)$ 0.84

References

  1. DailyMed. "IBUPROFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "ibuprofen". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "ibuprofen". http://www.drugbank.ca/drugs/DB01050 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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