What is Orex-M?
Orex-M is used to help treat periodontal disease (a disease of your gums), which is caused by bacteria growing beneath the gum line. Orex-M works by killing the bacteria. Up to eight Orex-M implants are placed between your teeth and gums in places where the gum has a deep pocket. Your dentist will place the Orex-M implants after your teeth have been thoroughly cleaned.
Orex-M is available only with your dentist's prescription.
Orex-M indications
For local use of Orex-M ICPA Health Products: trichomonas coleitis, cervical erosion, itching of the vulva, prevention of sexually transmitted diseases (including gonorrhea, syphilis, trichomoniasis, chlamydia, ureaplasmosis); gingivitis, stomatitis, aphthae, paradont, alveolitis, disinfection of removable dentures, sore throat; postoperative care for patients in ENT and dentistry.
Treatment of wounds, burn wounds and surfaces, disinfection of the patient's skin.
Treatment of surgeons', nurses' hands and operating field before diagnostic manipulation operation.
Disinfection of work surfaces of devices (including thermometers) and equipment which heat treatment is not desirable.
How should I use Orex-M?
Use Orex-M liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- To cleanse the skin, thoroughly rinse the area to be cleansed with water. Apply the minimum amount necessary to cover the skin or wound area and wash gently. Rinse thoroughly.
- If you miss a dose of Orex-M liquid, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Orex-M liquid.
Uses of Orex-M in details
Garlic has been used for hardening of the arteries (atherosclerosis) and high blood pressure (hypertension). Consult your doctor for more information if you have heart disease or high blood pressure. Garlic has also been used to prevent tick bites.
Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. Check with your pharmacist for more details about the brand you use.
The FDA has not reviewed this product for safety or effectiveness. Consult your doctor or pharmacist for more details.
How to use Orex-M
Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.
If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.
Orex-M description
Orex-M mouthwash contains Chlorhexidine digluconate 1% v/v, equivalent to Orex-M gluconate solution 0.2% w/v. It also contains ethanol, macrogolglycerol hydroxystearate, sorbitol, flavour and water.
Orex-M dosage
Usual Adult Dose for Gingivitis
15 mL twice daily after brushing.
Oral rinse should be retained for 30 seconds then expectorated after rinsing.
Usual Adult Dose for Mucositis
15 mL twice daily after brushing.
Oral rinse should be retained for 30 seconds then expectorated after rinsing.
Usual Adult Dose for Periodontitis
Initial: One 2.5 mg chip inserted into a periodontal pocket with probing pocket depth greater than or equal to 5 mm, up to 8 chips in one visit.
Maintenance: Administration is recommended once every 3 months in pockets with remaining probing depth greater than or equal to 5 mm.
Usual Adult Dose for Skin Disinfection, Preoperative
Orex-M gluconate 2% cloth:
Patient preoperative skin preparation:
Hold package in one hand and lift flap on backside of package with the other hand. Grasp flap at top and pull down to tear flap away and expose foam. Alternatively, using sterile scissors, cut off end seal of package. Transfer contents onto prep table, avoiding contact between cloths and outside of package to reduce risk of cloth contamination. Use the first cloth to prepare the skin area indicated for a moist or dry site, making certain to keep the second cloth where it will not be contaminated. Use the second cloth to prepare larger areas.
DRY SURGICAL SITES: (such as the abdomen or arm): Use one cloth to cleanse each 161 cm2 area (approximately 5 x 5 inches) of skin to be prepared. Vigorously scrub skin back and forth for 3 minutes, completely wetting treatment area, then discard. Allow area to air dry for one minute. Do not rinse.
MOIST SURGICAL SITES: (such as the inguinal fold): Use one cloth to cleanse each 65 cm2 area (approximately 2 x 5 inches) of skin to be prepared. Vigorously scrub skin back and forth for 3 minutes, completely wetting treatment area, then discard. Do not rinse.
Orex-M gluconate 4% solution:
SURGICAL HAND SCRUB: Do not dilute. Wet hands and forearms with water and scrub for 3 minutes with about 5 ml and a wet brush, paying close attention to the nails, cuticles, and interdigital spaces. Wash for an additional 3 minutes with 5 ml and rinse under running water. Dry thoroughly.
HEALTHCARE PERSONNEL HANDWASH: Do not dilute. Wet hands with water. Dispense about 5 ml into cupped hands and wash in a vigorous manner for 15 seconds. Rinse and dry thoroughly.
PATIENT PREOPERATIVE SKIN PREPARATION: Do not dilute. Apply liberally to surgical site and swab for at least 2 minutes. Dry with a sterile towel. Repeat procedure for an additional 2 minutes and dry with a sterile towel.
SKIN WOUND AND GENERAL SKIN CLEANSING: Do not dilute. Thoroughly rinse the area to be cleaned with water. Apply a minimum amount necessary to cover the skin or would area and wash gently. Rinse again thoroughly.
Usual Pediatric Dose for Gingivitis
The safety and efficacy of Orex-M gluconate has not been established in patients less than 18 years old. However, the use of Orex-M gluconate may be appropriate in some situations.
15 mL twice daily after brushing.
Oral rinse should be retained for 30 seconds then expectorated after rinsing.
Usual Pediatric Dose for Mucositis
The safety and efficacy of Orex-M gluconate has not been established in patients less than 18 years old. However, the use of Orex-M gluconate may be appropriate in some situations.
15 mL twice daily after brushing.
Oral rinse should be retained for 30 seconds then expectorated after rinsing.
Usual Pediatric Dose for Periodontitis
The safety and efficacy of Orex-M gluconate has not been established in patients less than 18 years old. However, the use of Orex-M gluconate may be appropriate in some situations.
Initial: One 2.5 mg chip inserted into a periodontal pocket with probing pocket depth greater than or equal to 5 mm, up to 8 chips in one visit.
Maintenance: Administration is recommended once every 3 months in pockets with remaining probing depth greater than or equal to 5 mm.
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
No adjustment recommended
Dialysis
No adjustment recommended
Other Comments
Orex-M topical cloths are not sterile.
Orex-M topical cloths should not be microwaved.
Orex-M solution should be used with care in premature infants or infants under 2 months of age. These products may cause irritation or chemical burns.
Orex-M topical cloths should not be used in premature or low birthweight infants, infants receiving phototherapy, or infants less than 2 months of age. Orex-M topical cloths and Orex-M 4% solution should not be used for lumbar punctures or in contact with the meninges, or on open wounds or as a general skin cleanser.
Orex-M topical cloths and Orex-M 4% solution should not make contact with the eyes, nose, or mouth. If contact occurs, the affected area should be washed with cold water and a doctor should be contacted.
Orex-M 4% solution should not be diluted.
Repeated general cleansing of large areas of the body with Orex-M 4% topical solution should be avoided except when the underlying condition makes it necessary to reduce the bacterial population of the skin.
Orex-M interactions
Orex-M is incompatible with the soap, and detergents containing anionic group (saponins, sodium lauryl sulfate, sodium carboxymethyl cellulose).
Orex-M ICPA Health Products is compatible with any medication containing cationic group (cetrimonium bromide, benzalkonium chloride).
Orex-M side effects
See also:
What are the possible side effects of Orex-M?
The most common side effects associated with Orex-M gluconate oral rinses are (1) an increase in staining of teeth and other oral surfaces, (2) an increase in calculus formation; and (3) an alteration in taste perception; see WARNINGS and PRECAUTIONS.
Oral irritation and local allergy-type symptoms have been spontaneously reported as side effects associated with the use of Orex-M gluconate rinse.
The following oral mucosal side effects were reported during placebo-controlled adult clinical trials: aphthous ulcer, grossly obvious gingivitis, trauma, ulceration, erythema, desquamation, coated tongue, keratinization, geographic tongue, mucocele, and short frenum. Each occurred at a frequency of less than 1.0%.
Among post marketing reports, the most frequently reported oral mucosal symptoms associated with Orex-M gluconate oral rinse are stomatitis, gingivitis, glossitis, ulcer, dry mouth, hypesthesia, glossal edema, and paresthesia.
Minor irritation and superficial desquamation of the oral mucosa have been noted in patients using Orex-M gluconate oral rinse.
There have been cases of parotid gland swelling and inflammation of the salivary glands (sialadenitis) reported in patients using Orex-M gluconate oral rinse.
Orex-M contraindications
See also:
What is the most important information I should know about Orex-M?
Orex-M gluconate oral rinse should not be used by persons who are known to be hypersensitive to Orex-M gluconate or other formula ingredients.
Active ingredient matches for Orex-M:
Chlorhexidine in India.
| Unit description / dosage (Manufacturer) | Price, USD |
| Orex-M Metronidazole 1 % w/w, Chlorhexidine gluconate 0.25 %w/w. CRM / 20g | $ 0.33 |
| 20g | $ 0.33 |
List of Orex-M substitutes (brand and generic names): | |
| Orex M | |
| Orex M Gel (Yash Vision) | $ 0.23 |
| Orex-M Gel (India) | |
| Orex-M Gel Metronidazole 1 % w/w, Chlorhexidine gluconate 0.25 %w/w. GEL / 10g (Yash Vision) | $ 0.19 |
| 10g (Yash Vision) | $ 0.19 |
| OREX-M GEL dental gel 10g (Yash Vision) | $ 0.19 |
| Oriflox M | |
| Oriflox M 30 ml Syrup (Kentreck Labs Pvt Ltd.) | $ 0.04 |
| Orinse (India) | |
| 0.2 % w/v x 100ml (Centaur Pharmaceuticals Pvt.Ltd.) | $ 0.39 |
| Orinse 0.2% w/v M-WASH / 100ml (Centaur Pharmaceuticals Pvt.Ltd.) | $ 0.39 |
| Mouthwash; Local Oral; Chlorhexidine Gluconate 0.2% (Centaur Pharmaceuticals Pvt.Ltd.) | |
| Orinse Mouth/Throat 100 ml Mouth Wash/Gargle (Centaur Pharmaceuticals Pvt.Ltd.) | $ 0.32 |
| ORINSE mouthwash 0.2 % w/v x 100ml (Centaur Pharmaceuticals Pvt.Ltd.) | $ 0.39 |
| Orivid M | |
| Orivid M 50 ml Suspension (Biocin Healthcare) | $ 0.04 |
| ORO Clear (Canada) | |
| Oro Clear liquid 0.12 % (Germiphene Corporation (Canada)) | |
| Oro-Clense (Canada) | |
| Liquid; Buccal; Chlorhexidine Gluconate 0.12% (Germiphene) | |
| Orofact Mouth Wash (India) | |
| Orofact Mouth Wash 0.2% M-WASH / 100ml (Medico HC) | $ 0.51 |
| 0.2 % x 100ml (Medico HC) | $ 0.51 |
| OROFACT MOUTH WASH mouthwash 0.2 % x 100ml (Medico HC) | $ 0.51 |
| Orogyl (Oman) | |
| Oroheks (Turkey) | |
| Oronine H | |
| Ointment; Topical; Chlorhexidine Gluconate 1% | |
| Ortoxine (Chile) | |
| Ortrizol (Mexico) | |
| Orvagil (Serbia) | |
| Orvagil D (Serbia) | |
| Oshnor M | |
| Oshnor M 400+600 Tablet (Oshin Laboratories Pvt. Ltd.) | $ 0.07 |
| Osigyl N | |
| Osigyl N 30 ml Suspension (Osho Pharma Pvt.Ltd.) | $ 0.02 |
| Osigyl N 60 ml Suspension (Osho Pharma Pvt.Ltd.) | $ 0.02 |
| Osigyl N Syrup | |
| Osigyl N Syrup 30 ml Syrup (Osho Pharma Pvt.Ltd.) | $ 0.05 |
| Osihex (India) | |
| Osihex 0.2% INJ / 100ml (Osper Pharmaceutics Pvt. Ltd.) | $ 0.46 |
| 0.2 % x 100ml (Osper Pharmaceutics Pvt. Ltd.) | $ 0.46 |
| Osihex Mouth/Throat 100 ml Mouth Wash/Gargle (Osper Pharmaceutics Pvt. Ltd.) | $ 0.46 |
| OSIHEX mouthwash 0.2 % x 100ml (Osper Pharmaceutics Pvt. Ltd.) | $ 0.46 |
| Ostar Antimicrobial Hand Soap | |
| Liquid; Topical; Chlorhexidine Gluconate 2% | |
| Otrozol (Ecuador, Mexico) | |
| Injectable; Injection; Metronidazole 5 mg / ml (Pisa) | |
| Otsol (Bangladesh) | |
| Ovazol-V (Mexico) | |
| Ovufem (Argentina) | |
| Ovufen (Argentina) | |
| Oxalic M | |
| Oxalic M 60 ml Suspension (Aronex Life Sciences Pvt. Ltd.) | $ 0.04 |
| Padet (Argentina) | |
| Padet 0.75% (Argentina) | |
| Padet 1% (Argentina) | |
| Panazole (Philippines) | |
| Panazole / vial 5 mg/1 mL x 100 mL | |
See 3954 substitutes for Orex-M | |
References
- DailyMed. "BISMUTH SUBCITRATE POTASSIUM; METRONIDAZOLE; TETRACYCLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "CHLORHEXIDINE GLUCONATE; ISOPROPYL ALCOHOL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "chlorhexidine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Orex-M are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Orex-M. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yet1 consumer reported age
| Users | % | ||
|---|---|---|---|
| < 1 | 1 | 100.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
