What is Osmovist 190?
There are many brands and forms of povidone Osmovist 190 topical available. Not all brands are listed on this leaflet.
Osmovist 190 is used on the skin to treat or prevent skin infection in minor cuts, scrapes, or burns. Osmovist 190 is also used in a medical setting to help prevent infection and promote healing in skin wounds, pressure sores, or surgical incisions.
Some forms of povidone Osmovist 190 topical are used inside the mouth to provide temporary relief of minor mouth pain or irritation, sore throat, or canker sore pain.
Osmovist 190 may also be used for purposes not listed in this medication guide.
Osmovist 190 indications
Intramuscular
Osmovist 190 deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Osmovist 190): Up to 45 yr: 380 mg Osmovist 190, as single IM doses to provide adequate protection from Osmovist 190 deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Osmovist 190 each yr.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Osmovist 190): 380 mg Osmovist 190, as single IM doses to provide adequate protection from Osmovist 190 deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Osmovist 190, as iodised oil (480 mg/ml Osmovist 190).
Oral
Grave's disease
Child: Neonates: 1 drop of strong Osmovist 190 solution every 8 hr.
Oral
Radiation protection against radioactive Osmovist 190
Adult: As potassium iodide: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.
Child: As potassium iodide: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.
Oral
Preoperative reduction of vascularity of the thyroid gland
Adult: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.
Child: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Osmovist 190 solution: 0.1-0.3 ml (or approx 3-5 drops) tid.
Oral
Cutaneous or lymphocutaneous sporotrichosis
Adult: As potassium iodide solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.
Child: As potassium iodide: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.
Oral
Thyroid storm
Adult: As potassium iodide: Up to 500 mg every 4 hr.
Oral
Osmovist 190 deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Osmovist 190): 400 mg Osmovist 190 once yrly. Pregnant patient: 200 mg Osmovist 190 as a single dose. Moderate to severe: 300-480 mg Osmovist 190 each yr or 100-300 mg Osmovist 190 every 6 mth and for at least 1 yr postpartum.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Osmovist 190): Infants up to 1 yr: Single dose of 100 mg Osmovist 190; 1-5 yr: 200 mg Osmovist 190; >6 yr: 400 mg Osmovist 190.
Topical/Cutaneous
Cleaning wet ulcers and wounds
Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
Topical/Cutaneous
Minor, superficial skin wounds
Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
How should I use Osmovist 190?
Use exactly as directed on the label, or as prescribed by your doctor.
Osmovist 190 is available in many different forms, such as a liquid, ointment, aerosol powder, cream, spray, swab, and soap. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Always follow directions on the medicine label about using this medicine on a child. Some forms of povidone Osmovist 190 topical should not be used in children of certain ages.
Osmovist 190 is usually applied to the skin as needed. First clean the area to be treated.
Shake Osmovist 190 spray well just before each use.
Allow the medicine to dry completely on the skin before applying a bandage. Do not apply a tight bandage.
Do not use this medicine on deep wounds, puncture wounds, animal bites, or serious burns. Do not apply over large skin areas.
When treating an infection, you may be given antibiotic medication to take by mouth. Use all medicines for the full prescribed length of time, even if your symptoms quickly improve.
Osmovist 190 used in the mouth may be used up to 4 times per day. How often you can use this medicine depends on what form you use. Follow all directions on the medicine label.
Do not use Osmovist 190 in the mouth if you are using a form that is made for use only on the skin.
To use Osmovist 190 spray in the mouth, spray directly into the mouth or throat. Leave the medicine in place for 15 seconds, then spit it out. Avoid swallowing the spray. Use once every 2 hours as needed.
To use Osmovist 190 as a mouth rinse, gargle or swish the liquid for 30 seconds, then spit it out. Do not swallow the liquid. Use up to 4 times per day.
You should not use Osmovist 190 for longer than 7 days without medical advice.
Call your doctor if your sore throat is severe or ongoing after 2 days, or if you also have a high fever, headache, nausea, and vomiting.
If you are using Osmovist 190 on your skin, seek medical advice if you have new or worsening symptoms of pain, redness, swelling, rash, or fever.
Store at room temperature away from moisture and heat. Do not freeze.
Each Osmovist 190 swab is for one use only.
Osmovist 190 can stain skin, teeth, and fabric. You may use rubbing alcohol to remove staining from your skin. Avoid getting alcohol onto a wound or irritated skin. Stains on fabric can be removed by rinsing with ammonia diluted with water. Avoid getting the medicine on jewelry, especially silver.
Osmovist 190 spray is flammable. Do not use near high heat or open flame. Do not smoke until the gel has completely dried on your skin.
Uses of Osmovist 190 in details
Use: Labeled Indications
Used topically as an antiseptic in the management of minor, superficial skin wounds and has been used to disinfect the skin preoperatively
Osmovist 190 description
Osmovist 190 as oral and topical/cutaneous formulations is prescribed for the treatment of Osmovist 190 deficiency disorders, pre-operative reduction of vascularity of thyroid glands, protection against radioactive Osmovist 190, cutaneous or lymphocutaneous sporotrichosis, Grave’s disease, cleaning of minor or superficial wounds, thyroid storm and cleaning of wet wounds and ulcers.
Osmovist 190 dosage
Oral
Preoperative reduction of vascularity of the thyroid gland
Adult: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery.
Child: As potassium iodide: 50-250 mg (approx 1-5 drops of a solution containing 1 g/ml) tid for 10-14 days before surgery. As strong Osmovist 190 solution: 0.1-0.3 ml (or approx 3-5 drops) tid.
Reconstitution: Administer potassium iodide oral solution in a large quantity (240 ml) of water, or in fruit juice, milk formula or broth.
Oral
Grave's disease
Child: Neonates: 1 drop of strong Osmovist 190 solution every 8 hr.
Oral
Radiation protection against radioactive Osmovist 190
Adult: As potassium iodide: 100-150 mg 24 hr before procedure and daily for up to 10 days after procedure.
Child: As potassium iodide: Infants from birth to 1 mth with a predicted thyroid exposure of ≥5 centigrays (cGy): 16 mg. >1 mth to 3 yr with a predicted thyroid exposure of ≥5 cGy: 32 mg. >3 yr to 18 yr (except adolescents approaching adult size) with a predicted thyroid exposure of ≥5 cGy: 65 mg. Do not exceed once-daily doses.
Reconstitution: 130-mg Tablet: Place 1 tablet in a small bowl and pulverise using a metal spoon. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 6.25 mg potassium iodide per 5 ml. 65-mg Tablet: Place 1 tablet in a small bowl and pulverise. Add 20 ml of water to the powder and mix until the powder dissolves. Then add 20 ml of the selected drink and mix. Resulting concentration: 8.125 mg potassium iodide per 5 ml.
Oral
Cutaneous or lymphocutaneous sporotrichosis
Adult: As potassium iodide solution containing 1 g/mL: Initially, 1 mL tid, should continue for at least 1 mth after disappearance or stabilisation of the lesions.
Child: As potassium iodide: Initially, 250 mg (approx 5 drops of a solution containing 1 g/ml) tid. Max: 1.25-2 g (approx 25-40 drops) tid. Duration: 3-6 mth.
Reconstitution: Administer potassium iodide solution in a large quantity (240 ml) of water, fruit juice, milk formula or broth.
Oral
Osmovist 190 deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Osmovist 190): 400 mg Osmovist 190 once yrly. Pregnant patient: 200 mg Osmovist 190 as a single dose. Moderate to severe: 300-480 mg Osmovist 190 each yr or 100-300 mg Osmovist 190 every 6 mth and for at least 1 yr postpartum.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Osmovist 190): Infants up to 1 yr: Single dose of 100 mg Osmovist 190; 1-5 yr: 200 mg Osmovist 190; >6 yr: 400 mg Osmovist 190.
Oral
Thyroid storm
Adult: As potassium iodide: Up to 500 mg every 4 hr.
Intramuscular
Osmovist 190 deficiency disorders
Adult: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Osmovist 190): Up to 45 yr: 380 mg Osmovist 190, as single IM doses to provide adequate protection from Osmovist 190 deficiency for up to 3 yr. Pregnant patient: Moderate to severe: 480 mg Osmovist 190 each yr.
Child: As iodised oil (poppyseed/peanut/rapeseed oil containing about 38% w/w or 480 mg/ml of Osmovist 190): 380 mg Osmovist 190, as single IM doses to provide adequate protection from Osmovist 190 deficiency for up to 3 yr. Infants up to 1 yr: 190 mg Osmovist 190, as iodised oil (480 mg/ml Osmovist 190).
Topical/Cutaneous
Minor, superficial skin wounds
Adult: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
Child: As 2% or 2.5% solution/ointment: Apply small amount to the affected area 1-3 times daily.
Topical/Cutaneous
Cleaning wet ulcers and wounds
Adult: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
Child: As 0.9% topical gel: Apply to clean wound. Max: 50 g/application and 150 g/wk. Change dressing about 3 times/wk and reduce applications as exudate decreases. Do not use for >3 mth and stop treatment when wound is free of exudate.
Osmovist 190 interactions
See also:
What other drugs will affect Osmovist 190?
There is a potential risk of interaction with lithium, resulting in an increased possibility of hypothyroidism.
this medicineshould not be used concomitantly with mercurial antiseptics, e.g. mercurochrome and thiomersal.
Since Osmovist 190 may be absorbed systemically, the result of tests of the thyroid function can be influenced.
Osmovist 190 side effects
See also:
What are the possible side effects of Osmovist 190?
Osmovist 190 and iodides, whether applied topically or given systemically, can give rise to hypersensitivity reactions which may include urticaria, angioedema, cutaneous haemorrhage or purpuras, fever, arthralgia, lymphadenopathy, and eosinophilia.
Inhalation of Osmovist 190 vapour is very irritating to mucous membranes.
Osmovist 190 and iodides have variable effects on the thyroid and can produce goitre and hypothyroidism as well as hyperthyroidism (the Iod-Basedow or Jod-Basedow phenomenon). Goitre and hypothyroidism have also occurred in infants born to mothers who had taken iodides during pregnancy.
Prolonged use may lead to a range of adverse effects, often called ’iodism’, some of which may again be due to hypersensitivity. Adverse effects include metallic taste, increased salivation, burning or painful mouth; there may be acute rhinitis, coryza-like symptoms, and swelling and inflammation of the throat. Eyes may be irritated and swollen and there may be increased lachrymation. Pulmonary oedema, dyspnoea, and bronchitis may develop. Skin reactions include acneform or, more rarely, severe eruptions (iododerma). Other reported effects include depression, insomnia, impotence, headache, and gastrointestinal disturbances, notably nausea, vomiting, and diarrhoea.
Osmovist 190 contraindications
Allergy to Osmovist 190,
- Class III patients with Okuda
- Extrahepatic metastases,
- Respiratory or renal insufficiencies severe
- Cons-indications for hepatic arteriography,
- Leukopenia below 1500/mm3 or thrombocytopenia less 50000/mm3,
- Pregnant woman: Osmovist 190 should not be administered to pregnant women. In women of childbearing age, suspicion of pregnancy must be excluded before the administration of Osmovist 190. Contraception must be instituted and prosecuted in the administration at least a year.
- Breastfeeding: Breastfeeding should be stopped.
Active ingredient matches for Osmovist 190:
| Unit description / dosage (Manufacturer) | Price, USD |
| Injectable; Intrathecal; Iodine / Iotrolan 40.6% | |
List of Osmovist 190 substitutes (brand and generic names): | |
| Osmovist 300 | |
| Injectable; Intrathecal; Iodine / Iotrolan 300 mg / ml | |
| P.V.P. Iodine Life | |
| Solution; Topical; Iodine 10% | |
| PA Iodo (Japan) | |
| Par Glycerol (United States) | |
| Pariodex | |
| Liquid; Topical; Iodine / Povidone-Iodine 1% | |
| Pencare | |
| Liquid; Topical; Ammonium Lauryl Sulfate Iodine Complex 5.5% | |
| Phyderm | |
| Liquid; Topical; Iodine 1% | |
| Pose-Iodophore (Thailand) | |
| Premise Disinfectant Liquid | |
| Liquid; Disinfectant / Barn; Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex 1.75% | |
| Liquid; Disinfectant / Food Premises; Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex 1.75% | |
| Prepodyne (Japan) | |
| Liquid; Topical; Iodine / Poloxamer Iodine Complex 1% | |
| Prepodyne 0.75% (Japan) | |
| Prepodyne 1% (Japan) | |
| Prepodyne Concentrate | |
| Liquid; Topical; Iodine / Polyethoxy Polypropoxy Polyethoxy Ethanol - Iodine Complex 5% | |
| Prepodyne Scrub | |
| Liquid; Topical; Iodine / Poloxamer Iodine Complex 6.35% | |
| ProActive (United Kingdom) | |
| Proactive Plus 0,15% (Belgium) | |
| Proviodine Ovules | |
| Suppositories; Vaginal; Iodine / Potassium Iodide 25 mg | |
| QuarterMate (United Kingdom) | |
| Liquid; Teat-Dip; Iodine / Hydriodic Acid - Iodine Complex 0.25% | |
| R-Gen | |
| Rapidyne | |
| Liquid; Disinfectant / Food Premises; Disinfectant / Medical Instruments; Iodine / Polyethoxy Polypropoxy Polyethoxy Ethanol - Iodine Complex 25% | |
| Ready To Use Iodine Kilco (United Kingdom) | |
| Rolderme No. 1 | |
| Liquid; Topical; Iodine 1% | |
| Roma-Nol (United States) | |
| Roztwor wodny jodu (Poland) | |
| Rx Plus (India) | |
| Rx Plus Carbohydrate 2.78 g, lysine 5mg, zinc 5 mg, vitamin B2 0.75mg, vitamin B6 0.5 mg, iodine38 mcg, copper 25 mcg, selenium 10 mcg, vitamin B12 5mcg, vitamin A 1250 IU, vitamin D3 100 IU, vitamin E2.5 IU, vitamin B5 1.25 mg, vitamin B1 0.75 mg, vitamin B (IPCA) | $ 0.96 |
| Rx Plus Carbohydrate 2.78 g, lysine 5mg, zinc 5 mg, vitamin B2 0.75mg, vitamin B6 0.5 mg, iodine38 mcg, copper 25 mcg, selenium 10 mcg, vitamin B12 5mcg, vitamin A 1250 IU, vitamin D3 100 IU, vitamin E2.5 IU, vitamin B5 1.25 mg, vitamin B1 0.75 mg, vitamin B (IPCA) | $ 0.96 |
| Rx Plus Carbohydrate 2.78 g, lysine 5mg, zinc 5 mg, vitamin B2 0.75mg, vitamin B6 0.5 mg, iodine38 mcg, copper 25 mcg, selenium 10 mcg, vitamin B12 5mcg, vitamin A 1250 IU, vitamin D3 100 IU, vitamin E2.5 IU, vitamin B5 1.25 mg, vitamin B1 0.75 mg, vitamin B (IPCA) | $ 0.96 |
| Rx Plus Carbohydrate 2.78 g, lysine 5mg, zinc 5 mg, vitamin B2 0.75mg, vitamin B6 0.5 mg, iodine38 mcg, copper 25 mcg, selenium 10 mcg, vitamin B12 5mcg, vitamin A 1250 IU, vitamin D3 100 IU, vitamin E2.5 IU, vitamin B5 1.25 mg, vitamin B1 0.75 mg, vitamin B (IPCA) | $ 0.96 |
| Rx Plus Carbohydrate 2.78 g, lysine 5mg, zinc 5 mg, vitamin B2 0.75mg, vitamin B6 0.5 mg, iodine38 mcg, copper 25 mcg, selenium 10 mcg, vitamin B12 5mcg, vitamin A 1250 IU, vitamin D3 100 IU, vitamin E2.5 IU, vitamin B5 1.25 mg, vitamin B1 0.75 mg, vitamin B (IPCA) | $ 0.96 |
| Rx Plus Carbohydrate 2.78 g, lysine 5mg, zinc 5 mg, vitamin B2 0.75mg, vitamin B6 0.5 mg, iodine38 mcg, copper 25 mcg, selenium 10 mcg, vitamin B12 5mcg, vitamin A 1250 IU, vitamin D3 100 IU, vitamin E2.5 IU, vitamin B5 1.25 mg, vitamin B1 0.75 mg, vitamin B (IPCA) | $ 0.96 |
| RX PLUS syr 200ml (IPCA) | $ 0.96 |
| Rx Plus Carbohydrate 2.78 g, lysine 5mg, zinc 5 mg, vitamin B2 0.75mg, vitamin B6 0.5 mg, iodine38 mcg, copper 25 mcg, selenium 10 mcg, vitamin B12 5mcg, vitamin A 1250 IU, vitamin D3 100 IU, vitamin E2.5 IU, vitamin B5 1.25 mg, vitamin B1 0.75 mg, vitamin B (IPCA) | $ 0.96 |
| Rx Plus Carbohydrate 2.78 g, lysine 5mg, zinc 5 mg, vitamin B2 0.75mg, vitamin B6 0.5 mg, iodine38 mcg, copper 25 mcg, selenium 10 mcg, vitamin B12 5mcg, vitamin A 1250 IU, vitamin D3 100 IU, vitamin E2.5 IU, vitamin B5 1.25 mg, vitamin B1 0.75 mg, vitamin B (IPCA) | $ 0.96 |
| Rx Plus Carbohydrate 2.78 g, lysine 5mg, zinc 5 mg, vitamin B2 0.75mg, vitamin B6 0.5 mg, iodine38 mcg, copper 25 mcg, selenium 10 mcg, vitamin B12 5mcg, vitamin A 1250 IU, vitamin D3 100 IU, vitamin E2.5 IU, vitamin B5 1.25 mg, vitamin B1 0.75 mg, vitamin B (IPCA) | $ 0.96 |
| San Iode | |
| Liquid; Disinfectant / Food Premises; Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex 1% | |
| Saniline | |
| Liquid; Disinfectant / Food Premises; Iodine / Nonyl Phenoxypoly Ethoxy Ethanol - Iodine Complex 11.25% | |
| Silkidip (United Kingdom) | |
| Siolan C Iodine Injection | |
| Siolan C Iodine Injection (Albert David Limited) | $ 0.01 |
| Sol-Jod (Italy) | |
| Solucio Iodi Spirituosa 5% (Georgia) | |
| Solunet 1 Brosse | |
| Liquid; Topical; Iodine / Povidone-Iodine 0.75% | |
See 433 substitutes for Osmovist 190 | |
References
- PubChem. "Iodine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Iodine". http://www.drugbank.ca/drugs/DB05382 (accessed September 17, 2018).
- DTP/NCI. "iodine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
