Ospen indications
Oral
Streptococcal infections of the upper respiratory tract, including scarlet fever and erysipelas
Adult: 125-250 mg 6-8 hrly for 10 days.
Oral
Fusospirochetosis (Vincent's infection) of the oropharynx, Staphylococcal infections of the skin and soft tissue
Adult: 250-500 mg 6-8 hrly.
Oral
Pneumococcal infections of the respiratory tract, including otitis media
Adult: 250-500 mg 6 hrly until the patient is afebrile for at least 2 days.
Child: <1 yr 62.5 mg 6 hrly; 1-5 yr 125 mg 6 hrly; 6-12 yr 250 mg 6 hrly.
Oral
Prophylaxis of recurrent rheumatic fever
Adult: 250 mg bid.
Child: <1 yr 62.5 mg 6 hrly; 1-5 yr 125 mg 6 hrly; 6-12 yr 250 mg 6 hrly.
Oral
Susceptible infections
Adult: 250-500 mg 6 hrly.
Child: <1 yr 62.5 mg 6 hrly; 1-5 yr 125 mg 6 hrly; 6-12 yr 250 mg 6 hrly.
Ospen description
Ospen (Penicillin V) is narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (S. agalactiae), S. viridans, and Enterococcus faecalis. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as Bacillus anthracis, Corynebacterium diphtheriae, and Erysipelothrix rhusiopathiae. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by Neisseria meningitidis and Pasteurella. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
Ospen dosage
Adults: 250-500 mg every 6 hrs.
Children: Suggested dosage for infants and children is 50 mg/kg body weight/day in 4 divided doses. To be given every 6 hrs.
Children 7-12 years: 5-10 mL (1-2 tsp) of Ospen 250 mg/5 mL; 3-6 years: 5-10 mL (1-2 tsp) of Ospen 125 mg/5 mL or 5 mL (1 tsp) of Ospen 250 mg/5 mL; 1-2 years: 5 mL (1 tsp) of Ospen 125 mg/5 mL or 2.5-5 mL of Ospen 250 mg/5 mL.
Usual duration of therapy is from 10-14 days. Or as prescribed by the physician.
Ospen interactions
Ospen should not be combined with bacteriostatic antibiotics. Combinations with other antibiotics should be considered if their effects can be expected to be synergistic or at least additive. The combination partners should be fully dosed. (Exception: In combination with a proven synergistic action, the dose of the more toxic combination partner may be reduced.) Competitive inhibition of drug elimination should be remembered, whenever anti-inflammatories, antirheumatics, antipyretics (particularly indomethacin, phenylbutazone, salicylates in high doses) or probenecid are used concomitantly. Ingestion of Ospen with meals reduce the absorption of the drug. Like other antibiotics, Ospen may reduce the efficacy of oral contraceptives. During treatment with Ospen non-enzymatic urinary glucose tests and uribilinogen tests may be false-positive. Urinary amino acid quantitations with ninhydrin may also be false-positive.
Ospen side effects
Ospen may produce diarrhoea, nausea and heartburn. Allergic reactions which may include exfoliative dermatitis, other skin rashes, interstitial nephritis and vasculitis, may occur.
A generalised sensitivity reaction with urticaria, fever, joint pains and eosinophilia can develop within a few hours to several weeks after starting treatment. Superinfection by resistant species, such as Pseudomonas or Candida, which do not respond to penicillin therapy may occur. A sore mouth and a black hairy tongue have been reported.
Increases in liver enzyme values have been reported. Care should be taken when high doses are given to patients with renal impairment (because of the risk of neurotoxicity) or congestive heart failure.
Renal and haematological systems should be monitored during prolonged and high dose therapy.
Care should be taken when treating patients with syphilis, as the Jarisch-Herxheimer reaction may occur shortly after starting treatment. This reaction, manifesting as fever, chills, headache and reactions at the site of the lesion, can be dangerous in cardiovascular syphilis or where there is a serious risk of increased local damage such as with optic atrophy.
Haemolytic anaemia and leucopenia, prolongation of bleeding time and defective platelet function have been observed. Convulsions and other signs of toxicity to the CNS may occur particularly in patients with renal failure.
Disturbances of blood electrolytes may follow the administrations of large doses of this medicine.
High doses should be used with caution in patients receiving potassium containing medicines or potassium-sparing diuretics.
Ospen contraindications
Ospen should not be given to patients known to be allergic to penicillin and should be given with care to patients with a history of allergy to cephalosporins. Cases of cross sensitivity have been reported. It should not be given to babies, in the neonatal period, born of hypersensitive mothers. It is not recommended for chronic, severe or deep-seated infections such as subacute bacterial endocarditis, meningitis or syphilis.
Active ingredient matches for Ospen:
Phenoxymethylpenicillin in Austria, Bahrain, Bosnia & Herzegowina, Costa Rica, Cyprus, Czech Republic, Dominican Republic, El Salvador, Estonia, Georgia, Greece, Guatemala, Hungary, Indonesia, Jordan, Kuwait, Latvia, Lebanon, Lithuania, Nicaragua, Oman, Panama, Poland, Qatar, Romania, Russian Federation, Saudi Arabia, Singapore, Slovakia, Slovenia, Sudan, Switzerland, Tunisia, United Arab Emirates, Yemen.
Benzathine Phenoxymethylpenicillin
Benzathine phenoxymethylpenicillin or phenoxymethylpenicillin potassium in Switzerland, Germany, Austria, Singapore, Malaysia, Greece, Hungary, Czech Republic, Venezuela, Poland, Indonesia, Romania.
Phenoxymethylpenicillin K in Hongkong.
Phenoxymethylpenicillin potassium in Hong Kong.
| Unit description / dosage (Manufacturer) | Price, USD |
| Suspension; Oral; Penicillin V Potassium 400, 000 IU / 5 ml | |
| Suspension; Oral; Penicillin V Potassium 750, 000 IU / 5 ml | |
| Syrup; Oral; Penicillin V Potassium 400, 000 IU / 5 ml | |
| Syrup; Oral; Penicillin V Potassium 750, 000 IU / 5 ml | |
| Tablet, Film-Coated; Oral; Penicillin V Potassium 1, 000, 000 IU | |
| Tablet, Film-Coated; Oral; Penicillin V Potassium 1, 500, 000 IU | |
| Tablet, Film-Coated; Oral; Penicillin V Potassium 500, 000 IU | |
| Ospen 250 mg x 10 x 10's | $ 15.10 |
| Ospen 625 mg x 10 x 10's | $ 29.76 |
| Ospen 250 mg/5 mL x 60 mL x 1's | $ 3.76 |
| Ospen 250 mg x 1000's | |
| Ospen 625 mg x 1000's | |
| Ospen 1 MIU x 1000's | |
| Ospen 1 MIU x 100 Blister x 10 Tablet | |
| Ospen 1 MIU x 12 Tablet | |
| Ospen 1 MIU x 30 Tablet | |
List of Ospen substitutes (brand and generic names): | |
| Ospaine 500 | |
| Ospen 1 000 000 NE (Bulgaria, Hungary) | |
| Ospen 1 500 000 NE (Bulgaria, Hungary) | |
| Ospen 1000 (Austria, Switzerland, Uruguay) | |
| Ospen 1500 (Austria, Switzerland) | |
| Ospen 250mg | |
| Ospen 400 (Austria, Switzerland, Uruguay) | |
| Ospen 400 000 NE/5 ml (Bulgaria, Hungary) | |
| Ospen 500 000 NE (Bulgaria, Hungary) | |
| Ospen 750 (Austria, Switzerland) | |
| Ospen 750 000 NE/5 ml (Hungary) | |
| Ospen K (Croatia (Hrvatska)) | |
| Ospen Krka (Czech Republic) | |
| Ospenine 500 | |
| Oxybion (India) | |
| OXYBION syr 200ml (Shinto Biotec) | $ 0.99 |
| P-Cillin V (Thailand) | |
| P-Cillin V 400000 IU x 1's | |
| P-Cillin V 200000 IU/5 mL x 1's | |
| P-Mega-Tablinen (Germany) | |
| Tablet; Oral; Penicillin V Potassium | |
| Pancillin (Denmark, Serbia) | |
| Tablet, Film-Coated; Oral; Penicillin V 1, 000, 000 IU (Sandoz) | |
| Tablet, Film-Coated; Oral; Penicillin V 1, 500, 000 IU (Sandoz) | |
| Tablet, Film-Coated; Oral; Penicillin V 500, 000 IU (Sandoz) | |
| Pen Mega-1A Pharma (Germany) | |
| Pen Oral (Argentina) | |
| Pen V Atlantic (Thailand) | |
| Pen V General Drugs House (Thailand) | |
| Pen V General Drugs House 400000 u x 100's (General Drugs House) | |
| Pen V General Drugs House 400000 u x 1, 000's (General Drugs House) | |
| Pen V General Drugs House 200000 u x 500's (General Drugs House) | |
| Pen V General Drugs House 200000 u x 60 mL (General Drugs House) | |
| Pen V General Drugs House cap 400000 u 100's (General Drugs House) | |
| Pen V General Drugs House cap 400000 u 1000's (General Drugs House) | |
| Pen V General Drugs House dry syr 200000 u 60 mL x 1's (General Drugs House) | |
| Pen V General Drugs House tab 200000 u 500's (General Drugs House) | |
| Pen V General Drugs House tab 400000 u 100's (General Drugs House) | |
| Pen V General Drugs House tab 400000 u 1000's (General Drugs House) | |
| Pen V Utopian (Thailand) | |
| Pen V Utopian 62.5 mg/5 mL x 60 mL | |
| Pen V Utopian 125 mg/5 mL x 60 mL | |
| Pen vee K (Colombia) | |
| Pen vee K Sandoz (Colombia) | |
| Pen-C (Bangladesh) | |
| Pen-Os (Turkey) | |
| Pen-Rafa (Israel) | |
| Pen-Rafa Forte (Israel) | |
See 333 substitutes for Ospen | |
Reviews
The results of a survey conducted on ndrugs.com for Ospen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Ospen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
3 consumers reported useful
Was the Ospen drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
| Users | % | ||
|---|---|---|---|
| Useful | 3 | 100.0% | |
2 consumers reported price estimates
Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?The below mentioned numbers have been reported by ndrugs.com website users about whether the Ospen drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
| Users | % | ||
|---|---|---|---|
| Not expensive | 2 | 100.0% | |
11 consumers reported time for results
To what extent do I have to use Ospen before I begin to see changes in my health conditions?As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Ospen. To get the time effectiveness of using Ospen drug by other patients, please click here.
| Users | % | ||
|---|---|---|---|
| 1 day | 3 | 27.3% | |
| 5 days | 2 | 18.2% | |
| 1 week | 2 | 18.2% | |
| > 3 month | 2 | 18.2% | |
| 2 days | 1 | 9.1% | |
| 1 month | 1 | 9.1% | |
54 consumers reported age
| Users | % | ||
|---|---|---|---|
| 1-5 | 13 | 24.1% | |
| 16-29 | 12 | 22.2% | |
| 6-15 | 11 | 20.4% | |
| 30-45 | 9 | 16.7% | |
| 46-60 | 4 | 7.4% | |
| > 60 | 3 | 5.6% | |
| < 1 | 2 | 3.7% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
