Papain/Pepsin/Sanzyme Uses

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Consists of Papain, Pepsin, Sanzyme

Papain indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Papain consists chiefly of a mixture of papain and chymopapain, proteolytic enzymes that hydrolyse polypeptides, amides, and esters, especially at bonds involving basic amino acids, or leucine or glycine, yielding peptides of lower molecular weight. It is used with urea as a topical debriding agent. It is also used for the removal of protein deposits from the surface of soft contact lenses ().

Preparations of papain, alone or combined with antibacterial agents and/or other substances, have been taken by mouth for their supposed anti-inflammatory properties, and it has also been used as an ingredient of various mixtures claimed to aid digestion.

Papain is widely used as a meat tenderiser and in the clarification of beverages.

Malignant neoplasms.

Papain has been included in proteolytic enzyme preparations used in oncology to reduce the adverse effects of chemotherapy and radiotherapy. Although the number of clinical studies on which to judge efficacy is limited, a review1 of such studies suggested that systemic enzyme therapy might be beneficial. Clinical studies have used a preparation containing papain, trypsin, and chymotrypsin in a weight ratio of 5:2:2, and the beneficial effect seems to be based on its anti-inflammatory potential.

Papain dosage

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Chew or suck 2 tab qds for the 1st day, then 1 tab qds for at least 5 days.

Papain interactions

Anti-coagulants.

Papain side effects

Hypersensitivity reactions have occurred.

Effects on the eyes.

Ocular and periorbital angioedema occurring within 4 hours of use of a contact lens cleansing solution containing papain has been reported.1

Extensive destruction of the oesophageal wall, with perforation, resulted from the use of a papain suspension given to treat an obstruction caused by impacted meat.1 The patient had been given 1.2 g of papain over a 12-hour period. Ten days after a thoracotomy, the descending thoracic aorta ruptured, and she died from haemorrhage.

Papain contraindications

Patients w/ generalised or systemic infections or w/ disorders of blood coagulation.

Pepsin indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

dyspepsia without hyperacidity, oral vehicle

Pepsin description

Diastase + Pepsin is indicated as a digestive aid and for the treatment of acid indigestion, sour stomach, flatulence, epigastric distress, dyspepsia, eructation and to increase appetite.

Active ingredient matches for Papain/Pepsin/Sanzyme:

Papain/Pepsin/Sanzyme


References

  1. PubChem. "Pepsin". https://pubchem.ncbi.nlm.nih.gov/sub... (accessed September 17, 2018).
  2. PubChem. "PAPAIN". https://pubchem.ncbi.nlm.nih.gov/sub... (accessed September 17, 2018).
  3. DrugBank. "Pepsin - DrugBank". http://www.drugbank.ca/drugs/DB13198 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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