Paracetamol Uses

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How times a day do you take this medicine?

What is Paracetamol?

Paracetamol (Paracetamol) is a pain reliever and a fever reducer. The exact mechanism of Paracetamol of is not known.

Paracetamol is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. It relieves pain in mild arthritis but has no effect on the underlying inflammation and swelling of the joint.

Paracetamol may also be used for other purposes not listed in this medication guide.

Paracetamol indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, Paracetamol or Paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of Paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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For systemic use of Paracetamol Sante Naturelle: prevention and treatment of hypo- and avitaminosis of vitamin C; providing increased need for vitamin C during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.

For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.

How should I use Paracetamol?

Use Paracetamol exactly as directed on the label, or as prescribed by your doctor.

Do not use more of this medication than is recommended. An overdose of Paracetamol can cause serious harm. The maximum amount for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Using more Paracetamol could cause damage to your liver. If you drink more than three alcoholic beverages per day, talk to your doctor before taking Paracetamol and never use more than 2 grams (2000 mg) per day. If you are treating a child, use a pediatric form of Paracetamol. Carefully follow the dosing directions on the medicine label. Do not give the medication to a child younger than 2 years old without the advice of a doctor.

Measure the liquid form of Paracetamol with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. You may need to shake the liquid before each use. Follow the directions on the medicine label.

The Paracetamol chewable tablet must be chewed thoroughly before you swallow it.

Make sure your hands are dry when handling the Paracetamol disintegrating tablet. Place the tablet on your tongue. It will begin to dissolve right away. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

To use the Paracetamol effervescent granules, dissolve one packet of the granules in at least 4 ounces of water. Stir this mixture and drink all of it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

Do not take a Paracetamol rectal suppository by mouth. It is for use only in your rectum. Wash your hands before and after inserting the suppository.

Try to empty your bowel and bladder just before using the Paracetamol suppository. Remove the outer wrapper from the suppository before inserting it. Avoid handling the suppository too long or it will melt in your hands.

For best results from the suppository, lie down and insert the suppository pointed tip first into the rectum. Hold in the suppository for a few minutes. It will melt quickly once inserted and you should feel little or no discomfort while holding it in. Avoid using the bathroom just after inserting the suppository.

Stop using Paracetamol and call your doctor if:

  • you still have a fever after 3 days of use;

  • you still have pain after 7 days of use (or 5 days if treating a child);

  • you have a skin rash, ongoing headache, or any redness or swelling; or

  • if your symptoms get worse, or if you have any new symptoms.

Urine glucose tests may produce false results while you are taking Paracetamol. Talk to your doctor if you are diabetic and you notice changes in your glucose levels during treatment.

Store Paracetamol at room temperature away from heat and moisture. The rectal suppositories can be stored at room temperature or in the refrigerator.

Uses of Paracetamol in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.

How to use Paracetamol

Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

There are many brands and forms of Paracetamol available. Read the dosing instructions carefully for each product because the amount of Paracetamol may be different between products. Do not take more Paracetamol than recommended.

If you are giving Paracetamol to a child, be sure you use a product that is meant for children. Use your child's weight to find the right dose on the product package. If you don't know your child's weight, you can use their age.

For suspensions, shake the medication well before each dose. Some liquids do not need to be shaken before use. Follow all directions on the product package. Measure the liquid medication with the provided dose-measuring spoon/dropper/syringe to make sure you have the correct dose. Do not use a household spoon.

For rapidly-dissolving tablets, chew or allow to dissolve on the tongue, then swallow with or without water. For chewable tablets, chew thoroughly before swallowing.

Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

For effervescent tablets, dissolve the dose in the recommended amount of water, then drink.

Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.

Do not take this medication for fever for more than 3 days unless directed by your doctor. For adults, do not take this product for pain for more than 10 days (5 days in children) unless directed by your doctor. If the child has a sore throat (especially with high fever, headache, or nausea/vomiting), consult the doctor promptly.

Tell your doctor if your condition persists or worsens or if you develop new symptoms. If you think you may have a serious medical problem, get medical help right away.

Paracetamol description

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Paracetamol is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Paracetamol exists as small alkaline deliquescent crystals with a saline tasteacinol was introduced to medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successfulacinol was first introduced as an anthelmintic in 1953. A large number of piperazine compounds have anthelmintic Paracetamol. Their mode of Paracetamol is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism.

Paracetamol dosage

Usual Adult Paracetamol Dose for Fever:

General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally.

Paracetamol 500mg tablets: Two 500 mg tablets orally every 4 to 6 hours

Usual Adult Paracetamol Dose for Pain:

General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally.

Paracetamol 500mg tablets: Two 500 mg tablets orally every 4 to 6 hours

Usual Pediatric Dose for Fever:

Oral or Rectal:

<=1 month: 10 to 15 mg/kg/dose every 6 to 8 hours as needed.

>1 month to 12 years: 10 to 15 mg/kg/dose every 4 to 6 hours as needed (Maximum: 5 doses in 24 hours)

Fever: 4 months to 9 years: Initial Dose: 30 mg/kg (Reported by one study (n=121) to be more effective in reducing fever than a 15 mg/kg maintenance dose with no difference regarding clinical tolerance.)

>=12 years: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours.

Usual Pediatric Dose for Pain:

Oral or Rectal:

<=1 month: 10 to 15 mg/kg/dose every 6 to 8 hours as needed.

>1 month to 12 years: 10 to 15 mg/kg/dose every 4 to 6 hours as needed (Maximum: 5 doses in 24 hours)

Fever: 4 months to 9 years: Initial Dose: 30 mg/kg (Reported by one study (n=121) to be more effective in reducing fever than a 15 mg/kg maintenance dose with no difference regarding clinical tolerance.)

>=12 years: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours.

Paracetamol interactions

See also:
What other drugs will affect Paracetamol?

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With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic Paracetamol of Paracetamol.

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of Paracetamol.

With the simultaneous use of oral contraceptives accelerated excretion of Paracetamol from the body and may reduce its analgesic Paracetamol.

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of Paracetamol.

When Paracetamol Guardian applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with Paracetamol. A case of severe toxic liver injury.

Described cases of toxic effects of Paracetamol, while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of Paracetamol, which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of Paracetamol and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of Paracetamol may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of Paracetamol and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of Paracetamol, with rifampicin, sulfinpyrazone - may increase clearance of Paracetamol due to increasing its metabolism in the liver.

At simultaneous application of Paracetamol Guardian with ethinylestradiol increases absorption of Paracetamol from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

Paracetamol side effects

See also:
What are the possible side effects of Paracetamol?

Effects due to the presence of acetylsalicylic acid.

Accidents awareness with respiratory or skin reactions (angioedema, urticaria, asthma, anaphylactic shock);

Cross hypersensitivity reactions with NSAIDs and with tartrazine;

At low doses recommended for the use of Paracetamol, side effects of aspirin are generally limited to some irritation of the gastro-intestinal tract.

At higher doses, side effects include gastrointestinal mucosal erosions, gastric ulcer or duodenal ulcer, occult blood loss, melena.

Acetylsalicylic acid may also increase the tendency to bleeding and bleeding time (the lengthening of bleeding continues 4-6 days after stopping the drug).

It may also worsen renal function including cases of pre-existing condition (the long-term use can cause chronic kidney disease).

The signs of salicylic overdose described under.

Effects due to the presence of Paracetamol.

At the doses and duration of recommended treatment, side effects are usually negligible, but the prolonged use of Paracetamol in therapeutic doses large (2-4 g per day, or 10-20 tablets Paracetamol) may cause the appearance chronic hepatitis. This justifies the recommendations of caution especially in patients with liver disease prior.

Very rarely, it can produce thrombocytopenia.

The acute liver toxicity in overdose massive (doses greater than 8 g of Paracetamol) is described in paragraph overdose.

Paracetamol contraindications

See also:
What is the most important information I should know about Paracetamol?

Paracetamol should not be used in patients who have previously exhibited hypersensitivity to aspirin and/or nonsteroidal antiinflammatory agents. Paracetamol should not be given to patients with a recent history of gastrointestinal bleeding or in patients with bleeding disorders (e.g., hemophilia).

Active ingredient matches for Paracetamol:

Paracetamol


Unit description / dosage (Manufacturer)Price, USD
Syrup; Oral; Acetaminophen 120 mg / 5 ml
Tablet; Oral; Acetaminophen 1 g
Tablet; Oral; Acetaminophen 500 mg
Capsule; Oral; Acetaminophen 500 mg
Tablet, Effervescent; Oral; Acetaminophen 1 g
Tablet, Effervescent; Oral; Acetaminophen 500 mg
Tablet; Oral; Acetaminophen 200 mg
Granules, Effervescent; Oral; Acetaminophen 1000 mg
Tablet; Oral; Acetaminophen 1000 mg
Tablet, Effervescent; Oral; Acetaminophen 1000 mg
Suppositories; Rectal; Acetaminophen 1000 mg
Suppositories; Rectal; Acetaminophen 120 mg
Suppositories; Rectal; Acetaminophen 240 mg
Suppositories; Rectal; Acetaminophen 500 mg
Tablet; Oral; Acetaminophen 100 mg
Suppositories; Rectal; Acetaminophen 250 mg
Suppositories; Rectal; Acetaminophen 125 mg
Suspension; Oral; Acetaminophen
Suspension; Oral; Acetaminophen 200 mg / 5 ml
Tablet; Oral; Acetaminophen
Suspension; Oral; Acetaminophen 120 mg / 5 ml
Drops; Oral; Acetaminophen 100 mg / ml / ml
Syrup; Oral; Acetaminophen 100 mg / 5 ml
Suppositories; Rectal; Acetaminophen 100 mg
Suppositories; Rectal; Acetaminophen 50 mg
Suspension; Oral; Acetaminophen 160 mg / 5 ml
Injectable; Injection; Acetaminophen 10 mg / ml
Tablet; Oral; Acetaminophen 80 mg
Paracetamol / Wah Foo 500 mg
Paracetamol / Kingdom 500 mg
Tablets; Oral; Acetaminophen 1 g
Tablets; Oral; Acetaminophen 500 mg
Capsules; Oral; Acetaminophen 500 mg
Tablets, Effervescent; Oral; Acetaminophen 1 g
Tablets, Effervescent; Oral; Acetaminophen 500 mg
Tablets; Oral; Acetaminophen 200 mg
Tablets; Oral; Acetaminophen 1000 mg
Tablets, Effervescent; Oral; Acetaminophen 1000 mg
Tablets; Oral; Acetaminophen 100 mg
Tablets; Oral; Acetaminophen
Tablets; Oral; Acetaminophen 80 mg

List of Paracetamol substitutes (brand and generic names):

PARACETAMOL TABLET 1 packet / 1000 tablets each (Cadila Pharmaceuticals Ltd)$ 2.98
PARACETAMOL 125MG/5ML SYRUP 1 bottle / 60 ML syrup each (Jan Aushadhi)$ 0.40
PARACETAMOL TABLET 1 strip / 10 tablets each (Wings Pharmaceuticals Pvt Ltd)$ 0.05
PARACETAMOL 250MG DS SYRUP 1 bottle / 60 ML syrup each (Jan Aushadhi)$ 0.16
Paracetamol 325 F.T Pharma 10 Packs x 2 g
PARACETAMOL 500MG TABLET 1 strip / 10 tablets each (Jan Aushadhi)$ 0.11
Paracetamol 500mg Tablet (Jagsonpal Pharmaceuticals Ltd)$ 0.07
PARACETAMOL 650MG TABLET 1 strip / 10 tablets each (Jan Aushadhi)$ 0.13

References

  1. DailyMed. "ACETAMINOPHEN; ASPIRIN; CAFFEINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "acetaminophen". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "acetaminophen". http://www.drugbank.ca/drugs/DB00316 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Paracetamol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Paracetamol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported useful

Was the Paracetamol drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Useful1
100.0%


4 consumers reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Paracetamol drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Expensive2
50.0%
Not expensive2
50.0%


6 consumers reported time for results

To what extent do I have to use Paracetamol before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes > 3 month and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Paracetamol. To get the time effectiveness of using Paracetamol drug by other patients, please click here.
Users%
> 3 month2
33.3%
3 days2
33.3%
2 weeks1
16.7%
1 week1
16.7%


15 consumers reported age

Users%
30-453
20.0%
6-153
20.0%
16-293
20.0%
< 12
13.3%
1-52
13.3%
> 601
6.7%
46-601
6.7%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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