Perclin Uses

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What is Perclin?

Benzoyl Peroxide (Perclin) and Clindamycin (Perclin) combination is used to treat acne. It works by killing the bacteria that cause acne and by keeping the skin pores clean (tiny openings on the skin).

This medicine is available only with your doctor's prescription.

Perclin indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Perclin Gel is indicated for the topical treatment of mild to moderate acne vulgaris, particularly inflammatory lesions, in adults and adolescents aged 12 years and above.

Perclin description

Perclin gel contains Clindamycin (Perclin) (as 1.2% Clindamycin (Perclin) phosphate) at a concentration equivalent to 1% w/w (10 mg/g) and Benzoyl Peroxide (Perclin) 5% w/w (50 mg/g).

Excipients/Inactive Ingredients: Carbomer (50000 mPa·s), Dimeticone (100 mm2·s-1), Disodium Lauryl Sulfosuccinate, Disodium Edetate, Glycerol, Silica, Colloidal Hydrated, Poloxamer 182, Purified Water, Sodium Hydroxide.

Perclin dosage

For cutaneous use only.

Adults and Adolescents (aged 12 years and above): Perclin Gel should be applied once daily in the evening, to the entire affected area.

Patients should be advised that excessive application will not improve efficacy, but may increase the risk of skin irritation. If excessive dryness or peeling occurs, frequency of application should be reduced or application temporarily interrupted.

An effect on inflammatory and non-inflammatory lesions may be seen as early as week 2-5 of treatment.

The safety and efficacy of Perclin Gel has not been studied beyond 12 weeks in acne vulgaris clinical trials. Treatment with Perclin Gel should not exceed more than 12 weeks of continuous use.

Paediatric Population: The safety and efficacy of Perclin Gel has not been established in children under 12 years of age, therefore Perclin Gel is not recommended for use in this population.

Elderly Patients: No specific recommendations.

Administration: Perclin Gel should be applied in a thin film after washing gently with a mild cleanser and fully drying. If the gel does not rub into the skin easily, too much is being applied.

Hands should be washed after application.

Perclin interactions

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No formal drug-drug interaction studies have been performed with Perclin Gel.

Concomitant topical antibiotics, medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol and/or astringents, should be used with caution as a cumulative irritant effect may occur.

Perclin Gel should not be used in combination with erythromycin-containing products due to possible antagonism to the Clindamycin (Perclin) component.

Clindamycin (Perclin) has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore caution should be exercised with concomitant use.

Concomitant application of Perclin Gel with tretinoin, isotretinoin and tazarotene should be avoided since Benzoyl Peroxide (Perclin) may reduce their efficacy and increase irritation. If combination treatment is required, the products should be applied at different times of the day (e.g. one in the morning and the other in the evening).

Using topical Benzoyl Peroxide (Perclin)-containing preparations at the same time as topical sulphonamide-containing products may cause skin and facial hair to temporarily change colour (yellow/orange).

Perclin side effects

See also:
What are the possible side effects of Perclin?

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Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Itching (pruritus)

Dry skin

Skin redness

Skin tingling

The side effects listed above may not include all of the side effects reported by the drug’s manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

Tell your doctor if you do not feel well while

you are using Perclin Gel.

Perclin Gel helps most people with

acne but it may have unwanted side effects in a

few people.

All medicines can have side effects. Sometimes

they are serious, most of the time they are not.

You may need medical treatment if you get some

of these side effects.

The gel may cause slight itching and burning

and make your skin feel warm, especially

when it is first applied. You may also notice

flaking and redness of your skin during the

first few weeks of use. These effects are

normal; if they bother you, try using the

product less often for a while, or stop for a few

days and start again.

If you suffer severe burning, peeling or

itching, or other effects not mentioned in this

leaflet, you should stop using Perclin

Gel and go back to your doctor for advice.

Perclin contraindications

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Perclin Gel must not be administered to patients with known hypersensitivity to Clindamycin (Perclin), lincomycin, Benzoyl Peroxide (Perclin), or any of the excipients in the formulation.

Active ingredient matches for Perclin:

Benzoyl Peroxide/Clindamycin in Argentina.

Benzoyl Peroxide/Clindamycin/Clindamycin phosphate in Argentina.

Permethrin in India.


Unit description / dosage (Manufacturer)Price, USD
5 % x 30g$ 0.87
Perclin 5% CRM / 30g$ 0.87
PERCLIN cream 5 % x 30g (Affy)$ 0.87
Perclin 5% CRM / 30g$ 0.87

List of Perclin substitutes (brand and generic names):

PERDANZA LOTION lotion 5 % w/v x 50ml (Zenon)
Perin 5% w/w LOTION / 50g (Psycorem)$ 0.94
Perin 10mg CRM / 50ml (Psycorem)$ 0.81
Perin 50mg CRM / 30g (Psycorem)$ 0.87
10 mg x 50ml (Psycorem)$ 0.81
50 mg x 30g (Psycorem)$ 0.87
5 % w/w x 50g (Psycorem)$ 0.94
PERIN 1% CREAM 1 tube / 50 GM cream each (Psycorem)$ 0.86
PERIN 5% CREAM 1 tube / 30 GM cream each (Psycorem)$ 0.94
PERIN 5% LOTION 1 bottle / 30 ML lotion each (Psycorem)$ 0.94
PERIN cream 10 mg x 50g (Psycorem)$ 0.81
PERIN cream 50 mg x 30g (Psycorem)$ 0.87
PERIN lotion 5 % w/w x 50ml (Psycorem)$ 0.94
Perin 1% 10mg CRM
Perin 1% Cream (Psycormedies)$ 0.86
Perin 5% 50mg CRM
Perin 5% Cream (Psycormedies)$ 0.94
Perin 5% Lotion (Psycormedies)$ 0.94
PERITOP 5%W/W CREAM 1 tube / 30 GM cream each (Monichem Healthcare Pvt Ltd)$ 0.93
PERITOP 5% W/W LOTION 1 bottle / 60 ML lotion each (Monichem Healthcare Pvt Ltd)$ 1.12
Peritop 5% w/w Lotion (Monichem Healthcare Pvt Ltd)$ 1.12
Peritop 5% w/v Cream (Monichem Healthcare Pvt Ltd)$ 0.93
Perlice 10mg/g CRM / 60g (Galderma)$ 1.13
10 mg x 1 g x 60g (Galderma)$ 1.13
PERLICE 1% W/W CREAM 1 tube / 30 GM cream each (Galderma)$ 0.97
PERLICE RINSE CREAM 1 tube / 60 GM cream each (Galderma)$ 2.08
PERLICE cream 10 mg x 1 g x 60g (Galderma)$ 1.58
Perlice 1%w/w Cream (Galderma)$ 2.08
PERLICE CREME per RINSE Liquid Liquid / 1/ % / 60g units (Galderma India)$ 0.84
Perlut 5%w/w CREAM / 30gm$ 0.89
Perlut 1% soap / 75GM$ 0.86
Perlut 5%w/w CRM / 30gm$ 0.89
5 % w/w x 30g (Nidus)$ 0.87
Permanid 5% w/w CRM / 30g (Nidus)$ 0.87
PERMANID cream 5 % w/w x 30g (Nidus)$ 0.84
PERMANID lotion 5 % w/v x 50ml (Nidus)$ 0.84
Permanid 5% w/w CRM / 30g (Nidus)$ 0.87
Permarid 5% LOTION / 30g (Micro Gratia)$ 0.94
Permarid 5% CRM / 30g (Micro Gratia)$ 0.92

References

  1. DailyMed. "PERMETHRIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "BENZOYL PEROXIDE; ERYTHROMYCIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "BENZOYL PEROXIDE". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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