What is Phenoleptil 25 mg für Hunde?
Phenoleptil 25 mg für Hunde is in a group of drugs called barbiturates (bar-BIT-chur-ates). Phenoleptil 25 mg für Hunde slows the activity of your brain and nervous system.
Phenoleptil 25 mg für Hunde is used to treat or prevent seizures. It is also used short-term to treat insomnia, or as a sedative before surgery.
Phenoleptil 25 mg für Hunde may also be used for purposes not listed in this medication guide.
Phenoleptil 25 mg für Hunde indications
Parenteral
- Sedative. Sedation is obtainable within an hour, and in adequate dosage, the duration of action is more than six hours. Included in the more common conditions in which the sedative action of this class of drugs is desired are anxiety-tension states, hyperthyroidism, essential hypertension, nausea and vomiting of functional origin, motion sickness, acute labyrinthitis, pylorospasm in infants, chorea and cardiac failure. Phenoleptil 25 mg für Hunde is also a useful adjunct in treatment of hemorrhage from the respiratory or gastrointestinal tract. Phenoleptil 25 mg für Hunde controls anxiety, decreases muscular activity and lessens nervous excitability in hyperthyroid patients. However, thyrotoxic individuals occasionally react poorly to barbiturates.
- Hypnotic, for the short-term treatment of insomnia, since it appears to lose its effectiveness for sleep induction and sleep maintenance after 2 weeks.
- Preanesthetic.
- Long-term anticonvulsant, (Phenoleptil 25 mg für Hunde, mephobarbital and metharbital) for the treatment of generalized tonic-clonic and cortical focal seizures. And, in the emergency control of certain acute convulsive episodes, e.g., those associated with status epilepticus, cholera, eclampsia, cerebral hemorrhage, meningitis, tetanus, and toxic reactions to strychnine or local anesthetics. Phenoleptil 25 mg für Hunde sodium may be administered intramuscularly or intravenously as an anticonvulsant for emergency use. When administered intravenously, it may require 15 or more minutes before reaching peak concentrations in the brain. Therefore, injecting Phenoleptil 25 mg für Hunde sodium until the convulsions stop may cause the brain level to exceed that required to control the convulsions and lead to severe barbiturate-induced depression.
- Phenoleptil 25 mg für Hunde is indicated in pediatric patients as an anticonvulsant and as a sedative, including its preoperative and postoperative use.
How should I use Phenoleptil 25 mg für Hunde?
Use Phenoleptil 25 mg für Hunde as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Phenoleptil 25 mg für Hunde is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Phenoleptil 25 mg für Hunde at home, a health care provider will teach you how to use it. Be sure you understand how to use Phenoleptil 25 mg für Hunde. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Phenoleptil 25 mg für Hunde if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Do not suddenly stop using Phenoleptil 25 mg für Hunde or change the dose without checking with your doctor.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Phenoleptil 25 mg für Hunde, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Phenoleptil 25 mg für Hunde.
Uses of Phenoleptil 25 mg für Hunde in details
This medication is used alone or with other medications to control seizures. Controlling and reducing seizures lets you do more of your normal daily activities, reduces your risk of harm when you lose consciousness, and lessens your risk for a possibly life-threatening condition of frequent, repeated seizures. Phenoleptil 25 mg für Hunde belongs to a class of drugs known as barbiturate anticonvulsants/hypnotics. It works by controlling the abnormal electrical activity in the brain that occurs during a seizure. This medication is also used for a short time (usually no more than 2 weeks) to help calm you or help you sleep during periods of anxiety. It works by affecting certain parts of the brain to cause calming.
How to use Phenoleptil 25 mg für Hunde
Take this medication by mouth with or without food, usually once daily at bedtime for seizure control, or as directed by your doctor. Take with food or milk if stomach upset occurs. If you are using the liquid form of this medication, measure the dose carefully using a special measuring device/cup. Do not use a household spoon because you may not get the correct dose.
Dosage is based on your medical condition, Phenoleptil 25 mg für Hunde blood levels, and response to treatment. The dosage in children may also be based on weight.
Your doctor may direct you to start this medication at a low dose and gradually increase your dose to prevent side effects such as drowsiness and dizziness. Follow your doctor's instructions carefully. Do not take more or less of this drug than prescribed.
It may take several weeks to reach the best dose for you and completely control your seizures. This medication works best when the amount of drug in your body is kept at a constant level. Therefore, take it at the same time(s) each day.
Do not stop taking this medication (and other anticonvulsant medications) without consulting your doctor. Your seizures may worsen or cause a very severe seizure that is difficult to treat (status epilepticus) when this drug is suddenly stopped.
This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as anxiety, hallucinations, twitching, trouble sleeping) may occur if you suddenly stop using this medication. Withdrawal from Phenoleptil 25 mg für Hunde can be severe and include seizures and (rarely) death. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.
Along with its benefits, this medication may rarely cause abnormal drug-seeking behavior (addiction). This risk may be increased if you have abused alcohol or drugs in the past. Take this medication exactly as prescribed to lessen the risk of addiction.
When this medication is used for a long time for anxiety or to help you sleep, it may not work as well. Phenoleptil 25 mg für Hunde should only be used for a short time for anxiety or sleep. Talk with your doctor if this medication stops working well.
Tell your doctor if your anxiety or seizure control worsens (such as the number of seizures increases).
Phenoleptil 25 mg für Hunde description
A barbiturate that is metabolized to Phenoleptil 25 mg für Hunde. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over Phenoleptil 25 mg für Hunde.
Phenoleptil 25 mg für Hunde dosage
Suggested doses of Phenoleptil 25 mg für Hunde for specific indications are as follows:
a. Pediatric
Oral Dosage (as recommended by the American Academy of Pediatrics):
Preoperative: 1 to 3 mg/kg.
b. Adult
Oral
Dosage:
Dosages of Phenoleptil 25 mg für Hunde must be individualized with full knowledge of their particular characteristics and recommended rate of administration. Factors of consideration are the patient's age, weight, and condition.
Parenteral routes should be used only when oral administration is impossible or impractical.
Anticonvulsant use: A therapeutic anticonvulsant level of Phenoleptil 25 mg für Hunde in serum is 10 to 25 µg/mL. To achieve the blood levels considered therapeutic in children, higher per-kilogram dosages are generally necessary for Phenoleptil 25 mg für Hunde and most other anticonvulsants. In children and infants, Phenoleptil 25 mg für Hunde at loading dose of 15 to 20 mg/kg produces blood levels of about 20 µg/mL shortly after administration.
In status epilepticus, it is imperative to achieve therapeutic blood levels of Phenoleptil 25 mg für Hunde as rapidly as possible. Because a barbiturate-induced depression may occur along with a postictal depression once the seizures are controlled, it is important, therefore, to use the minimal amount required, and to wait for the anticonvulsant effect to develop before administering a second dose.
Phenoleptil 25 mg für Hunde has been used in the treatment and prophylaxis of febrile seizures. However, it has not been established that prevention of febrile seizures influences the subsequent development of epilepsy.
Special patient population: Dosage should be reduced in the elderly or debilitated because these patients may be more sensitive to Phenoleptil 25 mg für Hunde. Dosage should be reduced for patients with impaired renal function or hepatic disease.
How supplied
Oral Tablets
15 mg - Each white round tablet imprinted Þ 026 contains 15 mg of Phenoleptil 25 mg für Hunde. Tablets are supplied in bottles of 1000 (NDC 0228-2026-96).
30 mg - Each white, round, scored tablet imprinted Þ 028 contains 30 mg of Phenoleptil 25 mg für Hunde. Tablets are supplied in bottles of 1000 (NDC 0228-2028-96).
100 mg - Each white, round, scored tablet imprinted Þ 030 contains 100 mg of Phenoleptil 25 mg für Hunde. Tablets are supplied in bottles of 1000 (NDC 0228-2030-96).
Dispense in well-closed containers as defined in the USP. Store at controlled room temperature 15º- 30º C (59º- 86º F).
Oral Elixir
Red, clear elixir contains 20 mg of Phenoleptil 25 mg für Hunde per teaspoon (5 ml). Alcohol 13% by volume. Elixir is supplied in pints (NDC 0228-2024-16).
Preserve and dispense in tight, light- resistant containers as defined in the USP. Store at controlled room temperature 15º- 30ºC (59º- 86º F).
Rx only.
Phenoleptil 25 mg für Hunde interactions
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What other drugs will affect Phenoleptil 25 mg für Hunde?
Most reports of clinically significant drug interactions occurring with the barbiturates have involved Phenoleptil 25 mg für Hunde.
1. Anticoagulants: Phenoleptil 25 mg für Hunde lowers the plasma levels of dicumarol (name previously used: bishydorxycoumarin) and causes a decrease in anticoagulant activity as measured by the prothrombin time. Phenoleptil 25 mg für Hunde can induce hepatic microsomal enzymes resulting in increased metabolism and decreased anticoagulant response of oral anticoagulants (e.g., warfarin, acenocournarol, dicumarol, and phenprocoumon). Patients stabilized on anticoagulant therapy may require dosage adjustments if Phenoleptil 25 mg für Hunde is added to or withdrawn from their dosage regimen.
2. Corticosteroids: Phenoleptil 25 mg für Hunde appears to enhance the metabolism of exogenous corticosteroids probably through the induction of hepatic microsomal enzymes. Patients stabilized on corticosteroid therapy may require dosage adjustments if Phenoleptil 25 mg für Hunde is added to or withdrawn from their dosage regimen.
3. Griseofulvin: Phenoleptil 25 mg für Hunde appears to interfere with the absorption of orally administered griseofulvin, thus decreasing its blood level. The effect of the resultant decreased blood levels of griseofulvin on therapeutic response has not been established. However, it would be preferable to avoid concomitant administration of these drugs.
4. Doxycycline: Phenoleptil 25 mg für Hunde has been shown to shorten the half- life of doxycycline for as long as 2 weeks after barbiturate therapy is discontinued. This mechanism is probably through the induction of hepatic microsomal enzymes that metabolize the antibiotic. If Phenoleptil 25 mg für Hunde and doxycycline are administered concurrently, the clinical response to doxycycline should be monitored closely.
5. Phenytoin, sodium valproate, valproic acid: The effect of Phenoleptil 25 mg für Hunde on the metabolism of phenytoin appears to be variable. Some investigators report an accelerating effect, while others report no effect. Because the effect of Phenoleptil 25 mg für Hunde on the metabolism of phenytoin is not predictable, phenytoin and Phenoleptil 25 mg für Hunde blood levels should be monitored more frequently if these drugs are given concurrently. Sodium valproate and valproic acid appear to decrease Phenoleptil 25 mg für Hunde metabolism; therefore, Phenoleptil 25 mg für Hunde blood levels should be monitored and appropriate dosage adjustments made as indicated.
6. Central nervous system depressants: The concomitant use of other central nervous system depressants including other sedatives or hypnotics, antihistamines, tranquilizers, or alcohol, may produce additive depressant effects.
7. Monoamine oxidase inhibitors (MAOIs): MAOIs prolong the effects of Phenoleptil 25 mg für Hunde probably because metabolism of the Phenoleptil 25 mg für Hunde is inhibited.
8. Estradiol, estrone, progesterone and other steroidal hormones: Pretreatment with or concurrent administration of Phenoleptil 25 mg für Hunde may decrease the effect of estradiol by increasing its metabolism. There have been reports of patients treated with antiepileptic drugs (e.g., Phenoleptil 25 mg für Hunde) who became pregnant while taking oral contraceptives. An alternate contraceptive method might be suggested to women taking Phenoleptil 25 mg für Hunde.
Phenoleptil 25 mg für Hunde side effects
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What are the possible side effects of Phenoleptil 25 mg für Hunde?
The following adverse reactions and their incidence were compiled from surveillance of thousands of hospitalized patients.
- Nervous system: Somnolence.
- Nervous system: Agitation, confusion, hyperkinesia, ataxia, CNS depression, nightmares, nervousness, psychiatric disturbance, hallucinations, insomnia, anxiety, dizziness, thinking abnormality.
- Respiratory system: Hypoventilation, apnea.
- Cardiovascular system: Bradycardia, hypotension, syncope.
- Digestive system: Nausea, vomiting, constipation.
- Other reported reactions: Headache, injection site reactions, hypersensitivity reactions (angioedema skin rashes, exfoliative dermatitis), fever, liver damage, megaloblastic anemia following chronic Phenoleptil 25 mg für Hunde use.
DRUG ABUSE AND DEPENDENCE
Symptoms of acute intoxication with Phenoleptil 25 mg für Hunde include unsteady gait, slurred speech, and sustained nystagmus. Mental signs of chronic intoxication include confusion, poor judgment, irritability, insomnia, and somatic complaints.
Symptoms of Phenoleptil 25 mg für Hunde dependence are similar to those of chronic alcoholism. If an individual appears to be intoxicated with alcohol to a degree that is radically disproportionate to the amount of alcohol in his or her blood, the use of barbiturates should be suspected. The lethal dose of a barbiturate is far less if alcohol is also ingested. The symptoms of Phenoleptil 25 mg für Hunde withdrawal can be severe and may cause death. Minor withdrawal symptoms may appear 8 to 12 hours after the last dose of Phenoleptil 25 mg für Hunde. These symptoms usually appear in the following order: anxiety, muscle twitching, tremor of hands and fingers, progressive weakness, dizziness, distortion in visual perception, nausea, vomiting, insomnia, and orthostatic hypotension. Major withdrawal symptoms (convulsions and delirium) may occur within 16 hours and last up to 5 days after abrupt cessation of this drug. Intensity of withdrawal symptoms gradually declines over a period of approximately 15 days. Individuals susceptible to Phenoleptil 25 mg für Hunde abuse and dependence include alcoholics and opiate abusers, as well as other sedative- hypnotic and amphetamine abusers.
Drug dependence on Phenoleptil 25 mg für Hunde arises from repeated administration of the barbiturate or an agent with barbiturate- like effect on a continuous basis, generally in amounts exceeding therapeutic dose levels. The characteristics of drug dependence on Phenoleptil 25 mg für Hunde include: (a) a strong desire or need to continue taking the drug, (b) a tendency to increase the dose, (c) a psychic dependence on the effects of the drug related to subjective and individual appreciation of those effects, and (d) a physical dependence on the effects of the drug requiring its presence for maintenance of homeostasis and resulting in a definite, characteristic, and self-limited abstinence syndrome when the drug is withdrawn.
Treatment of Phenoleptil 25 mg für Hunde dependence consists of cautious and gradual withdrawal of the drug. One method involves substituting a 30 mg dose of Phenoleptil 25 mg für Hunde for each 100 to 200 mg dose that the patient has been taking. The total daily amount of Phenoleptil 25 mg für Hunde is then administered in 3 to 4 divided doses, not to exceed 600 mg daily. Should signs of withdrawal occur on the first day of treatment, a loading dose of 100 to 200 mg of Phenoleptil 25 mg für Hunde may be administered IM in addition to the oral dose. After stabilization on Phenoleptil 25 mg für Hunde, the total daily dose is decreased by 30 mg a day as long as withdrawal is proceeding smoothly. A modification of this regimen involves initiating treatment at the patient's regular dosage level and decreasing the daily dosage by 10 percent if tolerated by the patient.
Infants physically dependent on Phenoleptil 25 mg für Hunde may be given a lower dose of Phenoleptil 25 mg für Hunde at 3 to 10 mg/kg/day. After withdrawal symptoms (hyperactivity, disturbed sleep, tremors, hyperreflexia) are relieved, the dosage of Phenoleptil 25 mg für Hunde should be gradually decreased and completely withdrawn over a 2-week period.
Phenoleptil 25 mg für Hunde contraindications
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What is the most important information I should know about Phenoleptil 25 mg für Hunde?
Do not use Phenoleptil 25 mg für Hunde if you are pregnant. It could harm the unborn baby. Phenoleptil 25 mg für Hunde may also cause addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy.
Phenoleptil 25 mg für Hunde can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Phenoleptil 25 mg für Hunde.
Phenoleptil 25 mg für Hunde may cause a severe allergic reaction. Stop taking Phenoleptil 25 mg für Hunde and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Do not stop using Phenoleptil 25 mg für Hunde without first talking to your doctor, even if you feel better. You may have increased seizures if you stop using Phenoleptil 25 mg für Hunde suddenly. You will need to use less and less before you stop the medication completely.
Some people using this medicine have engaged in activity such as driving, eating, or making phone calls and later having no memory of the activity. If this happens to you, stop taking Phenoleptil 25 mg für Hunde and talk with your doctor about another treatment for your sleep disorder.
Phenoleptil 25 mg für Hunde may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it.
Active ingredient matches for Phenoleptil 25 mg für Hunde:
Phenobarbital in Austria.
List of Phenoleptil 25 mg für Hunde substitutes (brand and generic names) | Sort by popularity |
Unit description / dosage (Manufacturer) | Price, USD |
Phenoleptil Chiens (Belgium) | |
Phenoluric | |
Phenolurio | |
Phenomav (Australia) | |
Phenomav 100mg for Dogs (Australia) | |
Phenomav 30mg for Dogs (Australia) | |
Phenomet (India) | |
60ml (Bennet) | $ 0.23 |
Phenomet Paracetamol 250 mg, Promethazine hydrochloride 5mg. SUSP / 60ml (Bennet) | $ 0.23 |
PHENOMET oral susp 60ml (Bennet) | $ 0.23 |
Phenomet Syrup (Bennet) | $ 0.28 |
Phenonyl | |
Phenoral (Netherlands) | |
Phenoral 100 mg (Netherlands) | |
Phenoral 12.5 mg voor honden (Netherlands) | |
Phenoral 25 mg (Netherlands) | |
Phenoral 50 mg voor honden (Netherlands) | |
Phenoson (Bangladesh) | |
Phenotal (Thailand) | |
Phenotal 20 mg/5 mL x 30 mL (Asian Pharm) | $ 0.18 |
Phenotal 20 mg/5 mL x 60 mL (Asian Pharm) | $ 0.36 |
Phenotal 20 mg/5 mL x 4 L (Asian Pharm) | $ 15.15 |
Phenotal syr 20 mg/5 mL 4 L x 1's (Asian Pharm) | $ 15.15 |
Phenotal syr 20 mg/5 mL 30 mL x 1's (Asian Pharm) | $ 0.18 |
Phenotal syr 20 mg/5 mL 60 mL x 1's (Asian Pharm) | $ 0.36 |
Phenoturic | |
Phenovet (United Kingdom) | |
Liquid; Disinfectant / Food Premises; Disinfectant / Hospital / Healthcare Facilities; Clorophene 11%; O-Phenylphenol 9%; P-Tert-Pentylphenol 2.25% | |
Phental (Indonesia) | |
Phental / amp 100 mg/1 mL x 1's | |
Phenyletten | |
Phenyral | |
Phob | |
PMS-Phenobarbital (Canada) | |
Tablet; Oral; Phenobarbital 100 mg | |
Tablet; Oral; Phenobarbital 15 mg | |
Tablet; Oral; Phenobarbital 30 mg | |
Tablet; Oral; Phenobarbital 60 mg | |
Tablets; Oral; Phenobarbital 100 mg | |
Tablets; Oral; Phenobarbital 15 mg | |
Tablets; Oral; Phenobarbital 30 mg | |
Tablets; Oral; Phenobarbital 60 mg | |
PMS-Phenobarbital Elixir | |
Elixir; Oral; Phenobarbital 5 mg / ml | |
Polcominal | |
Promptonal | |
Rhea Phenobarbital (Philippines) | |
Rhea Phenobarbital 15 mg x 100's (Philusa) | $ 3.19 |
Rhea Phenobarbital 30 mg x 100's (Philusa) | $ 4.06 |
See 775 substitutes for Phenoleptil 25 mg für Hunde |
References
- PubChem. "phenobarbital". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "phenobarbital". http://www.drugbank.ca/drugs/DB01174 (accessed September 17, 2018).
- DTP/NCI. "phenobarbital: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology